Dr. Maller's laboratory studies the
molecular regulation of decision points in the cell cycle
during which commitments are made to enter DNA synthesis
or mitosis. Both checkpoint decisions are
regulated by integrated signals that control the
activity of protein kinases and phosphatases which
regulate the phosphorylation state of key enzymes.
The overall goal is to learn how the cellular decision
to proceed in the cell cycle is elaborated at these
decision points. Dr. Maller is also interested in
signal transduction pathways that utilize sequential
phosphorylation and activation of several protein
kinases, resulting in a cascade of signaling modules
important for growth control and integrated cellular
function.
Selected Publications
Eyers, P.A., Erikson, E., Chen, L.G., and Maller, J.L. (2003) A Novel Mechanism for Activation of the Protein Kinase Aurora A. Curr. Biol. 13, 691-697.
Tunquist, B.J., Eyers, P.A., Chen, L.G., Lewellyn, A.L. and Maller, J.L. (2003) Spindle Checkpoint Proteins Mad1 and Mad2 Are Required for Cytostatic Factor (CSF)-Mediated Metaphase Arrest. J. Cell Biol., 163, 1231-1242.
Eyers, P.A. and Maller, J.L. (2004) Regulation of Xenopus Aurora A Activation by TPX2. J. Biol. Chem. 279, 9008-9015.
Liu, J., Lewellyn, A.L., Chen, L.G., and Maller, J.L. (2004) The Polo Box Is Required for Multiple Functions of Plx1 in Mitosis. J. Biol. Chem. 279, 21367-21373.
Erikson, E., Haystead, T.A., Qian, Y-W, and Maller, J.L. (2004) A Feedback Loop in the Polo-like Kinase Activation Pathway. J. Biol. Chem. 279, 32,219-32,224.
Conn, C.W., Lewellyn, A.L., and Maller, J.L. (2004) The DNA Damage Checkpoint In Embryonic Cell Cycles Is Dependent on the DNA to Cytoplasmic Ratio. Dev. Cell 7, 275-281.
Matsumoto, Y. and Maller, J.L. (2004) A Centrosomal Localization Signal in Cyclin E Required for Cdk2-Independent S Phase Entry. Science, 306, 885-888.
Eyers, P.A., Liu, J., Hayashi, N.R., Lewellyn, A.L., Gautier, J. and Maller, J.L. (2005) Regulation of the G2/M Transition in Xenopus Oocytes by the cAMP-Dependent Protein Kinase. J. Biol. Chem., 280, 24339-24346.
Eyers, P., Churchill, M., and Maller, J.L. (2005) The Aurora A and Aurora B Protein Kinases: A Single Amino Acid Difference Controls Intrinsic Activity and Activation by TPX2. Cell Cycle, 4, 784-789.
Liu, J.J. and Maller, J.L. (2005) Calcium Elevation at Fertilization Coordinates Phosphorylation of XErp1/Emi2 by Plx1 and CaMKII to Release Metaphase Arrest by Cytostatic Factor. Curr. Biol., 15, 1458-1468.
Liu, J. and Maller, J.L. (2005) The Xenopus Polo-like Kinase Plx1: A Multifunctional Mitotic Kinase Oncogene 24, 238-247.
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