Reference List - Chapter 2

(1) Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 2001; 358(9277):221-229.

(2) Achenbach P, Bonifacio E, Ziegler AG. Predicting type 1 diabetes. Curr Diab Rep 2005; 5(2):98-103.

(3) Bottazzo GF, Bosi E, Cull CA, Bonifacio E, Locatelli M, Zimmet P et al. IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71). diabetol 2005; 48(4):703-708.

(4) Eisenbarth GS. Italian Society of Diabetology Mentor Award. The stages of Type 1A diabetes: retrospective and prospective. Diabetes Nutr Metab 2004; 17(6):374-385.

(5) Bingley PJ, Gale EA. Progression to type 1 diabetes in islet cell antibody-positive relatives in the European Nicotinamide Diabetes Intervention Trial: the role of additional immune, genetic and metabolic markers of risk. diabetol 2006.

(6) Palmer JP, Fleming GA, Greenbaum CJ, Herold KC, Jansa LD, Kolb H et al. C-Peptide Is the Appropriate Outcome Measure for Type 1 Diabetes Clinical Trials to Preserve beta-Cell Function: Report of an ADA Workshop, 21-22 October 2001. diab 2004; 53(1):250-264.

(7) Bresson D, Togher L, Rodrigo E, Chen YL, Bluestone JA, Herold KC et al. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. Journal of Clinical Investigation 2006; 116(5):1371-1381.

(8) Dai YD, Jensen KP, Lehuen A, Masteller EL, Bluestone JA, Wilson DB et al. A peptide of glutamic acid decarboxylase 65 can recruit and expand a diabetogenic T cell clone, BDC2.5, in the pancreas. J Immunol 2005; 175(6):3621-3627.

(9) Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006; 203(7):1701-1711.

(10) Andre I, Gonzalez A, Wang B, Katz J, Benoist C, Mathis D. Checkpoints in the progression of autoimmune disease: lessons from diabetes models. Proc Natl Acad Sci U S A 1996; 93(6):2260-2263.

(11) Winer S, Tsui H, Lau A, Song A, Li X, Cheung RK et al. Autoimmune islet destruction in spontaneous type 1 diabetes is not beta-cell exclusive. Nat Med 2003; 9(2):198-205.

(12) Ashcroft FM, Rorsman P. Electrophysiology of the pancreatic beta-cell. Prog Biophys Mol Biol 1989; 54(2):87-143.

(13) Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B, Sussel L. Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci U S A 2004; 101(9):2924-2929.

(14) Daunt M, Dale O, Smith PA. Somatostatin inhibits oxidative respiration in pancreatic beta-cells. Endocrinology 2006; 147(3):1527-1535.

(15) Sorenson RL, Garry DG, Brelje TC. Structural and functional considerations of GABA in islets of Langerhans. Beta-cells and nerves. Diabetes 1991; 40(11):1365-1374.

(16) Doi A, Shono T, Nishi M, Furuta H, Sasaki H, Nanjo K. IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion. Proc Natl Acad Sci U S A 2006; 103(4):885-890.

(17) Hawkes CJ, Wasmeier C, Christie MR, Hutton JC. Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2. diab 1996; 45(9):1187-1192.

(18) Bartholomeusz RK, Campbell IL, Harrison LC. Pancreatic islet A2B5- and 3G5-reactive gangliosides are markers of differentiation in rat insulinoma cells. Endocrinology 1989; 124(6):2680-2685.

(19) Alejandro R, Shienvold FL, Hajek SAV, Pierce M, Paul R, Mintz DH. A ganglioside antigen on the rat pancreatic B cell surface identified by monoclonal antibody R2D6. J Clin Invest 1984; 74:25-38.

(20) Souza F, Simpson N, Raffo A, Saxena C, Maffei A, Hardy M et al. Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model. J Clin Invest 2006; 116(6):1506-1513.

(21) Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR et al. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev 2001; 15(6):672-686.

(22) Leibiger IB, Leibiger B, Moede T, Berggren PO. Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways. Mol Cell 1998; 1(6):933-938.

(23) Khan FA, Goforth PB, Zhang M, Satin LS. Insulin activates ATP-sensitive K(+) channels in pancreatic beta-cells through a phosphatidylinositol 3-kinase-dependent pathway. Diabetes 2001; 50(10):2192-2198.

(24) Schuit FC, In't Veld PA, Pipeleers DG. Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells. Proc Natl Acad Sci U S A 1988; 85(11):3865-3869.

(25) Fonseca SG, Fukuma M, Lipson KL, Nguyen LX, Allen JR, Oka Y et al. WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells. J Biol Chem 2005; 280(47):39609-39615.

(26) Hostens K, Pavlovic D, Zambre Y, Ling Z, Van Schravendijk C, Eizirik DL et al. Exposure of human islets to cytokines can result in disproportionately elevated proinsulin release. J Clin Invest 1999; 104(1):67-72.

(27) Cnop M, Welsh N, Jonas JC, Jorns A, Lenzen S, Eizirik DL. Mechanisms of Pancreatic {beta}-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities. Diabetes 2005; 54 Suppl 2:S97-S107.:S97-S107.

(28) Eizirik DL, Mandrup-Poulsen T. A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 2001; 44(12):2115-2133.

(29) Matschinsky FM, Glaser B, Magnuson MA. Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities. Diabetes 1998; 47(3):307-315.

(30) Schuit FC, Huypens P, Heimberg H, Pipeleers DG. Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. Diabetes 2001; 50(1):1-11.

(31) Drucker DJ. The biology of incretin hormones. Cell Metab 2006; 3(3):153-165.

(32) Triplitt C, Wright A, Chiquette E. Incretin mimetics and dipeptidyl peptidase-IV inhibitors: potential new therapies for type 2 diabetes mellitus. Pharmacotherapy 2006; 26(3):360-374.

