Tracy J. Horton, Ph.D.
Assistant Professor

Department/Division:
Pediatrics/Center for Human Nutrition

Contact information:
Office Location: JFK building, Room OL20
Phone number: (303)315-3048
email: Tracy.Horton@uchsc.edu

Education:

1985    BSc. in Nutrition
            Queen Elizabeth College, Univ. of London, U.K.

1989    Ph.D. in Nutrition
            Kings College (Kensington), Univ. of London, U.K.

1990    Post-Doc in Pediatrics
            Vanderbilt University

1985-1989         Postgraduate Research Student,
                          Department of Nutrition,
                          Kings College (Kensington) University of London, UK.,
                          Supervisor: Dr. Catherine Geissler, part-time employment.

1990-1992         Postdoctoral Research Fellow,
                          Vanderbilt University, Nashville, TN.
                          Supervisor: Dr. James Hill, Full-time employment.

1993-1995         Postdoctoral Research Associate,
                          Department of Pediatrics,
                          University of Colorado Health Sciences Center.
                          Supervisor: Dr. James Hill, Full-time employment.

1996-1998         Instructor, Department of Pediatrics,
                          University of Colorado Denver.
                          Supervisor: Dr. James Hill, Full-time employment.

1998-present     Assistant Professor, Department of Pediatrics,
                          University of Colorado Health Sciences Center.
                          Full-time employment, tenure-track.

2001                  Member, committee for the development of a Women's Research Program,
                          School of Medicine Research Retreat, UCD, Denver CO.

2001-present     Department of Pediatrics Faculty Senate Representative, UCD, Denver, CO.

2001-present     Member, Indirect Cost Recovery Committee, Department of Pediatrics,
                          UCD, Denver CO.

2001-present     Member, Womens Health Research Group, UCD, Denver, Co.

2002-present     Co-director, Nutrition Training Grant, Section of Nutrition,
                           Department of Pediatrics, UCD, Denver, CO.

1982                  Manchester Polytechnic. Manchester, UK Academic Honors Award.

1985                  University of London, Dept. Nutrition.
                          Award for highest academic achievement, BSc.

1992                  Finalist for NAASO Young Investigator's Award.

1997                  CNRU Pilot and Feasibility Award, UCD, Denver CO.

1998                  NIH FIRST Award (converted to R01) (HL59331).

Selected, Peer-Reviewed Publications:

1. Dulloo, A., Geissler, C., Horton, T., Collins, A., Miller, D. Caffeine consumption: Influence on thermogenesis and daily energy expenditure in the lean and post obese human. Am. J. Clin. Nut. 1989; 49:44 50.
2. Horton, T.J., Geissler, C.A. Aspirin potentiates the effect of ephedrine on the thermogenic response to a meal in obese but not lean women. Int. J. Obesity 1991:15;359-366.
3. Horton, T.J., Geissler, C.A. Effect of habitual exercise patterns on energy expenditure and metabolic rate during standardized activity protocols. Am. J. Clin. Nutr. 1994; 59:13-19.
4. Horton, T.J., Drougas, H.J., Sharp, T.A, Martinez, L.R., Reed, G.W., Hill, J.O. Energy balance in endurance-trained female cyclists and untrained controls. J. Appl. Physiol. 1994;76:1937-1945.
5. Pagliassotti, M.J., Horton, T.J. Hormonal and neural regulation of hepatic glucose uptake. In: The role of the liver in glucose homeostasis. Ed. M.J. Pagliassotti, S.N. Davis, A.D. Cherrington. Pub. R.G. Landes Company, Austin. 1994. pg 35-70.
6. Horton, T.J., Drougas, H., Brachey, A., Reed, G.W., Peters, J.C., Hill, J.O. Fat and carbohydrate overfeeding in humans. Different effects on energy storage. Am. J. Clin. Nutr. 1995;62:19-29.
7. Horton, T.J. Geissler, C.A. Post-prandial thermogenesis with ephedrine, caffeine and aspirin in lean, pre-disposed obese and obese women. Int. J. Obesity. 1996;20:91-99.
8. Horton, T.J., Hill, J.O. The influence of diet composition on exercise performance. In: Carbohydrates and Health: New Insights, New Diections. International Life Sciences Insitute, 1996
9. Horton, T.J., Gayles, E.C., Prach, P.A., Koppenhafer, T.A., Pagliassotti, M.J. Female rats do not develop sucrose-induced insulin resistance. Am. J. Physiol. 1997;41:R1571-R1576.
10. Pagliassoitti, M.J., Horton, T.J., Gayles, E.C., Koppenhafer, T.A., Rosenzweig, T.D., Hill, J.O. Reduced insulin suppression of glucose appearance is related to susceptibility to dietary obesity in rats. Am. J. Physiol. 1997;41:R1264-R1270.
11. Horton, T.J., Hill, J.O. Exercise and Obesity. Proc. Nut. Soc. 1998;57:85-91.
12. Horton, T.J., Pagliassotti, M.J., Hobbs, K., Hill, J.O. Fuel metabolism in men and women during and after long-duration exercise. J. Appl. Physiol. 1998;85:1823-1832.
13. Horton, T.J., Hill, J.O. Prolonged fasting significantly changes nutrient oxidation and glucose tolerance following a normal mixed meal. J. Appl. Physiol. 2001;90:155-163.
14. Davy, K.P., Horton, T.J., Davy, B.D., Bessesen, D., Hill, J.O. Regulation of macronutrient balance in healthy young and older men. Int. J. Obesity. 2001;25:1497-1502.
15. Braun, B., Horton, T.J. Endocrine regulation of substrate utilization in women. Exer. Sport Sci. Rev. 2001;29:149-154.
16. Melanson, E.L., Sharp,T.A., Seagle,H.M., Horton, T.J., Donahoo,W.T., Dgrunwald, G.K., Hamilton, J.T., Hill, J.O. The effect of exercise intensity on 24 h energy expenditure and nutrient oxidation. J. Appl. Physiol. 2002;92:1045-1052.
17. Horton, T.J., Miller, E.K., Glueck, D., Tench, K. No effect of menstrual cycle phase on glucose kinetics at rest or during 90 minutes of moderate intensity exercise. Am. J. Physiol. 2002;282:E752-E762.
18. Kohrt, W., Horton, T.J. Healthy aging in women. In. Women's Health In Primary Care. Supplement: Women's Health in Cardiovascular Disease and Diabetes. 2002;5:6-13.
19. Horton, T.J., Commerford, S.R., Pagliassoti, M.J., Bessesen, D.H. Post-prandial leg uptake of triglyceride is greater in women as compared to men. (Am. J. Physiol. in press).

