Willi K. Born, PhD.
Title(s): Professor
Primary Department: Immunology
Education: Diploma in Biologie ( MS) 1977
Dr. rer. nat. (Ph.D.) 1982 at the MPI and Albert Ludwigs University, Freiburg, Germany
Email: bornw@njc.org

 
 
 

Research Program

We are studying the biology of gamma-delta T cells. Problems of specific interest include ligands of the gamma-delta TCR, functional development of gamma-delta T cells, organization of the gamma-delta T cell system and interactions of gamma-delta T cells with other cells and systems in the vertebrate body. We are also interested in the role of gamma-delta T cells in diseases, and in possible therapeutic uses of gamma-delta T cell function.

Publications

  • Born, W., Yagüe, J., Palmer, E., Kappler, J. and Marrack, P. Rearrangement of T cell receptor  chain genes during T cell development. Proc. Natl. Acad. Sci. USA 82: 2925-2929, 1985.
  • Born, W., Rathbun, G., Tucker, P., Marrack, P. and Kappler, J. Synchronized rearrangements of T cell  and  chain genes in fetal thymocyte development. Science 234: 479-482, 1986.
  • Born, W., Miles, C., White, J., O'Brien, R., Freed, J. H., Marrack, P., Kappler, J. and Kubo, R.T. Peptide sequences of T cell receptor  and  chains are identical to predicted X and  proteins. Nature, 330: 572-574,1987.
  • Chien, Y., Iwashima, M. Wettstein, D., Kaplan, K., Elliott, J. F., Born, W., and Davis, M. M. T cell receptor gene rearrangement in early thymocytes. Nature, 330: 722-727,1987.
  • O'Brien, R. L., Happ, M. P., Dallas, A., Palmer, E., Kubo, R. and Born, W. Stimulation of a major subset of lymphocytes expressing T cell receptor gd by an antigen derived from Mycobacterium tuberculosis. Cell 57: 667-674, 1989.
  • White, J., Blackman, M., Bill, J., Kappler, J., Marrack, P. and Born, W. Two better cell lines for making hybridomas expressing specific T cell receptors. J. Immunol. 143: 1822-1825,1989.
  • Finkel, T. H., Cambier, J. C., Kubo, R. T., Born, W.K., Marrack, P. and Kappler, J. The thymus has two functionally distinct populations of immature gd+ T cells: one population is deleted by ligation of gd TCR. Cell 58: 1047-1054, 1989.
  • Happ, M.P., Kubo, R.T., Palmer, E., Born, W.K. and O'Brien, R.L. Limited receptor repertoire in a mycobacteria-reactive subset of gd T lymphocytes. Nature 342: 696-698, 1989
  • Born, W., Hall, L., Dallas, A., Boymel, J., Shinnick, T., Young, D., Brennan, P., and O'Brien, R. Recognition of a peptide antigen by heat shock reactive gdT lymphocytes. Science 249: 67-69, 1990.
  • Reardon, C., Lefrancois, L., Farr, A., Kubo, R., O’Brien, R. and Born, W. Expression of gd T-cell receptors on lymphocytes from the lactating mammary gland. J. Exp. Med.172:1263-1266, 1990.
  • O'Brien, R.L., Fu, Y.-X., Cranfill, R., Dallas, A., Reardon, C., Lang, J., Carding, S., Kubo, R., and Born, W. HSP-60 reactive gd T cells: a large, diversified T lymphocyte subset with highly focused specificity. Proc. Natl. Acad. Sci. USA 89:4348-4352, 1992.
  • Fu, Y.-X., Cranfill, R., Vollmer, M., van der Zee, R., O'Brien, R.L., and Born, W. In vivo response of murine gd T cells to an HSP-60 derived peptide. Proc. Natl. Acad. Sci. (USA) 90:322-326, 1993.
  • Fu, Y.-X., Ellis-Roark, C., Kelly, K., Drevets, D., Campbell, P., O'Brien, R. and Born, W. Immune protection and control of inflammatory tissue necrosis by gd T cells. J. Immunol. 153:3101-3115,1994.
  • Heyborne, K., Fu, Y.-X., Nelson, A., Farr, A., O'Brien, R. and Born, W. Recognition of trophoblasts by gd T cells. J. Immunol. 153:2918-2926,1994.