(33) Park S, Dong X, Fisher TL, Dunn S, Omer AK, Weir G et al. Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. J Biol Chem 2006; 281(2):1159-1168.

(34) Hay CW, Sinclair EM, Bermano G, Durward E, Tadayyon M, Docherty K. Glucagon-like peptide-1 stimulates human insulin promoter activity in part through cAMP-responsive elements that lie upstream and downstream of the transcription start site. J Endocrinol 2005; 186(2):353-365.

(35) de Sa SV, Correa-Giannella ML, Machado MC, de Souza JJ, Pereira MA, Patzina RA et al. Somatostatin receptor subtype 5 (SSTR5) mRNA expression is related to histopathological features of cell proliferation in insulinomas. Endocr Relat Cancer 2006; 13(1):69-78.

(36) Lundquist I, Sundler F, Ahren B, Alumets J, Hakanson R. Somatostatin, pancreatic polypeptide, substance P, and neurotensin: cellular distribution and effects on stimulated insulin secretion in the mouse. Endocrinology 1979; 104(3):832-838.

(37) Szecowka J, Tatemoto K, Rajamaki G, Efendic S. Effects of PYY and PP on endocrine pancreas. Acta Physiol Scand 1983; 119(2):123-126.

(38) Degano P, Peiro E, Miralles P, Silvestre RA, Marco J. Effects of rat pancreatic polypeptide on islet-cell secretion in the perfused rat pancreas. Metabolism 1992; 41(3):306-309.

(39) Takahashi H, Kurose Y, Kobayashi S, Sugino T, Kojima M, Kangawa K et al. Ghrelin enhances glucose-induced insulin secretion in scheduled meal-fed sheep. J Endocrinol 2006; 189(1):67-75.

(40) Stiernet P, Guiot Y, Gilon P, Henquin JC. Glucose acutely decreases pH of secretory granules in mouse pancreatic islets: mechanisms and influence on insulin secretion. J Biol Chem 2006; .

(41) Henquin JC. Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 2000; 49(11):1751-1760.

(42) Johnson KH, O'Brien TD, Betsholtz C, Westermark P. Islet amyloid polypeptide: mechanisms of amyloidogenesis in the pancreatic islets and potential roles in diabetes mellitus. Lab Invest 1992; 66:522-535.

(43) Juan-Pico P, Fuentes E, Javier Bermudez-Silva F, Javier Diaz-Molina F, Ripoll C, Rodriguez dF et al. Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell. Cell Calcium 2006; 39(2):155-162.

(44) Kubosaki A, Nakamura S, Notkins AL. Dense Core Vesicle Proteins IA-2 and IA-2{beta}: Metabolic Alterations in Double Knockout Mice. diab 2005; 54 Suppl 2:S46-S51.

(45) Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, Miao D et al. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 2005; 435(7039):220-223.

(46) Moriyama H, Abiru N, Paronen J, Sikora K, Liu E, Miao D et al. Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse. Proc Natl Acad Sci U S A 2003; 100(18):10376-10381.

(47) Han B, Serra P, Amrani A, Yamanouchi J, Maree AF, Edelstein-Keshet L et al. Prevention of diabetes by manipulation of anti-IGRP autoimmunity: high efficiency of a low-affinity peptide. Nat Med 2005; 11(6):645-652.

(48) Rotig A, Cormier V, Chatelain P, et al. Deletion of mitochondrial DNA in a case of early-onset diabetes mellitus, optic atrophy, and deafness (Wolfram syndrome, MIM 222300). J Clin Invest 1993; 91:1095-1098.

(49) Rabinovitch A, Pukel C, Baquerizo H. Interleukin-1 inhibits glucose-modulated insulin and glucagon secretion in rat islet monolayer cultures. Endocrinology 1988; 122(6):2393-2398.

(50) Nielsen K, Karlsen AE, Deckert M, Madsen OD, Serup P, Mandrup-Poulsen T et al. Beta-cell maturation leads to in vitro sensitivity to cytotoxins. Diabetes 1999; 48(12):2324-2332.

(51) Strandell E, Buschard K, Saldeen J, Welsh N. Interleukin-1 beta induces the expression of hsp70, heme oxygenase and Mn-SOD in FACS-purified rat islet beta-cells, but not in alpha-cells. Immunol Lett 1995; 48(2):145-148.

(52) Horio F, Fukuda M, Katoh H, Petruzzelli M, Yano N, Rittershaus C et al. Reactive oxygen intermediates in autoimmune islet cell destruction of the NOD mouse induced by peritoneal exudate cells (rich in macrophages) but not T cells. Diabetologia 1994; 37(1):22-31.

(53) Jorns A, Tiedge M, Lenzen S, Munday R. Effect of superoxide dismutase, catalase, chelating agents, and free radical scavengers on the toxicity of alloxan to isolated pancreatic islets in vitro. Free Radic Biol Med 1999; 26(9-10):1300-1304.

(54) Eizirik DL, Sandler S, Welsh N, Juntti-Berggren L, Berggren PO. Interleukin-1 beta-induced stimulation of insulin release in mouse pancreatic islets is related to diacylglycerol production and protein kinase C activation. Mol Cell Endocrinol 1995; 111(2):159-165.

(55) Chen MC, Paez-Espinosa V, Welsh N, Eizirik DL. Interleukin-1beta regulates phospholipase D-1 expression in rat pancreatic beta-cells. Endocrinology 2000; 141(8):2822-2828.

(56) Karlsen AE, Sparre T, Nielsen K, Nerup J, Pociot F. Proteome analysis--a novel approach to understand the pathogenesis of Type 1 diabetes mellitus. Dis Markers 2001; 17(4):205-216.

(57) Karlsen AE, Storling ZM, Sparre T, Larsen MR, Mahmood A, Storling J et al. Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3. Biochem Biophys Res Commun 2006; 344(1):406-415.

