Summary of Research:
I use the new baculovirus library technology developed by Dr. John Kappler to discover many new peptide mimotopes that elicit antitumor T cell responses. My goal is to add to the list of rules to design an effective mimotope vaccine. I am also determining what it means to be an “antigen-specific” T cell, as I have found 100s of peptides that elicit T cells that cross react with tumor.
I use the new baculovirus library technology developed by Dr. John Kappler to discover many new peptide mimotopes that elicit antitumor T cell responses. My goal is to add to the list of rules to design an effective mimotope vaccine. I am also determining what it means to be an “antigen-specific” T cell, as I have found 100s of peptides that elicit T cells that cross react with tumor.
Awards/Publications:
1. Jordan KR, RH McMahan, JZ Oh, MR Pipeling, DM Pardoll, RM Kedl, JW Kappler, JE Slansky. Baculovirus-infected insect cells expressing peptide-MHC complexes elicit protective antitumor immunity. (in press) 2008.
2. R. H. McMahan, J. A. McWilliams, K. R. Jordan, S. W. Dow, D. B. Wilson and J. E. Slansky. Relating MHC-peptide-TCR affinity to immunogenicity for the rational design of tumor vaccines. J Clin Invest. 2006 Sept; 116(9).
3. Crawford F, Jordan KR, Stadinski B, Wang Y, Huseby E, Marrack P, Slansky JE, Kappler JW. Use of baculovirus MHC/peptide display libraries to characterize T-cell receptor ligands Immunol Rev. 2006 Apr; 210:156-70.
4. Bajer AA, Garcia-Tapia D, Jordan KR, Haas KM, Werling D, Howard CJ, Estes DM Peripheral blood-derived bovine dendritic cells promote IgG1-restricted B cell responses in vitro. J Leukoc Biol. 2003 Jan;73(1):100-6
5. Carter DB, Lai L, Park KW, Samuel M, Lattimer JC, Jordan KR, Estes DM, Besch-Williford C, Prather RS. Phenotyping of transgenic cloned piglets. Cloning Stem Cells. 2002;4(2):131-45
Lab: Jill Slansky and John Kappler
Starting Year: 2002
e-mail: Kimberly.Jordan@uchsc.edu
Lab Phone: 303-398-1320
Undergrad: University of Missouri
Home Town: Missouri
Starting Year: 2002
e-mail: Kimberly.Jordan@uchsc.edu
Lab Phone: 303-398-1320
Undergrad: University of Missouri
Home Town: Missouri
Kim Jordan
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