Research Interests:

Immunobiology of Type I Diabetes; Immunology of privileged sites; Tumor Immunology; and T cell differentiation.

Recent Representative Research Publications

• Nelson, D., Setser, E., Akanbi, A., Hall, G., Klevitsky, R., Osinska, H., Bellgrau, D., Duke, R.C. and Robbins, J. 2000 Pro-inflammatory consequences of transgenic Fas ligand expression in the heart. Journal of Clinical Investigation 105:1199-1208
• Stubbs, A.C., Martin, K., Franzusoff, A., Bellgrau, D., Duke, R.C. and Wilson, C.C. 2001 Whole recombinant yeast vaccine activates dendritic cells and elicits protective cell mediated immunity. Nature Medicine 7 (5): 625-29
• Moore, J., Scheinman, R. and Bellgrau, D. 2001, The identification of a novel T cell activation state controlled by a diabetogenic gene.J. Immunol.,166:241-248
• Bellgrau, D. and Sun, J. 2002 The induction of graft specific toleranc e induction moves one step closer to the clinic. Transplantation 73:1384-85
• Lang, J. and Bellgrau, D. 2002 A T cell functional phenotype common among autoimmune-prone mouse strains. Scandinavian Journal of Immunology 55:546-59
• Zuraff-Perryman, L., Duke, R.C., Nelson, D.P, and Bellgrau, D. Murine heart transgenic Fas ligand expression protects against allograft rejection. 2002 Trans. Proc. 34(8): 3396-98
• Bianco, S.R., Fosmire, S., Hance, K., Padilla, M., Ritt, M.G., Getzy, D.M., Duke, R.C., Bellgrau, D., Cutter, G.R., Withrow, S.J., Lana, S., Matthiesen, D.T., Helfand, S.C. and Modiano, J.F. 2003 Enhancing anti-melanoma immune responses through gene therapy. Can. Gene Therapy 10:726-36
• Modiano, J.F.; Sun, J., Lang, J., Vacano, G., Patterson, D., Chan, D.Franzusoff, A.,Gianani, R.,., Meech, S.J., Duke, R. and Bellgrau, D. 2004 Fas ligand dependent suppression of autoimmunity via recruitment and subsequent termination of activated T cells. Clinical Immunology, in press
• Lang, J., Kominski, D., Scheinman, R. and Bellgrau, D. 2004 Partial activation leads to premature death of T cells harboring and Ian gene mutation. Eur. J. of Immunology in press

View of Recent Publications in PubMed