Chapter 10 - References

(1) Bottazzo GF, Florin-Christensen A, Doniach D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 1974;2(7892):1279-83.
http://www.ncbi.nlm.nih.gov/pubmed/4139522
(2) Palmer JP, Asplin CM, Clemons P, Lyen K, Tatpati O, Raghu PK, et al. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 1983;222(4630):1337-9.
http://www.ncbi.nlm.nih.gov/pubmed/6362005
(3) Seissler J, Scherbaum WA. Autoimmune diagnostics in diabetes mellitus. Clin Chem Lab Med 2006;44(2):133-7.
http://www.ncbi.nlm.nih.gov/pubmed/16475896
(4) Rustenbeck I, Lenzen S. Effects of lysophosphatidylcholine and arachidonic acid on the regulation of intracellular Ca2+ transport. Naunyn Schmiedebergs Arch Pharmacol 1989 Jan;339(1-2):37-41.
http://www.ncbi.nlm.nih.gov/pubmed/2498670
(5) Miao D, Yu L, Eisenbarth GS. Role of autoantibodies in type 1 diabetes. Front Biosci 2007 Jan 1;12:1889-98.:1889-98.
http://www.ncbi.nlm.nih.gov/pubmed/17127428
(6) Isermann B, Ritzel R, Zorn M, Schilling T, Nawroth PP. Autoantibodies in diabetes mellitus: current utility and perspectives. Exp Clin Endocrinol Diabetes 2007 Sep;115(8):483-90.
http://www.ncbi.nlm.nih.gov/pubmed/17853330
(7) Greenbaum C, Palmer JP, Kuglin B, Kolb H, and Participating Laboratories. Insulin autoantibodies measured by radioimmunoassay methodology are more related to insulin-dependent diabetes mellitus than those measured by enzyme-linked immunosorbent assay: results of the Fourth International Workshop on the Standardization of Insulin Autoantibody Measurement. J Clin Endocrinol Metab 1992;74(5):1040-4.
http://www.ncbi.nlm.nih.gov/pubmed/1569152
(8) Baekkeskov S, Aanstoot H-J, Christgau S, Reetz A, Solimena M, Cascalho M, et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase [published erratum appears in Nature 1990 Oct 25;347(6295):782]. Nature 1990;347(6289):151-6.
http://www.ncbi.nlm.nih.gov/pubmed/1697648
(9) Rabin DU, Pleasic SM, Palmer-Crocker R, Shapiro JA. Cloning and expression of IDDM-specific human autoantigens. diab 1992;41(2):183-6.
http://www.ncbi.nlm.nih.gov/pubmed/1733807
(10) Rabin DU, Pleasic SM, Shapiro JA, Yoo-Warren H, Oles J, Hicks JM, et al. Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J Immunol 1994;152(6):3183-8.
http://www.ncbi.nlm.nih.gov/pubmed/8144912
(11) Lan MS, LU J, Goto Y, Notkins AL. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol 1994;13(5):505-14.
http://www.ncbi.nlm.nih.gov/pubmed/8024693
(12) Wasmeier C, Hutton JC. Molecular cloning of phogrin, a protein-tyrosine phosphatase homologue localized to insulin secretory granule membranes. J Biol Chem 1996;271(30):18161-70.
http://www.ncbi.nlm.nih.gov/pubmed/8663434
(13) LU J, Li Q, Xie H, Chen Z-J, Borovitskaya AE, Maclaren NK, et al. Identification of a second transmembrane protein tyrosine phosphatase, IA-2β, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment. Proc Natl Acad Sci USA 1996;93:2307-11.
http://www.ncbi.nlm.nih.gov/pubmed/8637868
(14) Wenzlau JM, Moua O, Sarkar SA, Yu L, Rewers M, Eisenbarth GS, et al. SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes. Ann N Y Acad Sci 2008 Dec;1150:256-9.
http://www.ncbi.nlm.nih.gov/pubmed/19120307
(15) Wenzlau JM, Juhl K, Yu L, Moua O, Sarkar SA, Gottlieb P, et al. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci U S A 2007 Oct 23;104(43):17040-5.
http://www.ncbi.nlm.nih.gov/pubmed/17942684
(16) Castano L, Russo E, Zhou L, Lipes MA, Eisenbarth GS. Identification and cloning of a granule autoantigen (carboxypeptidase-H) associated with type I diabetes. J Clin Endocrinol Metab 1991;73(6):1197-201.
http://www.ncbi.nlm.nih.gov/pubmed/1955501
(17) Thomas NM, Ginsberg-Fellner F, Mcevoy RC. Strong association between diabetes and displacement of mouse anti-rat insulinoma cell monoclonal antibody by human serum in vitro. diab 1990;39:1203-11.
http://www.ncbi.nlm.nih.gov/pubmed/1698675
(18) Pan Y-X, Thomas NM, Mcevoy RC. Purification and partial characterization of 160 kD and 155 kD B cell membrane antigens detected by MAb 1A2. Autoimmunity 15,Supplement, 77A. 1993.
Ref Type: Abstract
http://www.sciencedirect.com/science?_ob=PublicationURL&_cdi=6847&_pubType=J&_acct=C000019840&_version=1&_urlVersion=0&_userid=8148748&md5=91386ca697f9790d8fc0613abc6f0446&jchunk=6#6
(19) Karounos DG, Wolinsky JS, Thomas JW. Monoclonal antibody to rubella virus capsid protein recognizes a β-cell antigen. J Immunol 1993;150:3080-5.
http://www.ncbi.nlm.nih.gov/pubmed/8454875
(20) Arden SD, Zahn T, Steegers S, Webb S, Bergman B, O'Brien RM, et al. Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. diab 1999 Mar;48(3):531-42.
http://www.ncbi.nlm.nih.gov/pubmed/10078553
(21) Canino GJ, Bird HR, Shrout PE, Rubio-Stipec M, Bravo M, Martinez R, et al. The prevalence of specific psychiatric disorders in Puerto Rico. Arch Gen Psychiatry 1987;44(8):727-35.
http://www.ncbi.nlm.nih.gov/pubmed/3498456
(22) Gurr W, Shaw M, Li Y, Sherwin R. RegII is a beta-cell protein and autoantigen in diabetes of NOD mice. Diabetes 2007 Jan;56(1):34-40.
http://www.ncbi.nlm.nih.gov/pubmed/17192462
(23) Dosch HM, Karjalainen J, VanderMeulen J. Lack of immunity to bovine serum albumin in insulin-dependent diabetes mellitus (letter). N Engl J Med 1994;330(22):1616-7.
http://www.ncbi.nlm.nih.gov/pubmed/8177260
(24) Pietropaolo M, Castano L, Babu S, Buelow R, Martin S, Martin A, et al. Islet cell autoantigen 69 kDa (ICA69): molecular cloning and characterization of a novel diabetes associated autoantigen. J Clin Invest 1993;92:359-71.
http://www.ncbi.nlm.nih.gov/pubmed/8326004
(25) Gordon TP, Cavill D, Neufing P, Zhang YJ, Pietropaolo M. ICA69 autoantibodies in primary Sjogren's syndrome. Lupus 2004;13(6):483-4.
http://www.ncbi.nlm.nih.gov/pubmed/15303579
(26) Spitzenberger F, Pietropaolo S, Verkade P, Habermann B, Lacas-Gervais S, Mziaut H, et al. Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells. J Biol Chem 2003 Jul 11;278(28):26166-73.
http://www.ncbi.nlm.nih.gov/pubmed/12682071
(27) Elias D, COHEN I, SHECHTER Y, Spirer Z, Golander A. Antibodies to insulin receptor followed by anti-idiotype. diab 1987;36:348-54.
http://www.ncbi.nlm.nih.gov/pubmed/3803741
(28) Birk OS, Elias D, Weiss AS, Rosen A, van-der ZR, Walker MD, et al. NOD mouse diabetes: the ubiquitous mouse hsp60 is a beta-cell target antigen of autoimmune T cells. J Autoimmun 1996;9(2):159-66.
http://www.ncbi.nlm.nih.gov/pubmed/8738959
(29) Huurman VA, van der Meide PE, Duinkerken G, Willemen S, Cohen IR, Elias D, et al. Immunological efficacy of heat shock protein 60 peptide DiaPep277 therapy in clinical type I diabetes. Clin Exp Immunol 2008 Jun;152(3):488-97.
http://www.ncbi.nlm.nih.gov/pubmed/18422727
(30) Atkinson MA, Maclaren NK, Scharp DW. No evidence for HSP65 in insulin dependent diabetes. Lancet 1990;337:263-4.
http://www.thelancet.com/journals/lancet/issue/current?tab=past
(31) Chang YH, Shiau MY, Tsai ST, Lan MS. Autoantibodies against IA-2, GAD, and topoisomerase II in type 1 diabetic patients. Biochem Biophys Res Commun 2004 Jul 30;320(3):802-9.
http://www.ncbi.nlm.nih.gov/pubmed/15240119
(32) Colman PG, Nayak RC, Campbell IL, Eisenbarth GS. Binding of cytoplasmic islet cell antibodies is blocked by human pancreatic glycolipid extracts. diab 1988;37(5):645-52.
http://www.ncbi.nlm.nih.gov/pubmed/3282949
(33) Pfleger C, Kaas A, Hansen L, Alizadeh B, Hougaard P, Holl R, et al. Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes. Clin Immunol 2008 Jul;128(1):57-65.
