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Pediatric CTRC
Research
The Pediatric Clinical Translational Research Center supports between 125-150 active protocols at any one time. Currently, there are 92 investigators with active protocols.
The following ongoing research protocols were approved by the Pediatric GCRC Scientific Advisory Committee in 2005:
1) A Multicenter Study of the Safety and Efficacy of N-Acetylcysteine in the Treatment of Acute Liver Failure Not Caused by Acetaminophen in Pediatric Patients, Michael R. Narkewicz, MD
2) Neurohormonal Regulation of Energy Balance among Pediatric Brain Tumor Subjects, Jill Simmons, MD
3) The EPIC Observational Study: Longitudinal Assessment of Risk Factors for and Impact of Pseudomonas aeruginosa Acquisition and Early Anti-Pseudomonal Treatment in Children with Cystic Fibrosis, Frank J. Accurso, MD
4) A Pilot Study to Evaluate the Navigator Continuous Glucose Sensor in the Management of Type 1 Diabetes in Children: A Multicenter Trial Being Conducted by the Diabetes Research in Children Network, H. Peter Chase, MD
5) DNA Extraction for Colorado Subjects with Autism, Susan L. Hepburn, PhD
6) Effects of Vitamin D Genes on Measures of Insulin Secretion, Insulin Sensitivity and Adiposity: An Ancillary Study to the Insulin Resistance Atherosclerosis Study (IRAS) Family Study, Jill M. Norris, PhD
7) A Comparison of the Pharmacokinetic Profile in Patients with Cystic Fibrosis Receiving Conventional vs. Once Daily Dosing of Tobramycin at a Children's Hospital, Jennifer Hamner, PharmD
8) Psychiatric Diagnoses in Preschool Children with Fetal Alcohol Spectrum Disorders (FASD), Jennifer Green, PhD
9) Epoetin Alpha Administration in the Neonate: Safety, Efficacy and Nurse Satisfaction with the Insuflon® Catheter vs. Standard Subcutaneous Injections, Michael Murphy, PharmD
10) The Effect of Intravenous Hydration on Labor in Nulliparous Women, Jill K. Davies, MD
11) A Multicenter, Double-Blind, Randomized, Placebo-Controlled, 28-Day Study of Denufosol Tetrasodium (INS37217) Inhalation Solution in Patients with Cystic Fibrosis Lung Disease, Robin R. Deterding, MD
12) Improving Metabolic Assessments in T1DM Clinical Trials - Study 1: To Compare the Reliability of MMTT and IV Glucagon Stimulation Tests, Peter A. Gottlieb, MD
13) Prevalence of Portopulmonary Hypertension and Hepatopulmonary Syndrome in Pediatric Patients with Portal Hypertension, John Whitworth, MD
14) PACTG 394: A Phase I Study of the Safety, Tolerance, and Pharmacokinetics of Tenofovir Disoproxil Fumarate in HIV-1 Infected Pregnant Women & Their Infants, Adriana Weinberg, MD
15) A Phase 3, Double-Blind, Multicenter, Randomized, Placebo-Controlled Trial with Aztreonam Lysinate for Inhalation in CF Patients with Pulmonary Pseudomonas aeruginosa Requiring Frequent Antibiotics (AIR-CF2), Frank J. Accurso, MD
16) ATN 024: Randomized, Open-Label Trial of Three Hepatitis B Vaccination Schemas in HIV-Positive Youth, Elizabeth J. McFarland, MD
17) Parent-Child Conflict, Autonomy and Diabetes Self-Care: Ancillary to the TODAY Study (GCRC #729), Philip S. Zeitler, MD, PhD
18) Formocresol Blood Levels During and After Pulpotomy in Preschool Children Undergoing Comprehensive Oral Rehabilitation under General Anesthesia, Jillian Easton, BDS, MS
19) Intestinal Permeability in Children with Autism Spectrum Disorders, Ann Reynolds, MD
20) Effects of Basal Insulin during Exercise on the Development of Hypoglycemia in Children with Type 1 Diabetes, H. Peter Chase, MD
21) Nitric Oxide Restores Hemostatic and Inflammatory Balance in Sickle Cell Disease, Rachelle Nuss, MD
22) EPIC Clinical Study: Effectiveness and Safety of Intermittent Antimicrobial Therapy for the Treatment of New Onset Pseudomonas aeruginosa (Pa) Airway Infection in Young Patients with Cystic Fibrosis, Frank J. Accurso, MD
23) Threonine and Lysine Requirements for Optimal Neonatal Protein Anabolism in Neonates: A Pilot Study, Melanie Reece, PhD
24) A Double-Blind, Randomized, Placebo-Controlled, 28-Day Study of Denufosol Tetrasodium (INS37217) Inhalation Solution in Pediatric Patients with Cystic Fibrosis Lung Disease, Robin R. Deterding, MD
25) Cytokine Levels and Neutrophil Priming as Markers for GI Dysfunction in Infants with Gastroschisis vs. AGA Matched Controls: A Pilot Study, Regina Reynolds, MD
26) Role of Complement Receptor 2 in Systemic Lupus Erythematosus, Susan A. Boackle, MD
27) Effects of Puberty on Antiretroviral Drug Pharmacokinetics in HIV-Infected Children, Adolescents and Young Adults, Elizabeth J. McFarland, MD
28) Protocol CP-AI-006: A Phase 3, Open-Label, Follow-on Study of Multiple Courses of Aztreonam Lysinate Inhalation (AI) in Cystic Fibrosis Patients (AIR-CF3), Frank J. Accurso, MD
29) Diagnostic and Clinical Characterization of Patients with Unusual Genetic Disorders of the Airways, Scott D. Sagel, MD
30) A Phase II Study of PTC124 as an Oral Treatment for Nonsense-Mutation-Mediated Cystic Fibrosis, Frank J. Accurso, MD
31) A Study of Safety and Pharmacokinetics of 552-02 Following Fourteen Days of Dosing by Inhalation in Patients with Cystic Fibrosis, Frank J. Accurso, MD
31) PACTG P1061S: Evaluation of Immunologic Memory Following Pneumococcal, Hepatitis B, and Measles Vaccination in HIV-Infected Children Treated with Highly Active Antiretroviral Therapy (HAART), Mark J. Abzug, MD
32) Diet Records: Are Pictures Really Worth a Thousand Words? Janine A. Higgins, PhD
33) PACTG P1055: Psychiatric Co-Morbidity in Perinatally HIV-Infected Children and Adolescents, Elizabeth J. McFarland, MD
34) A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Nitric Oxide for the Inhalation in the Acute Treatment of Sickle Cell Pain Crisis (DENOVO), Rachelle Nuss, MD
35) The Effects of Continuous Positive Airway Pressure on Superior Mesenteric Artery Blood Flow in Preterm Infants: A Pilot Study, Regina Reynolds, MD
36) Growth in Preterm Infants Receiving Nutrient Intakes Approximating Fetal Intakes at the Same for Gestational Age, Patti J. Thureen, MD
37) Lymphotropic Polyomavirus Infection and its Potential Role in Lymphoid Cancer in Humans, Michael Wang, MD
38) Lung Function Measures in Preschool Children with CF, Gwendolyn Kerby, MD
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