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| Schematic diagram of neuromuscular junction with acetylcholine receptors (green) at the tops of the postsynaptic folds and sodium channels (red) in the troughs and perisynaptic membrane. |  |
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Labeling of nodes of Ranvier by antibodies specific for sodium channel Nav1.6 (red) in axons of rat sciatic nerve. An antibody to a paranodal protein (caspr; green) borders the nodal membrane. Inset shows one node viewed obliquely to show the membrane labeling. |
| Diagram of a neuron illustrating the subcellular locations of voltage-gated sodium channel Nav1.6 in myelinated (#4) and unmyelinated (#3) axons, apical dendrites (#6), and presynaptic (#5) and postsynaptic (#7) membranes. |  |
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Recording of a single endogenous anion channel of the Golgi complex with multiple subconductance states. Channel was incorporated into a planar lipid bilayer. Channel is often in the open states (fully open indicated by O) and rarely in the closed state (C). A rapid closing and reopening (large arrow) is indicated in the portion of the record expanded in the lower trace. See Nordeen et al., Biophysical Journal. |
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Neuronal Development Cerebellar granule cell neurons (blue) express sodium channels (red) as soon as they leave the proliferative zone and begin to migrate to their final position in the internal granule cell layer. Thus, they have neuronal properties as soon as they stop dividing. |
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