Mucopolysaccharides,
Qualitative, Urine
Test Includes: Chondroitin sulfates A/C, dermatan sulfate,
heparan sulfate, keratan sufate.
Availability: Mon. - Fri., 0800 - 1700
Turnaround Time: 7 - 10 days.
Minimum Volume: 10.0 mL.
Specimen Handling: Random urine, morning specimen preferred. Refrigerate or freeze without
preservative.
Interpretive Reference Range: Subjective interpretation
based on results of screening tests and, if
indicated, separation of mucopolysaccharides by thin layer chromatography.
Use: Diagnosis of mucopolysaccharidoses (Hurler, Hunter,
Sanfilippo, Maroteaux-Lamy and Morquio
syndromes), b-glucuronidase
deficiency and multiple sulfatase deficiency.
Limitations: Screening tests may be normal in Sanfilippo
and Morquio syndromes.
Methodology: Alcian blue and acid albumin screening tests;
thin layer chromatography if necessary.
Additional Information: Specific enzyme assays may be
required for accurate diagnosis.
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Page updated 11/9/2009
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