Correct expression of genes encoded in the genome of every cell depends on the coordinated actions of gene-targeted and general mechanisms that modulate specific transcription factors and the accessibility of DNA.  We are particularly interested in understanding the molecular basis of these essential processes involved in gene regulation.  Our studies focus on:

1. how chromatin structure participates in gene activation and
2. quorum sensing in bacterial pathogens.

We use biophysical, biochemical methods, and structural methods, including X-ray crystallography, to study these molecular mechanisms.  Our insights into these fundamental mechanisms will contribute to the knowledge required to regulate gene regulatory processes involved in human diseases from cancer and heart disease to bacterial infections.

 see all my publications