Education:

• M.D Christian Medical College & Hospital, Punjab University, India

• M.B.B.S. Christian Medical College & Hospital, Punjab University, India

Postdoctoral Education:

Honors & Awards:
• 2006 College of American Pathologists’ Laboratory Accreditation Program, Commissioner for Colorado and Wyoming
• 2006-2007 President-Elect, Faculty Senate, University of Colorado School of Medicine
• July 2006: Colorado Society of Clinical Pathologists’ award for dedication, leadership and outstanding achievement (1999-2006)
• March 2006 Nominated by peers for the University of Colorado’s Elizabeth D. Gee Memorial Lectureship Award. Award recipient not announced at present.
• State of Colorado representative to the College of American Pathologists- House of Delegates
• Excellence in Teaching Lectures on Breast, Uterus and Ovary Pathology and small group sessions, multiple years since 1994 to present, Pathology 6000, CU-SOM
• Colorado Society of Clinical Pathologists. Dedication, Leadership and Outstanding Achievement Award as Chair of Education Program, 2002-04
• 2001-02 William S. Hammond, M.D., Excellence in Teaching Award for exceptional commitment to the education of Pathologists, by Pathology Residents, UCD-School of Medicine.

Selected Publications:

1. Singh M, Speolstra NS, Jean A, Howe EN, Shroyer KS, Torkko KC, Clark HR, Darling D, Horwitz KB, Broaddus RR and Richer JK. ZEB 1 expression in type I vs type II endometrial cancers: a marker of aggressive disease. Modern Pathology in press 2008.

2. Klopper JP, Berenz A, Hays WR, Sharma V, Pugazhenthi U, Janssen J, Singh M, Bissonnette RP and Haugen BR. In Vivo and Microarray Analysis of the Treatment Effects of a Rexinoid on the Anaplastic Thyroid Carcinoma Cell Line DRO-90. Clinical Cancer Research 2008;14(2), 589-96.

3. Raina K, Rajamanickam S, Deep G, Singh M, Agarwal R and Agarwal C. Chemopreventive effects of oral gallic acid feeding on tumor growth and progression in mice. Mol Cancer Therapeutics in press 3/2008.

4. Harvell DM, Spoelstra NS, Singh M, Finlayson C, Phang T, Trapp S, Hunter L, Borges VB, Elias A , KB Horwitz and JK Richer. Molecular Signatures of Response to Neoadjuvant Endocrine Therapy for Breast Cancer. Breast Cancer Res Treat 2008 Mar 9; [Epub ahead of print]

5. Harvell DM, Richer JK, Singh M, Spoelstra N, Finlayson C, Borges VB, Elias A , and KB Horwitz. Estrogen regulated gene expression in response to neoadjuvant hormone therapy of breast cancers: Tamoxifen agonist effects dominate in the presence of aromatase inhibitor. Breast Cancer Res Treat . 2008 Mar 13; [Epub ahead of print]

6. Leslie KK, Walter SA, Stephens JK, Thompson C, Singh, M. Effect of Tamoxifen on endometrial histology, hormone receptors and cervical cytology: a prospective study with follow up. Appl Immunohistochem Mol Morph 2007 Sept; 15(3):284-293.

7. Zhang Z, Singh M, Davidson S, Rosen DG, Yang G, Liu J. Activation of BTAK expression in primary ovarian surface epithelial cells carrying heterozygous BRCA mutation. Modern Pathology 2007;20:1078-84. Aug 3, Epub ahead of print.

8. Mugler KC, Singh M, Tringler B, Torkko KC, Liu W, Papkoff J, Shroyer KR. B7-H4 expression in a range of breast pathology: correlation with tumor T-cell infiltration. Appl Immunohistochem Mol Morph Dec 2007;15:363-370.

9. Bowles DW, Borges V, Urquhart A, Rabinovitch R, Singh M, Finlayson C and Elias A. a woman with estrogen receptor positive breast cancer, micrometastasis in an axillary node and an intermediate Oncotype DX recurrence score. Oncology (Williston Park). 2007 Sept; 21(10):1212-7.

10. Mugler K, Marshall C, Hardesty L, Finlayson C, Singh, M. Papillary lesions of the breast. Oncology (Williston Park) June 2007, 21(7):871-76.

11. Smith HO, Leslie K, Singh M, Qualls CR, Revankar CM, Joste N, Prossnitz. GPR30: a novel indicator of poor survival for endometrial carcinoma. Am J Ob and Gyn 2007 196(4); pages 386e1-386e11.

