PUBLICATIONS
Scientific Publications (peer-reviewed; * corresponding author)
T.D. Tullius*, B.A. Dombroski, M.E.A. Churchill, & L. Kam “Hydroxyl Radical Footprinting: A High Resolution Method for Mapping Protein-DNA Contacts.” (1987) Methods in Enzymology 155, 537-558.
K.E. Vrana, M.E.A. Churchill, T.D. Tullius, & D.D. Brown* “Mapping Functional Regions of the Transcription Factor TFIIIA.” (1988) Molecular and Cellular Biology 8, 1684-1696.
M.E.A. Churchill, T.D. Tullius, N.R. Kallenbach, & N.C. Seeman* “A Holliday Recombination Intermediate is Twofold Symmetric.” (1988) Proc. Natl. Acad. Sci. USA 85,4653-4656.
J.-H. Chen, M.E.A. Churchill, T.D. Tullius, N.R. Kallenbach, & N.C. Seeman* “The Construction and Analysis of Mono-Mobile DNA Junctions.” (1988) Biochemistry 27, 6032-6038.
Q. Guo, M. Lu, M.E.A. Churchill, T.D. Tullius, & N.R. Kallenbach* “Asymmetric Structure of a Three-Arm DNA Junction.” (1990) Biochemistry 29, 10927-10934.
M.E.A. Churchill, J. Hayes, & T.D. Tullius* “Detection of Drug Binding to DNA by Hydroxyl Radical Footprinting. Relationship of Distamycin Binding Sites to DNA Structure and Positioned Nucleosomes on 5S RNA Genes of Xenopus.” (1990) Biochemistry 29, 6043-6050.
M.E.A. Churchill* and M. Suzuki “'SPKK' Motifs Prefer to Bind to DNA at A/T-rich Sites.” (1989) EMBO J. 8, 4189-4195.
M.E.A. Churchill, T.D. Tullius, & A. Klug* “Mode of Interaction of the Zinc Finger Protein TFIIIA with a 5S RNA Gene of Xenopus.” (1990) Proc. Natl. Acad. Sci. USA 87, 5528-5532.
M.E.A. Churchill* & A.A. Travers “Protein Motifs that Recognize Structural Features of DNA.” (1991) Trends in Biochemical Sciences 16, 92-97.
M.E.A. Churchill*, R.G. Pritchard, & M. Helliwell “Structure of Barium Guanosine 5'-Monophosphate.” (1992) Acta Crystallographica C48, 1223-1227.
S.S. Ner, M.E.A. Churchill, S. Searles, & A.A. Travers* “dHMG-Z, A Second HMG-1-Related Protein in Drosophila Melanogaster” (1993) Nucleic Acids Research 21, 4369-4371.
A.A. Travers*, S.S. Ner, & M.E.A. Churchill “DNA Chaperones - A Solution to a Persistence Problem?” (1994) Cell 77, 167-169.
S.S. Ner, A.A. Travers*, & M.E.A. Churchill “Harnessing the Writhe - A Role for DNA Chaperones in Nucleoprotein Complex Formation.” (1994) Trends Biochem. Sci. 19, 185-187.
M.E.A. Churchill, E.A. Stura, C. Pinilla, J. R. Appel, R.A. Houghten, D.H. Kono, R.S. Balderas, G. Fieser, U. Schulze-Gahmen, & I.A. Wilson* “Crystal Structure of a Peptide Complex of Anti-Influenza Peptide Antibody Fab 26/9: Comparison of Two Different Antibodies Bound to the Same Peptide Antigen” (1994) J. Mol. Biol. 241, 534-556.
D.N.M. Jones, M.A. Searles, G.L. Shaw, M.E.A. Churchill, S.S. Ner, J. Keeler, A.A. Travers, & D. Neuhaus* “The Solution Structure and Dynamics of the DNA-binding Domain of HMG-D from Drosophila Melanogaster.” (1994) Structure 2, 609-627.
M.E.A. Churchill*, D.N.M. Jones, T. Glaser, H. Hefner, M.A. Searles, & A.A. Travers “HMG-D is an Architecture-Specific Protein that Preferentially Binds to DNA Containing the Dinucleotide TG.” (1995) EMBO J. 14, 1264-1275.
S.A. Wolfe, A.E. Ferentz, V. Grantcharova, M.E.A. Churchill, & G.L. Verdine* “Modifying the Helical Structure of DNA by Design: Recruitment of an Architecture-Specific Protein to an Enforced DNA Bend.” (1995) Chemistry and Biology 2, 213-221.
D.J. Lampe, M.E.A. Churchill, & H.M. Robertson* “A purified mariner transposase is sufficient to mediate transposition in vitro” (1996) EMBO J. 15, 5470-5479.
L.K. Dow, A. Changela, H.E. Hefner, & M.E.A. Churchill* “Oxidation of a Critical Methionine Modulates DNA Binding of the Drosophila melanogaster High-Mobility-Group Protein, HMG-D” (1997) FEBS Lett. 414, 514-520.
A. Balaeff, M.E.A. Churchill, & K. Schulten* “Structure Prediction of a Complex Between the Chromosomal Protein HMG-D and DNA.” (1998) Proteins: Structure Function and Genetics 30, 113-135.
M.-H. Kuo, J. Zhou, P. Jambeck, M.E.A. Churchill & C. D. Allis*, “Histone Acetyltransferase Activity of Yeast Gcn5p is Required for the Activation of Target Genes in vivo” (1998) Genes Dev., 12, 627-639.