(58) Eizirik DL. Interleukin-1 induced impairment in pancreatic islet oxidative metabolism of glucose is potentiated by tumor necrosis factor. Acta Endocrinol (Copenh) 1988; 119(3):321-325.

(59) Eizirik DL, Mandrup-Poulsen T. A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis. diabetol 2001; 44(12):2115-2133.

(60) Miura M, Endo S, Kaku LL, Inoue Y, Sato N, Wakabayshi G et al. Plasma type II phospholipase A2 levels in patients with acute pancreatitis. Res Commun Mol Pathol Pharmacol 2001; 109(3-4):159-164.

(61) Uhl W, Schrag HJ, Schmitter N, Aufenanger J, Nevalainen TJ, Buchler MW. Experimental study of a novel phospholipase A2 inhibitor in acute pancreatitis. Br J Surg 1998; 85(5):618-623.

(62) Gyulkhandanyan AV, Lee SC, Bikopoulos G, Dai F, Wheeler MB. The Zn2+-transporting Pathways in Pancreatic beta-Cells: A ROLE FOR THE L-TYPE VOLTAGE-GATED Ca2+ CHANNEL. J Biol Chem 2006; 281(14):9361-9372.

(63) Chimienti F, Favier A, Seve M. ZnT-8, a pancreatic beta-cell-specific zinc transporter. Biometals 2005; 18(4):313-317.

(64) Gromada J. The free fatty acid receptor GPR40 generates excitement in pancreatic beta-cells. Endocrinology 2006; 147(2):672-673.

(65) Feng DD, Luo Z, Roh SG, Hernandez M, Tawadros N, Keating DJ et al. Reduction in voltage-gated K+ currents in primary cultured rat pancreatic beta-cells by linoleic acids. Endocrinology 2006; 147(2):674-682.

(66) Itoh Y, Hinuma S. GPR40, a free fatty acid receptor on pancreatic beta cells, regulates insulin secretion. Hepatol Res 2005.

(67) Srikanta S, Telen M, Posillico JT, Dolinar R, Krisch K, Haynes BF et al. Monoclonal antibodies to a human islet cell surface glycoprotein: 4F2 and LC7-2. Endocrinology 1987; 120(6):2240-2244.

(68) Kim dK, Ahn SG, Park JC, Kanai Y, Endou H, Yoon JH. Expression of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (4F2hc) in oral squamous cell carcinoma and its precusor lesions. Anticancer Res 2004; 24(3a):1671-1675.

(69) Kanai Y, Endou H. Heterodimeric amino acid transporters: molecular biology and pathological and pharmacological relevance. Curr Drug Metab 2001; 2(4):339-354.

(70) Matschinsky FM. Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 1996; 45(2):223-241.

(71) Watada H, Kajimoto Y, Miyagawa J, Hanafusa T, Hamaguchi K, Matsuoka T et al. PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin. Diabetes 1996; 45(12):1826-1831.

(72) Leibiger B, Leibiger IB, Moede T, Kemper S, Kulkarni RN, Kahn CR et al. Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Mol Cell 2001; 7(3):559-570.

(73) Magnuson MA. Tissue-specific regulation of glucokinase gene expression. J Cell Biochem 1992; 48(2):115-121.

(74) German MS. Glucose sensing in pancreatic islet beta cells: the key role of glucokinase and the glycolytic intermediates. Proc Natl Acad Sci U S A 1993; 90(5):1781-1785.

(75) Halban PA, Praz GA, Wollheim CB. Abnormal glucose metabolism accompanies failure of glucose to stimulate insulin release from a rat pancreatic cell line (RINm5F). Biochem J 1983; 212(2):439-443.

(76) Ferber S, BeltrandelRio H, Johnson JH, Noel RJ, Cassidy LE, Clark S et al. GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity. J Biol Chem 1994; 269(15):11523-11529.

(77) Ling ZC, Khan A, Delauny F, Davani B, Ostenson CG, Gustafsson JA et al. Increased glucocorticoid sensitivity in islet beta-cells: effects on glucose 6-phosphatase, glucose cycling and insulin release. Diabetologia 1998; 41(6):634-639.

(78) Khan A, Chandramouli V, Ostenson CG, Berggren PO, Low H, Landau BR et al. Glucose cycling is markedly enhanced in pancreatic islets of obese hyperglycemic mice. Endocrinology 1990; 126(5):2413-2416.

(79) Khan A, Chandramouli V, Ostenson CG, Berggren PO, Low H, Landau BR et al. Glucose cycling is markedly enhanced in pancreatic islets of obese hyperglycemic mice. Endocrinology 1990; 126(5):2413-2416.

(80) Ebert DH, Bischof LJ, Streeper RS, Chapman SC, Svitek CA, Goldman JK et al. Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene. Diabetes 1999; 48(3):543-551.

(81) Sekine N, Cirulli V, Regazzi R, Brown LJ, Gine E, Tamarit-Rodriguez J et al. Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing. J Biol Chem 1994; 269(7):4895-4902.

(82) Giroix MH, Rasschaert J, Sener A, Leclercq-Meyer V, Bailbe D, Portha B et al. Study of hexose transport, glycerol phosphate shuttle and Krebs cycle in islets of adult rats injected with streptozotocin during the neonatal period. Mol Cell Endocrinol 1992; 83(2-3):95-104.

(83) Sener A, Malaisse WJ. Hexose metabolism in pancreatic islets. Ca(2+)-dependent activation of the glycerol phosphate shuttle by nutrient secretagogues. J Biol Chem 1992; 267(19):13251-13256.

(84) Farfari S, Schulz V, Corkey B, Prentki M. Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion. Diabetes 2000; 49(5):718-726.

(85) Schuit F, De Vos A, Farfari S, Moens K, Pipeleers D, Brun T et al. Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells. J Biol Chem 1997; 272(30):18572-18579.

