David Manchester, M.D.
Clinical Genetics
Dr. Manchester is Co-Director of the Division of Genetic Services. He is a clinical geneticist whose research interests are in mutagenesis and genetic toxicology; in particular, as these processes relate to birth defects and the origins of Mendelian disorders. Most of the laboratory work for these investigations is carried out in collaboration with off-campus investigators. However, a recent collaboration to investigate the origins of human Fibroblast Growth Factor Receptor gene mutations has been established with Dr. Gary Bellus at UCD.
Dr. Manchester and other members of the Division of Genetic Services also provide patient material for numerous ongoing gene discovery investigations.
Publications
Whyatt RM, Santella RM, Jedrychowshki W, Garte SJ, Bell DA, Ottmann R, Gladek-Yarborough A, Cosma, G, Young T-L, Coper T, Randall M, Manchester DK, Perera FP, Relationship between ambient air pollution and DNA damage in Polish mothers and newborns. Environ Health Perspect 106: 1998; 821-826.
Perera FP, Whyatt RM, Jedrdrychowski W, Rauh V, Manchester D, Santella RM, Ottman R, A study of the effects of environmental polycyclic aromatic hydrocarbons on birth outcomes in Poland. Am J Epidemiol 147: 1998; 309-314.
Prahalad AK, Manchester DK, Hsu IC, Inmon J, Gallagher JE Human placental microsomal activation and DNA adduction by air pollutants.Bull Environ Contam Toxicol 62: 1999; 93-100.
Manchester D, Allen J, Handler M, Schaefer F, Novel FGFR2 mutation associated with a partial Apert phenotype. American Society of Human Genetics 49th Annual Meeting, San Francisco, 1999.
