Welcome
Clinical Division
Research Division
Online Books
Children's Diabetes Foundation
Meetings
UCHSC&Disclaimers
LineDown
BDC Home Page
Clinical Division
Clinical Division Introduction
Pediatric Clinic
Young Adult Clinic
Ophthalmology Clinic
Clinical Division Faculty
Clinical Research
Children's Diabetes Foundation
Clinical Resources
Other Clinical Sites
Clinical Division Home

Research Interests

Marian Rewers, MD, PhD

 
Marian Rewers MD, PhD, MPH
Clinical Director of Barbara Davis Center,
Professor of Pediatrics & Preventive Medicine
Clinical Core Director, The Diabetes and Endocrinology Research Center (DERC)

 

 

 

 

e-mail: Marian Rewers, MD, PhD, MPH
BioSketch

Epidemiology/etiology of type I diabetes, including investigations of the geographic and temporal variability in the incidence of the disease, and of the natural history of beta-cell autoimmunity in newborns and infants from the general population and in very young relatives of type I patients.

Epidemiology/etiology of cardiovascular complications of both type I and type II diabetes, and of insulin resistance in type II diabetes.

Epidemiology/etiology of celiac disease.

Publications:

Young KA, Parrish LA, Zerbe GO, Rewers M, Deane KD, Michael Holers V, Norris JM.
Perinatal and early childhood risk factors associated with rheumatoid factor positivity in a healthy paediatric population.
Ann Rheum Dis. 2007 Feb;66(2):179-83.

Hagopian WA, Lernmark A, Rewers MJ, Simell OG, She JX, Ziegler AG, Krischer JP, Akolkar B.
TEDDY--The Environmental Determinants of Diabetes in the Young: an observational clinical trial.
Ann N Y Acad Sci. 2006 Oct;1079:320-6.

Wang J, Miao D, Babu S, Yu J, Barker J, Klingensmith G, Rewers M, Eisenbarth GS, Yu L.
Prevalence of autoantibody-negative diabetes is not rare at all ages and increases with older age and obesity.
J Clin Endocrinol Metab. 2007 Jan;92(1):88-92. Epub 2006 Oct 24.

Steck AK, Liu SY, McFann K, Barriga KJ, Babu SR, Eisenbarth GS, Rewers MJ, She JX.
Association of the PTPN22/LYP gene with type 1 diabetes.
Pediatr Diabetes. 2006 Oct;7(5):274-8.

Stene LC, Barriga K, Hoffman M, Kean J, Klingensmith G, Norris JM, Erlich HA, Eisenbarth GS, Rewers M.
Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY).
Pediatr Diabetes. 2006 Oct;7(5):247-53.

Stene LC, Honeyman MC, Hoffenberg EJ, Haas JE, Sokol RJ, Emery L, Taki I, Norris JM, Erlich HA, Eisenbarth GS, Rewers M.
Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study.
Am J Gastroenterol. 2006 Oct;101(10):2333-40.

Maahs DM, Rewers M.
Editorial: Mortality and renal disease in type 1 diabetes mellitus--progress made, more to be done.
J Clin Endocrinol Metab. 2006 Oct;91(10):3757-9.

Aly TA, Ide A, Jahromi MM, Barker JM, Fernando MS, Babu SR, Yu L, Miao D, Erlich HA, Fain PR, Barriga KJ, Norris JM, Rewers MJ, Eisenbarth GS.
Extreme genetic risk for type 1A diabetes.
Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14074-9.

Bhatia SS, Majka DS, Kittelson JM, Parrish LA, Ferucci ED, Deane KD, Arend WP, Rewers M, Michael Holers V, Norris JM.
Rheumatoid factor seropositivity is inversely associated with oral contraceptive use in women without rheumatoid arthritis.
Ann Rheum Dis. 2007 Feb;66(2):267-9.

Poole JA, Barriga K, Leung DY, Hoffman M, Eisenbarth GS, Rewers M, Norris JM.
Timing of initial exposure to cereal grains and the risk of wheat allergy.
Pediatrics. 2006 Jun;117(6):2175-82.

Aly TA, Eller E, Ide A, Gowan K, Babu SR, Erlich HA, Rewers MJ, Eisenbarth GS, Fain PR.
Multi-SNP analysis of MHC region: remarkable conservation of HLA-A1-B8-DR3 haplotype.
Diabetes. 2006 May;55(5):1265-9.

