|
|
Infectious Diseases
Research
Dr. Mark Abzug performs clinical research on pediatric viral infections, antiviral therapy and chronic sinusitis.
Dr. Marsha Anderson is involved in outcomes-related research, including development of a tool to assess inpatient outcomes and adverse events, as well as research regarding medical errors and Kawasaki disease.
Dr. Roberta DeBiasi is studying virus-induced apoptosis using mammalian reovirus infection as a model system. She is working to delineate signaling pathways that lead to apoptosis following reovirus infection of host cells and is manipulating these pathways in a murine model of reoviral myocarditis and encephalitis in attempts to derive novel antiviral therapies.
Dr. Mary Glodé is involved in clinical vaccine trials and pursues laboratory and clinical studies of the etiology, epidemiology and therapy of Kawasaki disease.
Drs. Myron Levin and Renee Finnen are studying the immune response to herpes virus infections and methods of treating and preventing such infections, including antiviral therapy and active immunization. A vaccine to prevent shingles in elderly individuals is being tested nationally.
Dr. Elizabeth McFarland is studying the maturation of cell-mediated immune responses in both normal and HIV-infected infants, immune responses to HIV vaccines in exposed newborns and the role of cytotoxic T-lymphocytes in the pathogenesis of congenitally acquired HIV infection.
Dr. Ann-Christine Nyquist serves as Medical Director for Infection Control at The Children's Hospital. She also directs the CHIP Youth Project that provides medical care, HIV testing, risk reduction and education for HIV-infected and at-risk youth ages 13-24 years old. Her research focus includes antimicrobial utilization and resistance and hospital epidemiology/ infection control.
Dr. Sarah Parker is studying the contributions of phospholipases to Mycobacterium tuberculosis virulence. The phospholipases may contribute to inflammation, or may serve in scavenging nutrients from the host.
Dr. Esther Ponnuraj is involved in delineating mechanisms of clearance of Cryptosporidium parvum, a parasite of importance in boys with XHIM and patients with HIV. This is being done using transgenic and knockout mice and by using micro arrays to look at different pathways that may be operational.
Dr. Harley Rotbart's research concentrates on the molecular and cellular mechanisms by which enteroviruses and rhinoviruses cause disease, as well as methods for rapid molecular diagnosis and treatment of these infections.
Dr. Eric Simoes is developing simple guidelines for the World Health Organization for the management of common pediatric conditions in developing countries (Integrated Management of Childhood Illness) and studies passive prophylaxis to prevent respiratory syncytial virus infection.
Dr. Adriana Weinberg is studying immune reconstitution in HIV-infected patients, with special emphasis on cell-mediated immune responses against CMV and VZV. Another research focus in Dr. Weinberg's laboratory is molecular methods applied to viral diagnosis and to mechanisms of resistance to antivirals.
|
|
