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Critical Care Medicine
Research Funding
(listed alphabetically by Principal Investigator)


Effects of Virus and Hypoxia on Lung Endothelin and Edema
Principal Investigator: Todd C. Carpenter, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - K01-8 AL04424-02
Amount: $631,000
Term: 2000-2005

PKC Isozymes in Hypoxia-Induced Fibroblast Proliferation
Principal Investigator: Mita Das, PhD
Co-Investigator: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - RO1 HL 64917-01A1
Amount: $1,250,000
Term: 2001-2009

Effects of HFOV and iNO in Acute Respiratory Failure in Pediatrics*
Principal Investigator: Emily L. Dobyns, MD
Source: National Institutes of Health, National Center for Research Resources - 5 K23RR16178-03
Amount: $640,190
Term: 2000-2005

Exracellular Superoxide Promotes Neonatal Chronic Hypoxia-Induced Pulmonary Vascular Remodeling
Principal Investigator: Eva N. Grayck, MD
Source: March of Dimes
Amount: $248,290
Term: 2006-2009

S-Nitrosylation of Alpha-1-Adrenergic Receptors in the Lung
Principal Investigator: Eva N. Grayck, MD
Source: National Institutes of Health - HL70088-05
Amount: $580,000
Term: 2002-2007

Nitric Oxide and G Protein-Coupled Alpha-1-Adrenergic and 5-HT Receptor Function in the Pulmonary Vasculature
Principal Investigator: Eva N. Grayck, MD
Source: American Lung Association - RG-139-N
Amount: $70,000
Term: 2003-2005

Respiration and Circulation During Hypoxia
Principal Investigator: Ivan F. McMurty, PhD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - T32HL07171
Amount: $308,688/yr
Term: 2002-2007

SCOR Grant: The Impact of Injury on the Immature Pulmonary Circulation**
Principal Investigator: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - P50 HL 57144
Amount: $6,415,929
Term: 2001-2006
  • Project I: G-Proteins in Hypoxic Pulmonary Vascular Remodeling
    Principal Investigator: Kurt R. Stenmark, MD
    Amount: $2,076,662
  • Project II: Inhaled NO and the Prevention of BPD
    Principal Investigator: Steven H. Abman, MD
    Co-Investigator: John P. Kinsella, MD
    Amount: $1,860,606
  • Project III: Prx Homeobox Genes in Pulmonary Vascular Homeostasis
    Principal Investigator: Peter L. Jones, PhD
    Amount: $1,456,087
  • Clinical Core
    Principal Investigator: John P. Kinsella, MD
    Co-Investigator: Steven H. Abman, MD
    Amount: $481,196
  • Administrative Core
    Principal Investigator: Kurt R. Stenmark, MD
    Amount: $543,369
Hypoxia Induces Pulmonary Fibroblast Differentiation
Principal Investigator: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - HL14985
Amount: $1,250,000
Term: 2003-2008

Project II in Program Project Grant: Adaptation to Hypoxia. Hypoxia Induces Pulmonary Fibroblast Differentiation
Principal Investigator: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - HL 14985
Amount: $1,146,238
Term: 2003-2008

Role of Ephrins in Lung Edema Due to Virus and Hypoxia
Principal Investigator: Todd Carpenter, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - 1 R01 HL077743-01
Amount: $1,250,000
Term: 2005-2009

Pathogenetic Mechanisms of Bronchopulmonary Dysplasia (K23)
Principal Investigator: Peter M. Mourani, MD
Source: National Institutes of Health, National Center for Research Resources
Amount: $688,148
Term: 2005-2010


2003-2004

Effects of Virus and Hypoxia on Lung Endothelin and Edema
Principal Investigator: Todd C. Carpenter, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - K01-8 AL04424-02
Amount: $631,000
Term: 2000-2005

PKC Isozymes in Hypoxia-Induced Fibroblast Proliferation
Principal Investigator: Mita Das, PhD
Co-Investigator: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - RO1 HL 64917-01A1
Amount: $1,250,000
Term: 2001-2006

Effects of HFOV and iNO in Acute Respiratory Failure in Pediatrics*
Principal Investigator: Emily L. Dobyns, MD
Source: National Institutes of Health, National Center for Research Resources - 5 K23RR16178-03
Amount: $640,190
Term: 2000-2005