Hokanson JE, Kinney GL, Cheng S, Erlich HA, Kretowski A, Rewers M.
Susceptibility to type 1 diabetes is associated with ApoCIII gene haplotypes.
Diabetes. 2006 Mar;55(3):834-8.

Wadwa RP, Kinney GL, Ogden L, Snell-Bergeon JK, Maahs DM, Cornell E, Tracy RP, Rewers M.
Soluble interleukin-2 receptor as a marker for progression of coronary artery calcification in type 1 diabetes.
Int J Biochem Cell Biol. 2006;38(5-6):996-1003.

Aly TA, Ide A, Humphrey K, Barker JM, Steck A, Erlich HA, Yu L, Miao D, Redondo MJ, McFann K, Roberts CM, Babu SR, Norris JM, Eisenbarth GS, Rewers MJ.
Genetic prediction of autoimmunity: initial oligogenic prediction of anti-islet autoimmunity amongst DR3/DR4-DQ8 relatives of patients with type 1A diabetes.
J Autoimmun. 2005;25 Suppl:40-5.

Ide A, Babu SR, Robles DT, Wang T, Erlich HA, Bugawan TL, Rewers M, Fain PR, Eisenbarth GS.
Homozygosity for premature stop codon of the MHC class I chain-related gene A (MIC-A) is associated with early activation of islet autoimmunity of DR3/4-DQ2/8 high risk DAISY relatives.
J Clin Immunol. 2005 Jul;25(4):303-8.

Dixon B, Peter Chase H, Burdick J, Fiallo-Scharer R, Walravens P, Klingensmith G, Rewers M, Garg SK.
Use of insulin glargine in children under age 6 with type 1 diabetes.
Pediatr Diabetes. 2005 Sep;6(3):150-4.

Emery LM, Babu S, Bugawan TL, Norris JM, Erlich HA, Eisenbarth GS, Rewers M.
Newborn HLA-DR,DQ genotype screening: age- and ethnicity-specific type 1 diabetes risk estimates.
Pediatr Diabetes. 2005 Sep;6(3):136-44.

Steck AK, Bugawan TL, Valdes AM, Emery LM, Blair A, Norris JM, Redondo MJ, Babu SR, Erlich HA, Eisenbarth GS, Rewers MJ.
Association of non-HLA genes with type 1 diabetes autoimmunity.
Diabetes. 2005 Aug;54(8):2482-6.

Libby P, Nathan DM, Abraham K, Brunzell JD, Fradkin JE, Haffner SM, Hsueh W, Rewers M, Roberts BT, Savage PJ, Skarlatos S, Wassef M, Rabadan-Diehl C; National Heart, Lung, and Blood Institute; National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Cardiovascular Complications of Type 1 Diabetes Mellitus.
Report of the National Heart, Lung, and Blood Institute-National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Cardiovascular Complications of Type 1 Diabetes Mellitus.
Circulation. 2005 Jun 28;111(25):3489-93.

Ide A, Babu SR, Robles DT, Wang T, Erlich HA, Bugawan TL, Rewers M, Fain PR, Eisenbarth GS.
"Extended" A1, B8, DR3 haplotype shows remarkable linkage disequilibrium but is similar to nonextended haplotypes in terms of diabetes risk.
Diabetes. 2005 Jun;54(6):1879-83.

Norris JM, Barriga K, Hoffenberg EJ, Taki I, Miao D, Haas JE, Emery LM, Sokol RJ, Erlich HA, Eisenbarth GS, Rewers M.
Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease.
JAMA. 2005 May 18;293(19):2343-51.

Wadwa RP, Kinney GL, Maahs DM, Snell-Bergeon J, Hokanson JE, Garg SK, Eckel RH, Rewers M.
Awareness and treatment of dyslipidemia in young adults with type 1 diabetes.
Diabetes Care. 2005 May;28(5):1051-6.

Rewers M.
Epidemiology of celiac disease: what are the prevalence, incidence, and progression of celiac disease?
Gastroenterology. 2005 Apr;128(4 Suppl 1):S47-51.

Liu E, Rewers M, Eisenbarth GS.
Genetic testing: who should do the testing and what is the role of genetic testing in the setting of celiac disease?
Gastroenterology. 2005 Apr;128(4 Suppl 1):S33-7. Review.

