Study of the morphogenesis of the pancreatic islets
and pancreatic endocrine cell differentiation with the objective
of achieving beta-cell regeneration for therapeutic purposes.
Islet Studies and Diabetes Pathogenesis Laboratory:
Principal Investigators:
John C Hutton PhD, BDC Research Director
Howard W Davidson PhD, Assistant Professor
Research Associates:
Jan Wenzlau PhD
Suparna Sarkar MBBS PhD
Postdoctoral Fellows:
Kim Fowler PhD (USA)
Yu Liu PhD (China)
Sampathkumar Rangasmy PhD (India)
Leah Sheridan, PhD (USA)
Graduate Students:
Roslyn Bauer BS (USA)
Professional Research Assistants:
Seija Hackl BS (Finland)
Anita Hohenstein BS (USA)
Champa Patel BS MA (USA)
Jay Walters BS (USA)
Randall Wong BS (USA)
Lisa Frisch (USA)
Publications:
Sarkar SA, Wong R, Hackl SI, Moua O, Gill RG, Wiseman A, Davidson HW, Hutton JC.
Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets.
Diabetes. 2007 Jan;56(1):72-9.
Wang Y, Oeser JK, Yang C, Sarkar S, Hackl SI, Hasty AH, McGuinness OP, Paradee W, Hutton JC, Powell DR, O'Brien RM.
Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon.
J Biol Chem. 2006 Dec 29;281(52):39982-9. Epub 2006 Oct 5.
Limesand SW, Rozance PJ, Zerbe GO, Hutton JC, Hay WW Jr.
Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction.
Endocrinology. 2006 Mar;147(3):1488-97. Epub 2005 Dec 8.
Wasmeier C, Burgos PV, Trudeau T, Davidson HW, Hutton JC.
An extended tyrosine-targeting motif for endocytosis and recycling of the dense-core vesicle membrane protein phogrin.
Traffic. 2005 Jun;6(6):474-87.
Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, Miao D, Yu L, Wegmann DR, Hutton JC, Elliott JF, Eisenbarth GS.
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.
Nature. 2005 May 12;435(7039):220-3.
Limesand SW, Jensen J, Hutton JC, Hay WW Jr.
Diminished beta-cell replication contributes to reduced beta-cell mass in fetal sheep with intrauterine growth restriction.
Am J Physiol Regul Integr Comp Physiol. 2005 May;288(5):R1297-305. Epub 2005 Jan 13.
Nakayama M, Moriyama H, Abiru N, Babu SR, Sikora K, Li M, Miao D, Hutton JC, Elliott JF, Eisenbarth GS.
Establishment of native insulin-negative NOD mice and the methodology to distinguish specific insulin knockout genotypes and a B:16 alanine preproinsulin transgene.
Ann N Y Acad Sci. 2004 Dec;1037:193-8.
Vo YP, Hutton JC, Angleson JK.
Recycling of the dense-core vesicle membrane protein phogrin in Min6 beta-cells.
Biochem Biophys Res Commun. 2004 Nov 19;324(3):1004-10.
Frigeri C, Martin CC, Svitek CA, Oeser JK, Hutton JC, Gannon M, O'Brien RM.
The proximal islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen promoter is sufficient to initiate but not maintain transgene expression in mouse islets in vivo.
Diabetes. 2004 Jul;53(7):1754-64.
Zahn TR, Angleson JK, MacMorris MA, Domke E, Hutton JF, Schwartz C, Hutton JC.
Dense core vesicle dynamics in Caenorhabditis elegans neurons and the role of kinesin UNC-104.
Traffic. 2004 Jul;5(7):544-59.
Kelemen K, Gottlieb PA, Putnam AL, Davidson HW, Wegmann DR, Hutton JC.
HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes.
J Immunol. 2004 Mar 15;172(6):3955-62.
Juhl K, Hutton J.
Stimulus-secretion coupling in the pancreatic beta-cell.
Adv Exp Med Biol. 2004;552:66-90. Review.
Hutton J, Wasmeier C, Amaria R, Bright N, Creemers J.
Proprotein processing and pancreatic islet function.
Adv Exp Med Biol. 2004;552:39-65. Review.
Jackson RS, Creemers JW, Farooqi IS, Raffin-Sanson ML, Varro A, Dockray GJ, Holst JJ, Brubaker PL, Corvol P, Polonsky KS, Ostrega D, Becker KL, Bertagna X, Hutton JC, White A, Dattani MT, Hussain K, Middleton SJ, Nicole TM, Milla PJ, Lindley KJ, O'Rahilly S.
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency.
J Clin Invest. 2003 Nov;112(10):1550-60.
Hutton JC, Eisenbarth GS.
A pancreatic beta-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes.
Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8626-8. Epub 2003 Jul 14.
Jambal P, Masterson S, Nesterova A, Bouchard R, Bergman B, Hutton JC, Boxer LM, Reusch JE, Pugazhenthi S.
Cytokine-mediated down-regulation of the transcription factor cAMP-response element-binding protein in pancreatic beta-cells.
J Biol Chem. 2003 Jun 20;278(25):23055-65. Epub 2003 Apr 5.
Nicolls MR, D'Antonio JM, Hutton JC, Gill RG, Czwornog JL, Duncan MW.
Proteomics as a tool for discovery: proteins implicated in Alzheimer's disease are highly expressed in normal pancreatic islets.
J Proteome Res. 2003 Mar-Apr;2(2):199-205.
Achenbach P, Kelemen K, Wegmann DR, Hutton JC.
Spontaneous peripheral T-cell responses to the IA-2beta (phogrin) autoantigen in young nonobese diabetic mice.
J Autoimmun. 2002 Nov;19(3):111-6.
Wasmeier C, Bright NA, Hutton JC.
The lumenal domain of the integral membrane protein phogrin mediates targeting to secretory granules.
Traffic. 2002 Sep;3(9):654-65.