  • Lahn, M., Kalataradi, H., Mittelstadt, P., Pflum, E., Vollmer, M., Cady, C., Mukasa, A., Vella, A., Ikle, D., Harbeck, R., O'Brien, R., and Born, W. Early preferential stimulation of gd T cells by tumor necrosis factor alpha. J. Immunol. 160:5221-5230,1998.
  • Lahn, M., Kanehiro, A., Takeda, K., Joetham, A., Schwarze, J., Kohler, G., O’Brien, R., Gelfand, E.W., Born, W. Negative regulation of airway responsiveness that is dependent on gd T cells and independent of gd T cells. Nature Medicine 5: 1150-1156, 1999.
  • Cady, C.T., Lahn, M., Vollmer, M., Tsuji, M., Seo, S.J., Reardon, C.L., O’Brien, R.L., and Born, W.K. Response of murine gd T cells to the synthetic polypeptide polu-Glu50Tyr50. J.Immunol. 165:1790-1798, 2000.
  • Huber, S.A., Graveline, D., Newell, M.K., Born, W.K., and O’Brien, R.L. V1+ T cells suppress and V4+ T cell promote susceptibility to coxsackievirus B3-induced myocarditis in mice. J.Immunol. 165:4174-4181, 2000.
  • O'Brien, R.L., Yin, Xiang, Huber, S., Ikuta, K., and Born, W.K. Depletion of a gd T cell subset can increase host resistance to a bacterial infection. J. Immunol. 165:6472-6479, 2000.
  • Lahn, M., Kanehiro, A., Takeda, K., Terry, J., Hahn, Y.-S., Aydintug, M.K., Konowal, A., Ikuta, K., O’Brien, R.L., Gelfand, E.W., and Born, W.K. MHC class I-dependent V4+ pulmonary T cells regulate gd T cell-independent airway responsiveness. Proc.Natl.Acad.Sci. (USA)., 99:8850-8855, 2002.
  • Born, W.K., Vollmer, M., Reardon, C., Matsuura, E., Voelker, D.R., Giclas, P.C., O’Brien, R.L. Hybridomas expressing gd T cell receptors respond to cardiolipin and beta-2-glycoprotein I (apolipoprotein H). Scand.J.Immunol.58:374-381, 2003
  • Hahn, Y.-S., Taube, C., Takeda, K., Jin, N., Takeda, K., Park J.-W., Wands, J.M., Aydintug M.K., Roark C.L., Lahn, M., O’Brien, R.L., Gelfand, E.W., and Born, W.K. V4+ T cells regulate airway hyperreactivity to methacholine in ovalbumin-sensitized and challenged mice. J.Immunol.171:3170-3178, 2003
  • Hahn, Y.-S., Taube, C., Jin, N., Sharp, L., Wands, J.M., Aydintug, M.K., Lahn, M., Huber, S., O’Brien, R.L., Gelfand, E.W., and Born, W.K. Different Potentials of gd T Cell Subsets in Regulating Airway Responsiveness: V1+ Cells, but not V4+ Cells, Promote Airway Hyperreactivity, Th-2 Cytokines and Airway Inflammation. J.Immunol. 172: 2894-2902, 2004
  • Aydintug, M.K., Roark, C.L., Saffrey, M., Yin, X., Wands, J.M., Born, W.K., O’Brien, R.L. Detection of Cell Surface Ligands for the gd TCR using soluble TCRs. J.Immunol., 172: 4167-4175, 2004.
  • Lahn, M., Kanehiro, A., Hahn, Y.-S., Wands, J.M., Aydintug, M.K., O’Brien, R.L., Gelfand, E.W., Born, W.K. Aerosolized anti-T cell receptor antibodies are effective against airway inflammation and hyperreactivity in allergic mice. Int. Arch. Allergy and Immunology, 134: 49-55, 2004.
  • Jin, N., Taube, C., Sharp, L., Hahn, Y.-S., Yin, X., Wands, JM., Roark, C. L., O’Brien, R.L., Gelfand, E.W., and Born, W.K. Mismatched antigen prepares gd T cells for suppression of airway hyperresponsiveness. J.Immunol., 174:2671-2679, 2005.
  • Wands, J.M., Roark, C.L., Aydintug, M.K., Jin, N., Hahn, Y.-S., Cook, L., Yin, X., Dalporto, J., Lahn, M., Hyde, D.M., Gelfand, E.W., Mason, R.J., O’Brien, R.L., and Born, W.K. Distribution and leukocyte contacts of gd T cells in the lung. J. Leukocyte Biol. 78: 1086-1096, 2005
  • French, J., Roark, C.L., Born, W.K., and O’Brien, R.L. Gamma delta T cell homeostasis is established in competition with gd T cells and NK cells. Proc.Natl.Acad.Sci. (USA), 102: 14741-14746, 2005.

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