http://www.ncbi.nlm.nih.gov/pubmed/18434252
(34) Aanstoot H-J, Kang S-M, Kim J, Lindsay L, Roll U, Knip M, et al. Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type I diabetes. J Clin Invest 1996;97(12):2772-83.
http://www.ncbi.nlm.nih.gov/pubmed/8675688
(35) Lampasona V, Scirpoli M, Bosi E, Bonifacio E. ICA12(SOX13) autoantibodies are unlikely to be a useful marker for pre-clinical Type I diabetes. diabetol 2001 Feb;44(2):267.
http://www.ncbi.nlm.nih.gov/pubmed/11270687
(36) Gupta M, Tandon N, Shtauvere-Brameus A, Sanjeevi CB. ICA12 autoantibodies are associated with non-DR3/non-DR4 in patients with latent autoimmune diabetes in adults from northern India. Ann N Y Acad Sci 2002 Apr;958:329-32.
http://www.ncbi.nlm.nih.gov/pubmed/12021135
(37) Lernmark Å, Freedman ZR, Hofmann C, Rubenstein AH, Steiner DF, Jackson RL, et al. Islet-cell-surface antibodies in juvenile diabetes mellitus. N Engl J Med 1978;299:375-80.
http://www.ncbi.nlm.nih.gov/pubmed/353557
(38) Fierabracci A, Biro PA, Yiangou Y, Mennuni C, Luzzago A, Ludvigsson J, et al. Osteopontin is an autoantigen of the somatostatin cells in human islets: identification by screening random peptide libraries with sera of patients with insulin-dependent diabetes mellitus. Vaccine 1999 Sep;18(3-4):342-54.
http://www.ncbi.nlm.nih.gov/pubmed/10506661
(39) Ola TO, Biro PA, Hawa MI, Ludvigsson J, Locatelli M, Puglisi MA, et al. Importin beta: A novel autoantigen in human autoimmunity identified by screening random peptide libraries on phage. J Autoimmun 2006 May;26(3):197-207.
http://www.ncbi.nlm.nih.gov/pubmed/16549322
(40) Winer S, Tsui H, Lau A, Song A, Li X, Cheung RK, et al. Autoimmune islet destruction in spontaneous type 1 diabetes is not beta-cell exclusive. Nat Med 2003 Feb;9(2):198-205.
http://www.ncbi.nlm.nih.gov/pubmed/12539039
(41) Rinta-Valkama J, Aaltonen P, Lassila M, Palmen T, Tossavainen P, Knip M, et al. Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes. Diabetes Metab Res Rev 2006 Jun 2;.
http://www.ncbi.nlm.nih.gov/pubmed/16741999
(42) Mallone R, Perin PC. Anti-CD38 autoantibodies in type? diabetes. Diabetes Metab Res Rev 2006 Mar 17;.
http://www.ncbi.nlm.nih.gov/pubmed/16544364
(43) Hu CY, Rodriguez-Pinto D, Du W, Ahuja A, Henegariu O, Wong FS, et al. Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. J Clin Invest 2007 Dec;117(12):3857-67.
http://www.ncbi.nlm.nih.gov/pubmed/18060033
(44) Greeley SA, Katsumata M, Yu L, Eisenbarth GS, Moore DJ, Goodarzi H, et al. Elimination of maternally transmitted autoantibodies prevents diabetes in nonobese diabetic mice. Nat Med 2002 Apr;8(4):399-402.
http://www.ncbi.nlm.nih.gov/pubmed/11927947
(45) Ziegler A-G, Hummel M, Schenker M, Bonifacio E. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes. The 2-year analysis of the German BABYDIAB study. diab 1999;48:460-8.
http://www.ncbi.nlm.nih.gov/pubmed/10078544
(46) Roll U, Christie MR, Füchtenbusch M, Payton MA, Hawkes CJ, Ziegler AG. Perinatal autoimmunity in offspring of diabetic parents. The German Multi-Center BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. diab 1996;45(7):967-73.
http://www.ncbi.nlm.nih.gov/pubmed/8666150
(47) Martin S, Wolf-Eichbaum D, Duinkerken G, Scherbaum WA, Kolb H, Noordzij JG, et al. Development of type 1 diabetes despite severe hereditary B-lymphocyte deficiency. N Engl J Med 2001 Oct 4;345(14):1036-40.
http://www.ncbi.nlm.nih.gov/pubmed/11586956
(48) Serreze DV, Fleming SA, Chapman HD, Richard SD, Leiter EH, Tisch RM. B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice. J Immunol 1998 Oct 15;161(8):3912-8.
http://www.ncbi.nlm.nih.gov/pubmed/9780157
(49) Yalow RS, Berson SA. Assay of plasma insulin in human subjects by immunological methods. Nature 1959 Nov 21;184 (Suppl 21):1648-9.
http://www.ncbi.nlm.nih.gov/pubmed/13846363
(50) Babaya N, Liu E, Miao D, Li M, Yu L, Eisenbarth GS. Murine high specificity/sensitivity competitive europium insulin autoantibody assay. Diabetes Technol Ther 2009 Apr;11(4):227-33.
http://www.ncbi.nlm.nih.gov/pubmed/19344197
(51) Barker JM, Barriga K, Yu L, Miao D, Erlich H, Norris JN, et al. Prediction of autoantibody positivity and progression to type 1 diabetes:  Diabetes Autoimmunity Study in the Young (DAISY). J Clin Endocrinol Metab 2004;89:3896-902.
http://www.ncbi.nlm.nih.gov/pubmed/15292324
(52) Achenbach P, Koczwara K, Knopff A, Naserke H, Ziegler AG, Bonifacio E. Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes. J Clin Invest 2004 Aug;114(4):589-97.
http://www.ncbi.nlm.nih.gov/pubmed/15314696
(53) Falorni A, Örtqvist E, Persson B, Lernmark Å. Radioimmunoassays for glutamic acid decarboxylase (GAD65) and GAD65 autoantibodies using 35S or 3H recombinant human ligands. J Immunol Methods 1995;186:89-99.
http://www.ncbi.nlm.nih.gov/pubmed/7561152
(54) Kawasaki E, Eisenbarth G. High-Throughput Radioassays for Autoantibodies to Recombinant Autoantigens. Frontiers in Bioscience 2000 Nov 1;5:181-90.
http://www.ncbi.nlm.nih.gov/pubmed/11056082
(55) Liu E, Eisenbarth GS. Accepting clocks that tell time poorly: fluid-phase versus standard ELISA autoantibody assays. Clin Immunol 2007 Nov;125(2):120-6.
http://www.ncbi.nlm.nih.gov/pubmed/17904423
(56) Yu L, Wang J, O'Dell JR, Oates J, Arend WP, Eisenbarth GS. Anti-dsDNA antibody assay: high specificity and sensitivity with a filtration radioassay in comparison to low specificity with the standard ELISA. J Rheumatol 2007 Apr;34(4):734-9.
http://www.ncbi.nlm.nih.gov/pubmed/17407230
(57) Bao F, Yu L, Babu S, Wang T, Hoffenberg EJ, Rewers M, et al. One third of HLA DQ2 homozygous patients with type 1 diabetes express celiac disease associated transglutaminase autoantibodies. J Autoimmunity 1999;13:143-8.
http://www.ncbi.nlm.nih.gov/pubmed/10441179
(58) Liu E, Li M, Bao F, Miao D, Rewers MJ, Eisenbarth GS, et al. Need for quantitative assessment of transglutaminase autoantibodies for celiac disease in screening-identified children. J Pediatr 2005 Apr;146(4):494-9.
http://www.ncbi.nlm.nih.gov/pubmed/15812452
(59) Falorni A, Nikoshkov A, Laureti S, Grenbäck E, Hulting A-L, Casucci G, et al. High diagnostic accuracy for idiopathic Addison's disease with a sensitive radiobinding assay for autoantibodies against recombinant human 21-hydroxylase. J Clin Endocrinol Metab 1995;80(9):2752-5.
http://www.ncbi.nlm.nih.gov/pubmed/7673419
(60) Laureti S, Aubourg P, Calcinaro F, Rocchiccioli F, Casucci G, Angeletti G, et al. Etiological diagnosis of primary adrenal insufficiency using an original flowchart of immune and biochemical markers. J Clin Endocrinol Metab 1998;89(9):3163-8.
http://www.ncbi.nlm.nih.gov/pubmed/9745420
(61) Yu L, Brewer KW, Gates S, Wu A, Wang T, Babu S, et al. DRB1*04 and DQ alleles: expression of 21-hydroxylase autoantibodies and risk of progression to Addison's disease. J Clin Endocrinol Metab 1999;84(1):328-35.
http://www.ncbi.nlm.nih.gov/pubmed/9920103
(62) Rulli M, Kuusisto A, Salo J, Kojola H, Simell O. Time-resolved fluorescence imaging in islet cell autoantibody quantitation. J Immunol Methods 1997 Oct 27;208(2):169-79.
http://www.ncbi.nlm.nih.gov/pubmed/9433472
(63) Hagopian WA, Sanjeevi CB, Kockum I, Landin-Olsson M, Karlsen AE, Sundkvist G, et al. Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J Clin Invest 1995;95:1505-11.
http://www.ncbi.nlm.nih.gov/pubmed/7706455
(64) Brooking H, Ananieva-Jordanova R, Arnold C, Amoroso M, Powell M, Betterle C, et al. A sensitive non-isotopic assay for GAD65 autoantibodies. Clin Chim Acta 2003 May;331(1-2):55-9.
