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 The CNRU Mass Spectrometry Core Facility is equipped for your advanced Proteomics research.
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Metabonomics/Metabolomics in Clinical ResearchAs defined by Nicholson, "metabonomics" describes the global biochemical profile of an organ or organism, while "metabolomics" describes the biochemical profile of an isolated cell (1). Since the global system reflects cellular changes, metabonomics is the sum of all metabolomic changes.As defined by the Metabolomics Society (2), metabolomics is the study of the small molecules, or metabolites, contained in a human cell, tissue or organ (including fluids) and involved in primary and intermediary metabolism. It encompasses metabolomics, metabolite target analysis, metabolite profiling, metabolic fingerprinting, metabolic profiling, and metabonomics (work done specifically using NMR technology). However you define it, the CNRU Mass Spectrometry Core Facility assists researchers by developing assays and providing quantitative mass spectrometry analyses to support both metabonomic and metabolomic projects. We perform assays involving plasma, urine or tissue extracts as well as those employing cell culture medium and cell extracts from cultures of isolated cell types. Our metabonomic and metabolomic assays include: Stable Isotope Enrichment Glucose and Glycerol Analysis Amino Acid Analysis Fatty Acid Analysis Doubly-Labeled Water: Total Energy Expenditure Total Body Water CO2 Enrichment Small Molecule and Hormone Analysis Drug Metabolism/Pharmacokinetics Please follow the links for more information about a particular assay, or contact us. (1) Lindon JC, Holmes E, Nicholson JK., Metabonomics: systems biology in pharmaceutical research and development. Curr Opin Mol Ther. 2004 Jun;6(3):265-72). (2) www.metabolon.com |
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