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Pediatric Heart Lung Center
Research
Research in the Pediatric Heart Lung Center (PHLC) includes diverse approaches to acute lung injury, neonatal pulmonary hypertension, respiratory distress syndrome in premature newborns, postoperative cardiac care, long-term management of pulmonary hypertension, and other areas.
Current studies include:
- basic science laboratory investigations
- single-center physiologic and outcome studies
- multicenter randomized clinical trials
Current topics of interest in the basic science laboratories include:
- mechanisms of lung vascular development
- alveolar growth
- growth factors in lung development and pulmonary hypertension
- endothelial cell function in the developing lung
- roles of nitric oxide in the pathophysiology and treatment of neonatal lung diseases
- mechanisms of acute lung injury
- role of progenitor cells during lung development and in the pathogenesis and treatment of childhood lung diseases, including pulmonary hypertension, BPD, and others
Clinical studies include:
- multicenter trials in the use of inhaled nitric oxide (iNO) to prevent bronchopulmonary dysplasia in premature babies
- the role of iNO therapy with high-frequency oscillation in the treatment of pediatric respiratory failure
- single-center studies of the safety, feasibility, and efficacy of home NO therapy and the effects of pulsed iNO therapy in postoperative cardiac patients
- treatment of pulmolnary hypertension in BPD
- biomarkers and genetic susceptibility in premature infants at risk for BPD
- the role of new oral agents for the treatment of chronic pulmonary hypertension
Faculty Research Interests
Faculty research interests are listed in each investigator’s section/program.
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