http://www.ncbi.nlm.nih.gov/pubmed/12691864
(65) Valdez SN, Iacono RF, Villalba A, Cardoso LA, Ermacora MR, Poskus E. A radioligand-binding assay for detecting antibodies specific for proinsulin and insulin using 35S-proinsulin. J Immunol Methods 2003 Aug;279(1-2):173-81.
http://www.ncbi.nlm.nih.gov/pubmed/12969558
(66) Nerup J. Addison's disease - clinical studies:  A report of 108 cases. Acta Endocrinol 1974;76:127-41.
http://www.ncbi.nlm.nih.gov/pubmed/4406578
(67) Eizirik DL, Sandler S, Palmer JP. Repair of pancreatic β-cells: a relevant phenomenon in early IDDM? diab 1993;42:1383-91.
http://www.ncbi.nlm.nih.gov/pubmed/8375580
(68) Thai A-C, Eisenbarth GS. Natural history of IDDM. Diabetes Rev 1993;1:1-14.
http://www.bentham.org/cdr/
(69) Schatz DA, Atkinson MA. Islet cell autoantibodies: a case of a premature obituary. Pediatr Diabetes 2005 Dec;6(4):181-3.
http://www.ncbi.nlm.nih.gov/pubmed/16390385
(70) Pietropaolo M, Yu S, Libman IM, Pietropaolo SL, Riley K, LaPorte RE, et al. Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies. Pediatr Diabetes 2005 Dec;6(4):184-92.
http://www.ncbi.nlm.nih.gov/pubmed/16390386
(71) Turner R, Stratton I, Horton V, Manley S, Zimmet P, Mackay IR, et al. UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group. Lancet 1997 Nov 1;350(9087):1288-93.
http://www.ncbi.nlm.nih.gov/pubmed/9357409
(72) Bottazzo GF, Bosi E, Cull CA, Bonifacio E, Locatelli M, Zimmet P, et al. IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71). diabetol 2005 Apr;48(4):703-8.
http://www.ncbi.nlm.nih.gov/pubmed/15765222
(73) Desai M, Cull CA, Horton VA, Christie MR, Bonifacio E, Lampasona V, et al. GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia 2007 Jul 27.
http://www.ncbi.nlm.nih.gov/pubmed/17657474
(74) Zimmet P. Antibodies to glutamic acid decarboxylase in the prediction of insulin dependency. [Review] [31 refs]. Diabetes Res Clin Pract 1996;34 Suppl:S125-31.
http://www.ncbi.nlm.nih.gov/pubmed/9015681
(75) Greenbaum CJ, Palmer JP, Nagataki S, Yamaguchi Y, Molenaar JL, Van Beers WAM, et al. Improved specificity of ICA assays in the Fourth International Immunology of Diabetes Exhange Workshop. diab 1992;41:1570-4.
http://www.ncbi.nlm.nih.gov/pubmed/1446798
(76) Bingley PJ, Bonifacio E, Mueller PW. Diabetes antibody standardization program: first assay proficiency evaluation. diab 2003 May;52(5):1128-36.
http://www.ncbi.nlm.nih.gov/pubmed/18373080
(77) Achenbach P, Schlosser M, Williams AJ, Yu L, Mueller PW, Bingley PJ, et al. Combined testing of antibody titer and affinity improves insulin autoantibody measurement: Diabetes Antibody Standardization Program. Clin Immunol 2007 Jan;122(1):85-90.
http://www.ncbi.nlm.nih.gov/pubmed/17059894
   (78) Henderson LO, Atkinson M, Bingley PJ, Bonifacio E, Bossi E, Ellis T, et al. Dried blood-spots as a matrix for Type-1 diabetes autoantibody detection. Diabetes 49 (Suppl 1)[A36]. 2000.
Ref Type: Abstract. 60th Annual Meeting/ADA Scientific Sessions, San Antonio, TX June 9-13, 2000
 http://diabetes.diabetesjournals.org/content/by/year/2000
(79) Krischer JP, Cuthbertson DD, Yu L, Orban T, Maclaren N, Jackson R, et al. Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes. J Clin Endocrinol Metab 2003 Jan;88(1):103-8.
http://www.ncbi.nlm.nih.gov/pubmed/12519837
(80) Gianani R, Pugliese A, Bonner-Weir S, Shiffrin AJ, Soeldner JS, Erlich H, et al. Prognostically significant heterogeneity of cytoplasmic islet cell antibodies in relatives of patients with type I diabetes. diab 1992;41(3):347-53.
http://www.ncbi.nlm.nih.gov/pubmed/1551494
(81) Genovese S, Bonifacio E, McNally JM, Dean BM, Wagner R, Bosi E, et al. Distinct cytoplasmic islet cell antibodies with different risks for type I (insulin-dependent) diabetes mellitus. diabetol 1992;35:385-8.
http://www.ncbi.nlm.nih.gov/pubmed/1516768
(82) Solimena M, Folli F, Denis-Donini S, Comi GC, Pozza G, De Camilli P, et al. Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitus. N Engl J Med 1988;318(16):1012-20.
http://www.ncbi.nlm.nih.gov/pubmed/3281011
(83) Verge CF, Gianani R, Kawasaki E, Yu L, Pietropaolo M, Jackson RA, et al. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. diab 1996;45(7):926-33.
http://www.ncbi.nlm.nih.gov/pubmed/8666144
(84) Verge CF, Stenger D, Bonifacio E, Colman PG, Pilcher C, Bingley PJ, et al. Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop. diab 1998 Dec;47(12):1857-66.
http://www.ncbi.nlm.nih.gov/pubmed/9836516
(85) Bingley PJ, Christie MR, Bonifacio E, Bonfanti R, Shattock M, Fonte M-T, et al. Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. diab 1994;43(11):1304-10.
http://www.ncbi.nlm.nih.gov/pubmed/7926304
(86) Achenbach P, Bonifacio E, Williams AJ, Ziegler AG, Gale EA, Bingley PJ. Autoantibodies to IA-2beta improve diabetes risk assessment in high-risk relatives. Diabetologia 2008 Jan 9.
http://www.ncbi.nlm.nih.gov/pubmed/18193190
(87) Achenbach P, Warncke K, Reiter J, Naserke HE, Williams AJ, Bingley PJ, et al. Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics. diab 2004 Feb;53(2):384-92.
http://www.ncbi.nlm.nih.gov/pubmed/14747289
(88) Park YS, Kawasaki E, Kelemme K, Yu L, Schiller MR, Rewers M, et al. Humoral autoreactivity to an alternative spliced variant of ICA512/IA2 in type 1 diabetes. diabetol 2000;50:895-900.
http://www.ncbi.nlm.nih.gov/pubmed/11079748
(89) Torn C, Mueller PW, Schlosser M, Bonifacio E, Bingley PJ. Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2. diabetol 2008 May;51(5):846-52.
http://www.ncbi.nlm.nih.gov/pubmed/18373080
(90) Mueller PW, Bingley PJ, Bonifacio E, Steinberg KK, Sampson EJ. Predicting type 1 diabetes using autoantibodies: the latest results from the diabetes autoantibody standardization program. Diabetes Technol Ther 2002;4(3):397-400.
http://www.ncbi.nlm.nih.gov/pubmed/12182146
(91) Erdo SL, Wolff JR. Gamma-aminobutyric acid outside the mammalian brain. J Neurochem 1990;54:363-72.
http://www.ncbi.nlm.nih.gov/pubmed/2405103
(92) Kanaani J, Diacovo MJ, El Husseini A, Bredt DS, Baekkeskov S. Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters. J Cell Sci 2004 Apr 15;117(Pt 10):2001-13.
http://www.ncbi.nlm.nih.gov/pubmed/15039456
(93) Petersen JS, Russel S, Marshall MO, Kofod H, Buschard K, Cambon N, et al. Differential expression of glutamic acid decarboxylase in rat and human islets. diab 1993;42:484-95.
http://www.ncbi.nlm.nih.gov/pubmed/8432419
(94) Kim J, Richter W, Aanstoot HJ, Shi Y, Fu Q, Rajotte R, et al. Differential expression of GAD65 and GAD67 in human, rat and mouse pancreatic islets. diab 1993;42:1799-808.
http://www.ncbi.nlm.nih.gov/pubmed/8243826
(95) Eisenbarth GS. Mouse or man: is GAD the cause of type I diabetes? Diab care 1994;17:1-3.
http://www.ncbi.nlm.nih.gov/pubmed/8082534
(96) Christie M, Landin-Olsson M, Sundkvist G, Dahlquist G, Lernmark Å, Baekkeskov S. Antibodies to a Mr-64,000 islet cell protein in Swedish children with newly diagnosed type I (insulin-dependent) diabetes. diabetol 1988;31(8):597-602.
http://www.ncbi.nlm.nih.gov/pubmed/3065114
(97) Baekkeskov S, Landin M, Kristensen JK, Srikanta S, Bruining GJ, Mandrup-Poulsen T, et al. Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes. J Clin Invest 1987;79:926-34.
http://www.ncbi.nlm.nih.gov/pubmed/3546382
(98) Hayakawa N, Premawardhana LD, Powell M, Masuda M, Arnold C, Sanders J, et al. Isolation and characterization of human monoclonal autoantibodies to glutamic acid decarboxylase. Autoimmunity 2002 Aug;35(5):343-55.
http://www.ncbi.nlm.nih.gov/pubmed/12515289
(99) Gianani R, Jackson R, Eisenbarth GS. Evidence that the autoantigen of restricted ICA is GAD. Diabetes Res Clin Prac 14 (suppl. 1), S13. 1991.