Mentored Clinician-Scientist Development Award
S-Nitrosylation of Alpha-1-Adrenergic Receptors in the Lung
Principal Investigator: Eva N. Grayck, MD
Source: National Institutes of Health - HL70088-05
Amount: $580,000
Term: 2002-2007

Nitric Oxide and G Protein-Coupled Alpha-1-Adrenergic and 5-HT Receptor Function in the Pulmonary Vasculature
Principal Investigator: Eva N. Grayck, MD
Source: American Lung Association - RG-139-N
Amount: $70,000
Term: 2003-2005

A Randomized, Open-Label, Multicenter, Multinational, Dose-Ranging Study of the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of Recombinant Human Acid Alpha-Glucosidase (rhGAA) Treatment in Patients < 6 Months Old with Infantile-Onset Glycogen Storage Disease Type II
Co-Investigators: Eva N. Grayck, MD, and Priya Kishnani, MD
Source: Genzyme Corporation - AGLU01602
Term: 2003-2004

An Open-Label, Multicenter, Multinational, Study of the Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Recombinant Human Acid Alpha-Glucosidase (rhGAA) Treatment in Patients > 6 and 36 Months Old with Infantile-Onset Pompe Disease
Co-Investigators: Eva N. Grayck, MD, and Priya Kishnani, MD
Source: Genzyme Corporation - AGLU01702
Term: 2003-2004

Prx Homeobox Genes in Pulmonary Vascular Homeostasis
Principal Investigator: Peter L. Jones, PhD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - 1 R01 HL68798-01
Amount: $375,000
Term: 2001-2006

Giles Filley Memorial Award for Excellence in Respiratory Medicine
Principal Investigator: Peter L. Jones, PhD
Source:American Physiological Society
Amount: $20,000
Term: 2003-2004

Respiration and Circulation During Hypoxia
Principal Investigator: Ivan F. McMurty, PhD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - T32HL07171
Amount: $308,688/yr
Term: 2002-2007

SCOR Grant: The Impact of Injury on the Immature Pulmonary Circulation**
Principal Investigator: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - P50 HL 57144
Amount: $6,415,929
Term: 2001-2006
  • Project I: G-Proteins in Hypoxic Pulmonary Vascular Remodeling
    Principal Investigator: Kurt R. Stenmark, MD
    Amount: $2,076,662
  • Project II: Inhaled NO and the Prevention of BPD
    Principal Investigator: Steven H. Abman, MD
    Co-Investigator: John P. Kinsella, MD
    Amount: $1,860,606
  • Project III: Prx Homeobox Genes in Pulmonary Vascular Homeostasis
    Principal Investigator: Peter L. Jones, PhD
    Amount: $1,456,087
  • Clinical Core
    Principal Investigator: John P. Kinsella, MD
    Co-Investigator: Steven H. Abman, MD
    Amount: $481,196
  • Administrative Core
    Principal Investigator: Kurt R. Stenmark, MD
    Amount: $543,369
Hypoxia Induces Pulmonary Fibroblast Differentiation
Principal Investigator: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - HL14985
Amount: $1,250,000
Term: 2003-2008

Project II in Program Project Grant: Adaptation to Hypoxia. Hypoxia Induces Pulmonary Fibroblast Differentiation
Principal Investigator: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - HL 14985
Amount: $1,146,238
Term: 2003-2008

Role of Novel Embryonic Genes in SMC Growth after Vascular Injury
Principal Investigator: Mary C. M. Weiser-Evans, PhD
Co-Investigator: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - RO1 HL 63946-01A1
Amount: $1,280,731
Term: 2000-2004

Role of PTEN in Vascular Smooth Muscle Cell Growth Inhibition
Principal Investigator: Mary C. M. Weiser-Evans, PhD
Source: University of Colorado Cancer Center Seed Grant
Amount: $20,000
Term: 2002-2003


2001-2002

Neprilysin and Endothelin: Interactions with Viral Infection and Hypoxia in Pulmonary Edema Formation
Principal Investigator: Todd Carpenter, MD
Source: American Heart Association Desert/Mountain Affiliate
Amount: $60,000
Term: 1999-2001