Liu E, Li M, Bao F, Miao D, Rewers MJ, Eisenbarth GS, Hoffenberg EJ.
Need for quantitative assessment of transglutaminase autoantibodies for celiac disease in screening-identified children.
J Pediatr. 2005 Apr;146(4):494-9.

Barker JM, Yu J, Yu L, Wang J, Miao D, Bao F, Hoffenberg E, Nelson JC, Gottlieb PA, Rewers M, Eisenbarth GS.
Autoantibody "subspecificity" in type 1 diabetes: risk for organ-specific autoimmunity clusters in distinct groups.
Diabetes Care. 2005 Apr;28(4):850-5.

Izuora KE, Chase HP, Jackson WE, Coll JR, Osberg IM, Gottlieb PA, Rewers MJ, Garg SK.
Inflammatory markers and diabetic retinopathy in type 1 diabetes.
Diabetes Care. 2005 Mar;28(3):714-5.

Park Y, Kim S, Park S, Kim T, Yu L, Rewers M, Eisenbarth GS.
Differential expression of nonislet autoimmunity: comparison of Korean and U.S. patients with type 1 diabetes.
Ann N Y Acad Sci. 2004 Dec;1037:69-73.

Maahs DM, Ogden LG, Kinney GL, Wadwa P, Snell-Bergeon JK, Dabelea D, Hokanson JE, Ehrlich J, Eckel RH, Rewers M.
Low plasma adiponectin levels predict progression of coronary artery calcification.
Circulation. 2005 Feb 15;111(6):747-53.

Maahs DM, Kinney GL, Wadwa P, Snell-Bergeon JK, Dabelea D, Hokanson J, Ehrlich J, Garg S, Eckel RH, Rewers MJ.
Hypertension prevalence, awareness, treatment, and control in an adult type 1 diabetes population and a comparable general population.
Diabetes Care. 2005 Feb;28(2):301-6.

Steck AK, Barriga KJ, Emery LM, Fiallo-Scharer RV, Gottlieb PA, Rewers MJ.
Secondary attack rate of type 1 diabetes in Colorado families.
Diabetes Care. 2005 Feb;28(2):296-300.

Ferucci ED, Majka DS, Parrish LA, Moroldo MB, Ryan M, Passo M, Thompson SD, Deane KD, Rewers M, Arend WP, Glass DN, Norris JM, Holers VM.
Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis.
Arthritis Rheum. 2005 Jan;52(1):239-46.

Rewers M, Norris J, Dabelea D.
Epidemiology of type 1 Diabetes Mellitus.
Adv Exp Med Biol. 2004;552:219-46. Review.

Rewers M, Zimmet P.
The rising tide of childhood type 1 diabetes--what is the elusive environmental trigger?
Lancet. 2004 Nov 6-12;364(9446):1645-7.

Chase HP, Cooper S, Osberg I, Stene LC, Barriga K, Norris J, Eisenbarth GS, Rewers M.
Elevated C-reactive protein levels in the development of type 1 diabetes.
Diabetes. 2004 Oct;53(10):2569-73.

Barker JM, Barriga KJ, Yu L, Miao D, Erlich HA, Norris JM, Eisenbarth GS, Rewers M; Diabetes Autoimmunity Study in the Young.
Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY).
J Clin Endocrinol Metab. 2004 Aug;89(8):3896-902.

Cruz TD, Valdes AM, Santiago A, Frazer de Llado T, Raffel LJ, Zeidler A, Rotter JI, Erlich HA, Rewers M, Bugawan T, Noble JA.
DPB1 alleles are associated with type 1 diabetes susceptibility in multiple ethnic groups.
Diabetes. 2004 Aug;53(8):2158-63.

Stene LC, Barriga K, Norris JM, Hoffman M, Erlich HA, Eisenbarth GS, McDuffie RS Jr, Rewers M.
Perinatal factors and development of islet autoimmunity in early childhood: the diabetes autoimmunity study in the young.
Am J Epidemiol. 2004 Jul 1;160(1):3-10.

Barker JM, Goehrig SH, Barriga K, Hoffman M, Slover R, Eisenbarth GS, Norris JM, Klingensmith GJ, Rewers M; DAISY study.
Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up.
Diabetes Care. 2004 Jun;27(6):1399-404.