Ref Type: Abstract
http://www.sciencedirect.com/science/journal/01688227
(100) Velloso LA, Kampe O, Hallberg A, Christmanson L, Betsholtz C, Karlsson FA. Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression. J Clin Invest 1993;91:2084-90.
http://www.ncbi.nlm.nih.gov/pubmed/8486775
(101) Harrison LC, Honeyman MC, DeAizpurua HJ, Schmidli RS, Colman PG, Tait BD, et al. Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes. Lancet 1993 May 29;341(8857):1365-9.
http://www.ncbi.nlm.nih.gov/pubmed/8098789
(102) Bingley PJ. Interactions of age, islet cell antibodies, insulin autoantibodies, and first-phase insulin response in predicting risk of progression to IDDM in ICA+ relatives:  the ICARUS data set. diab 1996;45:1720-8.
http://www.ncbi.nlm.nih.gov/pubmed/8922357
(103) Bu DF, Tobin AJ. The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD. Genomics 1994 May 1;21(1):222-8.
http://www.ncbi.nlm.nih.gov/pubmed/8088791
(104) Hagopian WA, Michelsen B, Karlsen AE, Larsen F, Moody A, Grubin CE, et al. Autoantibodies in IDDM primarily recognize the 65,000-M(r) rather than the 67,000-M(r) isoform of glutamic acid decarboxylase. diab 1993;42(4):631-6.
http://www.ncbi.nlm.nih.gov/pubmed/8454115
(105) Falorni A, Ackefors M, Carlberg C, Daniels T, Persson B, Robertson J, et al. Diagnostic sensitivity of immunodominant epitopes of glutamic acid decarboxylase (GAD65) autoantibodies in childhood IDDM. diabetol 1996;39(9):1091-8.
http://www.ncbi.nlm.nih.gov/pubmed/8877294
(106) Hallengren B, Falorni A, Landin-Olsson M, Lernmark A, Papadopoulos KI, Sundkvist G. Islet cell and glutamic acid decarboxylase antibodies in hyperthyroid patients: at diagnosis and following treatment. J Intern Med 1996 Jan;239(1):63-8.
http://www.ncbi.nlm.nih.gov/pubmed/8551202
(107) Bottini E, Gerlini G, Lucarini N, Amante A, Gloria-Bottini F. Evidence of selective interaction between adenosine deaminase and acid phosphatase polymorphisms in fetuses carried by diabetic women. Hum Genet 1991;87:199-200.
http://www.ncbi.nlm.nih.gov/pubmed/2066107
(108) Richter W, Seissler J, Northemann W, Wolfahrt S, Meinck H-M, Scherbaum WA. Cytoplasmic islet cell antibodies recognize distinct islet antigens in IDDM but not in stiff man syndrome. diab 1993;42:1642-8.
http://www.ncbi.nlm.nih.gov/pubmed/8405707
(109) Syren K, Lindsay L, Stoehrer B, Jury K, Luhder F, Baekkeskov S, et al. Immune reactivity of diabetes-associated human monoclonal autoantibodies defines multiple epitopes and detects two domain boundaries in glutamate decarboxylase. J Immunol 1996 Dec 1;157(11):5208-14.
http://www.ncbi.nlm.nih.gov/pubmed/8943434
(110) Daw K, Ujihara N, Atkinson M, Powers AC. Glutamic acid decarboxylase autoantibodies in Stiff-man syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognition. J Immunol 1996;156:818-25.
http://www.ncbi.nlm.nih.gov/pubmed/8543838
(111) Schwartz HL, Chandonia JM, Kash SF, Kanaani J, Tunnell E, Domingo A, et al. High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase. J Mol Biol 1999 Apr 16;287(5):983-99.
http://www.ncbi.nlm.nih.gov/pubmed/10222205
(112) Ronkainen MS, Savola K, Knip M. Antibodies to GAD65 epitopes at diagnosis and over the first 10 years of clinical type 1 diabetes mellitus. Scand J Immunol 2004 Mar;59(3):334-40.
http://www.ncbi.nlm.nih.gov/pubmed/15030586
(113) Hoppu S, Ronkainen MS, Kulmala P, Akerblom HK, Knip M. GAD65 antibody isotypes and epitope recognition during the prediabetic process in siblings of children with type I diabetes. Clin Exp Immunol 2004 Apr;136(1):120-8.
http://www.ncbi.nlm.nih.gov/pubmed/15030523
(114) Butler MH, Solimena M, Dirkx R, Hayday A, De Camilli P. Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in stiff-man syndrome. J Exp Med 1993;178:2097.
http://www.ncbi.nlm.nih.gov/pubmed/8245784
(115) Kim J, Namchuk M, Bugawan T, Fu Q, Jaffe M, Shi Y, et al. Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus. J Exp Med 1994 Aug 1;180(2):595-606.
http://www.ncbi.nlm.nih.gov/pubmed/7519242
(116) Björk E, Velloso LA, Kämpe O, Karlsson FA. GAD autoantibodies in IDDM, stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes. diab 1994;43:161-5.
http://www.ncbi.nlm.nih.gov/pubmed/7505244
(117) Powers AC, Bavik K, Tremble J, Daw K, Scherbaum WA, Banga JP. Comparative analysis of epitope recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different autoimmune disorders. Clin Exp Immunol 1999 Dec;118(3):349-56.
http://www.ncbi.nlm.nih.gov/pubmed/10594551
(118) Schories M, Peters T, Rasenack J, Reincke M. [Autoantibodies against islet cell antigens and type 1 diabetes after treatment with interferon-alpha]. Dtsch Med Wochenschr 2004 May 14;129(20):1120-4.
http://www.ncbi.nlm.nih.gov/pubmed/15143453
(119) Schreuder TC, Gelderblom HC, Weegink CJ, Hamann D, Reesink HW, Devries JH, et al. High incidence of type 1 diabetes mellitus during or shortly after treatment with pegylated interferon alpha for chronic hepatitis C virus infection. Liver Int 2008 Jan;28(1):39-46.
http://www.ncbi.nlm.nih.gov/pubmed/18031478
(120) Li Q, Xu B, Michie SA, Rubins KH, Schreriber RD, McDevitt HO. Interferon-alpha initiates type 1 diabetes in nonobese diabetic mice. Proc Natl Acad Sci U S A 2008 Aug 26;105(34):12439-44.
http://www.ncbi.nlm.nih.gov/pubmed/18716002
(121) Fenalti G, Hampe CS, Arafat Y, Law RH, Banga JP, Mackay IR, et al. COOH-terminal clustering of autoantibody and T cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity. Diabetes 2008 Jan 9;.
http://www.ncbi.nlm.nih.gov/pubmed/18184926
(122) Oak S, Gilliam LK, Landin-Olsson M, Torn C, Kockum I, Pennington CR, et al. The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes. Proc Natl Acad Sci U S A 2008 Mar 26.
http://www.ncbi.nlm.nih.gov/pubmed/18367670
(123) Christie MR, Tun RYM, Lo SSS, Cassidy D, Brown TJ, Hollands J, et al. Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM: Studies with identical twins. diab 1992;41:782-7.
http://www.ncbi.nlm.nih.gov/pubmed/1612192
(124) Christie MR, Genovese S, Cassidy D, Bosi E, Brown TJ, Lai M, et al. Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. diab 1994 Oct;43(10):1254-9.
http://www.ncbi.nlm.nih.gov/pubmed/7926297
(125) Payton MA, Hawkes CJ, Christie MR. Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). J Clin Invest 1995;96:1506-11.
http://www.ncbi.nlm.nih.gov/pubmed/7657822
(126) Kawasaki E, Yu L, Rewers MJ, Hutton JC, Eisenbarth GS. Definition of multiple ICA512/phogrin autoantibody epitopes and detection of intramolecular epitope spreading in relatives of patients with type 1 diabetes. diab 1998;47:733-42.
http://www.ncbi.nlm.nih.gov/pubmed/9588444
(127) Gianani R, Rabin DU, Verge CF, Yu L, Babu S, Pietropaolo M, et al. ICA512 autoantibody radioassay. diab 1995;44(11):1340-4.
http://www.ncbi.nlm.nih.gov/pubmed/7589834
(128) Norris JM, Beaty B, Klingensmith G, Yu L, Hoffman M, Chase HP, et al. Lack of association between early exposure to cow's milk protein and β-cell autoimmunity: Diabetes Autoimmunity Study in the Young (DAISY). JAMA 1996;276:609-14.
http://www.ncbi.nlm.nih.gov/pubmed/8773632
(129) Farilla L, Tiberti C, Luzzago A, Yu L, Eisenbarth GS, Cortese R, et al. ICA512bdc cDNA expression library displayed on the capsid protein D of bacteriophage lambda: a novel strategy to identify major antigenic epitopes in autoimmune diseases.  1999.
