Matthew Taylor, M.D.
Director, Adult Clinical Genetics
Dr. Taylor’s background clinical training is in the fields of internal medicine and clinical genetics. In conjunction with the Department of Medicine’s Adult Medical Genetics Program (AMGP) he has developed the Adult Medical Genetics Clinic, specifically focused on the evaluation and management of genetic disorders that affect adult patients. The AMGP clinic also employs two genetic counselors with experience in adult-onset genetic disorders. In addition, Dr. Taylor attends in the Cardiovascular Genetics Clinic, housed within the University Hospital Heart Center. In this novel genetic specialty clinic, heritable disorders with prominent cardiac phenotypes are evaluated.
Dr. Taylor’s primary research interest is in the area of inherited cardiomyopathies. The systematic characterization of the genetic epidemiology underlying the various cytoskeletal and sarcomeric genes represents a current research project within his laboratory. Genetic linkage analyses and candidate gene approaches designed to discover novel candidate genes for inherited cardiomyopathies complement the genetic epidemiology work. Another line of investigation involves collaboration with the Polycystic Kidney Disease Research (PKD) Group, which has been performing research into the pathogenesis and treatment of PKD for over a decade. The current genetic arm of this project focuses on understanding the genetic basis of modifier genes on the expressed phenotype of PKD.
A final area of interest, bridging clinical and research fields, involves the development of a regional center for the evaluation and treatment of lysosomal storage diseases. Dr. Taylor is collaborating with Dr. Janet Thomas, Director of the Inherited Metabolic Disease Clinic at the Children’s Hospital, in this effort which includes participation in ongoing phase IV clinical trials.
The AMGP program has a commitment to advancing understanding and knowledge about genetics among clinicians. Housestaff physicians in training are welcome to undertake clinical or research rotations through the AMGP. A monthly newsletter, the AMGP “Monthly Update in Genetics” provides an opportunity for regular exposure to genetic principles and advances that are relevant to adult clinical medicine. This newsletter is accessible through the AMGP’s web site: www.uchsc.edu/amgp.
Publications
McNair WP, Ku L, Taylor MRG, Fain PR, Dao D, Wolfel E, Mestroni L. A SCN5A
mutation associated with dilated cardiomyopathy, conduction disorder,
and arrhythmia. Circulation 2004;110:2163-67.
Taylor MRG, Robinson ML, Mestroni L. Analysis of genetic variations of lamin A/C gene (LMNA) by denaturing high-performance liquid chromatography. Journal of Biomolecular Screening 2004; 9:625-29)
Taylor MRG, Carniel E., Mestroni L. Familial hypertrophic cardiomyopathy: clinical features, molecular genetics and molecular genetic testing. Expert Rev. Mol. Diagn. 2004;4:99-113.
Taylor MRG, Carniel E., Mestroni L. Familial dilated cardiomyopathy. Orphanet (http://www.orpha.net/data/patho/GB/uk-FDCardiomyopathy.html), July 2003.
Taylor MRG. A Survey of Chairpersons of Departments of Medicine About the Current and Future Roles of Clinical Genetics in Internal Medicine. Genet Med 2003;5:328-31.
Ku L, Feiger J, Taylor MRG, Mestroni L. Familial Cardiomyopathy Registry. Cardiology patient page. Familial dilated cardiomyopathy. Circulation. 2003.108:1-4.
Taylor MRG, Fain PR, Robinson ML, Sinagra G, DiLenarda A, Brodsky GL,
Boucek MM, Lascor J, Moss AC, Li WP, Stetler G, Ferguson DN, Carniel E,
Spritz RA, Bristow MR, Mestroni L. Natural History of Dilated Cardiomyopathy
Due to Lamin A/C Gene Mutations. J Am Coll Cardiology 2003;41:771-80.
Taylor MRG, Mestroni L. Lamin A/C Mutations in Familial Dilated Cardiomyopathy.
Harrison’s Advances in Cardiology, Chapter 72, Braunwald. McGraw-Hill,
New York 2003.
Taylor MRG. Adult Thrombotic Disorders. Genetic Drift (Online publication
of Mountains States Regional Genetics Network) 2002;20 (http://www.mostgene.org/gd/gdlist.htm).
Startari U, Taylor MRG, Sinagra G, Di Lenarda A, Mestroni L. Cardimiopatia
dilatativa: eziologiz, criteri cliici di diagosi e screeing della forma
familiare. Italian Heart Journal 2002. Supplement;3:378-385.
Taylor MRG, Alman A, Manchester MD. Surfing the Web for Genetic Information:
Patient utilization of Internet as an informational source in a general
genetics setting. Mayo Clinic Proceedings (8/2001).
Sinagra G,Di Lenarda A, Brodsky GL, Taylor MRG, Muntoni F, Pinamonti B, Camiel E, Druissi M, Bristow MR, Mestroni L. Current perspective: New insights into the molecular basis of familial dilated cardiomyopathy. Italian Heart Journal 2000; April 2 (4): 280-6.
Taylor MRG. Consultation with the specialist: The Pierre Robin sequence: a concise review for the practicing pediatrician. Pediatrics in Review 2001; 4: 125-30.
Taylor MRG. Genetic Testing For Inherited Breast and Ovarian Cancer Syndromes:
Important Concepts for the Primary Care Physician, Postgrad Med J. 2001
Jan;77(903):11-15.
Nowbar S., Burkart K., Fedorowicz A., Gozansky W., Gaudio J., Taylor MRG, Meyer S., Zwillich C. The Obesity Hypoventilation Syndrome: A Common But Unrecognized Disorder Among Severely Obese Hospitalized Patients. (Submitted for publication)
Taylor MRG, Mestroni L. Lamin A/C mutations in familial dilated cardiomyopathy. Electronic paper for Harrison’s Principles of Internal Medicine Online (“Harrison’s Online”); http:www.harrisionsonline.com