Effects of Virus and Hypoxia on Lung Endothelin and Edema
Principal Investigator: Todd Carpenter, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - K01-8 AL04424-02
Amount: $631,000
Term: 2000-2005

PKC Isozymes in Hypoxia-Induced Fibroblast Proliferation
Principal Investigator: Mita Das, PhD
Co-Investigator: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - RO1 HL 64917-01A1
Amount: $1,250,000
Term: 2001-2006

Effects of HFOV and iNO in Acute Respiratory Failure in Pediatrics*
Principal Investigator: Emily L. Dobyns, MD
Source: National Institutes of Health, National Center for Research Resources - 5 K23RR16178-03
Amount: $640,190
Term: 2000-2005

Molecular Determinants of Tenascin-C Expression in Vascular Smooth Muscle Cells
Principal Investigator: Peter L. Jones, PhD
Source: American Heart Association, National Grant-In-Aid
Amount: $165,000
Term: 1999-2003

Prx Homeobox Genes in Pulmonary Vascular Homeostasis
Principal Investigator: Peter L. Jones, PhD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - 1 R01 HL68798-01
Amount: $375,000
Term: 2001-2006

SCOR Grant: The Impact of Injury on the Immature Pulmonary Circulation**
Principal Investigator: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - P50 HL 57144
Amount: $6,415,929
Term: 2001-2006
  • Project I: G-Proteins in Hypoxic Pulmonary Vascular Remodeling
    Principal Investigator: Kurt R. Stenmark, MD
    Amount: $2,076,662
  • Project II: Inhaled NO and the Prevention of BPD
    Principal Investigator: Steven H. Abman, MD
    Co-Investigator: John P. Kinsella, MD
    Amount: $1,860,606
  • Project III: Prx Homeobox Genes in Pulmonary Vascular Homeostasis
    Principal Investigator: Peter L. Jones, PhD
    Amount: $1,456,087
  • Clinical Core
    Principal Investigator: John P. Kinsella, MD
    Co-Investigator: Steven H. Abman, MD
    Amount: $481,196
  • Administrative Core
    Principal Investigator: Kurt R. Stenmark, MD
    Amount: $543,369
SCOR Grant: The Impact of Injury on the Immature Pulmonary Circulation**
Principal Investigator: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - P50 HL 57144
Amount: $7,145,567
Term: 1996-2001
  • Project I: SMC Heterogeneity in the Pulmonary Vasculature
    Principal Investigator: Kurt R. Stenmark, MD
    Amount: $1,324,572
  • Project II: Perlecan Heparan Sulfates: Molecular Mechanisms Underlying the Control of Vascular Smooth Muscle Cell Replication and Gene Expression During Normal Development and in Neonatal Pulmonary Hypertension
    Principal Investigator: Kurt R. Stenmark, MD
    Co-Investigator: Mary C. M. Weiser-Evans, PhD
    Amount: $962,228
  • Project III: NO-cGMP Cascade in Neonatal Pulmonary Hypertension
    Principal Investigator: Steven H. Abman, MD
    Co-Investigator: John P. Kinsella, MD
    Co-Investigators Clinical Core: John P. Kinsella, MD, and Steven H. Abman, MD
    Amount: $1,960,576
  • Project IV: Oxidants, Energy and Pulmonary Vascular Development
    Principal Investigator: Carl W. White, MD
    Amount: $657,184
  • Clinical Core
    Principal Investigator: Adam A. Rosenberg, MD
    Amount: $1,376,432
  • Administrative Core
    Principal Investigator: Kurt R. Stenmark, MD
    Amount: $371,168
Project II in Program Project Grant: Adaptation to Hypoxia. Distinct Mechanisms of Growth Control in Select SMC Subpopulations
Principal Investigator: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - HL 14985
Amount: $1,137,299
Term: 1998-2003

Growth Suppressive Mechanisms in Vascular SMC
Principal Investigator: Mary C. M. Weiser-Evans, PhD
Source: American Heart Association
Amount: $165,000
Term: 1999-2001

Role of Novel Embryonic Genes in SMC Growth after Vascular Injury
Principal Investigator: Mary C. M. Weiser-Evans, PhD
Co-Investigator: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute - RO1 HL 63946-01A1
Amount: $1,280,731
Term: 2000-2004

