Our lab studies various aspects of B cell development.  My project focuses on which signals may be mediating the survival and selection of immature B cells in the bone marrow.  We are investigating whether signaling events through non-autoreactive B cell antigen receptors (BCRs) and cytokine receptors cooperate to control the lifespan of these cells.  We hypothesize that tonic signals through non-autoreactive BCRs alter the expression of cytokine receptors on immature B cells, and the combination of survival signals through these receptors allow non-autoreactive immature B cells to continue development and enter the peripheral population.

 

 

 

 

Cancer Research Institute Predoctoral Emphasis Pathway in Tumor Immunology Fellowship (2005, 2006, 2007)