Denver Immunology History and Highlights
1959:  David Talmage, who together with Burnet formulated the clonal selection theory, moves to Denver to head the Division of Allergy at the University of Colorado

1967:  Henry Claman provides the first evidence that cells originating from the thymus and bone marrow collaborate in the antibody response (T-B lymphocyte collaboration)

1967:  Kimishige Ishiszaka discovers IgE

1983:  Kevin Lafferty, who developed the concept of co-stimulation for lymphocyte activation, is the first director of the Barbara Davis Center of Juvenile diabetes

1978-1988:  Howard Grey participates in defining how T lymphocytes recognize antigen

1987-1988:  John Kappler and Pippa Marrack provide the first evidence that autoreactive lymphocytes are negatively selected and also participate in identifying and characterizing the T cell antigen receptor

1989:  David Nemazee identifies receptor editing as a mechanism by which autoreactive B lymphocytes are rendered tolerant