Qualifications to volunteer:

• Healthy women between the age of 21-40 years
• Regular menstrual cycles
• No current use of hormonal contraceptives
• Physically active but not a competitive athlete
• Willing to wear a knee brace and use crutches for 9 days

Benefits for study volunteers include:

• Measurement of body composition and bone density
• Fitness testing
• Compensation will be provided for your time

The Principal Investigator for the MUSE study is Catherine Jankowski, PhD. For more information please contact Ellie Gibbons at 720-848-6408 or Ellie.Gibbons@ucdenver.edu. This study is funded by the UCD Department of Medicine and has been approved by the Colorado Multiple Institutional Review Board. (COMIRB #07-0379)

A Familiar IMAGE Face

Many of you will remember the winning smile and quick wit of Angie Moquin, the very first IMAGE professional research assistant. Angie was deeply involved with the AFTER and BONE studies and supervised exercise as recently as a year ago while working on her doctorate of physical therapy degree. We are proud to announce that Angie graduated from the University of Colorado Physical Therapy Program in May, 2009, and is now Dr. Angie (Angela) Moquin, MS, PT, DPT. She will begin working as a physical therapist in Nevada later this summer. Angie has a special interest in helping people with artificial limbs to not only rehabilitate but also to accomplish personal performance goals. Kudos to Angie!

Are you and Apple
or a Pear

    Sex Hormones,
    Coristol, and
    Adiposity
    Loss via
    Exercise

• The MOXI Study is examining how the use of ibuprofen in older, exercising women and men affects muscle and bone health. Eligible participants are 60-75 years of age who are not currently in a weight lifting program, have no history of peptic ulcers or stomach bleeding, and do not typically use acetaminophen, ibuprofen, or similar drugs more than 3 days per month. (COMIRB #06-0769)
• The POEM Study is examining whether 6 months of cardiovascular exercise training or a study drug (Pioglitazone) can improve memory function. Eligible participants are healthy adults over the age of 55 years who are experiencing mild memory problems, are slightly overweight and considered pre-diabetic, non-smokers, and not regularly exercising. (COMIRB # 07-1215)
• The Lose-It Study will investigate the amount of exercise that health care providers should prescribe in order for patients to maintain weight loss. Eligible participants are healthy men and women between 18-45 years of age. Participants must be willing to engage in lifestyle changes including diet modifications and up to 100 minutes of daily physical activity. (COMIRB # 06-0369)
• The Minimally Invasive Total Knee Replacement Study looks at different surgical approaches for total knee replacement and combines these with a progressive rehabilitation program. Eligible adults are 50 to 85 years of age and are candidates for knee replacement surgery with Dr. Michael Dayton at the University of Colorado Hospital. (COMIRB #06-0183)
• The Rehabilitation for Total Knee Replacement Study is investigating 2 rehabilitation programs designed to restore muscle strength more effectively to improve function with daily activities. Eligible adults are 50 to 85 years of age and are candidates for knee replacement surgery. (COMIRB #06-0074)

• The HRTEX Study is examining the effects of various types of hormone replacement therapies along with a walking exercise program on women’s health.  Eligible participants are postmenopausal healthy, sedentary women between the ages of 45-65 years of age and are not currently taking hormone replacement therapy. (COMIRB #05-0606)
• The POWER Study is examining the role of the female sex hormone estrogen in preventing excess fat gain in women. Eligible participants are healthy women aged 20-40, who have regular menstrual cycles, and are not currently using hormonal contraceptives. (COMIRB #06-0512)
• The FLARE Study is examining how leg and hip liposuction surgery affects fat metabolism and cardiovascular health. Eligible participants are healthy pre- or postmenopausal women aged 40-55 years who are good candidates for leg and hip liposuction surgery and not using oral contraceptives or hormone therapy. (COMIRB #07-0339)

• The SHAPE study is examining how short-term changes in estrogen affect cardiovascular health. Eligible participants are premenopausal women 21-35, perimenopausal women 40-55, and postmenopausal women 45-70 years, who are non-smokers, have normal blood pressure, and who are not taking birth control or hormone therapy. (COMIRB # 06-0537)
• The MUSE study is investigating the effects of estrogen on changes in muscle due to lack of use. Eligible participants are women aged 21-40, who have regular menstrual cycles, are not currently using hormonal contraceptives, are physically active but not competitive athletes, and willing to wear a knee brace and use crutches for 9 days. (COMIRB #07-0379)
• The SCALE study is examining the role of the sex hormone estrogen and weight loss on the metabolism of the stress hormone cortisol. Eligible participants are overweight/ obese but otherwise healthy, non-smoking postmenopausal (40-59 years), not currently on hormone replacement, and willing to take part in a 1 month estrogen therapy study followed by a 4 month supervised exercise program to lose weight. (COMIRB #07-0278)
• The BLAST Study is examining how arteries become stiffer in women with low levels of estrogen. Eligible women are premenopausal (18-40 years) and postmenopausal (50-65 years), are non-smokers, have normal blood pressure, and are not taking birth control or hormone therapy. (COMIRB #07-1097)

• The TEAM study is examining the effects of testosterone supplementation and exercise in men who have low-normal testosterone levels. Eligible participants are men, 60 years and older, non-smokers, in good general health, and not currently doing high-intensity weight lifting exercise. (COMIRB # 02-1056)
• The Mr. ACET study is examining how the use of acetaminophen and ibuprofen in older, exercising men, affects muscle and bone health. Eligible participants are men, 60 years and older, who are not currently in a weight lifting program, have no history of peptic ulcers or stomach bleeding, and do not typically use acetaminophen, ibuprofen, or similar drugs more than 3 days per month. (COMIRB # 06-0343)
• The PROXI study is determining if weight lifting helps to prevent the loss of muscle and bone mass that occurs in men with prostate cancer on androgen deprivation therapy (ADT). Eligible participants are men, 45-85 years, with prostate cancer, who are taking ADT or plan to start ADT. (COMIRB #02-958)