Glenn Simon Education: University of Delaware, BS Biology, 2003 Thesis Advisor: Rytis Prekeris UC D - Anschutz Medical Campus Mail Stop 8108 12801 East 17th Ave Aurora, CO 80045 Laboratory Phone: 303-724-3410 Email: Glenn.Simon@ucdenver.edu

Research Interest:

The main focus in our laboratory is Rab11 mediated membrane trafficking. We have previously shown that Rab11 interacting protein, Fip3, is required for cytokinesis. My work is on the role Fip3, and its associated small monomeric GTPases Rab11 and Arf6, and how they regulate cytokinesis. Currently I am working to resolve the signals that regulate Fip3 association during mitosis.

General Interests:
I enjoy: spending my time taking my dog to the park, watching the Philadelphia Eagles, making beer, playing powerball and wishing I had a boat. In the winter I ski.

Publications

Simon, G.C., E. Schonteich, C.C. Wu, D. Ekiert, A. Piekny, X. Yu, G.W. Gould, M. Glotzer and R. Prekeris (2008) Sequential Cyk4/MgcRacGAP binding to ECT2 and Rab11-FIP3 regulates cleavage furrow ingression and abscission during cytokinesis. EMBO J. In Press

Simon, G.C., R. Prekeris (2008) The mechanisms regulating targeting of recycling endosomes to the cleavage furrow during cytokinesis. Biochemical Society Transactions. 2008 Jun;36(Pt 3):391-4.

Schonteich E, Pilli M, Simon GC, Matern HT, Junutula JR, Sentz D, Holmes RK, Prekeris R. (2007) Molecular characterization of Rab11-FIP3 binding to ARF GTPases. Eur J Cell Biol. 2007 Aug;86(8):417-31

Westlake CJ, Junutula JR, Simon GC, Pilli M, Prekeris R, Scheller RH, Jackson PK, Eldridge AG. (2007) Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1236-41.

Wilson, G.M., Fielding, A.B., Simon, G., Yu, X., Andrews, P.D., Hames, R.S., Frey, A.M., Peden, A.A., Gould, G.W., and R. Prekeris. The FIP3 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. Mol. Biol. Cell 2005; 16:849-860.

Latest Publications in PubMed