(86) Malaisse WJ, Hutton JC, Kawazu S, Herchuelz A, Valverde I, Sener A. The stimulus-secretion coupling of glucose-induced insulin release. XXXV. The links between metabolic and cationic events. Diabetologia 1979; 16(5):331-341.

(87) Newgard CB, McGarry JD. Metabolic coupling factors in pancreatic beta-cell signal transduction. Annu Rev Biochem 1995; 64:689-719.:689-719.

(88) DeFronzo RA, Prato SD. Insulin resistance and diabetes mellitus. J Diabetes Complications 1996; 10(5):243-245.

(89) Williams JA. Electrical correlates of secretion in endocrine and exocrine cells. Fed Proc 1981; 40(2):128-134.

(90) Rorsman P, Bokvist K, Ammala C, Eliasson L, Renstrom E, Gabel J. Ion channels, electrical activity and insulin secretion. Diabete Metab 1994; 20(2):138-145.

(91) Ashcroft FM, Rorsman P. Electrophysiology of the pancreatic beta-cell. Prog Biophys Mol Biol 1989; 54(2):87-143.

(92) Cook DL, Satin LS, Ashford ML, Hales CN. ATP-sensitive K+ channels in pancreatic beta-cells. Spare-channel hypothesis. Diabetes 1988; 37(5):495-498.

(93) Loussouarn G, Pike LJ, Ashcroft FM, Makhina EN, Nichols CG. Dynamic sensitivity of ATP-sensitive K(+) channels to ATP. J Biol Chem 2001; 276(31):29098-29103.

(94) Song DK, Ashcroft FM. ATP modulation of ATP-sensitive potassium channel ATP sensitivity varies with the type of SUR subunit. J Biol Chem 2001; 276(10):7143-7149.

(95) Ashcroft FM, Gribble FM. ATP-sensitive K+ channels and insulin secretion: their role in health and disease. Diabetologia 1999; 42(8):903-919.

(96) Ashcroft SJ, Ashcroft FM. Properties and functions of ATP-sensitive K-channels. Cell Signal 1990; 2(3):197-214.

(97) Ashcroft FM, Rorsman P. ATP-sensitive K+ channels: a link between B-cell metabolism and insulin secretion. Biochem Soc Trans 1990; 18(1):109-111.

(98) Bryan J, Aguilar-Bryan L. The ABCs of ATP-sensitive potassium channels: more pieces of the puzzle. Curr Opin Cell Biol 1997; 9(4):553-559.

(99) Sakura H, Ashcroft FM. Identification of four trp1 gene variants murine pancreatic beta-cells. Diabetologia 1997; 40(5):528-532.

(100) Gembal M, Detimary P, Gilon P, Gao ZY, Henquin JC. Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells. J Clin Invest 1993; 91(3):871-880.

(101) Gembal M, Gilon P, Henquin JC. Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells. J Clin Invest 1992; 89(4):1288-1295.

(102) Komatsu M, Noda M, Sharp GW. Nutrient augmentation of Ca2+-dependent and Ca2+-independent pathways in stimulus-coupling to insulin secretion can be distinguished by their guanosine triphosphate requirements: studies on rat pancreatic islets. Endocrinology 1998; 139(3):1172-1183.

(103) Komatsu M, Schermerhorn T, Noda M, Straub SG, Aizawa T, Sharp GW. Augmentation of insulin release by glucose in the absence of extracellular Ca2+: new insights into stimulus-secretion coupling. Diabetes 1997; 46(12):1928-1938.

(104) Komatsu M, Sharp GW, Aizawa T, Hashizume K. Glucose stimulation of insulin release without an increase in cytosolic free Ca2+ concentration: a possible involvement of GTP. Jpn J Physiol 1997; 47 Suppl 1:S22-4.:S22-S24.

(105) Regazzi R, Li G, Ullrich S, Jaggi C, Wollheim CB. Different requirements for protein kinase C activation and Ca2+-independent insulin secretion in response to guanine nucleotides. Endogenously generated diacylglycerol requires elevated Ca2+ for kinase C insertion into membranes. J Biol Chem 1989; 264(17):9939-9944.

(106) Li GD, Luo RH, Metz SA. Effects of inhibitors of guanine nucleotide synthesis on membrane potential and cytosolic free Ca2+ levels in insulin-secreting cells. Biochem Pharmacol 2000; 59(5):545-556.

(107) Babenko AP, Aguilar-Bryan L, Bryan J. A view of sur/KIR6.X, KATP channels. Annu Rev Physiol 1998; 60:667-87.:667-687.

(108) Ashcroft FM. K(ATP) channels and insulin secretion: a key role in health and disease. Biochem Soc Trans 2006; 34(Pt 2):243-246.

(109) Polak M, Shield J. Neonatal Diabetes Mellitus -- genetic aspects 2004. Pediatr Endocrinol Rev 2004; 2(2):193-198.

(110) Suzuki M, Fujikura K, Inagaki N, Seino S, Takata K. Localization of the ATP-sensitive K+ channel subunit Kir6.2 in mouse pancreas. Diabetes 1997; 46(9):1440-1444.

(111) Miki T, Nagashima K, Seino S. The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells. J Mol Endocrinol 1999; 22(2):113-123.

(112) Bokvist K, Olsen HL, Hoy M, Gotfredsen CF, Holmes WF, Buschard K et al. Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells. Pflugers Arch 1999; 438(4):428-436.

(113) Suzuki M, Fujikura K, Kotake K, Inagaki N, Seino S, Takata K. Immuno-localization of sulphonylurea receptor 1 in rat pancreas. Diabetologia 1999; 42(10):1204-1211.

(114) Gopel SO, Kanno T, Barg S, Rorsman P. Patch-clamp characterisation of somatostatin-secreting -cells in intact mouse pancreatic islets. J Physiol 2000; 528(Pt 3):497-507.

