Education:

• B.S., Microbiology, Univ. Massachusetts

• M.S., Microbiology, Univ. Georgia

• Ph.D., Microbiology, Univ. Georgia

Postdoctoral Education:

Christina Leslie, PhD

Research Activities:

• Biochemical properties and regulation of mammalian phospholipases A2

• Regulation of phospholipase A2 and lipid mediator production in macrophages during infection

Selected Publications:

• Gijon, M.A., Spencer, D.M., Siddiqi, A.R., Bonventre, J.V. and Leslie, C.C. Cytosolic phosholipase A2 is required for macrophage arachidonic acid release by agonists that do and do not mobilize calcium. J. Biol. Chem., 275:20146-20156 (2000).

• Evans, J.H., Spencer, D.M., Zweifach, A. and Leslie, C.C. Calcium requirements for cytosolic phospholipase A2 translocation to internal membranes. J. Biol. Chem., 276:30150-30160 (2001).

• Panini, S., Yang, L., Rusinol, A., Bonventre, J., Sinensky, M. and Leslie, C. Arachidonate metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol. J. Lipid Research, 42:1678-1686 (2001).

• Stewart, A. and Leslie, C.C. Properties and regulation of human cytosolic phospholipase A2?. J. Biol. Chem. 277:29525-29536 (2002).

• Evans, J.H, Fergus, D.J. and Leslie, C.C. Inhibition of the MEK1/ERK pathway reduces arachidonic acid release independently of cPLA2 phosphorylation and translocation. BMC Biochem. 3:30 (2002).

• Ghosh, M., Stewart, A., Tucker, D.E., Bonventre, J.V., Murphy, R.C. and Leslie, C.C. Role of cytosolic phospholipase A2 in prostaglandin E2 production by lung fibroblasts. Amer. J. Respir. Cell Mol. Biol. 30:91-100 (2004).

• Evans, J. H., Gerber, S. H., Murray, D. and Leslie, C. C. The calcium binding loops of the cytoplasmic phospholipase A2 C2 domain specify targeting to Golgi and ER in live cells. Mol. Biol. Cell 15:371-383 (2004).

• Evans, J. H. and Leslie, C. C. The cytosolic phospholipase A2 catalytic domain modulates association and residence time at Golgi membranes. J. Biol. Chem. 279:6005-6016 (2004).

• Leslie, C. C. and Gelb, M. H. Assaying phospholipase A2 activity. Methods Mol. Biol. 284:229-242 (2004).

• Leslie, C. C. Regulation of arachidonic acid availability for eicosanoid production. Biochem. Cell Biol. 82: 1-17 (2004).

• Leslie, C. C. Regulation of the specific release of arachidonic acid by cytosolic phospholipase A2. Prostaglandins Leukotrienes Essen. Fatty Acids 70:373-376 (2004).

• Girotti, M., Evans, J. H., Burke, D. and Leslie, C. C. Cytosolic phospholipase A2 translocates to forming phagosomes during phagocytosis of zymosan in macrophages. J. Biol. Chem. 279:19113-19121 (2004).

Office Location:

National Jewish Medical and Research Ctr.

Department of Pediatrics, K906

1400 Jackson St.

Denver, CO 80206

Contact Information: