Poster Session Abstract Titles Abstract titles are posted as they are received. If you would like to read an entire abstract, please email Brooke Petro at petrob@njhealth.org. Stephanie Dillon- Stimulating human lamina propria CD1c+ dendritic cells through TLR7/8 alters intestinal immune homeostasis by inducing IL-23 production Barney Collins - Ikaros Family Proteins Regulate T Cell Development by Controlling TCR alpha Gene Rearrangement Members of the highly-conserved Ikaros family of transcription factors play critical roles in the development and maintenance of the lymphoid system.  Jenny Chain - The Use of Soluble T Cell Receptors to Identify Ligands for gamma/delta T Cells Chain JL, Aydintug MK, Roark CL, Born WK, O’Brien RL. Integrated Department of Immunology, National Jewish Health, Denver, CO. Darlynn Korns - Defective apoptotic cell clearance by Non Obese Diabetic (NOD) macrophages, but not dendritic cells: a role for oxidants and Rho GTPases Jena French- FoxP3+ Regulatory T Lymphocytes are Consistently Found in Association with Papillary Thyroid Cancer and May Predict Lymph Node Metastases.  Jena D. French, Deborah L. Fretwell, Zachary J. Weber, and Bryan R. Haugen.  Department of Endocrinology, Metabolism, and Diabetes, University of Colorado Denver, Aurora, CO 80045. Brian Freed- HLA Epitopes in Rheumatoid Arthritis Katherine Lee - Murine gammaherpesvirus 68 infection of IFNg deficient mice on a BALB/c background results in acute lethal pneumonia that is dependent on specific viral genes Katherine S. Lee1, Carlyne D. Cool3,4 and Linda F. van Dyk1,2 1Departments of Microbiology, 2Immunology and 3Pathology, University of Colorado Denver School of Medicine, Aurora, CO, and 4National Jewish Health, Denver, CO Tolya Rubtsov - TLR7 signaling leads to accumulation of a novel population of autoreactive CD11c+ B cells that may contribute to female-biased susceptibility to autoimmunity Tobias Eckle - Period in Cardioprotection Megan MacLeod - CD4 memory T cells provide enhanced help to primary responding B cells Megan K.L. MacLeod, Amy McKee, Frances Crawford, Alexandria David, John Kappler, Philippa Marrack Paul Waterman - Consequences of GIDE Expression on Lymphopoiesis Paul M. Waterman, Bicheng Zhang, John Cambier and Phillipa Marrack Integrated Department of Immunology, University of Colorado Denver and National Jewish Health, Denver, CO, USA, 80206 Daniel Silberman - The importance of conserved MHC Class II residues that interact with germline encoded amino acids of T cell receptors. Rocky Baker - Blockade of CD40 Signaling on Diabetogenic T Cells Alters Effector Function Rocky Lee Baker, Thierry Mallevaey, Laurent Gapin and Kathryn Haskins Department of Immunology, University of Colorado at Denver and National Jewish Health Julie Lang - A Humanized Mouse Model for the Study of B Cell Tolerance in Human Lymphocytes Julie Lang, Ginger Woznicki and Roberta Pelanda.  Department of Immunology, National Jewish Health, Denver, CO USA 80206 James Scott-Brown - Germline-encoded amino acids in the αβ T cell receptor control thymic selection James P. Scott-Browne, Janice White, John W. Kappler, Laurent Gapin, and Philippa Marrack\ Dongfeng Qu - CD73-Generated Adenosine Regulates Thrombomodulin Expression Dongfeng Qu1, Naomi L. Esmon2, Charles T. Esmon2,3, and Linda F. Thompson1 1Immunobiology and Cancer Program, 2Cardiovascular Biology Program, and 3Howard Hughes Medical Institute Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK  73104 Michelle Joachims - Human B cell subset analysis in SLE patients and controls: response to influenza vaccination Michelle L. Joachims1, Wendy Klein2, Virginia Roberts2, Sherry Crowe2, Joel Guthridge2, Patrick C. Wilson1, Judith A. James2 and Linda F. Thompson1 Immunobiology and Cancer1 and Clinical Immunology2 Research Programs; Oklahoma Medical Research Foundation; Oklahoma City, OK 73104 Curtis Henry - Delineating the Relationship Between Aging and Increased Leukemogenesis Erin Donavan - During B cell development in the bone marrow, immature B cells must assemble an antigen receptor that is capable of signaling but does not react with self-antigens.  Accordingly, the fate of an immature B cell is determined by whether the B cell antigen receptor (BCR) is engaged in the bone marrow microenvironment. Jen Manuzak - The Regulatory IL-10 Response of Blood Myeloid Dendritic Cells to E. coli is Suppressed by Co-stimulation with a Viral TLR7/8 Ligand.  