1. Perreault, L., Lavely, J., Bergman, B, Horton, T.J. The effect of acute exercise on insulin action in men and women. To be presented at the American Diabetes Meeting, June 2002.
2. Perreault, L., Lavely, J., Horton, T.J. Gender differences in lipoprotein lipase activity following acute exercise and/or insulin infusion. Presented at FASEB, April 2002.
3. Melanson, E.L., Horton, T.J., Hill, J.O. Insulin resistance and weight gain during fat and carbohydrate overfeeding in lean and obese men. Obesity Research. 2001;9:156S.
4. Horton, T.J., Pagliassotti, M.J., S.R. Commerford. Post-prandial lipid metabolism differs between men and women. . FASEB 2000;14:A430.
5. Rongen, J.C., Johnson, S.L., Sharp, T.A., Bell, M.L., Grunwald, G.K., Hill, J.O., Horton, T.J. The effects of aerobic or resistance exercise on appetite. Abstract for presentation at the American Dietetics Association annual meeting, 2000.
6. Horton, T.J., Miller, E.K., Pagliassotti, M.J. Menstrual cycle effects on exercise fuel metabolism. FASEB 1999:13;A1051.
7. Horton, T.J., Hill, J.O. Fasting for 72 hours significantly impacts post-prandial nutrient metabolism. Submitted to Expt. Biology, 1999. FASEB1999:13;A78.
8. Davy, K.P., Horton, T,J., Davy, B.M., Bessesen, D., Flannagan, M., Hill, J.O. Regulation of nutrient balance in healthy young and older men. FASEB1999:13;A374.
9. Davy, B.M., Horton, T.J., Hill, J.O. Resting metabolic rate is reduced following weight loss and weight maintenance in obese humans. SCAN Symposium. Scottsdale, Arizona, 1996.
10. Horton, T.J., Sun, M., Hill, J.O. A new approach to the measurement of activity and work in a whole-room indirect calorimeter. Proc. Nutr. Soc. 1992;51:70A
11. Horton, T.J., Reed, G.W., Drougas, H., Brachey, A., Sun, M., Carlson, M.G., Peters, J., Hill, J.O. Nutrient balance during fat and carbohydrate overfeeding in males. Obesity Research. 1992:15;359-366.

RO1 HL59331-02 (PI-T.J.Horton) 03/01/98-02/29/02
NIH
The effect of gender and menopause on nutrient and energy metabolism
Role: PI
The major goal of this project is to compare differences between men and women in lipid and carbohydrate metabolism following specific interventions including a) exercise b) catecholamine infusions c) intravenous fat tolerance test and d) the hyperinsulinemic/ euglycemic clamp.

K02 HL04226-01 (PI-T.J.Horton) 03/01/00-02/29/05
NIH
The regulation of nutrient metabolism in males and females
Role: PI
The major goals of this project compliment those of the above RO1, that is, is to compare differences between men and women in lipid and carbohydrate metabolism following specific interventions including a) catecholamine infusions b) intravenous fat infusion c) the hyperinsulinemic/ euglycemic clamp with and without exercise d) meal ingestion with and without exercise.

Endocrine Fellows Foundation, Fellowship Award. 11/01/99-10/31/00.
Foundation.
The Effect of Acute Exercise on Insulin Action in Men and Women.
Role: Mentor.
The goal of this project was to determine the effect of exercise on insulin's action with respect to glucose production and utilization, as well as lipoprotein lipase activity, in men vs women using the hyperinsulinemic/euglycemic clamp technique.

Sugar Association Inc (PI-D.Bessesen) 01/01/96-06/30/99
Non-Federal
Post-prandial Nutrient Partitioning In Humans
Role: Co-PI
The major goals of this project were to a) compare post-prandial lipid and glucose metabolism in the fed and fasted states, in men and women and b) to determine the interaction of sucrose and dietary fat on post-prandial lipid and glucose metabolism.

Colorado Clinical Nutrition Research Unit, Pilot and Feasibility Project 01/01/97-01/01/98
NIH
Menstrual Cycle Effects on Resting, Exercise and Post-exercise Nutrient Metabolism.
The major goals of this project were to determine whether the normal cyclical fluctuations in the sex steroids can significantly effect nutrient metabolism under resting conditions or when metabolic demands are increased such as during exercise.

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