Elizabeth Connick, M.D.

Associate Professor of Medicine

Phone: 303-724-4922
E-mail: liz.connick@uchsc.edu
Address:  University of Colorado Denver
                  Division of Infectious Diseases
                 12700 E. 19th Avenue, Box B168
                  Aurora, CO 80045

Medical School
Harvard Medical School
Residency
Columbia Presbyterian Medical Center, New York, NY
Fellowship
University of Colorado Denver, Division of Infectious Diseases
Research and/or Clinical Interests
Dr. Connick's research focuses on understanding the immunopathogenesis of HIV-1 infection. She has been involved in clinical trials as well as laboratory-based translational research studies of HIV-1 infection for the past 13 years. She has specific expertise in areas of immune reconstitution and lymphoid tissue studies. She has a longstanding interest in both clinical and immunopathogenesis studies of acute and early HIV infection and is the Principal Investigator of a program project grant entitled "Pathogenesis of Acute HIV Infection." She is also interested in sex-based differences in HIV-1 infection and is currently funded through an R21 to investigate the underlying basis of sex differences in plasma HIV-1 RNA concentrations. Lastly, she is involved in investigations of the pathogenesis of accelerated cardiovascular disease in HIV-1 infected individuals and is a co-investigator on an R21 to investigate this phenomenon.

Selected Publications:

  1. Connick E, Lederman MM, Kotzin BL, Spritzler J, Kuritzkes DR, St. Clair M, Sevin AD, Fox L, Heath Chiozzi M, Leonard JM, Rousseau F, Wade M, Roe JD, Martinez A, Kessler H, Landay A. Immune reconstitution in the first year of potent antiretroviral therapy and its relationship to virologic response. J Infect Dis 2000;181:358-63.
  2. Connick E, Schlichtemeier RL, Purner MB, et al. Relationship between Human Immunodeficiency Virus Type 1 (HIV-1)-specific memory cytotoxic T lymphocytes and virus load after recent HIV-1 seroconversion. J Infect Dis 2001;184:1465-9.
  3. Folkvord JM, Anderson DM, Arya J, MaWhinney S, Connick E. Microanatomic relationships between CD8+ cells and HIV-1-producing cells in human lymphoid tissue in vivo. J Acquired Immune Defic Syndr 2003; 32:469-76.
  4. Campbell TB, Schneider K, Wrin T, Petropoulos CJ, Connick E. Relationship between in vitro HIV-1 replication rate and plasma virus load. J Virol 2003;77:12105-12.
  5. Connick E, Kane M, White IE, Ryder J, Campbell TB. Immune reconstitution inflammatory syndrome (IRIS) to Kaposi's Sarcoma (KS) during potent antiretroviral therapy. Clin Infect Dis 2004;39:1852-5.
  6. Campbell TB, Staskus KA, Folkvord J, White IE, Neid J, Zhang X, Connick E. Persistence of Kapsoi's Sarcoma-Associated Herpesvirus (KSHV) Infected Cells in HIV-1 Co-Infected Persons without KSHV-Associated Diseases. J Infect Dis 2005;191:367-71.
  7. Folkvord JM, Armon C, Connick E. Lymphoid follicles are sites of heightened human immunodeficiency virus type 1 (HIV-1) replication and reduced antiretroviral effector mechanisms. AIDS Research and Human Retroviruses 2005;21:363-70.
  8. Folkvord JM, McCarter MD, Ryder J, Meditz AL, Forster JE, Connick E. Alpha-Defensins 1, 2, and 3 are expressed by granulocytes in lymphoid tissues of HIV-1 seropositive and seronegative individuals. J AIDS 2006;42:529-36.
  9. Berges BK, Wheat WH, Palmer BE, Connick E, Akkina R. HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gammac-/-(RAG-hu) mouse model. Retrovirology 2006 3:76.
  10. Connick E, Mattila T, Folkvord JM, Schlichtemeier R, Meditz AL, Ray MG, McCarter MD, MaWhinney S, Hage A, White C, Skinner PJ. Cytotoxic T cells fail to accumulate at sites of HIV-1 replication in lymphoid tissue. J Immunol 2007; 178:6975-83.