HMGP - Harry Drabkin, M.D.

Harry Drabkin, M.D.
Associate Professor
Human disease genes on chromosome 3; genetics of acute myelogenous leukemia

Medical School: University of Kansas
Residency: University of Cincinnati
Fellowship: Eleanor Roosevelt Institute for Cancer Research; University of Colorado
Board Certification: Internal Medicine, Medical Oncology

Lay Summary of Research Objectives
Isolation and characterization of genes responsible for cancer and other developmental diseases.

M Sugita, N Tanaka, S Davidson, S Sekiya, M Varella-Garcia, J West, HA Drabkin and RM Gemmill. Molecular definition of an amplification domain within 3q26 in tumors of cervix, ovary and lung. Cancer Genet Cytogenet. 2000 Feb;117(1):9-18.

Brambilla E., Constantin B., Drabkin H and Roche J. (2000). SEMA3F (H.SemaIV) localization in malignant human lung and dividing cells: a suggested role in cell adhesion and cell migration. Am. J. Path.156:939-950.

Keith RL, Miller YE, Gemmill RM, Drabkin HA, Dempsey EC, Haney J, La Rosa FG, Folkvord J, Kennedy TC, Prindiville S, Franklin WA (2000): Angiogenic squamous dysplasia in bronchi of individuals at high risk for lung cancer. Clin Cancer Res. 6(5):1616-25.

R Calvo, W Franklin, J West, R Rosell, RM Gemmill and HA Drabkin (2000). Altered HOX and WNT7a Expression in Human Lung Cancer - PNAS 97(23):12776-12781.

Calvo R, Drabkin HA. Embryonic genes in cancer. Ann Oncol 2000;11 Suppl 3:207-18

L. Daheron, A. Veinstein, F. Brizard, H. Drabkin, L. Lacotte, F. Guilhot, C.J. Larsen, A Brizard and J. Roche (2001). The human LPP gene is fused to MLL in a secondary acute leukemia with a translocation t(3;11) (q28;q23). Genes chromosome and cancer, 31: 382-389.

Ueda M, Gemmill RM, West J, Winn R, Sugita M, Tanaka N and Drabkin HA (2001). Mutations of b- and g-catenin gene s are uncommmon in human lung, breast, kidney, cervical and ovarian carcinomas. Br J Cancer. 2001 Jul;85(1):64-8.

Tomizawa Y, Sekido Y, Kondo M, Yokota J, Roche R, Drabkin H, Lerman MI, Gazdar AF and Minna JD (2001). Inhibition of Lung Cancer Cell Growth and Induction of Apoptosis Following Re-expression of 3p21.3 Tumor Suppressor Gene Candidate SEMA3B PNAS 98 : 13954–13959.

Varella-Garcia M, Hogan CJ, Odom LF, Murata-Collins JL, Ai H, Chen L, Richkind K, Paskulin G, Andreeff M, Brizard A, McGavran L, Gemmill RM, Berger R, Drabkin HA. Minimal residual disease (MRD) in remission t(8;21) AML and in vivo differentiation detected by FISH and CD34+ cell sorting. Leukemia 2001 Sep;15(9):1408-1414.

RM Bremnes, R Veve, E Gabrielson, FR Hirsch, A Baron, L Bemis, RM Gemmill, HA Drabkin and WA Franklin (2001). High Throughput Tissue Microarray Analysis Used to Evaluate the Prognostic Role of the E-cadherin Pathway in Non-Small Cell Lung Cancer. J Clin Oncol. 2002 May 15;20(10):2417-28.

Joëlle Roche and Harry A. Drabkin (2001). The Role Of Semaphorins in Lung Cancer. Clinical Lung Cancer. 3 (2):145-150.

HA Drabkin, C Parsy, K Ferguson, F Guilhot, L Lacotte, L Roy, C Zeng, A Baron, SP Hunger, M Varella-Garcia, R Gemmill, F Brizard, A Brizard and Joëlle Roche. Quantitative Hox Expression In Chromosomally Defined Subsets Of Acute Myelogenous Leukemia. Leukemia (2002) 16, 186–195.

