 |
|
Roslyn Bauer
Education:
University of Denver, MS Biological Sciences, 2002
Colorado State University, BS Microbiology 1997
Honors and Awards:
| • |
Ruth L. Kirschstein National Research Service Award, 2003-04 |
|
|
Research Interests:
The research in the Hutton laboratory is focused on the molecular cell biology, biochemistry and immunology of mechanisms by which insulin is secreted by the pancreatic beta cell. Secretion of insulin occurs by regulated fusion of secretory vesicles with the plasma membrane (exocytosis). The mechanisms that control vesicle movement, both pre- and post-exocytosis, however, are not fully understood. My project focuses on identification of localization signals that regulate the movement of one of the few known vesicle proteins, Phogrin. Specifically, I am looking for how localization signals in the cytoplasmic region of the protein contribute to the kinetics of membrane retrieval and recycling using biochemical methods combined with immunofluorescence and Total Internal Reflectance Fluorescence (TIRF) microscopy.
General Interests:
In my free time I enjoy skiing, hiking, rock climbing, swimming, gardening, photography, and playing the piano.
Publications:
Pores-Fernando AT, Bauer RA, Wurth GA, Zweifach A. Exocytic responses of single leukaemic human cytotoxic T lymphocytes stimulated by agents that bypass the T cell receptor. J Physiol. 2005 Sep 15;567(Pt 3):891-903. Epub 2005 Jul 14.
Overlease RL, Bauer RA, Angleson JK. Retention of peptide hormones during partial secretion in pituitary somatotrophs and corticotrophs. Pflugers Arch. 2005 Feb;449(5):458-62.
Bauer RA, Khera RS, Lieber JL, Angleson JK. Recycling of intact dense core vesicles in neurites of NGF-treated PC12 cells. FEBS Lett. 2004 Jul 30;571(1-3):107-11.
Bauer RA, Overlease RL, Lieber JL, Angleson JK. Retention and stimulus-dependent recycling of dense core vesicle content in neuroendocrine cells. J. Cell Sci. 2004 May 1;117(Pt 11):2193-202.
Maier LA, Sawyer RT, Bauer RA, Kittle LA, Lympany P, Mcgrath D, Dubois R, Daniloff E, Rose CS, Newman LS. High beryllium-stimulated TNF-alpha is associated with the -308 TNF-alpha promoter polymorphism and with clinical severity in chronic beryllium disease. Am. J. Respir. Crit. Care Med. 2001 Oct 1;164(7):1192-9.
Bauer RA, Sawyer RT, Daniloff E, Balkissoon R, Rose CS, Newman LS. Bronchoalveolar lavage macrophage-lymphocyte clusters in granulomatous disease are linked to lymphocytosis. Sarcoidosis Vas. Difuse Lung Dis. 2000 Jun;17(2):174-80.
Latest Publications in PubMed
|