Ref Type: Unpublished Work
http://d.wanfangdata.com.cn/NSTLQK_NSTL_QK5743848.aspx
(130) Bonifacio E, Scirpoli M, Kredel K, Fuchtenbusch M, Ziegler AG. Early autoantibody responses in prediabetes are IgG1 dominated and suggest antigen-specific regulation. J Immunol 1999 Jul 1;163(1):525-32.
http://www.ncbi.nlm.nih.gov/pubmed/10384157
(131) Kundu SK, Pleatman MA, Redwine WA, Boyd AE, Marcus DM. Binding of monoclonal antibody A2B5 to gangliosides. Biochem Biophys Res Commun 1983 Nov 15;116(3):836-42.
http://www.ncbi.nlm.nih.gov/pubmed/6651849
(132) Nayak RC, Attawia NA, Cahill CJ, King GL, Ohashi O, Moromisato R. Expression of a monoclonal antibody (3G5) defined ganglioside antigen in renal cortex. Kidney Int 1992;41:1638-45.
http://www.ncbi.nlm.nih.gov/pubmed/1501420
(133) Alejandro R, Shienvold FL, Hajek SAV, Pierce M, Paul R, Mintz DH. A ganglioside antigen on the rat pancreatic B cell surface identified by monoclonal antibody R2D6. J Clin Invest 1984;74:25-38.
http://www.ncbi.nlm.nih.gov/pubmed/6376545
(134) Srikanta S, Krisch K, Eisenbarth GS. Islet cell proteins defined by monoclonal islet cell antibody HISL-19. diab 1986;35(3):300-5.
http://www.ncbi.nlm.nih.gov/pubmed/3512340
(135) Srikanta S, Telen M, Posillico JT, Dolinar R, Krisch K, Haynes BF, et al. Monoclonal antibodies to a human islet cell surface glycoprotein: 4F2 and LC7-2. Endocrinology 1987;120(6):2240-4.
http://www.ncbi.nlm.nih.gov/pubmed/2436897
(136) Gillard BK, Thomas JW, Nell LJ, Marcus DM. Antibodies against ganglioside GT3 in the sera of patients with type I diabetes mellitus. J Immunol Methods 1989;142(11):3826-32.
http://www.ncbi.nlm.nih.gov/pubmed/2654294
(137) Buschard K, Josefsen K, Horn T, Larsen S, Fredman P. Sulphatide and anti-sulphatide antibodies in type I diabetes mellitus. Diabetes 42 (Suppl 1), 5A. 1993.
Ref Type: Abstract
http://www.ncbi.nlm.nih.gov/pubmed/8110453
(138) Dotta F, Previti M, Lenti L, Dionisi S, Casetta B, D'Erme M, et al. GM2-1 pancreatic islet ganglioside: identification and characterization of a novel islet-specific molecule. diabetol 1995;38:1117-21.
http://www.ncbi.nlm.nih.gov/pubmed/8591828
(139) Dotta F, Gianani R, Dionisi S, Tiberti C, Eisenbarth GS, DiMario U. Expression of anti-GM2-1 islet ganglioside antibodies in ICA+ relatives of type I diabetics. Autoimmunity 15 (suppl), 70. 1993.
Ref Type: Abstract
http://www.ncbi.nlm.nih.gov/pubmed/8772721
(140) Dotta F, Colman PG, Lombardi D, Scharp DW, Andreani D, Pontieri GM, et al. Ganglioside expression in human pancreatic islets. diab 1989;38(11):1478-83.
http://www.ncbi.nlm.nih.gov/pubmed/2695376
(141) Pugliese A, Zeller M, Fernandez A, Zalcberg LJ, Bartlett RJ, Ricordi C, et al. The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type I diabetes. Nat Genet 1997;15(3):293-7.
http://www.ncbi.nlm.nih.gov/pubmed/9054945
(142) Pugliese A, Fernandez A, Zeller M, Zalcberg LJ, Ricordi C, Pietropaolo M, et al. Ectopic transcription of IDDM-associated islet cell autoantigen genes and monoallelic expression of the insulin gene in human thymus. submitted 1996.
(143) Garcia CA, Prabakar KR, Diez J, Cao A, Allende G, Zeller M, et al. Dendritic cells in human thymus and periphery display a proinsulin epitope in a transcription-dependent, capture-independent fashion. J Immunol 2005;175:2111-22.
http://www.ncbi.nlm.nih.gov/pubmed/16081777
(144) Vafiadis P, Bennett ST, Todd JA, Nadeau J, Grabs R, Goodyer CG, et al. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet 1997;15:289-92.
http://www.ncbi.nlm.nih.gov/pubmed/9054944
(145) Chentoufi AA, Palumbo M, Polychronakos C. Proinsulin expression by Hassall's corpuscles in the mouse thymus. diab 2004;53(2):354-9.
http://www.ncbi.nlm.nih.gov/pubmed/14747285
(146) Palumbo MO, Levi D, Chentoufi AA, Polychronakos C. Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clones. Diabetes 2006 Sep;55(9):2595-601.
http://www.ncbi.nlm.nih.gov/pubmed/16936209
(147) Hanahan D. Peripheral-antigen-expressing cells in thymic medulla: factors in self- tolerance and autoimmunity. Curr Opin Immunol 1998 Dec;10(6):656-62.
http://www.ncbi.nlm.nih.gov/pubmed/9914224
(148) Davidson HW, Hutton JC. The insulin-secretory-granule carboxypeptidase H. Biochem J 1993;245:575-82.
http://www.ncbi.nlm.nih.gov/pubmed/2822027
(149) Berson SA, Yallow RS. Quantitative aspects of the reaction between insulin and insulin-binding antibody. J Clin Invest 1959;38:1996-2016.
http://www.ncbi.nlm.nih.gov/pubmed/13799922
(150) Davidson JK, DeBra DW. Immunologic insulin resistance. diab 1978;27(3):307-18.
http://www.ncbi.nlm.nih.gov/pubmed/640236
(151) Hirata Y, Tominaga M, Ito J, Noguchi A. Spontaneous hypoglycaemia with insulin autoimmunity in Graves' disease. Ann Intern Med 1974;81:214-8.
http://www.ncbi.nlm.nih.gov/pubmed/4407888
(152) Uchigata Y, Hirata Y. Insulin Autoimmune Syndrome (IAS, Hirata Disease). In: Eisenbarth G, editor. Molecular Mechanisms of Endocrine and Organ Specific Autoimmunity.Austin, Texas: R.G.Landes; 1999. p. 133-48.
http://www.ncbi.nlm.nih.gov/pubmed/10445096
(153) Ito Y, Nieda M, Uchigata Y, Nishimura M, Tokunaga K, Kuwata S, et al. Recognition of human insulin in the context of HLA-DRB1*0406 products by T cells of insulin autoimmune syndrome patients and healthy donors. J Immunol 1993 Nov 15;151(10):5770-6.
http://www.ncbi.nlm.nih.gov/pubmed/8228261
(154) Ziegler AG, Vardi P, Gross DJ, Bonner-Weir S, Villa-Kamaroff L, Halban P, et al. Production of insulin antibodies by mice rejecting insulin transfected cells. J Autoimmun 1989;2(3):219-27.
http://www.ncbi.nlm.nih.gov/pubmed/2669799
(155) Srikanta S, Ricker AT, McCulloch DK, Soeldner JS, Eisenbarth GS, Palmer JP. Autoimmunity to insulin, beta cell dysfunction, and development of insulin-dependent diabetes mellitus. diab 1986;35(2):139-42.
http://www.ncbi.nlm.nih.gov/pubmed/3510920
(156) Castano L, Ziegler AG, Ziegler R, Shoelson S, Eisenbarth GS. Characterization of insulin autoantibodies in relatives of patients with type 1 diabetes. diab 1993 Aug;42:1202-9.
http://www.ncbi.nlm.nih.gov/pubmed/8325453
(157) Tiittanen M, Knip M, Vaarala O. Anti-insulin activity in IgG-fractions from children with newly-diagnosed type 1 diabetes and negative for insulin autoantibodies. Autoimmunity 2004 Feb;37(1):45-9.
http://www.ncbi.nlm.nih.gov/pubmed/15115311
(158) Pugliese A, Bugawan T, Moromisato R, Awdeh ZL, Alper CA, Jackson RA, et al. Two subsets of HLA-DQA1 alleles mark phenotypic variation in levels of insulin autoantibodies in first degree relatives at risk for insulin-dependent diabetes. J Clin Invest 1994;93:2447-52.
http://www.ncbi.nlm.nih.gov/pubmed/8200980
(159) Vardi P, Ziegler AG, Matthews JH, Dib S, Keller RJ, Ricker AT, et al. Concentration of insulin autoantibodies at onset of type I diabetes. Inverse log-linear correlation with age. Diab care 1988;11(9):736-9.
http://www.ncbi.nlm.nih.gov/pubmed/3066606
(160) Williams AJK, Bingley PJ, Bonifacio E, Palmer JP, Gale EAM. A novel micro-assay for insulin autoantibodies. J Autoimmun 1997;10:473-8.
http://www.ncbi.nlm.nih.gov/pubmed/9376075
(161) Bilbao JR, Calvo B, Urrutia I, Linares A, Castaño L. Anti-insulin activity in normal newborn cord-blood serum. diab 1997;46:713-6.
http://www.ncbi.nlm.nih.gov/pubmed/9075816
(162) Naserke HE, Bonifacio E, Ziegler A-G. Immunoglobulin G insulin autoantibodies in BABYDIAB offspring appear postnatally: sensitive early detection using a protein A/G-based radiobinding assay. J Clin Endocrinol Metab 1999;84(4):1239-43.
http://www.ncbi.nlm.nih.gov/pubmed/10199761
(163) Yu L, Robles DT, Abiru N, Kaur P, Rewers M, Kelemen K, et al. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. Proc Natl Acad Sci USA 2000 Feb 15;97(4):1701-6.
