Bolin Liu, MD

Research Activities:

• ErbB receptor tyrosine kinase-mediated signaling in breast cancer.

• Biological functions of death effector domains (DEDs) in caspase-8 activation during apoptosis.

• Epigenetic modulation in multiple myeloma

Selected Publications:

1. Liu, B., Sun, D., Xia, W., Hung, M.-C., and Yu, D. Cross-reactivity of C219 anti-p170mdr-1 antibody with p185c-erbB2 in breast cancer cells: cautions on evaluating p170mdr-1. Journal of the National Cancer Institute 89: 1524-1529, 1997 (Editorials by Helen S. L. Chan, Victor Ling).

2. Yu, D., Jing, T., Liu, B., Yao, J., Tan, M., McDonnell TJ. and Hung, M.-C. Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21cip1 that inhibits p34cdc2 kinase. Molecular Cell 2(5): 581-591, 1998.

3. Liu, B., Fang, M., Schmidt, M., Lu, Y., Mendelsohn, J., and Fan, Z. Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity. British Journal of Cancer 82(12): 1991-1999, 2000.

4. Liu, B. and Fan, Z. The monoclonal antibody 225 activates caspase-8 and induces apoptosis through a tumor necrosis factor receptor family-independent pathway. Oncogene 20: 3726-3734, 2001.

5. Liu, B., Fang, M., Lu, Y., Mendelsohn, J., and Fan, Z. Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody. Oncogene 20: 1913-1922, 2001.

6. Liu, B., Peng, D., Lu, Y., Jin, W., and Fan, Z. A Novel Single Amino Acid Deletion Caspase-8 Mutant in Cancer Cells That Lost Proapoptotic Activity. Journal of Biological Chemistry. 277: 30159-30164, 2002.

7. Liu, B., Edgerton, S.M., Yang, X., Ordonez-Ercan, D., Kim, A., Mason, T.L., Alvarez, K.M., McKimmey, C.C., Liu, N., Thor, A.D. Dietary Phytoestrogen Abrogates Tamoxifen Associated Mammary Tumor Prevention. Cancer Research. 65(3): 879-886, 2005.

8. Ding, W-Q., Liu, B., Vaught, J.L., Yamauchi, H., and Lind, S.E. Anti-Cancer Activity of the Antibiotic Clioquinol. Cancer Research. 65(8): 3389-3395, 2005.

9. *Kim, A., *Liu, B., Ordonez-Ercan, D., Alvarez, K.M., Jones, L., McKimmey, C., Edgerton, S.M., Yang, X., and Thor, A.D. Functional interactions between mouse erbB-3 and wild type rat c-neu in transgenic mouse mammary tumor cells. Breast Cancer Research 7:R708-R718, 2005 * Equal contribution.

10. Ding, W-Q., Liu, B., Vaught, J.L., Richard D. Palmiter, R.D., and Lind, S.E. Clioquinol and docosahexaenoic acid act synergistically to kill tumor cells. Molecular Cancer Therapeutics. 5(7): 1864-72, 2006

11. Liu, B.*, Ordonez-Ercan, D., Fan, Z., Edgerton, S.M., Yang, X., and Thor, A.D. Down-regulation of ErbB3 Abrogates ErbB2-mediated Tamoxifen Resistance in Breast Cancer Cells. International Journal of Cancer. 120: 1874-1882, 2007 * Corresponding Author

Office Location

UCD-School of Medicine, Anschutz Medical Campus

RC-1 South L18-5118

12801 E. 17th Ave.

Contact Information

Tel.: 303-724-3749 (off)

303-724-3750 (Lab)

FAX: 303-724-3712

E-mail: Bolin.Liu@ucdenver.edu

Mailing Address

UCD-School of Medicine, Anschutz Medical Campus

Department of Pathology

Mail Stop - 8104, P. O. Box - 6511

12801 E. 17th Ave.

Aurora, CO 80045