RM Gemmill, LT Bemis, JP Lee, MA Sozen, A Baron, C Zeng , PF Erickson, JE Hooper and HA Drabkin (2002). The TRC8 Hereditary Kidney Cancer Gene Suppresses Growth and Functions with VHL in a Common Pathway. Oncogene. 2002 May 16;21(22):3507-16.

de Guzman CG, Warren AJ, Zhang Z, Gartland L, Erickson P, Drabkin H, Hiebert SW, Klug CA (2002). Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation. Mol Cell Biol 22(15):5506-17.

P Nasarre, B Constantin, L Rouhaud, V Castellani, G Raymond, HA Drabkin and J Roche (2003). Semaphorin SEMA3F Inhibits Cell Attachment and Spreading and Induces Cell Death in Human Mammary Tumor Cells. Neoplasia 5(1):83-92.

S. Lantuejoul, B. Constantin, H. Drabkin, C.Brambilla, J. Roche and E. Brambilla (2003). VEGF, Semaphorin SEMA3F and their common receptors neuropilins NP1 and NP2 expressions in preinvasive bronchial lesions and lung tumors. J Pathol. 200(3):336-47

S. Kusy, L. Funkelstein, D. Bourgais, H. Drabkin, G. Rougon, J. Roche and V. Castellani (2003). Redundant functions but temporal and regional regulation of two alternatively-spliced isoforms of Semaphorin 3F in the nervous system. Molecular and Cellular Neurosciences 24:409-418.

Puig-Kröger, T. Sánchez-Elsner, N. Ruiz, E.J. Andreu, F. Prosper, U.B. Jensen, J. Gil, P. Erickson, H. Drabkin , Y. Groner and A.L. Corbí (2003). RUNX/AML and C/EBP factors regulate CD11a integrin expression in myeloid cells through overlapping regulatory elements. Blood. 2003 Nov 1;102(9):3252-61.

T Ohira, RM Gemmill, L Bemis, P Erickson, K Ferguson, S Kusy, J Roche, E Brambilla, C Zeng, A Baron, E Wilder, A Rustgi, J Kitajewski, E Gabrielson, R Bremnes, W Franklin and HA Drabkin (2003). WNT7a induces E-cadherin in lung cancer cells (2003). PNAS 100(18):10429-34.

J Roche, C Zeng, A Baron, S Gadgil, RM Gemmill, I Tigaud, X Thomas and HA Drabkin (2004). HOX Expression in AML Identifies A Distinct Subset Of Patients With Intermediate Cytogenetics. Leukemia. Jun;18(6):1059-63.

RM Gemmill, J Lee, D Chamovitz, D Segal, JE Hooper and HA Drabkin. Growth Suppression Induced by the TRC8 Hereditary Renal Cell Cancer Gene is Dependent upon JAB1/CSN5. Oncogene - in press (2005).

P. Nasarre, S. Kusy, B. Constantin, V. Castellani, H. Drabkin, D. Bagnard & J. Roche (2003). Semaphorin SEMA3F has a repulsing activity on breast cancer cells and inhibits E-cadherin-mediated cell adhesion. Neoplasia, Jan-Feb;5(1):83-92.

Kusy S, Nasarre P, Chan D, Potiron V, Constantin B, Gemmill R, Drabkin H & Roche J (2004). Inhibition of Lung Tumorigenesis by SEMA3F. accepted pending revision.

P. Nasarre, B. Constantin, HA Drabkin et J. Roche (2005). Sémaphorines et cancers : état des lieux. Médecine et Sciences – submitted

M Dohadwala, SC Yang, J Luo, S Sharma, RK Batra, M Huang, Y Lin, L Goodglick, K Krysan, MC Fishbein, L Hong, R Cameron, RM Gemmill, HA Drabkin and SM Dubinett (2005). Cyclooxygenase-2-dependent regulation of E-cadherin expression: PGE2 induces E-cadherin transcriptional repressors ZEB1 and Snail in NSCLC - submitted.