Organic
Acid Screen, Urine
Test Includes: All nonamino organic acids.
Availability: Mon. - Fri., 0800 - 1700
Turnaround Time: 5 - 7 days.
Minimum Volume: 2.0 mL.
Secimen Handling: Random urine, morning specimen preferred. Refrigerate or freeze without
preservative.
Interpretive Reference Range: Subjective interpretation
based on identity and pattern of
organic acids.
Use: Diagnosis of organic acidemias.
Methodology: Gas chromatography with peak identification by gas chromatography-mass
spectrometry if indicated.
Additional Information: A variety of inherited disorders
result in organic aciduria. These include
maple syrup urine disease, propionic acidemia, methylmalonic acidemia, glutaric acidemia and isovaleric
acidemia. Indications for organic acid screening include acute disease in infancy, especially if associated
with acidosis, hyperammonemia or hypoglycemia; Reye's syndrome; syndrome of ataxia, alopecia and
seborrhic rash; progressive or static extrapyramidal movement disorder in childhood; and anion gap
metabolic acidosis.
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Page updated 11/9/2009
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