Graduate Program in Cell and Developmental Biology
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Find out more about these research areas:

Cell Biology
Developmental Biology
Stem Cell Biology
Neuroscience
Molecular Biology
Human Disease



Research in the area of human disease is a special interest among the faculty in the Graduate Program in Cell Biology, Stem Cells and Development. Although all of the faculty in the program are conducting research that may be relevant to the basis and treatment of disease, the work of the faculty below has the most clear and direct connection.

These faculty members are examining the anatomical, cellular and molecular bases of diseases such as cancer, diabetes, infection, metabolic disorders, developmental malformations, and disorders of specific organ systems such as the lung, liver, nervous system and heart disease. Research approaches include the full range of biochemical, cell biological, molecular, genetic, physiological and morphological techniques.

These integrative studies apply a rigorous analysis of fundamental biological processes to understanding the underpinnings of the disease state. Determining the underlying origins of human disease can then be applied to the development of effective therapies.

Human Disease Research Faculty

Name Research Interests
Neil Box Mouse modeling of ribosomal protein loss
David Clouthier Signaling pathways regulating craniofacial and cardiovascular development
James Crapo Molecular regulation of superoxide dismutases in lung biology
Frank Frerman Biochemistry of electron transport protein mutations: role in human metabolic disease
Robert Garcea Molecular and structural approaches to polyomavirus assembly
Stephen Goodman Biochemistry and genetics of the human diseases glutaric acidemia types I and II
Eva Grayck Hypoxia and pulmonary hypertension
John Hutton Secretory granule biogenesis and exocytosis in the endocrine pancreas: role in human diabetes
Peter Koch Cell adhesion molecules in embryonic development and diseases
Maranke Koster Signaling pathways that control epidermal development and differentiation
Jan Kraus Molecular basis of inherited mitochondrial disease
Susan Majka Mesenchymal stem cells in pulmonary hypertension
Margaret Neville Mammary gland biology and the molecular switch between pregnancy and lactation
Lee Niswander Genetic mechanisms of limb, lung, and neural development
Mary Reyland Role of protein kinase C signaling in programmed cell death
Dennis Roop Skin development and disease
Pepper Schedin Stromal-epithelial interactions in mammary gland development, carcinogenesis and breast cancer prevention
Claude Selitrennikoff Mechanisms of fungal wall assembly; development of antifungal therapy 
Trevor Williams Transcriptional regulation of mouse embryonic development and the role of transcription factors in mammary gland development and breast cancer
Virginia Winn Human Placental Development, Preeclampsia Pathogenesis