(115) Gopel SO, Kanno T, Barg S, Weng XG, Gromada J, Rorsman P. Regulation of glucagon release in mouse -cells by KATP channels and inactivation of TTX-sensitive Na+ channels. J Physiol 2000; 528(Pt 3):509-520.

(116) Proks P, Girard C, Haider S, Gloyn AL, Hattersley AT, Sansom MS et al. A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome. EMBO Rep 2005; 6(5):470-475.

(117) Hattersley AT, Pearson ER. Mini Review: Pharmacogenetics and beyond: the interaction of therapeutic response, beta-cell physiology and genetics in diabetes. Endocrinology 2006.

(118) Koster JC, Remedi MS, Dao C, Nichols CG. ATP and sulfonylurea sensitivity of mutant ATP-sensitive K+ channels in neonatal diabetes: implications for pharmacogenomic therapy. diab 2005; 54(9):2645-2654.

(119) Hattersley AT, Ashcroft FM. Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy. diab 2005; 54(9):2503-2513.

(120) Nestorowicz A, Glaser B, Wilson BA, Shyng SL, Nichols CG, Stanley CA et al. Genetic heterogeneity in familial hyperinsulinism [published erratum appears in Hum Mol Genet 1998 Sep;7(9):1527]. Hum Mol Genet 1998; 7(7):1119-1128.

(121) Ashcroft FM. ATP-sensitive potassium channelopathies: focus on insulin secretion. J Clin Invest 2005; 115(8):2047-2058.

(122) Kawajiri M, Okano Y, Kuno M, Tokuhara D, Hase Y, Inada H et al. Unregulated insulin secretion by pancreatic beta cells in hyperinsulinism/hyperammonemia syndrome: role of glutamate dehydrogenase, ATP-sensitive potassium channel, and nonselective cation channel. Pediatr Res 2006; 59(3):359-364.

(123) Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB et al. Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression. J Biol Chem 2004; 279(49):51049-51056.

(124) Chan CB, Saleh MC, Koshkin V, Wheeler MB. Uncoupling protein 2 and islet function. diab 2004; 53 Suppl 1:S136-S142.

(125) Ann K, Kowalchyk JA, Loyet KM, Martin TF. Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis. J Biol Chem 1997; 272(32):19637-19640.

(126) Bokvist K, Eliasson L, Ammala C, Renstrom E, Rorsman P. Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells. EMBO J 1995; 14(1):50-57.

(127) Wiser O, Trus M, Hernandez A, Renstrom E, Barg S, Rorsman P et al. The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery. Proc Natl Acad Sci U S A 1999; 96(1):248-253.

(128) Nilius B, Hess P, Lansman JB, Tsien RW. A novel type of cardiac calcium channel in ventricular cells. Nature 1985; 316(6027):443-446.

(129) Gutnick MJ, Lux HD, Swandulla D, Zucker H. Voltage-dependent and calcium-dependent inactivation of calcium channel current in identified snail neurones. J Physiol 1989; 412:197-220.:197-220.

(130) Ammala C, Ashcroft FM, Rorsman P. Calcium-independent potentiation of insulin release by cyclic AMP in single beta-cells. Nature 1993; 363(6427):356-358.

(131) Dean PM. Ultrastructural morphometry of the pancreatic -cell. Diabetologia 1973; 9(2):115-119.

(132) Eliasson L, Renstrom E, Ding WG, Proks P, Rorsman P. Rapid ATP-dependent priming of secretory granules precedes Ca(2+)-induced exocytosis in mouse pancreatic B-cells. J Physiol 1997; 503(Pt 2):399-412.

(133) Rorsman P, Eliasson L, Renstrom E, Gromada J, Barg S, Gopel S. The Cell Physiology of Biphasic Insulin Secretion. News Physiol Sci 2000; 15:72-77.:72-77.

(134) Gromada J, Hoy M, Renstrom E, Bokvist K, Eliasson L, Gopel S et al. CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells. J Physiol 1999; 518(Pt 3):745-759.

(135) Ammala C, Eliasson L, Bokvist K, Berggren PO, Honkanen RE, Sjoholm A et al. Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells. Proc Natl Acad Sci U S A 1994; 91(10):4343-4347.

(136) Rorsman P. The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint. Diabetologia 1997; 40(5):487-495.

(137) Huang JD, Brady ST, Richards BW, Stenolen D, Resau JH, Copeland NG et al. Direct interaction of microtubule- and actin-based transport motors. Nature 1999; 397(6716):267-270.

(138) Easom RA. Beta-granule transport and exocytosis. Semin Cell Dev Biol 2000; 11(4):253-266.

(139) Sollner T, Bennett MK, Whiteheart SW, Scheller RH, Rothman JE. A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion. Cell 1993; 75(3):409-418.

(140) Rupnik M, Kreft M, Sikdar SK, Grilc S, Romih R, Zupancic G et al. Rapid regulated dense-core vesicle exocytosis requires the CAPS protein. Proc Natl Acad Sci U S A 2000; 97(10):5627-5632.

(141) Fukui K, Yang Q, Cao Y, Takahashi N, Hatakeyama H, Wang H et al. The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab 2005; 2(6):373-384.

(142) Evans GJ, Barclay JW, Prescott GR, Jo SR, Burgoyne RD, Birnbaum MJ et al. Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size. J Biol Chem 2006; 281(3):1564-1572.

(143) Jahn R, Sudhof TC. Membrane fusion and exocytosis. Annu Rev Biochem 1999; 68:863-911.:863-911.

(144) Izumi T, Gomi H, Torii S. Functional analysis of Rab27a effector granuphilin in insulin exocytosis. Methods Enzymol 2005; 403:216-229.

(145) Gomi H, Mizutani S, Kasai K, Itohara S, Izumi T. Granuphilin molecularly docks insulin granules to the fusion machinery. J Cell Biol 2005; 171(1):99-109.

(146) Jacobsson G, Bean AJ, Scheller RH, Juntti-Berggren L, Deeney JT, Berggren PO et al. Identification of synaptic proteins and their isoform mRNAs in compartments of pancreatic endocrine cells. Proc Natl Acad Sci U S A 1994; 91(26):12487-12491.

(147) Lang J. Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur J Biochem 1999; 259(1-2):3-17.

(148) Lao G, Scheuss V, Gerwin CM, Su Q, Mochida S, Rettig J et al. Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly. Neuron 2000; 25(1):191-201.

(149) Fisher RJ, Pevsner J, Burgoyne RD. Control of fusion pore dynamics during exocytosis by Munc18. Science 2001; 291(5505):875-878.

(150) Huang X, Kang YH, Pasyk EA, Sheu L, Wheeler MB, Trimble WS et al. Ca(2+) influx and cAMP elevation overcame botulinum toxin A but not tetanus toxin inhibition of insulin exocytosis. Am J Physiol Cell Physiol 2001; 281(3):C740-C750.

(151) Land J, Zhang H, Vaidyanathan VV, Sadoul K, Niemann H, Wollheim CB. Transient expression of botulinum neurotoxin C1 light chain differentially inhibits calcium and glucose induced insulin secretion in clonal beta-cells. FEBS Lett 1997; 419(1):13-17.

(152) Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Sudhof TC. Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins. Nature 1995; 375(6532):594-599.

(153) Loyet KM, Kowalchyk JA, Chaudhary A, Chen J, Prestwich GD, Martin TF. Specific binding of phosphatidylinositol 4,5-bisphosphate to calcium-dependent activator protein for secretion (CAPS), a potential phosphoinositide effector protein for regulated exocytosis. J Biol Chem 1998; 273(14):8337-8343.

(154) Lang J. Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur J Biochem 1999; 259(1-2):3-17.

(155) Sollner T, Bennett MK, Whiteheart SW, Scheller RH, Rothman JE. A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion. Cell 1993; 75(3):409-418.

(156) Lao G, Scheuss V, Gerwin CM, Su Q, Mochida S, Rettig J et al. Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly. Neuron 2000; 25(1):191-201.

(157) Broer A, Friedrich B, Wagner CA, Fillon S, Ganapathy V, Lang F et al. Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains. Biochem J 2001; 355(Pt 3):725-731.

(158) Xu T, Ashery U, Burgoyne RD, Neher E. Early requirement for alpha-SNAP and NSF in the secretory cascade in chromaffin cells. EMBO J 1999; 18(12):3293-3304.

(159) Iezzi M, Escher G, Meda P, Charollais A, Baldini G, Darchen F et al. Subcellular distribution and function of Rab3A, B, C, and D isoforms in insulin-secreting cells. Mol Endocrinol 1999; 13(2):202-212.

(160) Kajio H, Olszewski S, Rosner PJ, Donelan MJ, Geoghegan KF, Rhodes CJ. A low-affinity Ca2+-dependent association of calmodulin with the Rab3A effector domain inversely correlates with insulin exocytosis. Diabetes 2001; 50(9):2029-2039.

(161) Balsinde J, Balboa MA, Insel PA, Dennis EA. Regulation and inhibition of phospholipase A2. Annu Rev Pharmacol Toxicol 1999; 39:175-89.:175-189.

(162) Lai MM, Hong JJ, Ruggiero AM, Burnett PE, Slepnev VI, De Camilli P et al. The calcineurin-dynamin 1 complex as a calcium sensor for synaptic vesicle endocytosis. J Biol Chem 1999; 274(37):25963-25966.

(163) Bauerfeind R, Takei K, De Camilli P. Amphiphysin I is associated with coated endocytic intermediates and undergoes stimulation-dependent dephosphorylation in nerve terminals. J Biol Chem 1997; 272(49):30984-30992.

(164) Kang G, Chepurny OG, Malester B, Rindler MJ, Rehmann H, Bos JL et al. cAMP Sensor Epac As A Determinant Of ATP-Sensitive Potassium Channel Activity In Human Pancreatic Beta Cells And Rat INS-1 Cells. J Physiol 2006.

(165) Waselle L, Gerona RR, Vitale N, Martin TF, Bader MF, Regazzi R. Role of phosphoinositide signaling in the control of insulin exocytosis. Mol Endocrinol 2005; 19(12):3097-3106.

(166) Renstrom E, Eliasson L, Rorsman P. Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells. J Physiol 1997; 502(Pt 1):105-118.

(167) Hamilton PB, Stevens JR, Gidley J, Holz P, Gibson WC. A new lineage of trypanosomes from Australian vertebrates and terrestrial bloodsucking leeches (Haemadipsidae). Int J Parasitol 2005; 35(4):431-443.

(168) Ashcroft FM, Proks P, Smith PA, Ammala C, Bokvist K, Rorsman P. Stimulus-secretion coupling in pancreatic beta cells. J Cell Biochem 1994; 55 Suppl:54-65.:54-65.

(169) McPhail LC, Clayton CC, Snyderman R. A potential second messenger role for unsaturated fatty acids: activation of Ca2+-dependent protein kinase. Science 1984; 224(4649):622-625.

(170) Murakami K, Chan SY, Routtenberg A. Protein kinase C activation by cis-fatty acid in the absence of Ca2+ and phospholipids. J Biol Chem 1986; 261(33):15424-15429.

(171) Prescott SM. A thematic series on phospholipases. J Biol Chem 1997; 272(24):15043.

(172) Tischfield JA. A reassessment of the low molecular weight phospholipase A2 gene family in mammals. J Biol Chem 1997; 272(28):17247-17250.

(173) Clark JD, Lin LL, Kriz RW, Ramesha CS, Sultzman LA, Lin AY et al. A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP. Cell 1991; 65(6):1043-1051.

