Stijn P. De Langhe Assistant Professor Cell and Developmental Biology Ph.D., Ghent University (Belgium)/Childrens Hospital Los Angeles, PhD, Biotechnology, 2005 Department of Pediatrics National Jewish Health 1400 Jackson Street, K107 Denver, Colorado 80206 Phone: 303-398-1763 Email: DeLangheS@njc.org

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Departmental Affiliations Dept of Pediatrics, National Jewish Medical and Research Center Cell and Developmental Biology

Research Statement

Our group focuses on lung development, lung regeneration and lung stem cells. We are especially interested in how Wnt and FGF signaling pathways control the differentiation, proliferation and maintenance of several mesenchymally derived cell lineages, in particular the parabronchial smooth muscle cells. For our research, we make extensive use of transgenic and knock out mice.

Selected Publications

De Langhe, S.P., Carraro, G., Tefft, D., Li, C., Xu, X., Chai, Y., Minoo, P., Hajihosseini, M.K., Drouin, J., Kaartinen, V., et al. (2008). Formation and Differentiation of Multiple Mesenchymal Lineages during Lung Development Is Regulated by beta-catenin Signaling. PLoS ONE 3, e1516.

De Langhe, S.P., Carraro, G., Warburton, D., Hajihosseini, M. K., and Bellusci, S. (2006). Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev Biol 299, 52-62.

del Moral,P.M., De Langhe,S.P., Sala,F.G., Veltmaat,J.M., Tefft,D., Wang,K., Warburton,D., and Bellusci,S. (2006). Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung. Dev. Biol. 293, 77-89.

Mailleux,A.A., Kelly,R., Veltmaat,J.M., De Langhe,S.P., Zaffran,S., Thiery,J.P., and Bellusci,S. (2005). Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development 132, 2157-2166.

De Langhe,S.P., Sala,F.G., del Moral,P.M., Fairbanks,T.J., Yamada,K.M., Warburton,D., Burns,R.C., and Bellusci,S. (2005). Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung. Dev. Biol. 277, 316-331.

Latest Publications in PubMed