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TCH CTRC
Research
The TCH Clinical Translational Research Center supports between 125-150 active protocols at any one time. Currently, there are 49 investigators with active protocols.
Among currently active TCH CTRC protocols, the following ongoing research protocols were approved by the TCH CTRC Scientific Advisory and Review Committee in 2007:
Frank J. Accurso, MD
- A Double-Blind, Multicenter, Multinational, Randomized, Placebo-Controlled Trial Evaluating Aztreonam Lysine for Inhalation in Patients with Cystic Fibrosis, Mild Lung Disease, and Pseudomonas aeruginos
- A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Crossover Study to Evaluate the Effectiveness and Safety of PANCRECARB MS-16 (Pancrelipase) in Reducing Steatorrhea in Children and Adults with Cystic Fibrosis
- A Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Study Evaluating the Efficacy and Safety of ALTU-135 Treatment in Patients with Cystic Fibrosis-Related Exocrine Pancreatic Insufficiency
- A Phase I/II Randomized, Double-Blind, Placebo-Controlled, Single-Dose, Dose Escalation Study of KB001 in Cystic Fibrosis Patients Infected with Pseudomonas aeruginos
Susan Apkon, MD
- Estimation of the Energy Savings Attributed to Control of Spasticity in Children with Cerebral Palsy Using an Intrathecal Baclofen Pump
Jennifer M. Barker, MD
- Oral Insulin for the Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus
Frederick C. Battaglia, MD
- Transplacental Gradients,Transport, and Production of Polyols and Manose in Normal and IUGR Pregnancies
Melissa A. Cadnapaphornchai, MD
- Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus
James Carollo, PhD, PE
- Rhythmic Auditory Stimulation as a Gait Intervention for Children with Cerebral Palsy
Emily L. Dobyns, MD
- Evaluation of Adrenal Reserve and Response to Low-Dose ACTH (Corticotrophin) Stimulation in Critically Ill Children
Rosanna V. Fiallo-Scharer, MD
- The Effect of Using Terbutaline or a Reduction in Basal Insulin Infusion as a Therapeutic Agent to Prevent Delayed Nocturnal Hypoglycemia in Children and Adolescents with Type 1 Diabetes
- Reversal of Hypoglycemia Unawareness Using Continuous Glucose Monitoring
Robert Friesen, MD
- Depth of Anesthesia and the Incidence of Emergence Agitation and Post-Operative Behavioral Changes in a Population of Pediatric Dental Patients
Robin L. Gabriels, PsyD
- Evaluating the Effects of a Visual Pedagogy and Structure on the Successful Completion of the Medical Office Visit and Physical Examination with Pre-Pubescent Children with Autism
Peter A. Gottlieb, MD
- Effects of CTLA4-log (Abatacept) on the Progression of Type 1 Diabetes in New Onset Subjects
D. Dunbar Ivy, MD, and David Badesch, MD
- Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy
John P. Kinsella, MD
- Pilot Trial of rhSOD in Term Newborns with PPHN
Ulrich Klein, DDS
- Immunological Marker Assays in Children Receiving Dental Rehabilitation Under General Anesthesia Before and After Extraction: A Pilot Study
Nancy F. Krebs, MD
- Meeting Zinc (Zn) and Iron (Fe) Requirements for Older Breastfed Infants: Comparison of Complementary Feeding Strategies
Myron J. Levin, MD
- IMPAACT P1065: Phase I/II Study of Safety and Immunogenicity of Quadrivalent Meningococcal Conjugate Vaccine in HIV-Infected Youth
David M. Maahs, MD
- Trial of Zocor and Vytorin in Adolescents with Type 1 Diabetes
Elizabeth McFarland, MD
- Surveillance Monitoring for ART Toxicities Study in HIV-uninfected Children Born to HIV-infected Women (SMARTT Study)
- IMPAACT P1066: Phase I/II Multicenter, Open-Label, Noncomparative Study of the International Maternal, Pediatric, Adolescent AIDS Clinical Trials (IMPAACT) Group to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antiretroviral Activity of Raltegravir (MK-0518) in HIV-1 Infected Children and Adolescents
James McManaman, MD
- March of Dimes UCD Preterm Birth Biomarker Study
Lisa Miller, MD
- National CADDRE Study: Child Development and Autism
Elaine H. Morrato, DrPH
- Periodontal Health Status of Adolescents with Type 1 Diabetes
Michael R. Narkewicz, MD
- Fecal Behenic Acid: A New Marker for Fat Malabsorption
Rachelle Nuss, MD
- Effectiveness of Hydroxyurea and Magnesium Pidolate Alone and in Combination in Hemoglobin SC Disease A Phase II Trial
David Partrick, MD, and Robert McIntyre, MD
- The Effect of Blunt Trauma and Burn Injury on the Inflammatory Response in Pediatric Patients
David Polaner, MD
- Does Total Intravenous Anesthesia with Propofol for Greater than 4 Hours Produce Occult Biochemical Evidence of the Propofol Infusion Syndrome?
Melanie S. Reece, PhD, and Linda A. Barbour, MD, MSPH
- Regulation of Maternal Fuel Supply and Neonatal Adiposity
Tonia M. Sabo-Graham, MD
- Pilot Study to Define Nutritional Interrelationships of CoQ10, Riboflavin, and Magnesium in the Evaluation and Treatment of Childhood Migraine Headaches
Scott D. Sagel, MD
- Longitudinal Study of Primary Ciliary Dyskinesia: Participants 5-18 Years of Age
- A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study of VX-770 to Evaluate Safety, Pharmacokinetics, and Biomarkers of CFTR Activity in Cystic Fibrosis (CF) Subjects with Genotype G551D
- Safety and Efficacy of a Novel Antioxidant-Rich Multivitamin Supplement for Persons with Cystic Fibrosis
- Multicenter Trial to Validate Protein Biomarkers of a Pulmonary Exacerbation in Cystic Fibrosis
Teresa A. Sharp, PhD
- Endothelial Function and its Relationship to Cardiovascular Disease Risk Factors in Lean and Overweight Pre- and Early-Pubertal Children
Ronald J. Sokol, MD
- Randomized, Double-Blind, Placebo-Controlled Trial of Corticosteroid Therapy Following Portoenterostomy in Infants with Biliary Atresia
- Biliary Atresia Study in Infants and Children (BASIC)
- Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis
Marci Sontag, PhD
- Gene Modifiers of Early CF Pulmonary Disease
Shikha S. Sundaram, MD, MSCI
- Isoprostanes: A Marker of Oxidative Injury in Fatty Liver Disease
Joanne Valvano, PhD
- Measurement of Voluntary Motor Control in the Affected Upper Extremity of the Child with Hemiplegic Cerebral Palsy
R. Paul Wadwa, MD
- Determinants of Macrovascular Disease Risk in Adolescents with Type 1 Diabetes
Lisa Willis, MD
- Assessment of Feeding Tolerance in Neonates with Ductal Dependent Cardiac Defects While Receiving Prostaglandin Therapy
Edith Zemanick, MD
- Early Staphylococcal and Polymicrobial Bacterial Infection in CF
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