Haihua Gu, PhD

Associate Professor

Education:

  • Ph.D., Molecular, Celluar, and Developmental Biology, Tufts University, 1995

  • B.S. in Biology, Fudan University, China, 1985

Postdoctoral Education:

  • Postdoctoral Research Fellow, Cancer Biology Program, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 1995-1999

Haihua Gu, PhD
 Haihua Gu, PhD

Research Activities:

  • Mechanism of protein tyrosine phosphatases and scaffolding adapter proteins in signal transduction initiated by tyrosyl phosphorylation

  • Molecular mechanisms that control the growth, migration, and interaction between tumor and stromal cells during beast cancer progression

  • Mast cell activation in allergic responses

RECENT PUBLICATIONS:   Journal Articles in Pub Med (www.pubmed.gov)

   

Selected Publications:

  • Gu H, Griffin J, and Neel BG. Characterization of a major SHP2 associating tyrosyl phosphorylated 97 kD protein in cytokine stimulated and BCR-ABL transformed hematopoietic cells. J. Biol. Chem. 1997; 272:16421-16430.

  • Gu H, Pratt JC, Burakoff SJ, and Neel BG. Cloning of p97/Gab2, the major SHP-2 binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Mol. Cell 1998; 2:729-740.

  • Oh, E-S, Gu H,* Saxton T, Timms JF, Hausdorff S, Kamatkar S, Frevert EU, Kahn BB, Pawson T, Neel BG, and Thomas SM. Regulation of early events in integrin signaling by the protein-tyrosine phosphatase SHP-2. Mol. Cell. Biol. 1999; 19:3205-3215.

  • Gu H, Maeda H, Moon JJ, Lord JD, Yoakim M, Nelson BH and Neel BG. A new role for Shc in activation of the PI-3K/Akt pathway. Mol. Cell. Biol., 2000; 20:7109-7120.

  • Pratt JC, Igras VE, Maeda H, Baksh S, Gelfand EW, Burakoff SJ, Neel BG and Gu H. Gab2 mediates an inhibitory phosphatidylinositol 3’kinase pathway in T cell antigen receptor signaling. J. Immunol. 2000; 165:4158-4163.

  • Gu H, Saito K, Klaman L, Shen JQ, Fleming T, Wang YP, Pratt JC, Kinet JP and Neel BG. Essential role of Gab2 in allergic response. Nature 2001, 412:186-190.

  • Sattler M, Mohi MG, Pride YB, Li SG, Quinnan LR, Malouf NA, Podar K, Gesbert F, Van Etten RA, Gu H, Griffin JD, and Neel BG. Essential role for Gab2 in transformation by BCR/ABL. Cancer Cell 2002;1:479-492.

  • Daly RJ, Gu H, Parmar J, Malaney S, Lyons RJ, Kairouz R, Head DR, Henshall SM, Neel BG, Sutherland RL. The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer. Oncogene. 2002; 21:5175-5181.

  • Gu H, Botelho RJ, Yu M, Grinstein S, and Neel BG. Critical role for scaffolding adapter Gab2 in FcammaR-Mediated phagocytosis. J. Cell Biol., 2003; 161:1151-1161.

  • Bentires-Alj M, Gil SG, Chan R, Wang ZC, Wang, YP, Imanaka N, Harris L, Richardson A, Neel BG, and Gu H. Causal role of the scaffolding adapter Gab2 in breast cancer. Nat. Med. 2006; 12:114-121.

  • Min Yu, Cliff A. Lowell CA, Benjamin G. Neel BG, and Gu H. Scaffolding adapter Gab2 requires Syk to transmit signals from FcepsilonRI. J. Immunol. 2006; 176:2421-2429.

  • Yu M, Luo J, Yang W, Wang Y, Mizuki M, Kanakura Y, Besmer P, Neel BG, Gu H. The scaffolding adapter Gab2, via SHP-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway. J Biol Chem. 2006; 281:28615-26.

Mailing Address:

UCD-School of Medicine, Anschutz Medical Campus
Department of Pathology
Mail Stop 8104, P.O. Box 6511
Aurora, CO 80045

 

Phone:  303-724-3734

 

E-mail:  Haihua.Gu@ucdenver.edu