(174) Sharp JD, White DL, Chiou XG, Goodson T, Gamboa GC, McClure D et al. Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2. J Biol Chem 1991; 266(23):14850-14853.

(175) Leslie CC. Properties and regulation of cytosolic phospholipase A2. J Biol Chem 1997; 272(27):16709-16712.

(176) Sapirstein A, Bonventre JV. Specific physiological roles of cytosolic phospholipase A(2) as defined by gene knockouts. Biochim Biophys Acta 2000; 1488(1-2):139-148.

(177) Bonventre JV, Huang Z, Taheri MR, O'Leary E, Li E, Moskowitz MA et al. Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2. Nature 1997; 390(6660):622-625.

(178) Murakami M, Nakatani Y, Kuwata H, Kudo I. Cellular components that functionally interact with signaling phospholipase A(2)s. Biochim Biophys Acta 2000; 1488(1-2):159-166.

(179) Balsinde J, Dennis EA. Function and inhibition of intracellular calcium-independent phospholipase A2. J Biol Chem 1997; 272(26):16069-16072.

(180) Winstead MV, Balsinde J, Dennis EA. Calcium-independent phospholipase A(2): structure and function. Biochim Biophys Acta 2000; 1488(1-2):28-39.

(181) Ramanadham S, Hsu FF, Bohrer A, Ma Z, Turk J. Studies of the role of group VI phospholipase A2 in fatty acid incorporation, phospholipid remodeling, lysophosphatidylcholine generation, and secretagogue-induced arachidonic acid release in pancreatic islets and insulinoma cells. J Biol Chem 1999; 274(20):13915-13927.

(182) Dennis EA. The growing phospholipase A2 superfamily of signal transduction enzymes. Trends Biochem Sci 1997; 22(1):1-2.

(183) Stafforini DM, McIntyre TM, Zimmerman GA, Prescott SM. Platelet-activating factor acetylhydrolases. J Biol Chem 1997; 272(29):17895-17898.

(184) Ramanadham S, Ma Z, Arita H, Zhang S, Turk J. Type IB secretory phospholipase A2 is contained in insulin secretory granules of pancreatic islet beta-cells and is co-secreted with insulin from glucose-stimulated islets. Biochim Biophys Acta 1998; 1390(3):301-312.

(185) Metz S, Holmes D, Robertson RP, Leitner W, Draznin B. Gene expression of type I phospholipase A2 in pancreatic beta cells. Regulation of mRNA levels by starvation or glucose excess. FEBS Lett 1991; 295(1-3):110-112.

(186) Loweth AC, Scarpello JH, Morgan NG. Phospholipase A2 expression in human and rodent insulin-secreting cells. Mol Cell Endocrinol 1995; 112(2):177-183.

(187) Niwa T, Matsukawa Y, Senda T, Nimura Y, Hidaka H, Niki I. Acetylcholine activates intracellular movement of insulin granules in pancreatic beta-cells via inositol trisphosphate-dependent [correction of triphosphate-dependent] mobilization of intracellular Ca2+. Diabetes 1998; 47(11):1699-1706.

(188) Parker KJ, Jones PM, Hunton CH, Persaud SJ, Taylor CG, Howell SL. Identification and localisation of a type IV cytosolic phospholipase A2 in rat pancreatic beta-cells. J Mol Endocrinol 1996; 17(1):31-43.

(189) Eddlestone GT. ATP-sensitive K channel modulation by products of PLA2 action in the insulin-secreting HIT cell line. Am J Physiol 1995; 268(1 Pt 1):C181-C190.

(190) Gross RW, Ramanadham S, Kruszka KK, Han X, Turk J. Rat and human pancreatic islet cells contain a calcium ion independent phospholipase A2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine triphosphate and is specifically localized to islet beta-cells. Biochemistry 1993; 32(1):327-336.

(191) Kashiwagi M, Friess H, Uhl W, Graber H, Duarte R, Zimmermann A et al. Phospholipase A2 isoforms are altered in chronic pancreatitis. Ann Surg 1998; 227(2):220-228.

(192) Seeds MC, Jones DF, Chilton FH, Bass DA. Secretory and cytosolic phospholipases A2 are activated during TNF priming of human neutrophils. Biochim Biophys Acta 1998; 1389(3):273-284.

(193) Turk J, Wolf BA, Lefkowith JB, Stump WT, McDaniel ML. Glucose-induced phospholipid hydrolysis in isolated pancreatic islets: quantitative effects on the phospholipid content of arachidonate and other fatty acids. Biochim Biophys Acta 1986; 879(3):399-409.

(194) Ma Z, Ramanadham S, Kempe K, Chi XS, Ladenson J, Turk J. Pancreatic islets express a Ca2+-independent phospholipase A2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrin. J Biol Chem 1997; 272(17):11118-11127.

(195) Ma Z, Zhang S, Turk J, Ramanadham S. Stimulation of insulin secretion and associated nuclear accumulation of iPLA(2)beta in INS-1 insulinoma cells. Am J Physiol Endocrinol Metab 2002; 282(4):E820-E833.

(196) Wolf BA, Turk J, Sherman WR, McDaniel ML. Intracellular Ca2+ mobilization by arachidonic acid. Comparison with myo-inositol 1,4,5-trisphosphate in isolated pancreatic islets. J Biol Chem 1986; 261(8):3501-3511.

(197) Wolf BA, Pasquale SM, Turk J. Free fatty acid accumulation in secretagogue-stimulated pancreatic islets and effects of arachidonate on depolarization-induced insulin secretion. Biochemistry 1991; 30(26):6372-6379.

(198) Bell RL, Stanford N, Kennerly DA, Majerus PW. Diglyceride lipase: a pathway for arachidonate release from human platelets. Adv Prostaglandin Thromboxane Res 1980; 6:219-24.:219-224.