http://www.ncbi.nlm.nih.gov/pubmed/10677521
(164) Hummel M, Bonifacio E, Schmid S, Walter M, Knopff A, Ziegler AG. Brief communication: Early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents. Annals of Internal Medicine 2004;140(11):882-6.
http://www.ncbi.nlm.nih.gov/pubmed/15172902
(165) Hoppu S, Ronkainen MS, Kimpimaki T, Simell S, Korhonen S, Ilonen J, et al. Insulin autoantibody isotypes during the prediabetic process in young children with increased genetic risk of type 1 diabetes. Pediatr Res 2004 Feb;55(2):236-42.
http://www.ncbi.nlm.nih.gov/pubmed/14605243
(166) Abiru N, Maniatis AK, Yu L, Miao D, Moriyama H, Wegmann D, et al. Peptide and MHC specific breaking of humoral tolerance to native insulin with the B:9-23 peptide in diabetes prone and normal mice. diab 2001 Jun;50:1274-81.
http://www.ncbi.nlm.nih.gov/pubmed/11375327
(167) Moriyama H, Abiru N, Paronen J, Sikora K, Liu E, Miao D, et al. Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse. Proc Natl Acad Sci U S A 2003 Sep 2;100(18):10376-81.
http://www.ncbi.nlm.nih.gov/pubmed/12925730
(168) Liu E, Moriyama H, Abiru N, Miao D, Yu L, Taylor RM, et al. Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23. J Clin Invest 2002 Oct;110(7):1021-7.
http://www.ncbi.nlm.nih.gov/pubmed/12370280
(169) Liu E, Abiru N, Moriyama H, Miao D, Eisenbarth GS. Induction of Insulin Autoantibodies and Protection from Diabetes with Subcutaneous Insulin B:9-23 Peptide Without Adjuvant. Annals New York Academy of Sciences 2002;958:224-7.
http://www.ncbi.nlm.nih.gov/pubmed/12021111
(170) Moriyama H, Wen L, Abiru N, Liu E, Yu L, Miao D, et al. Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide. Proc Natl Acad Sci U S A 2002 Apr 16;99(8):5539-44.
http://www.ncbi.nlm.nih.gov/pubmed/11943868
(171) Devendra D, Paronen J, Moriyama H, Miao D, Eisenbarth GS, Liu E. Differential immune response to B:9-23 insulin 1 and insulin 2 peptides in animal models of type 1 diabetes. Journal of Autoimmunity 2004;23(1):17-26.
http://www.ncbi.nlm.nih.gov/pubmed/15236749
(172) Yu L, Eisenbarth GS, Bonifacio E, Thomas J, Atkinson M, Wasserfall C. The Second Murine Autoantibody Workshop: remarkable inter-laboratory concordance for radiobinding assays to identify insulin autoantibodies in non-obese diabetic mice. NY Acad Sci 2003;100:1-12.
http://www.ncbi.nlm.nih.gov/pubmed/14679035
(173) Rojas M, Hulbert C, Thomas JW. Anergy and not clonal ignorance determines the fate of B cells that recognize a physiological autoantigen. J Immunol 2001 Mar 1;166(5):3194-200.
http://www.ncbi.nlm.nih.gov/pubmed/11207272
(174) Thebault-Baumont K, Dubois-LaForgue D, Krief P, Briand JP, Halbout P, Vallon-Geoffroy K, et al. Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice. J Clin Invest 2003 Mar 15;111(6):851-7.
http://www.ncbi.nlm.nih.gov/pubmed/12639991
(175) Faideau B, Briand JP, Lotton C, Tardivel I, Halbout P, Jami J, et al. Expression of preproinsulin-2 gene shapes the immune response to preproinsulin in normal mice. J Immunol 2004 Jan 1;172(1):25-33.
http://www.ncbi.nlm.nih.gov/pubmed/14688305
(176) Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, Miao D, et al. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 2005 May 12;435(7039):220-3.
http://www.ncbi.nlm.nih.gov/pubmed/15889095
(177) Kobayashi M, Jasinski J, Liu E, Li M, Miao D, Zhang L, et al. Conserved T cell receptor alpha-chain induces insulin autoantibodies. Proc Natl Acad Sci U S A 2008 Jul 22;105(29):10090-4.
http://www.ncbi.nlm.nih.gov/pubmed/18626021
(178) Wenzlau JM, Liu Y, Yu L, Moua O, Fowler KT, Rangasamy S, et al. A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes. diab 2008 Oct;57(10):2693-7.
http://www.ncbi.nlm.nih.gov/pubmed/18591387
(179) Pietropaolo M, Babu S, Buelow R, Eisenbarth GS. ICA69: Cloning/sequencing/expression/assay development. Diabetes 42 (Suppl 1), 4A. 1993.
Ref Type: Abstract
http://diabetes.diabetesjournals.org/content/by/year/1993
(180) Mathews CE, Pietropaolo SL, Pietropaolo M. Reduced thymic expression of islet antigen contributes to loss of self-tolerance. Ann N Y Acad Sci 2003 Nov;1005:412-7.
http://www.ncbi.nlm.nih.gov/pubmed/14679103
(181) Stassi G, Schloot N, Pietropaolo M. Islet cell autoantigen 69 kDa (ICA69) is preferentially expressed in the human islets of Langerhans than exocrine pancreas. diabetol 1997;40:120-1.
http://www.ncbi.nlm.nih.gov/pubmed/9028728
(182) Pilon M, Peng XR, Spence AM, Plasterk RH, Dosch HM. The diabetes autoantigen ICA69 and its Caenorhabditis elegans homologue, ric-19, are conserved regulators of neuroendocrine secretion. Mol Biol Cell 2000 Oct;11(10):3277-88.
http://www.ncbi.nlm.nih.gov/pubmed/11029035
(183) Winer S, Astsaturov I, Gaedigk R, Hammond-McKibben D, Pilon M, Song A, et al. ICA69(null) nonobese diabetic mice develop diabetes, but resist disease acceleration by cyclophosphamide. J Immunol 2002 Jan 1;168(1):475-82.
http://www.ncbi.nlm.nih.gov/pubmed/11751995
(184) Karges W, Gaedigk R, Hui MF, Cheung R, Dosch HM. Molecular cloning of murine ICA69: diabetes-prone mice recognize the human autoimmune-epitope, Tep69, conserved in splice variants from both species. Biochim Biophys Acta 1997 Apr 12;1360(2):97-101.
http://www.ncbi.nlm.nih.gov/pubmed/9128175
(185) Martin S, Kardorf J, Schulte B, Lampeter EF, Gries FA, Melchers I, et al. Autoantibodies to the islet antigen ICA69 occur in IDDM and in rheumatoid arthritis. diabetol 1995;38(3):351-5.
http://www.ncbi.nlm.nih.gov/pubmed/7758883
(186) Atkinson MA, Bowman MA, Kao K, Campbell L, Dush PJ, Shah SC, et al. Lack of immune responsiveness to bovine serum albumin in insulin- dependent diabetes. N Engl J Med 1993;329:1853-8.
http://www.ncbi.nlm.nih.gov/pubmed/8247037
(187) Winer S, Gunaratnam L, Astsatourov I, Cheung RK, Kubiak V, Karges W, et al. Peptide dose, MHC affinity, and target self-antigen expression are critical for effective immunotherapy of nonobese diabetic mouse prediabetes. J Immunol 2000 Oct 1;165(7):4086-94.
http://www.ncbi.nlm.nih.gov/pubmed/11034420
(188) Fida S, Myers MA, Whittingham S, Rowley MJ, Ozaki S, Mackay IR. Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases. J Autoimmun 2002 Dec;19(4):251-7.
http://www.ncbi.nlm.nih.gov/pubmed/12473246
(189) Davis TME, Mehta Z, Mackay IR, Cull CA, Bruce DG, Fida S, et al. Autoantibodies to the islet cell antigen SOX-13 are associated with duration but not type of diabetes. Diabetic Med 2003;20(3):198-204.
http://www.ncbi.nlm.nih.gov/pubmed/12675663
(190) Karounos DG, Simmerman L, Hickman SL, Jacob RJ. Identification of the p52-Rubella related autoantigen as an insulin secretory granule protein. Diabetes 42 (Suppl 1), 221A. 1993.
