Department of Immunology -Program Faculty

T Cell Development & Function

Rafeul Alam, MD/PhD - Mechanism of activation of Src family kinases in T cells

Willi Born, PhD - Role of dendritic cells in gamma/delta T cell development.

Rebecca O'Brien, PhD - The role of the TCR in gamma/delta T cell responses.

Susan Boackle, MD - Role of complement receptor 2 in antigen presentation and T cell tolerance.

John Cambier, PhD - GP 120 induced CD4 signaling of cell death

Leonard Dragone, MD/PhD - The role of Src-like adaptor (SLAP) In T-cell repertoire selection and autoimmune pathogenesis.

Erwin Gelfand, MD - Influence of age on the T-cell response to allergen or viral infection.

Erwin Gelfand, MD - Lucas Cell cycle regulation of T-cell differentiation and function.

Kathryn Haskins, PhD - Effector T cell function of pathogenic CD4 Th1 T cell clones in type 1 diabetes - in vitro T cell clones and TCR transgenic mice.

Dirk Homann, MD/MA Regulation of antiviral CD8 and CD4 T cell immunity (primary, memory and secondary responses).

Hua Huang, PhD - Interaction between T cells and bone marrow progenitor cells.

John Kappler, PhD - Role of T cell affinity/avidity in T cell fate decisions.

Philippa Marrack, PhD and John Kappler, PhD - Relationship between TCR and MHC.

Ross Kedl, PhD - The control of CD8+ T cell expansion in memory.

Jaime Modiano, VMD/PhD - Regulation of T cell cycle entry and progression.

Mark Nicolls, MD - Mechanisms of T cell activation in experimental lung transplantation.

Terry Potter, PhD - Role of CD8 in T cell activation and in the death of thymocytes.

Yosef Refaeli, PhD - Mechanisms that control T-cell homeostasis, and their role in transformation.

Jill Slansky, PhD - CD8+T cell response to self/tumor antigens. T cell response and hypoxia.

Cara Wilson, MD - HIV-specific T cell function and maturation.

Lawrence Wysocki, PhD - T cell reactions to antibody V regions as a potential source of help to autoreactive B cells in arthritic disease and the basis of undesirable immune reactions against therapeutic monoclonal antibodies.

NK T Cells

Laurent Gapin, PhD - Molecular Basis of NKT cell development Basis of glycolipid recognition by NKT cells

Eosinophils

Rafeul Alam, MD/PhD - Mechanism of differentiation of eosinophils.

B Cells

Susan Boackle, MD - Role of complement receptor 2 in B cell tolerance.

John Cambier, PhD - Aging associated defects in B cell development and function. Molecular basis of B cell anergy. Molecular basis and physiologic function of MHC class II signaling. BCR and FcgRIIB cross talk in regulation of B cell function.

Leonard Dragone, MD/PhD - The role of Src-like adaptor (SLAP) In B-cell development, receptor editing and the pathogenesis of SLE.

James Hagman, PhD - Determination of how nuclear proteins guide stem cells to become B cells Determination of how nuclear proteins activate gene targets necessary for antibody production in the immune response Determination of how nuclear proteins control numbers and functions of B cells as they transit from bone marrow to peripheral organs of the immune system.

V. Michael Holers, MD - Role of Complement in B cell activation and autoimmunity.

Roberta Pelanda, PhD - Autoreactive and non-autoreactive B cell development and selection. Molecular basis of B cell survival. Mechanisms of autoantibody production.

Yosef Refaeli, PhD - Alteration of normal B-cell development and function by dysregulated oncogenes.

Hong Bing Shu, PhD - TALL1/BAFF-mediated B cell survival and differentiation.

Raul Torres, PhD - Signals guiding B cell development and function. Chemokine response and adhesion of developing B lineage cells. Chemokine response and adhesion of mature B cells during a humoral immune response.

Linda van Dyk, PhD - B cell signaling and differentiation in viral infection.

Lawrence Wysocki, PhD - Somatic mutation in autoimmunity. Regulatory B cells in autoimmunity and transplantation. Memory B cell development.