12. Singh, M., Zaino, R., Brunetto, V., and Leslie, K.K. Gynecologic Oncology Group 119, A Study of the use of Provera and Tamoxifen citrate (NSC #180973) for the treatment of advanced, recurrent or metastatic endometrial carcinoma: Relationship of Estrogen Receptor-a and Progesterone Receptors A and B to clinical outcome. Gynecologic Oncology 2007, May 24; [Epub ahead of print]. 106(2):325-33.

13. Singh M. Book review: “Breast Pathology, a volume in the series Foundations in Diagnostic Pathology” by Frances P. O’Malley and Sarah E. Pinder. Churchill Livingston, Elsevier 2006, Philadelphia, PA, first edition. Am J Surg Pathol 31(6):978, June 2007.

14. Singh, M. Book Review: Breast Pathology Diagnosis by Needle Core Biopsy, by Paul Peter Rosen and Syed A. Hoda, 2nd edition. Am J Surg Pathol Jan 2007, 31;159.

15. Balmer N, Richer J, Spoelstra N, Lyle PL, Torkko K, Singh M. Steroid receptor coactivator AIB 1 in endometrial carcinoma, hyperplasia and normal endometrium: correlation with clinco-pathologic parameters and biomarkers. Modern Pathology Sep 15’ 2006 [Epub ahead of print]; Modern Pathology 2006:19;1593-1605.

16. Fong D, Lann M, Finlayson C, Page DL, Singh M. Exuberant lymphohistiocytic response in diabetic mastopathy mimics Rosai-Dorfman disease: a case report and review of the literature. Am J Surg Path 2006, Oct;30(10):1330-1336.

17. Akalin A, Vang, R, Davidson S, Singh M. Does this woman have Gestational Trophoblastic Disease? Oncology (Williston Park). 2006 Nov; 20(13):1699-703.

18. Mentor A, Uruquhart A, Rabinovitch R, Robinson W, Singh M, Seligman P, Finlayson C, Hardesty L, Elias A. A woman with primary breast cancer and a solitary sternal metastasis. Oncology (Williston Park) 2006, 20 (9): 1068-80.

19. Grupka N, Parnes MB, Bloom C, Singh M. Expression of retinoblastoma protein in breast cancer metastases to sentinel nodes: comparison with p16INK4a as a possible marker for the presence of metastases in additional axillary nodes. Appl Immunohistochem Mol Morphol 2006;14 (1):63-70.

20. Storfa A, Davidson S, Singh M. Polypoidal tumors of the lower female genital tract. Invited paper “second opinion series” Oncology (Williston Park) 2006 April, 20(4).

21. Spoelstra NS, Manning NG, Higashi Y, Darling D, Singh M, Shroyer K, Broaddus RR, Horwitz KB, Richer J. The transcription factor ZEB1 is aberrantly expressed in aggressive uterine tumors. Cancer Research 2006; 66 3893-3902.

22. McDaniel S, Rumer KK, Biroc S, Metz R, Singh M, Porter W, Schedin P. Remodeling of the mammary tumor microenvironment following lactation promotes tumor cell metastasis. Am J Pathology 2006 Feb;168(2):608-20. This paper is the topic for the editorial commentary by Sonnenschein and Soto: Carcinogenesis and metastasis now in the third dimension - what’s in it for pathologists? Am J Pathology 2006 Feb; 168 (2):363-366.

23. Shroyer KR, Homer P, Heinz D, Singh M. Validation of a novel immunocytochemical assay for topoisomerase II alpha and minichromosome maintenance protein 2 expression in cervical cytology. Cancer 2006 Aug 25; [Epub ahead of print] Cancer. 2006 Oct 25;108(5):324-30

24. Jiu KF, Lewin JM, Issacs PK, Singh M, Leung JWT. Unusual sonographic appearance of melanoma metastases to breast. J of Ultrasound Med 2006; 25(5):663-6.

25. Lyle P, Evans R, Jarboe E, Fong D, Behbakht K, Davidson S, Singh M. Biphasic tumors of the female genital tract. Oncology (Williston Park) 19(9):1178-1196, 2005.

26. Tringler B, Zhuo S, Pilkington G, Torkko KC, Singh M, Lucia MS, Heinz DE, Papkoff J, Shroyer KR. B7-H4 is highly expressed in ductal and lobular breast cancer. Clinical Cancer Research 2005; 11:1842-48. Front cover of the Journal.