Ref Type: Abstract
http://diabetes.diabetesjournals.org/content/by/year/1993
(191) Honeyman MC, Cram DS, Harrison LC. Transcription factor jun-B is target of autoreactive T-cells in IDDM. diab 1993;42:626-30.
http://www.ncbi.nlm.nih.gov/pubmed/8454114
(192) Pak CY, Cha CY, Rajotte RV, McArthur RG, Yoon JW. Human pancreatic islet cell specific 38 kilodalton autoantigen identified by cytomegalovirus-induced monoclonal islet cell autoantibody. diabetol 1990;33:569-72.
http://www.ncbi.nlm.nih.gov/pubmed/2174808
(193) Arden SD, Roep BO, Neophytou PI, Usac EF, Duinkerken G, De Vries RRP, et al. Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type I diabetic patient. J Clin Invest 1996;97(2):551-61.
http://www.ncbi.nlm.nih.gov/pubmed/8567980
(194) Winnock F, Christie MR, Batstra MR, Aanstoot HJ, Weets I, Decochez K, et al. Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: association with IA-2 and islet cell autoantibodies. Diab care 2001 Jul;24(7):1181-6.
http://www.ncbi.nlm.nih.gov/pubmed/11423499
(195) Saudek CD. When does diabetes start? J A M A 1990;263:2934.
http://www.ncbi.nlm.nih.gov/pubmed/2338755
(196) Palmen T, Ahola H, Palgi J, Aaltonen P, Luimula P, Wang S, et al. Nephrin is expressed in the pancreatic beta cells. Diabetologia 2001 Oct;44(10):1274-80.
http://www.ncbi.nlm.nih.gov/pubmed/11692176
(197) Yagui K, Shimada F, Mimura M, Hashimoto N, Suzuki Y, Tokuyama Y, et al. A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro. diabetol 1998;41(9):1024-8.
http://www.ncbi.nlm.nih.gov/pubmed/9754820
(198) Antonelli A, Baj G, Marchetti P, Fallahi P, Surico N, Pupilli C, et al. Human anti-CD38 autoantibodies raise intracellular calcium and stimulate insulin release in human pancreatic islets. diab 2001 May;50(5):985-91.
http://www.ncbi.nlm.nih.gov/pubmed/11334442
(199) Park Y, Park H, Yoo E, Kim D. SOX13 autoantibodies are likely to be a supplementary marker for type 1 diabetes in Korea. Ann N Y Acad Sci 2003 Nov;1005:253-8.
http://www.ncbi.nlm.nih.gov/pubmed/14679071
(200) Cohen IR. Thoughts on the pathogenesis of type 1 diabetes and on the arrest of autoimmune beta-cell destruction by peptide p277 vaccination. Isr Med Assoc J 2004 May;6(5):260-1.
http://www.ncbi.nlm.nih.gov/pubmed/15151361
(201) Elias D, Reshef T, Birk OS, Van der Zee R, Walker MD, Cohen IR. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci USA 1991;88(8):3088-91.
http://www.ncbi.nlm.nih.gov/pubmed/1707531
(202) Brugman S, Klatter FA, Visser J, Bos NA, Elias D, Rozing J. Neonatal oral administration of DiaPep277, combined with hydrolysed casein diet, protects against Type 1 diabetes in BB-DP rats. An experimental study. diabetol 2004 Jul;47(7):1331-3.
http://www.ncbi.nlm.nih.gov/pubmed/15248047
(203) Bowman M, Atkinson MA. Heat shock protein therapy fails to prevent diabetes in NOD mice. diabetol 2002 Sep;45(9):1350-1.
http://www.ncbi.nlm.nih.gov/pubmed/12242470
(204) Jones DB, Hunter NR, Duff GW. Heat-shock protein 65 as a B cell antigen of insulin-dependent diabetes. Lancet 1990;336:583-5.
http://www.ncbi.nlm.nih.gov/pubmed/1975377
(205) Horvath L, Cervenak L, Oroszlan M, Prohaszka Z, Uray K, Hudecz F, et al. Antibodies against different epitopes of heat-shock protein 60 in children with type 1 diabetes mellitus. Immunol Lett 2002 Mar 1;80(3):155-62.
http://www.ncbi.nlm.nih.gov/pubmed/11803047
(206) Elias D, Meilin A, Ablamunits V, Birk OS, Carmi P, Könen-Waisman S, et al. Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various β-cell antigens. diab 1997;46:758-64.
http://www.ncbi.nlm.nih.gov/pubmed/9133541
(207) Inman LR, McAllister CT, Chen L, Hughes S, Newgard CB, Kettman JR, et al. Autoantibodies to the GLUT-2 glucose transporter of β cells in insulin-dependent diabetes mellitus of recent onset. Proc Natl Acad Sci USA 1993;90:1281-4.
http://www.ncbi.nlm.nih.gov/pubmed/8433987
(208) Johnson JH, Crider BP, McCorkle K, Alford M, Unger RH. Inhibition of glucose transport into rat islet cells by immunoglobulins from patients with new-onset insulin-dependent diabetes mellitus. N Engl J Med 1990;322:653-9.
http://www.ncbi.nlm.nih.gov/pubmed/2406597
(209) Tsai S, Shameli A, Santamaria P. CD8+ T cells in type 1 diabetes. Adv Immunol 2008;100:79-124.
http://www.ncbi.nlm.nih.gov/pubmed/19111164
(210) Medarova Z, Tsai S, Evgenov N, Santamaria P, Moore A. In vivo imaging of a diabetogenic CD8+ T cell response during type 1 diabetes progression. Magn Reson Med 2008 Apr;59(4):712-20.
http://www.ncbi.nlm.nih.gov/pubmed/18302224
(211) Lieberman SM, Evans AM, Han B, Takaki T, Vinnitskaya Y, Caldwell JA, et al. Identification of the {beta} cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes. Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8384-8.
http://www.ncbi.nlm.nih.gov/pubmed/12815107
(212) Hutton JC, Eisenbarth GS. A pancreatic {beta}-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes. Proc Natl Acad Sci U S A 2003 Jul 14;100:8626-8.
http://www.ncbi.nlm.nih.gov/pubmed/12861077
(213) Trudeau JD, Kelly-Smith C, Verchere CB, Elliott JF, Dutz JP, Finegood DT, et al. Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood. J Clin Invest 2003 Jan;111(2):217-23.
http://www.ncbi.nlm.nih.gov/pubmed/12531877
(214) Qin H, Trudeau JD, Reid GS, Lee IF, Dutz JP, Santamaria P, et al. Progression of spontaneous autoimmune diabetes is associated with a switch in the killing mechanism used by autoreactive CTL. Int Immunol 2004 Nov;16(11):1657-62.
http://www.ncbi.nlm.nih.gov/pubmed/15466911
(215) Krishnamurthy B, Dudek NL, McKenzie MD, Purcell AW, Brooks AG, Gellert S, et al. Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP. J Clin Invest 2006 Dec 1;116(12):3258-65.
http://www.ncbi.nlm.nih.gov/pubmed/17143333
(216) Krishnamurthy B, Mariana L, Gellert SA, Colman PG, Harrison LC, Lew AM, et al. Autoimmunity to Both Proinsulin and IGRP Is Required for Diabetes in Nonobese Diabetic 8.3 TCR Transgenic Mice. J Immunol 2008 Apr 1;180(7):4458-64.
http://www.ncbi.nlm.nih.gov/pubmed/18354167
(217) Fisher LD, Kennedy JW, Davis KB, Maynard C, Fritz JK, Kaiser G, et al. Association of sex, physical size, and operative mortality after coronary artery bypass in the Coronary Artery Surgery Study (CASS). J Thorac Cardiovasc Surg 1982;84:334-41.
http://www.ncbi.nlm.nih.gov/pubmed/6981033
(218) Wong FS, Siew LK, Scott G, Thomas IJ, Chapman S, Viret C, et al. Activation of insulin-reactive CD8 T cells for development of autoimmune diabetes. diab 2009 Feb 10.
http://www.ncbi.nlm.nih.gov/pubmed/19208910
(219) Haskins K. Pathogenic T-cell clones in autoimmune diabetes: more lessons from the NOD mouse. Adv Immunol 2005;87:123-62.:123-62.
http://www.ncbi.nlm.nih.gov/pubmed/16102573
(220) Dobbs C, Haskins K. Comparison of a T cell clone and of T cells from a TCR transgenic mouse: TCR transgenic T cells specific for self-antigen are atypical. J Immunol 2001 Feb 15;166(4):2495-504.
http://www.ncbi.nlm.nih.gov/pubmed/11160310
(221) Hoglund P, Mintern J, Waltzinger C, Heath W, Benoist C, Mathis D. Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J Exp Med 1999 Jan 18;189(2):331-9.
http://www.ncbi.nlm.nih.gov/pubmed/9892615
(222) Andre-Schmutz I, Hindelang C, Benoist C, Mathis D. Cellular and molecular changes accompanying the progression from insulitis to diabetes. Eur J Immunol 1999 Jan;29(1):245-55.
http://www.ncbi.nlm.nih.gov/pubmed/9933106
(223) Roep BO, Atkinson MA, Van Endert PM, Gottlieb PA, Wilson SB, Sachs JA. Autoreactive T cell Responses in Insulin-dependent (Type 1) Diabetes Mellitus. Report of the First International Workshop for Standardization of T cell assays. J Autoimmun 1999 Sep;13(2):267-82.
http://www.ncbi.nlm.nih.gov/pubmed/10479395
(224) Schloot NC, Meierhoff G, Karlsson FM, Ott P, Putnam A, Lehmann P, et al. Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells. Report of the third immunology of diabetes society T-cell workshop. J Autoimmun 2003 Dec;21(4):365-76.
http://www.ncbi.nlm.nih.gov/pubmed/14624759
(225) Pinkse GG, Boitard C, Tree TI, Peakman M, Roep BO. HLA class I epitope discovery in type 1 diabetes: independent and reproducible identification of proinsulin epitopes of CD8 T cells--report of the IDS T Cell Workshop Committee. Ann N Y Acad Sci 2006 Oct;1079:19-23.
http://www.ncbi.nlm.nih.gov/pubmed/17130527
(226) Di Lorenzo TP, Peakman M, Roep BO. Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes. Clin Exp Immunol 2007 Apr;148(1):1-16.
http://www.ncbi.nlm.nih.gov/pubmed/17349009
(227) Skowera A, Ellis RJ, Varela-Calvino R, Arif S, Huang GC, Van-Krinks C, et al. CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J Clin Invest 2008 Oct;118(10):3390-402.
