Kenneth L. Tyler, MD

Reuler-Lewin Family Professor of Neurology
(Secondary: Professor of Medicine & Microbiology)

Phone: 303-393-2874
E-mail: Ken.Tyler@uchsc.edu
Address:Denver Veterans Affairs Medical Center, Neurology (127),
1055 Clermont St., Denver, CO 80220

 

 

 

Medical School
Johns Hopkins
Residency
Internal Medicine: Brigham & Womens' Hospital, Boston, MA
Neurology: Massachusetts General Hospital, Boston, MA
Fellowship
Microbiology & Molecular Genetics, Harvard Medical School
Research Interests
Dr. Tyler's clinical research involves study of virus infections of the CNS including West Nile, herpes simplex, Epstein-Barr virus, and progressive multifocal leukoencephalopathy. He has been a lead investigator at UCD for studies sponsored by the Collaborative Antiviral Study Group (CASG) on treatment of West Nile virus infection of the nervous system and of studies sponsored by the Neurological AIDS Research Consortium (NARC) and the AIDS Clinical Trial Group (ACTG) related to neurological complications of HIV infection. His laboratory is funded by the NIH and Department of Veterans Affairs for their studies of viral pathogenesis including understanding how viruses kill cells, including the effects of viral infection on apoptotic signaling pathways, transcription factor activation, and mitogen activated protein kinase (MAPK) signaling cascades.

Selected Publications

  1. Beckham JD, Goody RJ, Clarke P, Bonny C, Tyler KL. A novel strategy for the treatment of viral CNS infection utilizing a cell-permeable inhibitor of c-Jun N-terminal kinase. J Virol. 2007 May 2; [Epub ahead of print] PMID: 17475657 [PubMed - as supplied by publisher]
  2. Anderson CA, Bosque P, Filley CM, Arciniegas DB, Kleinschmidt-Demasters BK, Pape WJ, Tyler KL. Colorado surveillance program for chronic wasting disease transmission to humans: lessons from 2 highly suspicious but negative cases. Arch Neurol. 2007 Mar;64(3):439-41. PMID: 17353391 [PubMed - indexed for MEDLINE]
  3. Clarke P, Tyler KL. Down-regulation of cFLIP following reovirus infection sensitizes human ovarian cancer cells to TRAIL-induced apoptosis. Apoptosis. 2007 Jan;12(1):211-23. PMID: 17136319 [PubMed - indexed for MEDLINE]
  4. Davis LE, DeBiasi R, Goade DE, Haaland KY, Harrington JA, Harnar JB, Pergam SA, King MK, DeMasters BK, Tyler KL. West Nile virus neuroinvasive disease. Ann Neurol. 2006 Sep;60(3):286-300. Review. PMID: 16983682 [PubMed - indexed for MEDLINE]
  5. Debiasi RL, Tyler KL. West Nile virus meningoencephalitis. Nat Clin Pract Neurol. 2006 May;2(5):264-75. Review. PMID: 16932563 [PubMed - indexed for MEDLINE]
  6. Tyler KL, Pape J, Goody RJ, Corkill M, Kleinschmidt-DeMasters BK. CSF findings in 250 patients with serologically confirmed West Nile virus meningitis and encephalitis. Neurology. 2006 Feb 14;66(3):361-5. Epub 2005 Dec 28. PMID: 16382032 [PubMed - indexed for MEDLINE]
  7. Goody RJ, Hoyt CC, Tyler KL. Reovirus infection of the CNS enhances iNOS expression in areas of virus-induced injury. Exp Neurol. 2005 Oct;195(2):379-90. PMID: 16004984 [PubMed - indexed for MEDLINE]
  8. Kleinschmidt-DeMasters BK, Tyler KL. Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis. N Engl J Med. 2005 Jul 28;353(4):369-74. Epub 2005 Jun 9. PMID: 15947079 [PubMed - indexed for MEDLINE]
  9. Clarke P, Debiasi RL, Meintzer SM, Robinson BA, Tyler KL. Inhibition of NF-kappa B activity and cFLIP expression contribute to viral-induced apoptosis. Apoptosis. 2005 May;10(3):513-24. PMID: 15909114 [PubMed - indexed for MEDLINE]
  10. Richardson-Burns SM, Tyler KL. Minocycline delays disease onset and mortality in reovirus encephalitis. Exp Neurol. 2005 Apr;192(2):331-9. PMID: 15755550 [PubMed - indexed for MEDLINE]