27. Dai D, Al-Bitar L, Nguyen T, Laidler L, Singh M, Leslie KK. A Therapeutic Model for Advanced Endometrial Cancer: Systemic Progestin in Combination with Local Adenoviral Mediated Progesterone Receptor Expression. Mol Cancer Ther 2005; 4(1): 169-75.

28. Gottschall EB, McGinley JN, Spoelstra N, Knott K, Wolfe W, Rose C, Singh M, Thompson HJ. Effect of cytological fixative and environmental conditions on nuclear morphometric characteristics of squamous epithelial cells in sputum. Cytometry B Clin Cytom. 2005. Sep; 67(1):19-26.

29. Singh M, Capocelli KE, Marks JL, Schleicher RB, Finlayson CA, Seligman PA. The expression of vascular endothelial growth factor and the proliferation marker MIB-1 are influenced by neoadjuvant chemotherapy in locally advanced breast cancer. App Imm & Mol Morph June 2005; 13:147-156.

30. Urquhart A, Borges V, Rabinovitch R, Singh M, Robinson W, Finlayson C, Seligman P, Arya J, Elias A. A postmenopausal woman with early stage breast cancer and borderline hormone receptor staining. Oncology (Williston Park) 2005 Mar; 19 (3):278-84.

31. Tayal S, Davidson S, Singh M. Endometrial carcinoma and a distinct second malignancy (endometrial stromal sarcoma) of the uterus. Oncology (Williston Park) 2004;18 (11):1363-66.

32. Moore J, Davidson SA, Singh M. Endometrial carcinoma arising in one horn of a bicornuate uterus: a case report. Gynecologic Oncology 2004; 95:729-32.

33. Singh M, Parnes MB, Spoelstra N, Bleile MJ, Robinson WA. p16 expression in sentinel nodes with metastatic breast carcinoma: a marker for developing triaging strategies for axillary node dissection and a marker for poor prognosis. Human Pathol 2004; 35(12):1524-30.

34. Groshong S, Davidson S, Schefter T, Singh M. Immature teratomas of the ovary. Oncology (Williston Park) 2004; 18(4):474-7.

35. Singh M, Bleile MJ, Shroyer LA, Heinz D, Jarboe EA, Shroyer KR. Analysis of Survivin expression in a spectrum of benign to malignant lesions of the breast. Appl Immunohistochem Mol Morphol. 2004 Dec; 12(4):296-304.

36. Tringler B, Gup CJ, Singh M, Groshong S, Shroyer AL, Heinz DE, Shroyer KR. Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia. Human Pathol 2004; 35: 689-96.

37. Grupka N, Lear-Kaul KC, Kleinschmidt-DeMasters BK, Singh M. Epidermal growth factor receptor status in breast cancer metastases to the central nervous system. Arch of Path & Lab Med. 2004; 128: 974-9. Front cover of the Journal.

38. Prescott JD, Koto KS, Singh M, Gutierrez-Hartmann A. Cytoplasmic localization of the oncogenic transcription factor ESX correlates with transformation of human breast cells. Mol Cell Biol 2004; 24:5548-64.

39. Diallo R, Schaefer K-L, Bankfalvi A, Decker T, Ruhnke M, Wulfing P, Jackisch C, Luttges J, Sorensen P, Singh M, Poremba C. Secretory carcinoma of the breast: a distinct variant of invasive ductal carcinoma assessed by comparative genomic hybridization and immunohistochemistry. Human Pathol 2003; 34(12):1299-305.

40. Lear-Kaul KC, Yoon H-R, Kleinschmidt-DeMasters BK, McGavran L, Singh M. HER/2neu status in breast cancer metastases to the central nervous system. Arch Path & Lab Med 2003; 127:1451-7.

41. Stefka J, Cleveland J, Lucia S, Singh M. Sarcomatoid intracardiac metastasis of a testicular germ cell tumor: a case report and review of the literature. Human Pathology 2003, 34: 1074-77.

42. Liu L, Davidson S, Singh M. Mullerian adenosarcoma of vagina arising in persistent endometriosis: report of a case and review of the literature. Gynecologic Oncology 2003, 90:486-90.

43. Tayal S, Lewin J, Singh M. A comparison of the findings in breast needle core biopsies with atypical hyperplasia to those in excision specimens. The Breast Journal 2003, 9(6): 533-34.

