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Research in the area of human disease is a special interest among
the faculty in the Graduate
Program in Cell Biology, Stem Cells and Development. Although all of the
faculty in the program are conducting research that may be relevant
to the basis and treatment of disease, the work of the faculty below
has the most clear and direct connection.
These faculty members are examining the anatomical, cellular and
molecular bases of diseases such as cancer, diabetes, infection,
metabolic disorders, developmental malformations, and disorders
of specific organ systems such as the lung, liver, nervous system
and heart disease. Research approaches include the full range of
biochemical, cell biological, molecular, genetic, physiological
and morphological techniques.
These integrative studies apply a rigorous analysis of fundamental
biological processes to understanding the underpinnings of the disease
state. Determining the underlying origins of human disease can then
be applied to the development of effective therapies.
Human Disease Research Faculty
| Name |
Research Interests |
| Neil Box |
Mouse modeling of ribosomal protein loss |
| David Clouthier |
Signaling pathways regulating craniofacial and cardiovascular development |
| James
Crapo |
Molecular regulation of superoxide
dismutases in lung biology |
| Frank
Frerman |
Biochemistry of electron
transport protein mutations: role in human metabolic disease
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| Robert
Garcea |
Molecular and structural
approaches to polyomavirus assembly |
| Stephen
Goodman |
Biochemistry and genetics
of the human diseases glutaric acidemia types I and II |
| Eva Grayck |
Hypoxia and pulmonary hypertension |
| John
Hutton |
Secretory granule biogenesis
and exocytosis in the endocrine pancreas: role in human diabetes
|
| Peter Koch |
Cell adhesion molecules in embryonic development and diseases |
| Maranke Koster |
Signaling pathways that control epidermal development and differentiation |
| Jan
Kraus |
Molecular basis of inherited
mitochondrial disease |
| Susan Majka |
Mesenchymal stem cells in pulmonary hypertension |
| Margaret
Neville |
Mammary gland biology and
the molecular switch between pregnancy and lactation |
| Lee Niswander |
Genetic mechanisms of limb, lung, and neural development |
| Mary
Reyland |
Role of protein kinase C signaling
in programmed cell death |
| Dennis Roop |
Skin development and disease |
| Pepper Schedin |
Stromal-epithelial interactions in mammary gland development, carcinogenesis and breast cancer prevention |
| Claude
Selitrennikoff |
Mechanisms of fungal wall
assembly; development of antifungal therapy |
| Trevor
Williams |
Transcriptional regulation
of mouse embryonic development and the role of transcription
factors in mammary gland development and breast cancer |
| Virginia Winn |
Human Placental Development,
Preeclampsia Pathogenesis |

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