Jonathan Kurche - DIFFERENCES IN TNF RECEPTOR EXPRESSION BETWEEN CD4+ AND CD8+ T CELLS CORRELATE WITH THE ROLE OF THEIR RESPECTIVE LIGANDS IN VIVO. Kurche JS, Sanchez PJ, Haluszczak C, Kedl RM. Yuval Yarkoni - Stim1 phoshorylation leads to functional block by prevention of interaction with Orai1. Laura Shaw - Pregnancy-Induced Amelioration of Rheumatoid Arthritis in SKG Mice Laura A Shaw2, Kristen K Rumer3, Shimon Sakaguchi4, Virginia D Winn3 and Leonard Dragone1 1Pediatrics and Immunology, 2Pediatrics, National Jewish Health, Denver,Colorado, 3OB/GYN, UCD, Aurora, Colorado, 4Medicine, Kyoto University, Kyoto, Japan Sarah Rowland - Suboptimal BCR levels and tonic BCR signals prevent differentiation of immature B cells Sarah Rowland, Regina Halverson, Raul Torres, and Roberta Pelanda, Integrated Department of Immunology, University of Colorado Denver and National Jewish Health, Denver, CO, USA, 80206 Ryan Bjordahl - Opposing subsets of NKT cells regulate tumor growth in murine Burkitt’s lymphoma.  Ryan Bjordahl, Carl Ware, Philippa Marrack, and Yosef Refaeli Shannon O’Neill - B cell-specific ablation of SHIP disrupts B cell anergy, which could depend upon the disruption of an inhibitory cascade that is enacted via the monophosphorylation of the Ig-alpha ITAM. Shannon K. O’Neill, Andrew Getahun, Stephen B. Gauld, Kevin T. Merrell, John C. Cambier. Integrated Department of Immunology, University of Colorado Denver and National Jewish Health, Denver, CO, USA, 80206 Lei Guo - MAPK Pathway Mediated T cell Resistance against Homeostatic Regulation in Human Asthma Alexis Franks - Mimotopes target both unique T cells and T cells that naturally respond to the tumor. Alexis Franks, Kimberly Jordan, Jill Slansky Lance U’Ren - The effects of HIF-1a expression on T cell function and antitumor immunity. Lance U’Ren, Philippa Marrack, Jill E. Slansky Integrated Department of Immunology, University of Colorado Denver and National Jewish Health, Denver, CO Jennifer Larson - Investigating the role of gamma-herpesvirus infection in B cell tolerance and autoimmunity Jennifer D. Larson, Regina Halverson, Philippa Marrack, Raul Torres, Linda van Dyk, and Roberta Pelanda Charles Kemmler - Determining the Contribution of CD8+ T cell-produced IFNg To Peptide vaccine-elicited Tumor Protection Charles B Kemmler and Jill E Slansky, Integrated Department of Immunology, University of Colorado Denver, Denver, CO USA 80206 Lenka Teodorovic - Role of GITR in B cell function Rachel McMahan - BILE-ACID RECEPTOR ACTIVATION IMPROVES NON-ALCOHOLIC FATTY LIVER DISEASE AND INCREASES INTRAHEPATIC MYELOID SUPPRESSOR CELLS  R. McMahan1, T. Krisko1, T. Jiang2, X. Wang2, R. Nash4, M. Pruzanski5, L. Adorini5, L. Golden-Mason1,  M. Levi2, H.R.  Rosen1,3.  Divisions of Gastroenterology1 and Nephrology & Hypertension2, University of Colorado at Denver and Integrated Program in Immunology3, National Jewish Hospital, Denver, CO. Colorado GI Pathology4, Centennial, CO.  Intercept Pharmaceuticals, New York, NY5. Tracy Voss Condon - Surfactant Proteins Decrease Uptake of Bacillus anthracis Spores Thomas Delong - Chromogranin A - A New Antigen for Autoreactive T Cells in Type 1 Diabetes Corinne De Persis - Exploring the Contribution of Ig-b’s Serine and Threonine Residues on BCR Signaling CORINNE DE PERSIS, Integrated Department of Immunology at the University of Colorado at Denver and National Jewish Health, Denver, Colorado. Nichole Reisdorph, David Riches, John Cambier, Raul Torres, and Roberta Pelanda.  Francina Deason - Got Mg2+ ? The emerging role of Mg2+ availability on BCR signaling Deason-Towne F, Schmitz C, Zhao X, Perraud AL Lisa Peterson - Src-like adaptor protein (SLAP)-deficiency prevents chronic arthritis in SKG mice Lisa Peterson, Ph.D1, Laura Shaw1, Shimon Sakaguchi4 and Leonard L. Dragone MD, Ph.D 1,2,3. 1National Jewish Health, Denver, Colorado 80206, 2University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, 80045, 3The Children’s Hospital, Aurora, Colorado 80045. 4Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507. Greg Kirchenbaum - Functional and Phenotypic Investigation of IgH knock-in “Canonical” Ars-binding B cells. Jens Eberlein - Development of the 'chemokine flow cytometry assay' and its application to the characterization of pathogen-specific T cells. Jens Eberlein1, Tom T. Nguyen1, Francisco Ramirez-Victorino1, Lucy Golden-Mason2,3, Hugo R. Rosen2,3, Leah Sheridan1, Jessica Human4, Laurel L. Lenz4, Thomas E. Lane5 and Dirk Homann1,3 1Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora CO; 2Division of Gastroenterology & Hepatology, Hepatitis C Center, Department of Medicine, University of Colorado Denver, Aurora, CO; 3Integrated Department of Immunology, University of Colorado Denver and National Jewish Medical and Research Center, Denver CO; 4Department of Immunology, National Jewish Medical and Research Center, Denver CO; 5Department of Molecular Biology and Biochemistry, University of California, Irvine CA Jonathan Buhrman - Enrichment of Baculovirus Encoding Peptide-MHC Libraries Using Antigen-specific T Cells Jon Buhrman and Jill Slansky Kavita Tundwal - Sprouty2 Mediates Opposing Signaling Outcomes in Acute Vs Chronic IL-13 Stimulations Thiago Detanico - T Cell Tolerance to a Immunoglobulin V-region Peptide: More than just Negative Selection in the Thymus Thiago Detanico, Ryan Heizer, Katja Aviszus and Lawrence J. Wysocki. Integrated Department of Immunology, National Jewish Health. Bennett Davenport - Molecular Determinants in the Progressive Differentiation of Anti-Viral CD8 Memory T cells Samantha Friend - Identifying the deubiquitinase USP10 within the TCR complex through its interaction with SLAP Samantha Friend1, Laura Travers3, Staci Kearney1,2, Dmitri Ryenkov2, Nicole Reisdorph2, Laura A Shaw2 and Leonard Dragone1,2,4 1Pediatrics and Immunology, University of Colorado Denver School of Medicine, Aurora, Colorado 2Immunology, National Jewish Health, Denver, Colorado, 3University of Colorado Boulder, 4The Children’s Hospital, Aurora, Colorado Eric Clambey - MicroRNAs in the Regulation of Acute Lung Injury, Hypoxia and Inflammation Eric T. Clambey, Kelley S. Brodsky, Holger K. Eltzschig.  Mucosal Inflammation Program, Integrated Dept. of Immunology, Dept. of Anesthesiology, University of Colorado Denver, Denver, CO. Tom Packard - Is COPD an autoimmune disease?: Defining autoantibody specificity in COPD Francesca Alvarez-Calderon - Altered glucose utilization contributes to BCR-ABL+ CML survival upon imatinib mesylate treatment Francesca Alvarez-Calderon; Mark Gregory; Natalie Serkova; James Degregori Kimberly Jordan - Characterization of T cells responding to tumor mimotope vaccines Kimberly R. Jordan, John W. Kappler, Jill E. Slansky Yuan Li - In vitro analysis of TRPM2 ion channel function in innate immunity Andrew Getahun - Gammaherpesvirus 68 infection and the loss of B cell anergy Andrew Getahun, Linda van Dyk and John Cambier. Janie Akerlund - Mechanisms and receptor targets of SHIP-1/Dok-1-mediated trans-inhibitory signaling Almut Grenz - Adenosine-dependent renal protection from ischemia: Selective role for the A2B adenosine receptor Almut Grenz,1,2 Jessica Bauerle,2 Dan Yang,3 Zung Vu Tran,4 Katya Ravid,3 and Holger K. Eltzschig2 1Department of Pharmacology and Toxicology, Tübingen University Hospital, Tübingen, Germany, 2Mucosal Inflammation Program, Department of Anesthesiology and Perioperative Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA, 3Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA, 4Department of Biostatistics, University of Colorado, Denver, Colorado, USA Kara Lukin - In Class Debates Enhance Student Learning Communities  **&**  Teaching Opportunities at NJH. Beth Tamburini - Memory CD8 T cells are unable to respond to persistent antigen Beth A. Tamburini and Ross Kedl University of Colorado Denver and National Jewish Health Matthew Burchill - TNFR:TNFR-ligand Interactions Program CD8 T Cell Competition Matthew A. Burchill, Phillip J. Sanchez, Philippa Marrack and Ross M. Kedl.  Integrated Department of Immmunology, University of Colorado Denver, National Health, Denver, CO, USA, 80206 Kara Lukin - Loss of Pax5 heterozygosity results in lymphoproliferative disease Shannon Oda - Lysophosphatidic acid regulation of B and T cell function Shannon Oda, Jiancheng Hu, Erin Donovan, Roberta Pelanda, and Raul Torres. Glen McConville - Investigation on the Influence of Stray Light in the Dobson Spectrophotometer Lindsay Pujanauski - Characterizing the primary B cell antibody response to HIV Lindsey Pujanauski1, Ted Ross2, Roberta Pelanda1, Raul Torres1 Integrated Department of Immunology, University of Colorado Denver and National Jewish Health1 and University of Pittsburgh School of Medicine2 Christina Roark - Beacon Biotechnology’s Point of Care Type I Diabetes Screen. Christina L. Roark, Roberta Thimmig, Ted Cull, and Millard Cull. Beacon Biotechnology, LLC., Aurora, CO 80045