44. Crawford D. Second opinion case series. Authors: Eisenberg R, Singh M, Finlayson C, Rabinovitch R, Lewin J, Robinson WA, Seligman P, Elias A. 42 year old woman with Breast carcinoma. Oncology (Williston Park) 2003;15 (5):614-20.

45. Singh M, Wu E, Shroyer KR. Macrophage rich reaction in lymph node: mimic of metastatic renal cell carcinoma on fine needle aspiration cytology. Acta Cytologica, 45: 454-458; 2001.

46. Thompson HJ, Singh M. Rat models of pre-malignant breast disease. Journal of Mammary Gland Biology and Neoplasia, 5:409-420; 2000.

47. Thompson HJ, Singh M, McGinley J. Classification of pre-malignant and malignant lesions developing in the rat mammary gland after injection of sexually immature rats with 1-methyl-1-nitrosourea. Journal of Mammary Gland Biology and Neoplasia, 5:201-210, 2000.

48. Singh M, McGinley JN, Thompson HJ. A comparison of the histopathology of pre-malignant and malignant mammary gland lesions induced in sexually immature rats with those occurring in the human. Laboratory Investigation 80(2): 221-231, 2000.

49. Thompson HJ, McGinley JN, Wolfe P, Singh M, Steele VE, Kellof GJ. Temporal sequence of mammary intraductal proliferations, ductal carcinomas in situ and adenocarcinomas induced by 1-methyl-1-nitrosourea in rats. Carcinogenesis, 19 (12), 2181-2185, 1998.

50. Singh M, Nawaz S. Fine needle aspiration cytology of breast hamartoma. Acta Cytologica, 42 (2), 437, 1998.

51. Singh M, Corboy J, DeMasters BK. Leptomeningeal gliomatosis associated with subependymoma and multifocal CNS infarcts. Surgical Neurology, 1998, 50 (4): 356-362.

52. Thompson HJ, McGinley JN, Rothhammer K, Singh M. Ovarian hormone dependence of malignant and premalignant mammary gland lesions in prepubertal rats by 1‑methyl‑l‑nitrosourea. Carcinogenesis 19(3) 101‑104, 1998.

53. Singh M, Thompson HW. Cartwright Blood Group System: Evaluation of Clinical Significance. American Society of Clinical Pathologists. Check Sample # TM 96‑5 (TM‑209), 1996.

54. Thompson HJ, McGinley JN, Rothhammer K, Singh M. Rapid Induction of mammary intraductal proliferations, ductal carcinoma in situ and carcinomas by the injection of sexually immature rats with 1 ‑methyl‑l‑nitrosourea. Carcinogenesis 16(10) 2407‑2411, 1995.

55. Thompson HJ, Westerlind KC, Snedden JR, Briggs S, Singh M. Exercise intensity dependent inhibition of 1-methyl‑1‑nitrosourea induced mammary carcinogenesis in female F344 rats. Carcinogenesis 16(B) 1783‑1786, 1995.

56. Schedin PJ, Strange R, Singh M, Kaeck M, Thompson HJ. Treatment with chemopreventive agents, DFMO and Retinyl acetate, results in altered mammary extracellular matrix. Carcinogenesis 16(8) 1787‑1794, 1995.

57. Thompson HJ, Westerlind KC, Snedden JR, Briggs S, Singh M. Inhibition of mammary carcinogenesis by treadmill exercise. Journal of National Cancer Institute 87(6) 453‑455, 1995.

58. Singh M, Lu J, Briggs S, McGinley JN, Thompson HJ. Effect of excess dietary iron on Promotion stage of 1-methyl‑l‑nitrosourea induced mammary carcinogenesis: pathogenetic characteristics and distribution of iron. Carcinogenesis, 15(8): 1567‑70, 1994.

59. Ip C, Singh M, Thompson HJ, Scimeca J. Conjugated Linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat. Cancer Research 54: 1212‑1215, 1994.

60. Thompson HJ, Wilson A, Lu J, Singh M, Ip C. Comparison of the effect of an organic and inorganic form of selenium on a mammary carcinoma cell line. Carcinogenesis 15 (2), pp 183-186, 1994.

61. Thompson HT, Adlakha H, Singh M. Effect of carcinogen dose and age at administration on induction of mammary carcinogenesis by 1‑methyl‑l‑nitrosourea. Carcinogenesis 13:1535-1539, 1992.