Saad MF, Rewers M, Selby J, Howard G, Jinagouda S, Fahmi S, Zaccaro D, Bergman RN, Savage PJ, Haffner SM.
Insulin resistance and hypertension: the Insulin Resistance Atherosclerosis study.
Hypertension. 2004 Jun;43(6):1324-31. Epub 2004 May 3.

Hoffenberg EJ, Emery LM, Barriga KJ, Bao F, Taylor J, Eisenbarth GS, Haas JE, Sokol RJ, Taki I, Norris JM, Rewers M.
Clinical features of children with screening-identified evidence of celiac disease.
Pediatrics. 2004 May;113(5):1254-9.

Hokanson JE, MacKenzie T, Kinney G, Snell-Bergeon JK, Dabelea D, Ehrlich J, Eckel RH, Rewers M.
Evaluating changes in coronary artery calcium: an analytic method that accounts for interscan variability.
AJR Am J Roentgenol. 2004 May;182(5):1327-32.

Rewers M, Liu E, Simmons J, Redondo MJ, Hoffenberg EJ.
Celiac disease associated with type 1 diabetes mellitus.
Endocrinol Metab Clin North Am. 2004 Mar;33(1):197-214, xi. Review.

Chase HP, MacKenzie TA, Burdick J, Fiallo-Scharer R, Walravens P, Klingensmith G, Rewers M.
Redefining the clinical remission period in children with type 1 diabetes.
Pediatr Diabetes. 2004 Mar;5(1):16-9.

Liu E, Bao F, Barriga K, Miao D, Yu L, Erlich HA, Haas JE, Eisenbarth GS, Rewers MJ, Hoffenberg EJ.
Fluctuating transglutaminase autoantibodies are related to histologic features of celiac disease.
Clin Gastroenterol Hepatol. 2003 Sep;1(5):356-62.

Rewers M, Zaccaro D, D'Agostino R, Haffner S, Saad MF, Selby JV, Bergman R, Savage P; Insulin Resistance Atherosclerosis Study Investigators.
Insulin sensitivity, insulinemia, and coronary artery disease: the Insulin Resistance Atherosclerosis Study.
Diabetes Care. 2004 Mar;27(3):781-7.

Stanley HM, Norris JM, Barriga K, Hoffman M, Yu L, Miao D, Erlich HA, Eisenbarth GS, Rewers M; Diabetes Autoimmunity Study in the Young (DAISY).
Is presence of islet autoantibodies at birth associated with development of persistent islet autoimmunity? The Diabetes Autoimmunity Study in the Young (DAISY).
Diabetes Care. 2004 Feb;27(2):497-502.

Chase HP, Dixon B, Pearson J, Fiallo-Scharer R, Walravens P, Klingensmith G, Rewers M, Garg SK.
Reduced hypoglycemic episodes and improved glycemic control in children with type 1 diabetes using insulin glargine and neutral protamine Hagedorn insulin.
J Pediatr. 2003 Dec;143(6):737-40.

Fronczak CM, Baron AE, Chase HP, Ross C, Brady HL, Hoffman M, Eisenbarth GS, Rewers M, Norris JM.
In utero dietary exposures and risk of islet autoimmunity in children.
Diabetes Care. 2003 Dec;26(12):3237-42.

Dabelea D, Kinney G, Snell-Bergeon JK, Hokanson JE, Eckel RH, Ehrlich J, Garg S, Hamman RF, Rewers M; The Coronary Artery Calcification in Type 1 Diabetes Study.
Effect of type 1 diabetes on the gender difference in coronary artery calcification: a role for insulin resistance? The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study.
Diabetes. 2003 Nov;52(11):2833-9. Erratum in: Diabetes. 2004 Aug;53(8):2177.

Stene LC, Barriga K, Norris JM, Hoffman M, Klingensmith G, Erlich HA, Eisenbarth GS, Rewers M.
Symptoms of common maternal infections in pregnancy and risk of islet autoimmunity in early childhood.
Diabetes Care. 2003 Nov;26(11):3136-41.

Norris JM, Barriga K, Klingensmith G, Hoffman M, Eisenbarth GS, Erlich HA, Rewers M.
Timing of initial cereal exposure in infancy and risk of islet autoimmunity.
JAMA. 2003 Oct 1;290(13):1713-20.

