HMGP - Matthew Taylor, M.D.

Dr. Taylor’s background clinical training is in the fields of internal medicine and clinical genetics. In conjunction with the Department of Medicine’s Adult Medical Genetics Program (AMGP) he has developed the Adult Medical Genetics Clinic, specifically focused on the evaluation and management of genetic disorders that affect adult patients. The AMGP clinic also employs two genetic counselors with experience in adult-onset genetic disorders. In addition, Dr. Taylor attends in the Cardiovascular Genetics Clinic, housed within the University Hospital Heart Center. In this novel genetic specialty clinic, heritable disorders with prominent cardiac phenotypes are evaluated.

Dr. Taylor’s primary research interest is in the area of inherited cardiomyopathies. The systematic characterization of the genetic epidemiology underlying the various cytoskeletal and sarcomeric genes represents a current research project within his laboratory. Genetic linkage analyses and candidate gene approaches designed to discover novel candidate genes for inherited cardiomyopathies complement the genetic epidemiology work. Another line of investigation involves collaboration with the Polycystic Kidney Disease Research (PKD) Group, which has been performing research into the pathogenesis and treatment of PKD for over a decade. The current genetic arm of this project focuses on understanding the genetic basis of modifier genes on the expressed phenotype of PKD.

A final area of interest, bridging clinical and research fields, involves the development of a regional center for the evaluation and treatment of lysosomal storage diseases. Dr. Taylor is collaborating with Dr. Janet Thomas, Director of the Inherited Metabolic Disease Clinic at the Children’s Hospital, in this effort which includes participation in ongoing phase IV clinical trials.

The AMGP program has a commitment to advancing understanding and knowledge about genetics among clinicians. Housestaff physicians in training are welcome to undertake clinical or research rotations through the AMGP. A monthly newsletter, the AMGP “Monthly Update in Genetics” provides an opportunity for regular exposure to genetic principles and advances that are relevant to adult clinical medicine. This newsletter is accessible through the AMGP’s web site: www.uchsc.edu/amgp.

Sinagra G,Di Lenarda A, Brodsky GL, Taylor MRG, Muntoni F, Pinamonti B, Camiel E, Druissi M, Bristow MR, Mestroni L. Current perspective: New insights into the molecular basis of familial dilated cardiomyopathy. Italian Heart Journal 2000; April 2 (4): 280-6.

Taylor MRG, Alman A, Manchester MD. Surfing the Web for Genetic Information: Patient utilization of Internet as an informational source in a general genetics setting. Mayo Clinic Proceedings (8/2001).

Startari U, Taylor MRG, Sinagra G, Di Lenarda A, Mestroni L. Cardimiopatia dilatativa: eziologiz, criteri cliici di diagosi e screeing della forma familiare. Italian Heart Journal 2002. Supplement;3:378-385.

Taylor MRG. Adult Thrombotic Disorders. Genetic Drift (Peer-Reviewed Online publication of Mountains States Regional Genetics Network) 2002;20 (http://www.mostgene.org/gd/gdlist.htm).

Taylor MRG, Fain PR, Robinson ML, Sinagra G, DiLenarda A, Brodsky GL, Boucek MM, Lascor J, Moss AC, Li WP, Stetler G, Ferguson DN, Carniel E, Bristow MR, Mestroni L. Natural History of Dilated Cardiomyopathy Due to Lamin A/C Gene Mutations. J Am Coll Cardiology 2003;41:771-80.

Ku L, Feiger J, Taylor MRG, Mestroni L. Familial Cardiomyopathy Registry. Cardiology patient page. Familial dilated cardiomyopathy. Circulation. 2003.108:1-4.

Taylor MRG. A Survey of Chairpersons of Departments of Medicine About the Current and Future Roles of Clinical Genetics in Internal Medicine. Genet Med 2003;5:328-31.

Taylor MRG, Carniel E., Mestroni L. Familial hypertrophic cardiomyopathy: clinical features, molecular genetics and molecular genetic testing. Expert Rev. Mol. Diagn. 2004;4:99-113.

Taylor MRG, Robinson ML, Mestroni L. Analysis of genetic variations of lamin A/C gene (LMNA) by denaturing high-performance liquid chromatography. Journal of Biomolecular Screening 2004; 9:625-29)

McNair WP, Ku L, Taylor MRG, Fain PR, Dao D, Wolfel E, Mestroni L. A SCN5A mutation associated with dilated cardiomyopathy, conduction disorder, and arrhythmia. Circulation 2004;110:2163-67.

Everson GT, Taylor MRG, Doctor RB. Polycystic disease of the liver. Hepatology 2004;40:774-82.

Everson GT, Taylor MRG. Management of polycystic liver disease. Curr Gastroenterol Rep. 2005;7:19-25.

Fain PR, McFann KK, Taylor MRG, Tison M, Johnson AM, Reed B, Schrier RW. Modifier genes play a significant role in the phenotypic expression of PKD1. Kidney International 2005; 67: 1256-1267.

McNair WP, Ku L, Taylor MRG, Fain PR, Wolfel E, Mestroni L. Correspondence: A SCN5A Mutation Associated with Dilated Cardiomyopathy, Conduction Disorder and Arrhythmia. Circulation 2005; 112:e9-10.

Carniel E, Taylor MRG, Sinagra G, Di Lenarda A, Ku L, Fain PR, Boucek MM, Cavanaugh J, Miocic S, Slavov D, Graw SL, Feiger J, Zhu XZ, Dao D, Ferguson DA, Bristow MR, Mestroni L. Alpha-myosin heavy chain: a sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy. Circulation 2005. 112: 54-9.

