The research interests of the more than forty program faculty include structure and function of nucleic acids,
mechanisms of DNA replication, RNA transcription and mRNA translation, the structure and function of viruses, genes
and gene products controlling cell cycle progression, cell death and development, protein trafficking, signal
transduction, hormone receptors, and structural biology. To study these important and exciting fields, our faculty
employ experimental systems such as bacteria, viruses, yeast cells, Xenopus oocytes, Drosophila, C. elegans, human
tissue culture cells, and genetically engineered mice. Our faculty also provide training in high resolution structure
of proteins and RNA/DNA by x-ray crystallography and NMR. Because of the solid funding record of all participating
faculty, graduate students find unlimited opportunities to perform research in an atmosphere of both guidance and
freedom.
Anderson, Steven M. - Signal
Transduction by cytokine receptors, breast cancer.
Artinger, Kristin - Molecular, genetic, and developmental mechanisms involved in the patterning of the early spinal cord (neural plate) during vertebrate embryogenesis.
Barton, David - Enterovirus RNA
replication.
Bayer, Ulli - Molecular memory and synaptic plasticity, cellular signal transduction and
neuronal function, CaMKII and Ca2+ signaling.
Bentley, David - Eukaryotic mRNA biogenesis: transcription and RNA processing.
Bradford, Andrew - Regulation of tissue specific gene expression in response to hormonal
and growth factor stimuli, characterization of fibroblast growth factor signaling in the pituitary, and the role of protein
kinase C in endometrial cancer.
Britt, Steven - Visual system development and function using molecular-genetic approaches in
Drosophila.
Churchill, Mair E. A. - Structural biology of gene regulatory mechanisms
Davis, Richard . - Spliced leader RNA trans-splicing and its role in post-transcriptional
gene expression. Structure/function of mRNA cap-interacting proteins.
DeGregori, James. - Leukemia initiation and maintenance
Eisenmesser, Elan - Viral protein/host protein interactions and enzyme motions
Evans, Thomas - The control of embryonic polarity.
Ford, Heide - The SIX family of homeobox
genes and their role in development, cell cycle control and tumorigenesis.
Gutierrez-Hartmann, Arthur -
My laboratory focuses on two main projects: (1) elucidating the molecular
mechanisms governing pituitary-specific gene expression; and, (2)
determining the role of Ets transcription factors in breast cancer.
Hagman, James
- Regulation of B lymphocyte - specific transcription and
differentiation
Holers, Michael -
Signal transduction through complement receptors.
Holmes, Kathryn V. - Virus receptors
and their roles in virus pathogenesis and evolution.
Holmes, Randall K. - Molecular
characterization of bacterial toxins - gene regulation in pathogenic
bacteria.
Hooper, Joan E. - Molecular genetics
of pattern formation -- Drosophila segmentation
Howell, Kathryn E. - Membrane traffic in
both exocytic and endocytic pathways.
Huang, Mingxia - Function and regulation of
the DNA damage response.
Hu, Cheng-Jun - Role of hypoxic response in tumor progression and metastasis
Jones, David - How the three-dimensional structure of proteins and nucleic acids
controls their biological function. NMR is used to study the structure and dynamics of biological molecules
implicated in the development and progression of disease.
Kieft, Jeffrey - Control of translation by RNA structure. RNA-protein interactions.
Krushel, Leslie - Mechanisms and
regulation of protein synthesis in the nervous system.
Kutateladze, Tatiana -
Molecular mechanisms of protein-phospholipid interactions; structure and function of proteins implicated in cancer by NMR
spectroscopy; structure-based drug design.
Li, Chuan-Yuan - Deciphering the molecular mechanisms of tumor response to
treatment, including how tumors regeneration/repopulate after therapy, by use of state-of-the-art molecular biology and
imaging tools and animal models
Liu, Changwei - The ubiquitin proteasome pathway.
Low, Robert L. - Replication of mammalian
mitochondrial (mt) DNA.
Maller, James L. - Biochemical and
molecular basis of the control of cell division.
Martin, Sandy L. - Mechanism of LINE-1
retrotransposition. Differential gene expression during hibernation.
McManaman, James - Lactation and Lipid secretion.
Megee, Paul - Molecular basis of sister
chromatid cohesion and chromosome segregation.
Niswander, Lee - Genetic and Cellular Control of Vertebrate Embryonic Development
Nordeen, Steven K. - Molecular mechanisms
of steroid receptor mediated regulation of gene expression. Regulation
of oncogene and mammary tumor virus transcription.
Prekeris, Rytis - Molecular mechanisms
regulating the establishment and maintenance of cellular polarity in epithelial
cells and neurons.
Refaeli, Yosef - We are interested in the function of oncogenes in regulating normal immune function and their contribution to
lymphoid malignancies.
Reyland, Mary -
Regulation of apoptosis in epithelial cells by signal transduction
pathways.
Roop, Dennis - Skin development and disease.
Schaack, Jerome - Gene therapy vectors;
adenovirus preterminal protein function in the
regulation of the infectious cycle
Sclafani, Robert A. - The
regulation of the eukaryotic cell cycle.
Thorburn, Andrew - Apoptosis regulation in cancer development and treatment.
Tyler, Jessica -
Epigenetic regulation of gene expression and genomic integrity
VanDyk, Linda - Control of growth regulation and differentiation
of host cells in viral infection and persistence.
Vasil, Michael L. - Molecular mechanisms of
bacterial pathogenesis and gene regulation in procaryotes, including Mycobacteria
tuberculosis and Pseudomonas aeruginosa.
Voskuil, Martin - Mechanisms of Mycobacterium tuberculosis for survival during latent disease.
Williams,Trevor - Transcriptional
regulation of mouse embryonic development and the role of transcription factors
in mammary gland development and breast cancer.
Zhao, Rui - Structural studies of the pre-mRNA splicing machinery.
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