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Hugo R. Rosen, MD, FACP
Waterman Professor of Medicine and Immunology
Head, Division of Gastroenterology & Hepatology

Education

  • Medical School: University of Miami School of Medicine, 1989
  • Internship/Residency: Beth Israel Deaconess Medical Center, 1989-1992
  • Fellowship: University of California, Los Angeles, 1992-1995
  • Board Certified in Internal Medicine and Gastroenterology

Honors and Awards

  • University of Miami Presidential Academic Scholarship
  • NIH training grant (UCLA)
  • Senator Mark Hatfield Award for Clinical Research
  • American Society of Transplantation Award for Research Excellence in Clinical Science (two times)
  • Guest Editor, Clinics in Liver Disease (four times)
  • Merit Review Award (three times)

Faculty Appointments

  • Portland VA Medical Center
  • Oregon Health & Sciences University, 1995-2005
  • Associate Professor of Medicine, Molecular Biology, and Immunology, 2000-2005
  • Professor of Medicine and Head, Division of Gastroenterology & Hepatology, University of Colorado, July, 2005 - present

Committees and Responsibilities

  • Director, NIH-sponsored Hepatitis C Center Grant
  • Member, NIH Hepatobiliary Study Section
  • Executive Planning Committee, American Society Transplantation
  • Associate Editor, Liver Transplantation 2005-present
  • Board of Directors, American Society Transplantation
  • Board of Directors, Clinical Care Options
  • NIH Action Plan in Liver Disease
  • Chairman, Liver and Intra-abdominal Organs, American Society of Transplant Physicians (developed guidelines for transplant hepatology training)

Clinical Interests:

Hepatitis C, general hepatology and liver transplantation

Research Interests

The focus of our laboratory is to understand the immune response to hepatitis C virus (HCV), particularly the mechanisms associated with spontaneous or therapeutic clearance versus viral persistence. The balance between HCV and host immune response depends on multiple factors such as nature of the infecting virus, route of infection and initial viral burden, genetic background of the individual as well as the immune status of the infected host. The interplay between these parameters ultimately determines the spectrum of possible clinical outcomes associated with viral infection. We currently have 5 federally funded research programs, including a recently awarded NIH HCV Center grant.

Representative Publications

  1. Golden-Mason L, Palmer B, Klarquist J, Mengshol JA, Castelblanco N, Rosen HR. Upregulation of PD-1 expression on circulating and intrhepatic HCV- specific CD8+ T cells associated with reversible immune dysfunction. J Virol. 2007 June 13; [Epub ahead of print]
  2. Golden-Mason L, Castelblanco N, O’Farrelly C, Rosen HR. Phenotypic and functional changes of cytotoxic CD56pos NT cells determine outcome of acute HCV infection. J Virol. 2007 Jun 6; [Epub ahead of print]
  3. Wertheimer AM, Polyak SJ, Leistikow R, Rosen HR. Engulfment of apoptotic cells expressing HCV proteins leads to differential chemokine expression and STAT signaling in human dendritic cells. Hepatology 2007 Jun;45(6):1422-32.
  4. Golden-Mason L, Burton JR Jr., Castelblanco N, Klarquist J, Benlloch S, Wang C, Rosen HR. Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistence. Hepatology 2006 Nov;44(5):1098-109.
  5. Smyk-Pearson S, Tester IA, Lezotte D, Sasaki AW, Lewinsohn DM, Rosen HR. Differential antigenic hierarchy associated with spontaneous recovery from hepatitis C virus infection: implications for vaccine design. J Infect Dis 2006 Aug; 15;194(4):454-63.
  6. Tester I, Smyk-Pearson S, Wang P, Wertheimer A, Yao E, Lewinsohn DM, Tavis JE, Rosen HR. Immune evasion versus recovery after acute hepatitis C virus infection from a shared source. J Exp Med. 2005 Jun 6;201(11):1725-31 (see comments). (download PDF)
  7. Weston S, Leistikow, Reddy R, Wertheimer AM, Lewinsohn DM, Chou S, Corless CL, O'Farrelly C, Nelson D, Rosen HR. Reconstitution of hepatitis C virus-specific T cell-mediated immunity following liver transplantation. Hepatology 2005 Jan;41(1):72-81. (download PDF)
  8. Rosen HR, Hinrichs DJ, Leistikow RL, Calendar G, Nishimura M, Lewinsohn. Selection of HCV-specific CD8+ T cells by donor HLA alleles following liver transplantation. J Immunology Cutting Edge 2004 Nov 1;173(9):5355-9. (download PDF)
  9. Burton JR, Sonnenberg A, Rosen HR. Retransplantation for recurrent HCV in the MELD era: Maximizing utility. Liver Transplantation 2004 Oct; 10 Suppl 10:S59. (download PDF)
  10. Wertheimer AW, Bakke A, Rosen HR. Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease; Hepatology; 2004: 40: 335-345. (download PDF)
  11. Simon B, Cornell K, Clark T, Chou S, Rosen HR, Barry R. DNA vaccination protect mice against challenge with recombinant Listeria monocytogenes expressing hepatitis C virus NS3 protein. Infect Immun. 2003 Nov; 71(11): 6372-80. (download PDF)
  12. Wertheimer AM, Miner C, Lewinsohn DM, Sasaki AW, Kaufman E, Rosen HR. Novel CD4+ and CD8+ T-cell determinants within the NS3 protein in subjects with spontaneously resolved HCV infection. Hepatology 2003; 37:577-89. (download PDF)
  13. Rosen HR, Miner C, Sasaki AW, Lewinsohn DM, Conrad AJ, Bakke A, Bouwer HG, Hinrichs DJ. Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: correlation with clinical disease stages. Hepatology 2002; 35:190-8. (download PDF)
  14. Rosen HR, Fontana RJ, Brown RS, Wiesner RH, Schiano TD, Bass NM, Bloomer JR, Kaplan L. Curricular guidelines for training in transplant hepatology. Liver Transpl 2002; 8:85-7. (download PDF)
  15. Rosen HR, Madden JP, Martin P. A model to predict survival following liver retransplantation. Hepatology 1999; 29:365-70. (download PDF)