CTRC Data Analysis

The services offered by the Biostatistical Core of the Pediatric CTRC include:

• Study design together with endpoint definitions, power and sample size calculations, and construction of the analysis plan
  
• Advice on which variables should be included in the analysis
  
• Advice on how to record those variables, in conjunction with database design support from the Bioinformatics Core
  
• Review of protocols submitted to the Pediatric CTRC for funding
  
• Randomization lists
  
• Data Safety Monitoring Board (DSMB) support
  
• Provision of ad hoc statistical consulting whilst CTRC studies are active (how to handle protocol deviations, unscheduled interim analyses, protocol amendments, etc.)
  
• Statistical programming support to analyze the data at study end
  
• Interpretation of the results
  
• Assistance with writing up the results for abstract and manuscript submission
  
• Review of manuscript drafts
  
• Assistance with replying to journal reviewers’ comments
  
• Education about statistical methodology
  

Investigators are strongly encouraged to approach the Biostatistical Core at the study design phase, i.e. at the time the protocol is being drafted. The biostatisticians may be contacted as follows:

Jane Gralla, PhD
303-315-0322

Zhaoxing Pan, PhD
303-315-0329