Role of PTEN in Vascular Smooth Muscle Cell Growth Inhibition
Principal Investigator: Mary C. M. Weiser-Evans, PhD
Source: University of Colorado Cancer Center Seed Grant
Amount: $20,000
Term: 2002-2003


1999-2000

The Roles of Neutral Endopeptidase and Endothelin in Hypoxia-Induced Pulmonary Edema
Principal Investigator: Todd Carpenter, MD
Source: American Heart Association of Colorado and Wyoming
Amount: $25,000
Term: July 1998-June 1999

Neprilysin and Endothelin: Interactions with Viral Infection and Hypoxia in Pulmonary Edema Formation
Principal Investigator: Todd Carpenter, MD
Source: American Heart Association Desert/Mountain Affiliate
Amount: $60,000
Term: July 1999-June 2001

Effects of Virus and Hypoxia on Lung Endothelin and Edema
Principal Investigator: Todd Carpenter, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute
Amount: $631,000
Term: September 2000-July 2005

Cellular Mechanisms of Interaction Between Viral Infection and Hypoxia in the Development of Pulmonary Edema
Principal Investigator: Todd Carpenter, MD
Source: Professional Development Award, The Children's Hospital Research Institute
Amount: $70,000
Term: March 1999-February 2000

Adventitial Remodeling in Neonatal Pulmonary Hypertension
Principal Investigator: Mita Das, PhD
Source: American Lung Association
Amount: $50,000
Term: July 1998-June 2000

Effects of HFOV and iNO in Acute Respiratory Failure in Pediatrics*
Principal Investigator: Emily Dobyns, MD
Source: National Center for Research Resources - K23 [National Institutes of Health]
Amount: $640,190
Term: 2000-2005

Physiologic and Cellular Interactions of Parainfluenza Virus and Hypoxia on the Development of Lung Edema
Principal Investigator: Anthony G. Durmowicz, MD
Source: The Children's Hospital Research Institute
Amount: $40,000
Term: July 1998-June 1999

Project III in Program Project Grant: Adaptation to Hypoxia. Distinct Mechanisms of Growth Control in Select SMC Subpopulations
Principal Investigator: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute
Amount: $1,137,299
Term: April 1998-March 2003

SCOR Grant: Impact of Injury on the Immature Pulmonary Circulation
Principal Investigator: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute
Amount: $7,145,567
Term: December 1996-November 2001

SCOR Grant: Impact of Injury on the Immature Pulmonary Circulation. Project I: SMC Heterogeneity in the Pulmonary Vasculature
Principal Investigator: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute
Amount: $1,324,572
Term: December 1996-November 2001

SCOR Grant: Impact of Injury on the Immature Pulmonary Circulation. Project II: Perlecan Heparan Sulfates: Molecular Mechanisms Underlying the Control of Vascular Smooth Muscle Cell Replication and Gene Expression During Normal Development and in Neonatal Pulmonary Hypertension
Principal Investigator: Kurt R. Stenmark, MD
Co-Investigator: Mary C.M. Weiser, PhD
Source: National Institutes of Health, National Heart, Lung and Blood Institute
Amount: $962,228
Term: December 1996-November 2001

The IGF Axis in Neonatal Pulmonary Vascular Remodeling
Principal Investigator: Susan F. Townsend, MD
Sponsor: Kurt R. Stenmark, MD
Source: National Institutes of Health, National Heart, Lung and Blood Institute
Amount: $385,270
Term: May 1994-April 1999

Role of Novel Embryonic Genes in SMC Growth After Vascular Injury
Principal Investigator: Mary Weiser-Evans, PhD
Source: National Institutes of Health, National Heart, Lung and Blood Institute
Amount: $1,280,731
Term: October 2000-September 2004

Growth Suppressive Mechanisms in Vascular SMC
Principal Investigator: Mary Weiser-Evans, PhD
Source: American Heart Association
Amount: $165,000
Term: 1999-2001

Matrix-Injury Regulated Expression of Serum Response Factor in Vascular SMC
Principal Investigator: Mary Weiser-Evans, PhD
Source: American Heart Association
Amount: $132,000
Term: 1996-1999

* Supporting research funding in the Pediatric Heart Lung Center
** Supporting research funding in Neonatology, Pulmonary Medicine, the Pediatric Heart Lung Center and the Perinatal Research Center

 
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