http://www.ncbi.nlm.nih.gov/pubmed/18802479
(228) Atkinson MA, Kaufman DL, Campbell L, Gibbs KA, Shah SC, Bu DF, et al. Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet 1992;339(8791):458-9.
http://www.ncbi.nlm.nih.gov/pubmed/1346821
(229) Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kaufman DL, Maclaren NK. Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J Clin Invest 1994;94(5):2125-9.
http://www.ncbi.nlm.nih.gov/pubmed/7962558
(230) Herskowitz R, Jackson RA. despite oral nicotinamide. diab 1988;37:59A.
http://diabetes.diabetesjournals.org/content/by/year/1988
(231) Mannering SI, Morris JS, Jensen KP, Purcell AW, Honeyman MC, Van Endert PM, et al. A sensitive method for detecting proliferation of rare autoantigen-specific human T cells. J Immunol Methods 2003 Dec;283(1-2):173-83.
http://www.ncbi.nlm.nih.gov/pubmed/14659909
(232) Van der Auwera B, Van Waeyenberge C, Schuit F, Heimberg H, Vandewalle C, Gorus F, et al. DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/DQA1*501-DQB1*0201 genotype. diab 1995;44:527-30.
http://www.ncbi.nlm.nih.gov/pubmed/7729610
(233) Tisch R, Yang X-D, Singer SM, Liblau RS, Fugger L, McDevitt HO. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 1993;366:72-5.
http://www.ncbi.nlm.nih.gov/pubmed/8232539
(234) Tisch R, Liblau RS, Yang X-D, Liblau P, McDevitt HO. Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice. diab 1998;47:894-9.
http://www.ncbi.nlm.nih.gov/pubmed/9604865
(235) Mallone R, Kochik SA, Laughlin EM, Gersuk VH, Reijonen H, Kwok WW, et al. Differential Recognition and Activation Thresholds in Human Autoreactive GAD-Specific T-Cells. diab 2004 Apr;53(4):971-7.
http://www.ncbi.nlm.nih.gov/pubmed/15047612
(236) Nepom GT, Lippolis JD, White FM, Masewicz S, Marto JA, Herman A, et al. Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65). Proc Natl Acad Sci U S A 2001 Feb 13;98(4):1763-8.
http://www.ncbi.nlm.nih.gov/pubmed/11172025
(237) Laughlin E, Burke G, Pugliese A, Falk B, Nepom G. Recurrence of autoreactive antigen-specific CD4+ T cells in autoimmune diabetes after pancreas transplantation. Clin Immunol 2008 Jul;128(1):23-30.
http://www.ncbi.nlm.nih.gov/pubmed/18455963
(238) Seyfert-Margolis V, Gisler TD, Asare AL, Wang RS, Dosch HM, Brooks-Worrell B, et al. Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study. Diabetes 2006 Sep;55(9):2588-94.
http://www.ncbi.nlm.nih.gov/pubmed/16936208
(239) Wegmann DR, Norbury-Glaser M, Daniel D. Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur J Immunol 1994;24(8):1853-7.
http://www.ncbi.nlm.nih.gov/pubmed/8056042
(240) Daniel D, Gill RG, Schloot N, Wegmann D. Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur J Immunol 1995;25(4):1056-62.
http://www.ncbi.nlm.nih.gov/pubmed/7537670
(241) Daniel D, Wegmann DR. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc Natl Acad Sci USA 1996;93(2):956-60.
http://www.ncbi.nlm.nih.gov/pubmed/8570667
(242) Abiru N, Wegmann D, Kawasaki E, Gottlieb P, Simone E, Eisenbarth GS. Dual overlapping peptides recognized by insulin peptide B:9-23 reactive T cell receptor AV13S3 T cell clones of the NOD mouse. J Autoimmun 2000;14(3):231-7.
http://www.ncbi.nlm.nih.gov/pubmed/10756085
(243) Simone E, Daniel D, Schloot N, Gottlieb P, Babu S, Kawasaki E, et al. T cell receptor restriction of diabetogenic autoimmune NOD T cells. Proc Natl Acad Sci USA 1997;94(6):2518-21.
http://www.ncbi.nlm.nih.gov/pubmed/9122227
(244) Zhang L, Jasinski JM, Kobayashi M, Davenport B, Johnson K, Davidson H, et al. Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains. J Autoimmun 2009 Mar 13.
http://www.ncbi.nlm.nih.gov/pubmed/19286348
(245) Alleva DG, Crowe PD, Jin L, Kwok WW, Ling N, Gottschalk M, et al. A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin. J Clin Invest 2001 Jan;107(2):173-80.
http://www.ncbi.nlm.nih.gov/pubmed/11160133
(246) Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, et al. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 2005 May 20;435(7039):224-8.
http://www.ncbi.nlm.nih.gov/pubmed/15889096
(247) Wong FS, Karttunen J, Dumont C, Wen L, Visintin I, Pilip IM, et al. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. Nature Medicine 1999;5(9):1026-31.
http://www.ncbi.nlm.nih.gov/pubmed/10470079
(248) Chen W, Bergerot I, Elliott JF, Harrison LC, Abiru N, Eisenbarth GS, et al. Evidence that a peptide spanning the B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of type 1 diabetes. J Immunol 2001 Nov 1;167(9):4926-35.
http://www.ncbi.nlm.nih.gov/pubmed/11673498
(249) Halbout P, Briand JP, Becourt C, Muller S, Boitard C. T cell response to preproinsulin I and II in the nonobese diabetic mouse. J Immunol 2002 Sep 1;169(5):2436-43.
http://www.ncbi.nlm.nih.gov/pubmed/12193712
(250) Durinovic-Bello I, I, Boehm BO, Ziegler AG. Predominantly Recognized ProInsulin T Helper Cell Epitopes in Individuals With and Without Islet Cell Autoimmunity. J Autoimmun 2002 Feb;18(1):55-66.
http://www.ncbi.nlm.nih.gov/pubmed/11869047
(251) Narendran P, Mannering SI, Harrison LC. Proinsulin - a pathogenic autoantigen in type 1 diabetes. Autoimmunity Reviews 2003;2(4):204-10.
http://www.ncbi.nlm.nih.gov/pubmed/12848947
(252) Maniatis AK, Yu L, Miao D, Nelson K, Eisenbarth GS. Rapid Assays for Detection of Anti-islet Autoantibodies: Implications for Organ Donor Screening. J Autoimmun 2001;16(1):71-6.
http://www.ncbi.nlm.nih.gov/pubmed/11221998
(253) Gianani R, Putnam A, Still T, Yu L, Miao D, Gill RG, et al. Initial results of screening of non - diabetic organ donors for expression of islet autoantibodies. J Clin Endocrinol Metab 2006 Feb 14;91:1855-61.
http://www.ncbi.nlm.nih.gov/pubmed/16478822
(254) Bosi E, Braghi S, Maffi P, Scirpoli M, Bertuzzi F, Pozza G, et al. Autoantibody response to islet transplantation in type 1 diabetes. diab 2001 Nov;50(11):2464-71.
http://www.ncbi.nlm.nih.gov/pubmed/11679423
(255) Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med 2006 Sep 28;355(13):1318-30.
http://www.ncbi.nlm.nih.gov/pubmed/17005949
(256) Bingley PJ, Bonifacio E, Williams AJK, Genovese S, Bottazzo GF, Gale EAM. Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers. diab 1997;46:1701-10.
http://www.ncbi.nlm.nih.gov/pubmed/9356015
(257) Maclaren N, Lan M, Coutant R, Schatz D, Silverstein J, Muir A, et al. Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2beta predict immune-mediated (Type 1) diabetes in relatives. J Autoimmun 1999 Jun;12(4):279-87.
http://www.ncbi.nlm.nih.gov/pubmed/10330299
(258) Hummel M, Ziegler AG, Roth R. Psychological impact of childhood islet autoantibody testing in families participating in the BABYDIAB study. Diabet Med 2004 Apr;21(4):324-8.
http://www.ncbi.nlm.nih.gov/pubmed/15049933
(259) Carmichael SK, Johnson SB, Baughcum A, North K, Hopkins D, Dukes MG, et al. Prospective assessment in newborns of diabetes autoimmunity (PANDA): maternal understanding of infant diabetes risk. Genet Med 2003 Mar;5(2):77-83.
http://www.ncbi.nlm.nih.gov/pubmed/12644776
(260) Gustafsson SU, Ludvigsson J, Liss PE, Svensson T. Bioethical theory and practice in genetic screening for type 1 diabetes. Med Health Care Philos 2003;6(1):45-50.
http://www.ncbi.nlm.nih.gov/pubmed/12710563
(261) Yu MS, Norris JM, Mitchell CM, Butler-Simon N, Groshek M, Follansbee D, et al. Impact on maternal parenting stress of receipt of genetic information regarding risk of diabetes in newborn infants. Am J Med Genet 1999 Sep;86(3):219-26.
http://www.ncbi.nlm.nih.gov/pubmed/10482869
(262) Hahl J, Simell T, Ilonen J, Knip M, Simell O. Costs of predicting IDDM. diabetol 1998;41:79-85.
http://www.ncbi.nlm.nih.gov/pubmed/9498634
(263) Barker JM, Goehrig SH, Barriga K, Hoffman M, Slover R, Eisenbarth GS, et al. Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up. Diab care 2004 Jun;27(6):1399-404.
http://www.ncbi.nlm.nih.gov/pubmed/15161795