Education:
Medical School: University of Miami School of Medicine, 1989
Internship/Residency: Beth Israel Deaconess Medical Center, 1989-1992
Fellowship: University of California, Los Angeles, 1992-1995
Board Certified in Internal Medicine and Gastroenterology

Honors:

• University of Miami Presidential Academic Scholarship
• NIH training grant (UCLA)
• Senator Mark Hatfield Award for Clinical Research
• American Society of Transplantation Award for Research Excellence in Clinical Science (two times)
• Guest Editor, Clinics in Liver Disease (four times)
• Merit Review Award (three times)

Faculty Appointments:
Portland VA Medical Center
Oregon Health & Sciences University, 1995-2005
Associate Professor of Medicine, Molecular Biology, and Immunology, 2000-2005
Professor of Medicine and Head, Division of Gastroenterology & Hepatology, University of Colorado, July, 2005-

National Committees/Responsibilities:

• Director, NIH-sponsored Hepatitis C Center Grant
• Executive Planning Committee, American Society Transplantation
• Associate Editor, Liver Transplantation
• Board of Directors, American Society Transplantation
• NIH Action Plan in Liver Disease
• Chairman, Liver and Intra-abdominal Organs, American Society of Transplant Physicians (developed guidelines for transplant hepatology training)
• Nominating Committee, American Association for the Study of Liver Diseases
• Public Policy Committee, American Association for the Study of Liver Diseases

Clinical Interests:
Hepatitis C, general hepatology and liver transplantation.

Research Interests:

The focus of our laboratory (hyperlink to lab webpage) is to understand the immune response to hepatitis C virus (HCV), particularly the mechanisms associated with spontaneous or therapeutic clearance versus viral persistence. The balance between HCV and host immune response depends on multiple factors such as nature of the infecting virus, route of infection and initial viral burden, genetic background of the individual as well as the immune status of the infected host. The interplay between these parameters ultimately determines the spectrum of possible clinical outcomes associated with viral infection. We currently have 5 federally funded research programs, including a recently awarded NIH HCV Center grant.

Representative Publications:

• Tester I, Smyk-Pearson S, Wang P, Wertheimer A, Yao E, Lewinsohn DM, Tavis JE, Rosen HR. Immune evasion versus recovery after acute hepatitis C virus infection from a shared source. J Exp Med. 2005 Jun 6;201(11):1725-31 (see comments).
• Weston S, Leistikow, Reddy R, Wertheimer AM, Lewinsohn DM, Chou S, Corless CL, O'Farrelly C, Nelson D, Rosen HR. Reconstitution of hepatitis C virus-specific T cell-mediated immunity following liver transplantation. Hepatology 2005 Jan;41(1):72-81.
• Rosen HR, Hinrichs DJ, Leistikow RL, Calendar G, Nishimura M, Lewinsohn. Selection of HCV-specific CD8+ T cells by donor HLA alleles following liver transplantation. J Immunology Cutting Edge 2004 Nov 1;173(9):5355-9.
• Burton JR, Sonnenberg A, Rosen HR. Retransplantation for recurrent HCV in the MELD era: Maximizing utility. Liver Transplantation 2004 Oct; 10 Suppl 10:S59.
• Wertheimer AW, Bakke A, Rosen HR. Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease; Hepatology; 2004: 40: 335-345.
• Simon B, Cornell K, Clark T, Chou S, Rosen HR, Barry R. DNA vaccination protect mice against challenge with recombinant Listeria monocytogenes expressing hepatitis C virus NS3 protein. Infect Immun. 2003 Nov; 71(11): 6372-80.
• Wertheimer AM, Miner C, Lewinsohn DM, Sasaki AW, Kaufman E, Rosen HR. Novel CD4+ and CD8+ T-cell determinants within the NS3 protein in subjects with spontaneously resolved HCV infection. Hepatology 2003; 37:577-89.
• Rosen HR, Miner C, Sasaki AW, Lewinsohn DM, Conrad AJ, Bakke A, Bouwer HG, Hinrichs DJ. Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: correlation with clinical disease stages. Hepatology 2002; 35:190-8.
• Rosen HR, Fontana RJ, Brown RS, Wiesner RH, Schiano TD, Bass NM, Bloomer JR, Kaplan L. Curricular guidelines for training in transplant hepatology. Liver Transpl 2002; 8:85-7.
• Rosen HR, Madden JP, Martin P. A model to predict survival following liver retransplantation. Hepatology 1999; 29:365-70.

View of Recent Publications in PubMed