(199) Konrad RJ, Major CD, Wolf BA. Diacylglycerol hydrolysis to arachidonic acid is necessary for insulin secretion from isolated pancreatic islets: sequential actions of diacylglycerol and monoacylglycerol lipases. Biochemistry 1994; 33(45):13284-13294.

(200) Konrad RJ, Jolly YC, Major C, Wolf BA. Inhibition of phospholipase A2 and insulin secretion in pancreatic islets. Biochim Biophys Acta 1992; 1135(2):215-220.

(201) Metz SA. Pancreatic islet phospholipase A2: differential, Ca2+-dependent effects of lysophospholipids, arachidonic acid, and its lipoxygenase-derived metabolites on insulin release. Adv Prostaglandin Thromboxane Leukot Res 1987; 17B:668-76.:668-676.

(202) Shuttleworth TJ. Arachidonic acid activates the noncapacitative entry of Ca2+ during [Ca2+]i oscillations. J Biol Chem 1996; 271(36):21720-21725.

(203) Damron DS, Van Wagoner DR, Moravec CS, Bond M. Arachidonic acid and endothelin potentiate Ca2+ transients in rat cardiac myocytes via inhibition of distinct K+ channels. J Biol Chem 1993; 268(36):27335-27344.

(204) Graber MN, Alfonso A, Gill DL. Ca2+ pools and cell growth: arachidonic acid induces recovery of cells growth-arrested by Ca2+ pool depletion. J Biol Chem 1996; 271(2):883-888.

(205) McPhail LC, Clayton CC, Snyderman R. A potential second messenger role for unsaturated fatty acids: activation of Ca2+-dependent protein kinase. Science 1984; 224(4649):622-625.

(206) Metz SA. Exogenous arachidonic acid promotes insulin release from intact or permeabilized rat islets by dual mechanisms. Putative activation of Ca2+ mobilization and protein kinase C. Diabetes 1988; 37(11):1453-1469.

(207) Metz SA. The pancreatic islet as Rubik's Cube. Is phospholipid hydrolysis a piece of the puzzle? Diabetes 1991; 40(12):1565-1573.

(208) Ramanadham S, Gross R, Turk J. Arachidonic acid induces an increase in the cytosolic calcium concentration in single pancreatic islet beta cells. Biochem Biophys Res Commun 1992; 184(2):647-653.

(209) Hirabayashi T, Shimizu T. Localization and regulation of cytosolic phospholipase A(2). Biochim Biophys Acta 2000; 1488(1-2):124-138.

(210) Kimple ME, Nixon AB, Kelly P, Bailey CL, Young KH, Fields TA et al. A role for G(z) in pancreatic islet beta-cell biology. J Biol Chem 2005; 280(36):31708-31713.

(211) Kato R, Yamamoto S, Nakadate T, Nakaki T. Possible involvement of phospholipase A2 activation and lipoxygenase product(s) in the mechanism of insulin secretion. Adv Prostaglandin Thromboxane Leukot Res 1983; 12:265-70.:265-270.

(212) Zhou YP, Teng D, Dralyuk F, Ostrega D, Roe MW, Philipson L et al. Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism. J Clin Invest 1998; 101(8):1623-1632.

(213) Ma Z, Zhang S, Turk J, Ramanadham S. Stimulation of insulin secretion and associated nuclear accumulation of iPLA(2)beta in INS-1 insulinoma cells. Am J Physiol Endocrinol Metab 2002; 282(4):E820-E833.

(214) Metz SA. Mobilization of cellular Ca2+ by lysophospholipids in rat islets of Langerhans. Biochim Biophys Acta 1988; 968(2):239-252.

(215) Rustenbeck I, Lenzen S. Effects of lysophosphatidylcholine and arachidonic acid on the regulation of intracellular Ca2+ transport. Naunyn Schmiedebergs Arch Pharmacol 1989; 339(1-2):37-41.

(216) Gasser KW, Holda JR. ATP-sensitive potassium transport by pancreatic secretory granule membrane. Am J Physiol 1993; 264(1 Pt 1):G137-G142.

(217) Metz SA. Ether-linked lysophospholipids initiate insulin secretion. Lysophospholipids may mediate effects of phospholipase A2 activation on hormone release. Diabetes 1986; 35(7):808-817.

(218) Frossard JL, Bhagat L, Lee HS, Hietaranta AJ, Singh VP, Song AM et al. Both thermal and non-thermal stress protect against caerulein induced pancreatitis and prevent trypsinogen activation in the pancreas. Gut 2002; 50(1):78-83.

(219) Ramsingh AI, Chapman N, Tracy S. Coxsackieviruses and diabetes. Bioessays 1997; 19(9):793-800.

(220) Sevilla N, Homann D, von Herrath M, Rodriguez F, Harkins S, Whitton JL et al. Virus-induced diabetes in a transgenic model: role of cross-reacting viruses and quantitation of effector T cells needed to cause disease. J Virol 2000; 74(7):3284-3292.

(221) Gu D, Sarvetnick N. Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice. Development 1993; 118(1):33-46.

(222) Pruzanski W, Vadas P. Phospholipase A2--a mediator between proximal and distal effectors of inflammation. Immunol Today 1991; 12(5):143-146.

(223) van Puijenbroek AA, Wissink S, van der Saag PT, Peppelenbosch MP. Phospholipase A2 inhibitors and leukotriene synthesis inhibitors block TNF-induced NF-kappaB activation. Cytokine 1999; 11(2):104-110.

(224) Cuellar TL, McManus MT. MicroRNAs and endocrine biology. J Endocrinol 2005; 187(3):327-332.

(225) Lee JY, Ristow M, Lin X, White MF, Magnuson MA, Hennighausen L. RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J Biol Chem 2006; 281(5):2649-2653.

(226) Wiederkehr A, Wollheim CB. Implication of mitochondria in insulin secretion and action. Endocrinology 2006.