Eskelinen EL, Cuervo AM, Taylor MRG, Nishino I, Blum JS, Dice JF, Sandoval IV, Lippincott-Schwartz J, August JT, Saftig P. Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2. Traffic 2005; 6:1058-61.

Taylor MRG, Johnson AM, Tison M, Fain P, Schrier RW. Earlier diagnosis of autosomal dominant polycystic kidney disease: importance of family history and implications for cardiovascular and renal complications. American Journal of Kidney Diseases 2005;46: 415-423

Taylor MRG, Slavov D, Gajewski A, Vlcek S, Ku L, Fain PR, Carniel E, di Lenarda A, Sinagra G, Boucek MM, Cavanaugh J, Graw SL, Ruegg P, Feiger J, Zhu X, Ferguson DA, Bristow MR, Gotzmann J, Foisner R, Mestroni L. Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy. Human Mutation 2005. 26;566-574.

Taylor MRG, Pharmacogenetics of the human beta-adrenergic receptors. Pharmacogenomics J. 2006;7:29-37.

Prall FR, Drack A, Taylor MRG, Ku L, Olson JL, Gregory D, Mestroni L, Mandava N. Ophthalmic manifestations of Danon disease. Ophthalmology. 2006;113:1010-3

Taylor MRG, Bristow MR 2006 Alterations in myocardial gene expression as a basis for cardiomyopathies and heart failure. Novartis Found Symp 2006;274:73-89.

Taylor MRG, Carniel E. Mestroni L. Cardiomyopathy, familial dilated. Orphanet J Rare Dis. 2006;1:27.

Taylor MRG, Edwards J, Ku L. Lost in Transition: Challenges In the Expanding Field of Adult Genetics. American Journal of Medical Genetics. 2006;142C;294-303.

Taylor MRG, Slavov D, Ku L, Di Lenarda A, Sinagra G, Carniel E, Haubold K, Boucek MM, Ferguson D, Graw SL, Zhu X, Cavanaugh J, Sucharov CC, Long CS, Lavori P, Mestroni L. Prevalence of desmin mutations in dilated cardiomyopathy. Circulation 2007;115:21244-51.

Taylor MRG, Ku L, Slavov D, Cavanaugh J, Boucek M, Zhu X, Graw S, Carniel E, Barnes C, Quan D, Prall R, Lovell MA, Mierau G, Ruegg P, Mandava N, Bristow MR, Towbin JA, Mestroni L. Danon disease presenting with dilated cardiomyopathy and a complex phenotype. Journal of Human Genetics. J Hum Genet. 2007; 52: 830-835.

Mestroni L, Miyamoto S, Taylor MRG. Genetics of dilated cardiomyopathy conduction disease. Prog. in Peds. Cardio 2007;24:3-13.

Taylor MRG. When echocardiography is not enough. Progress in Pediatric Cardiology 2007;24:79-80.

di San Filippo CA, Taylor MRG, Mestroni L, Botto LD, Longo N. Cardiomyopathy and carnitine deficiency. Molecular Genetics and Metabolism 2008;94:162-66.

Taylor MRG, Slavov D, Humphrey K, Zhao L, Cockroft J, Zhu X, Lavori P, Bristow MR, Mestroni L, Lazzeroni LC. A pharmacogenetic effect of an endothelin-1 haplotype on response to bucindolol therapy in chronic heart failure. Pharmacogenetics and genomics (in press)

Taylor MRG. Genetic Testing For Inherited Breast and Ovarian Cancer Syndromes: Important Concepts for the Primary Care Physician, Postgrad Med J. 2001 Jan;77(903):11-15.

Taylor MRG. Consultation with the specialist: The Pierre Robin sequence: a concise review for the practicing pediatrician. Pediatrics in Review 2001; 4: 125-30.

Taylor MRG, Bristow MR. The emerging pharmacogenomics of the beta-adrenergic receptors. Congestive Heart Failure 2004; 10:281-8.

Taylor MRG. Danon disease entry for National Organization of Rare Diseases (www.rarediseases.org), 2007

Taylor MRG. Genetics in Your Practice: ‘Genetic Medicine’ for Internists. Published in Internal Medicine News, August 2007.

Taylor MRG. Genetics in Your Practice: Identifying Hereditary Cancer Syndromes, Published in Internal Medicine News, January 2008.

Mestroni L, Taylor MRG. Lamin A/C gene and the heart: how genetics may impact clinical care. J Am Coll Cardiol. 2008;52:1261-2.

Taylor MRG, Mestroni L. Lamin A/C mutations in familial dilated cardiomyopathy. Electronic paper for Harrison’s Principles of Internal Medicine Online (“Harrison’s Online”); http:www.harrisionsonline.com

Taylor MRG, Mestroni L. Lamin A/C Mutations in Familial Dilated Cardiomyopathy. Harrison’s Advances in Cardiology, Chapter 72, Braunwald. McGraw-Hill, New York 2003.

Taylor MRG, Barnes CV, Mestroni L. Complex cardiomyopathies: laminopathies and arrhythmogenic right ventricular dysplasia/cardiomyopathy. In Molecular Mechanisms of Cardiac Hypertrophy. Walsh RA (editor). Taylor and Francis, London, 2005 (Chapter 33):569-86.

Taylor MRG. Brochure on Basic Genetics 2005. Commissioned, 80-page brochure on genetic principles and relationship to insurance. Developed for Assicuarzioni Generali (Italy), Marocco, P. (editor)

Medical genetic services in developing countries. The ethical, Legal, and Social Implications of genetic testing and screening. World Health Organization statement from Human Genetics, Chronic Disease and Health Promotion Division. Member of expert author panel. 2007