Hoffenberg EJ, MacKenzie T, Barriga KJ, Eisenbarth GS, Bao F, Haas JE, Erlich H, Bugawan Tl T, Sokol RJ, Taki I, Norris JM, Rewers M.
A prospective study of the incidence of childhood celiac disease.
J Pediatr. 2003 Sep;143(3):308-14.

Snell-Bergeon JK, Hokanson JE, Jensen L, MacKenzie T, Kinney G, Dabelea D, Eckel RH, Ehrlich J, Garg S, Rewers M.
Progression of coronary artery calcification in type 1 diabetes: the importance of glycemic control.
Diabetes Care. 2003 Oct;26(10):2923-8.

Kauffman LD, Sokol RJ, Jones RH, Awad JA, Rewers MJ, Norris JM.
Urinary F2-isoprostanes in young healthy children at risk for type 1 diabetes mellitus.
Free Radic Biol Med. 2003 Sep 15;35(6):551-7.

Eisenbarth GS, Moriyama H, Robles DT, Liu E, Yu L, Babu S, Redondo MJ, Gottlieb P, Wegmann D, Rewers M.
Insulin autoimmunity: prediction/precipitation/prevention type 1A diabetes.
Autoimmun Rev. 2002 May;1(3):139-45. Review. Erratum in: Autoimmun Rev. 2006 May;5(5):364.

Schwenke DC, D'Agostino RB Jr, Goff DC Jr, Karter AJ, Rewers MJ, Wagenknecht LE; Insulin resistance atherosclerosis study.
Differences in LDL oxidizability by glycemic status: the insulin resistance atherosclerosis study.
Diabetes Care. 2003 May;26(5):1449-55.

Henkin L, Bergman RN, Bowden DW, Ellsworth DL, Haffner SM, Langefeld CD, Mitchell BD, Norris JM, Rewers M, Saad MF, Stamm E, Wagenknecht LE, Rich SS.
Genetic epidemiology of insulin resistance and visceral adiposity. The IRAS Family Study design and methods.
Ann Epidemiol. 2003 Apr;13(4):211-7.

Parrish LA, Marshall JA, Krebs NF, Rewers M, Norris JM.
Validation of a food frequency questionnaire in preschool children.
Epidemiology. 2003 Mar;14(2):213-7.

Graves PM, Rotbart HA, Nix WA, Pallansch MA, Erlich HA, Norris JM, Hoffman M, Eisenbarth GS, Rewers M.
Prospective study of enteroviral infections and development of beta-cell autoimmunity. Diabetes autoimmunity study in the young (DAISY).
Diabetes Res Clin Pract. 2003 Jan;59(1):51-61.

Rewers A, Chase HP, Mackenzie T, Walravens P, Roback M, Rewers M, Hamman RF, Klingensmith G.
Predictors of acute complications in children with type 1 diabetes.
JAMA. 2002 May 15;287(19):2511-8.

Rewers M.
Islet autoantibodies in cord blood: maternal, fetal, or neither?
Diabetes Metab Res Rev. 2002 Jan-Feb;18(1):2-4.

Hokanson JE, Cheng S, Snell-Bergeon JK, Fijal BA, Grow MA, Hung C, Erlich HA, Ehrlich J, Eckel RH, Rewers M.
A common promoter polymorphism in the hepatic lipase gene (LIPC-480C>T) is associated with an increase in coronary calcification in type 1 diabetes.
Diabetes. 2002 Apr;51(4):1208-13.

Miao D, Yu L, Tiberti C, Cuthbertson DD, Rewers M, di Mario U, Eisenbarth GS, Dotta F.
ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodies.
J Autoimmun. 2002 Mar;18(2):191-6.

Robles DT, Eisenbarth GS, Wang T, Erlich HA, Bugawan TL, Babu SR, Barriga K, Norris JM, Hoffman M, Klingensmith G, Yu L, Rewers M; Diabetes Autoimmunity Study in the Young.
Millennium award recipient contribution. Identification of children with early onset and high incidence of anti-islet autoantibodies.
Clin Immunol. 2002 Mar;102(3):217-24.

To access a more complete listing of publications, please go to PubMed:
http://www.ncbi.nlm.nih.gov/PubMed/ and use the search term:
Barbara Davis Center for Childhood Diabetes
or enter individual author names.
Please direct inquiries to specific e-mail addresses listed within individual entries. For all other general Research inquiries, please contact:
kathryn.gray@uchsc.edu

Click Here To Return To Complete List of Clinical Research Faculty.