J. Fred Kolhouse
M.D.
Professor of Medicine
Go To Full Curriculum Vitae
- Medical School:
- Indiana University School of Medicine, Indianapolis,
Indiana
- Postgraduate training:
- 1968-1971 Intern & Resident in Medicine, Vanderbilt University Hospital,
Nashville, Tennessee
1971-1972 Fellow in Hematology & Instructor of Medicine, Vanderbilt
University Hospital & School of Medicine, Nashville, Tennessee
1972-1974 U.S. Navy, Naval Hospital Memphis Millington, Tennessee
1974-1975 Fellow in Clinical Hematology, Washington University School
of Medicine, St. Louis, Missouri
1975-1977 Fellow in Research Hematology, Washington University School
of Medicine,
St. Louis, Missouri
- When arrived at UCD:
- 1977
- Past and current professional positions:
- 1977-1982 Assistant Professor of Medicine, University of Colorado Denver, Denver, Colorado
1982-1988 Associate Professor of Medicine, University of Colorado Denver, Denver, Colorado
1988-present Professor of Medicine, University of Colorado Denver, Denver, Colorado
1999-present Director of the University of Colorado Clinical Cancer Center
with reporting responsibility to the Dean of the School of Medicine and
President of University Hospital
2003-present Chairman of the Board of Directors of the Clinical Cancer
Center
- Memberships and other information:
- American Society of Hematology
American Society for Clinical Investigation
Association of American Physicians
- Board Certification:
- Internal Medicine - 1973
Hematology - 1980
- Awards received:
- 1968 Alpha Omega Alpha
1982 Chancellor’s Teaching Recognition Award
1989 Chancellor’s Teaching Recognition Award
1991 President’s Teaching Award
2002 Outstanding Clinical Teacher Class of 2003
- Major Scientific Interest:
- Targeted cancer therapy and development of
the Cancer Pharmacogenomics Program. Folate/methotrexate metabolism.
- Major Clinical Interest:
- Build out of cancer operations including: 1) improvement
in patient services and throughput in clinics; 2) increase recruitment
of patients into clinical trials; 3) recruitment of new faculty; 4) improvement
in financial performance; 5) development of the statewide University
of
Colorado cancer network.
- Representative Publications:
-
- Antony, A.C., Utley, C.S., Van Horne, K.C., and Kolhouse, J.F. Isolation
and characterization of a folate receptor from human placenta. J Biol
Chem 256:9684-9692, 1981.
- Kolhouse, J.F., Utley, C.S., and Rosenberg, L.E. Immunochemical studies
on cultured fibroblasts from patients with inherited methylmalonic academia.
Proc Natl Acad Sci U.S.A. 78:7737-7741, 1981.
- Antony, A.C., Kane, M.A.,
and Kolhouse, J.F. Studies of the role of a particulate folate-binding
protein in the uptake of 5-methyltetrahydrofolate
by cultured human KB cells. J Biol Chem 260:14911-14917, 1985.
- Deutsch,
J.C., and Kolhouse, J.F. Folate and methotrexate interactions in
the rat kidney. Cancer Res 49:5858-5862, 1989.
- Kolhouse, J.F., Deutsch,
J.C., Hassell, K.L. and Santhosh-Kumar, C.R. Are neuropsychiatric
manifestations of folate, cobalamin and
pyridoxine deficiency mediated through imbalances in excitatory
sulfur amino acids?
Med hypotheses 43:239-244, 1994.
- Kolhouse, J.F., Kolhouse, N.M., Hassell, K.L., Deutsch, J.C.,
and Santhosh-Kumar, C.R. Quantitation of red blood cell folates
by stable isotope dilution gas chromatography-mass spectrometry
utilizing a
folate
internal
standard. Anal Biochem 225:1-9, 1995.
- Deutsch, J.C., Santhosh-Kumar,
C.R., and Kolhouse, J.F. Glutathione oxidation in real time by thermospray
liquid chromatography mass
spectrometry. J Chromatogr A 862:161-168, 1999.
- Santhosh-Kumar,
C.R., Deutsch, J.C., Kick, S.D., Bisping, J.S., Hassell, K.L., Kolhouse,
J.F., Analysis of Methods to
Assess Subclinical
Folate
Deficiency. Am J Hematol submitted, 2002.
