SUSAN M. JONES, Ph.D

   I am interested in the mechanisms involved in neurodegeneration. Currently, we are examining the role of brain NADPH oxidase in generating superoxide radical in response to the neurotoxin MPP+. We are using an immortalized cell line of rat midbrain dopaminergic cells to examine the signaling pathways leading to ROS production, as well as pathways that may potentially mediate ROS after it is produced. Basic understanding of these processes may yield information about targets for neuroprotective therapies.



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Publications

Grammatopoulos, T.N., Ahmadi, F., Jones, S.M., Fariss, M.W., Weyhenmeyer, J.A. and Zawada, W.M. . Angiotensin II protects cultured midbrain dopaminergic neurons against rotenone-induced cell death. Brain Research (in press).

Cavazos, J.E., Jones, S.M., and Cross, D. J. Sprouting and synaptic reorganization in the subiculum and CA1 region of the hippocampus in acute and chronic models of partial-onset epilepsy. Neuroscience 126:677-688, 2004.

Ahmadi F.A., Linseman D.A., Grammatopoulos T.N., Jones, S.M., Bouchard R.J., Freed C.R., Heidenreich K.A., Zawada W.M. The pesticide rotenone induces caspase-3-mediated apoptosis in ventral mesencephalic dopaminergic neurons. J Neurochem. 87(4):914-21, 2003.

Jones, S.M., Hofmann, A.D., Lieber, J.L. and Ribera, A.B. Overexpression of potassium channel RNA rescues neurons from suppression of morphological differentiation in vitro. J. Neurosci, 15:2867-2874, 1995.

Jones, S.M. and Ribera, A.B. Overexpression of a potassium channel gene perturbs neural differentiation. J. Neurosci. 14:2789-2799, 1994.

Johnson, K.M., Snell, L.D., Sacaan, A.I. and Jones, S.M. Pharmacologic regulation of the NMDA receptor-ionophore complex. In Sigma, PCP and NMDA Receptors, ed. by E.B. De Souza, D. Clouet, and E.D. London, NIDA Res. Monograph Series, pp 13-40, 1993.

Jones, S.M. and Rogawski, M.A. The anticonvulsant (+)-5-aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10,-imine (ADCI) selectively blocks NMDA-activated current in cultured hippocampal neurons under voltage-clamp: kinetic analysis and comparison with MK-801. Mol. Neuropharmacol., 2:303-310, 1992.

Donevan, S.D., Jones, S.M. and Rogawski, M.A. Arcaine blocks N-methyl-D-aspartate receptor responses by an open channel mechanism: whole-cell and single-channel recording studies in cultured hippocampal neurons. Mol. Pharmacol.,41:727-735, 1992.

Rogawski, M.A., Yamaguchi, S-I., Blake, P.A., Jones, S.M., Bieda, M.C., de Costa, B.R. and Thurkauf, A. Anticonvulsant 1-phencycloalkylamine analogs: uncompetitive NMDA antagonists with low motor toxicity. In Multiple Sigma and PCP Receptor Ligands: Mechanisms for Neuromodulation and Neuroprotection?, ed. by J.M. Kamenka and E.F. Domino, pp. 747-758, NPP Books, Ann Arbor, MI, 1992.

Rogawski M.A., Yamaguchi S., Jones, S.M., Rice K.C., Thurkauf A., Monn J.A. Anticonvulsant activity of the low affinity uncompetitive NMDA antagonist 5-aminocarbonyl-5H-dibenzo[a,d]cyclohepten-5,10-imine (ADCI): Comparison with the structural analogs dizolcilpine (MK-801) and carbamazepine. J. Pharmacol. Exp. Therap. 259:30-37, 1991.

Johnson, K.M. and Jones, S.M. Neuropharmacology of phencyclidine: basic mechanisms and therapeutic potential. Ann. Rev. Pharmacol. Toxicol., 30:707-750, 1990.

Jones, S.M. and Johnson, K.M. Effects of amygdaloid kindling on NMDA receptor function and regulation. Exp. Neurol., 106:52-60, 1989.

Jones, S.M., Snell, L.D. and Johnson, K.M. Characterization of the binding of radioligands to the N-methyl-D-aspartate, phencyclidine and glycine receptors in buffy coat membranes. J. Pharmacol. Methods, 21:161-168, 1989.

Ferkany, J.W., Kyle, D.J., Willetts, J., Rzeszotarski, W.J., Guzewska, M.E., Ellenberger, S.R., Jones, S.M., Sacaan, A.I., Snell, L.D., Borosky, S., Jones, B.E., Johnson, K.M., Balster, R.L., Burchett, K., Kawasaki, K., Hoch, D.B. and Dingledine, R. Pharmacological profile of NPC 12626, a novel, competitive N-methyl-D-aspartate receptor antagonist. J. Pharmacol. Exp. Therap. 250:100-109, 1989.

Jones, S.M., Snell, L.D. and Johnson, K.M. Phencyclidine selectively inhibits N-methyl-D-aspartate-induced hippocampal [3H]norepinephrine release. J. Pharmacol. Exp. Therap. 240:492-497, 1987.

Jones, S.M., Snell, L.D. and Johnson, K.M. Inhibition by phencyclidine of excitatory amino acid-stimulated release of neurotransmitter in the nucleus accumbens. Neuropharmacol. 26:173-179, 1987.

Snell, L.D., Jones, S.M. and Johnson, K.M. Inhibition of N-methyl-D-aspartate-induced hippocampal [3H] norepinephrine release by phencyclidine is dependent on potassium concentration. Neurosci. Lett. 78:333-337, 1987.

Scharoun, S.L., Barone, F.C., Wayner, M.J., Jones, S.M. Vagal and gastric connections to the central nervous system determined by the transport of horseradish peroxidase. Brain Res. Bull., 13:573-583, 1984.

Adams, J. and Jones, S.M. Age differences in water maze performance and swimming behavior in the rat. Physiol. and Behav. 33:851-855, 1984.