M.E.A. Churchill*, A. Changela, L.K. Dow, & A.J. Krieg “Interactions of HMG-box Proteins with DNA and Chromatin” (1999) Methods in Enzymology 304, 99-131.
F.V. Murphy IV, J. V. Sehy, Y.G. Gao, L.K. Dow & M.E.A. Churchill* “Co-crystallization and Preliminary Crystallographic Analysis of the HMG Domain of HMG-D Bound to DNA.” (1999) Acta Crystallographica D55, 1594-1597.
F.V. Murphy IV, R. M. Sweet, & M.E.A. Churchill* “The Structure of a Chromosomal High-Mobility-Group Protein-DNA Complex Reveals Sequence-neutral Mechanisms Important for Non-sequence-specific DNA Recognition.” (1999) EMBO J. 18, 6610-6618.
L.K. Dow, D.N.M. Jones, S.A. Wolfe, G.L. Verdine, and M.E.A. Churchill* “Structural Studies of the High Mobility Group Globular Domain and Basic Tail of HMG-D Bound to Disulfide Cross-linked DNA”(2000) Biochemistry 39, 9725-9736.
F.V. Murphy IV & M.E.A. Churchill* “Non-sequence-specific DNA recognition: a structural perspective.” Invited Mini-Review (2000) Structure 8, R83-89.
R.D. Scavetta, C.B. Thomas, M.A. Walsh, S. Szegedi, A. Joachimiak, R.I. Gumport, M.E.A. Churchill* “Structure of RsrI methyltransferase, a member of the N6-Adenine beta class of DNA methyltransferases” (2000) Nucleic Acids Research, 28, 3950-3961 (with cover photo).
W.T. Watson, F.V. Murphy IV, T.A. Gould, P. Jambeck, D. L. Val, J. E. Cronan,Jr., S. Beck von Bodman, and M.E.A. Churchill* “Crystallization and Rhenium MAD Phasing of the Acyl-homoserinelactone Synthase EsaI.” (2001) Acta Crystallographica, D57, 1945-1949.
W.T. Watson, T. D. Minogue, Dale L. Val, S. Beck von Bodman, and M.E.A. Churchill* (2002) “Structural Basis and Specificity of Acyl-homoserine lactone Signal Production in Bacterial Quorum Sensing” (2002) Molecular Cell, 9, 685-694 (with cover photo).
.S. Melvin, S.C. Roemer, M.E.A. Churchill, D.P. Edwards* “The carboxyl-terminal extension (CTE) of the nuclear hormone receptor DNA binding domain determines interactions and functional response to the HMGB-1/-2 co-regulatory proteins.” (2002) J. Biological Chemistry 277, 25115-24.
J. Klass, F.V. Murphy IV, S. Fouts, M. Serenil, A. Changela, J. Siple, and M.E.A. Churchill* “The Role of Intercalating Residues in Chromosomal High-Mobility-Group Protein DNA Binding, Bending and Specificity.” (2003) Nucleic Acids Research, 31, 2852-64.
C.B. Thomas, R.D. Scavetta, R.I. Gumport, and M.E.A. Churchill* “Structures of liganded and unliganded RsrI N6-Adenine DNA methyltransferase: a distinct orientation for active cofactor binding” (2003) J. Biological Chemistry 278, 26094-26101 (with cover photo).
A.I. Dragan, J. Klass, C. Read, M.E.A. Churchill, C., Crane-Robinson, and P.L. Privalov* “DNA Binding of a Non-Sequence Specific HMG-D Protein is Entropy Driven with a Substantial Non-Electrostatic Contribution.” (2003) J. Molecular Biology 331, 795-813.
T.A. Gould, W.T. Watson, K.-H. Choi, H.P. Schweizer, and M.E.A. Churchill* “Crystallization of Pseudomonas aeruginosa AHL synthase LasI using beta-turn crystal engineering .” (2004) Acta Cryst. D60, 518-520.
V.S. Melvin, C. Harrell, J.S. Adelman, W.L. Kraus, M.E.A. Churchill, D.P. Edwards* “The Role of the Carboxyl Terminal Extension (CTE) of the Estrogen Receptor a and b DNA Binding Domain in DNA Binding and Interaction with HMGB.” (2004) J. Biological Chemistry279, 14763-14771.
T.A. Gould, H.P. Schweizer, and M.E.A. Churchill* “Structure of the Pseudomonas aeruginosa Acyl-homoserinelactone Synthase LasI.”(2004) Molecular Microbiology 53, 1135-1146.
A.I. Dragan, C.M. Read, E.N. Makeyeva, E.I. Milgotina, M.E.A. Churchill, C. Crane-Robinson & P.L. Privalov*, “DNA binding and bending by HMG boxes: energetic determinants of specificity” (2004) J. Molecular Biology 343, 371-393.
P.A. Eyers, M.E.A. Churchill, & J.L. Maller*, “The Aurora A and Aurora B Protein Kinases: A Single Amino Acid Difference Controls Intrinsic Activity and Activation by TPX2” (2005) Cell Cycle 4, 684-689.
C.M. English, N.K. Maluf, B. Tripet, M.E.A. Churchill, & J.K. Tyler* “ASF1 binds to a heterodimer of histones H3-H4: A two-step mechanism for the assembly of the H3-H4 heterotetramer on DNA”(2005) Biochemistry44, 13673-13682.
T.A. Gould, J. Herman, J. Krank, R.C. Murphy, and M.E.A. Churchill*, “Specificity of acyl-homoserine lactone syntheses examined by mass spectrometry” (2006) J. Bacteriology 188, 773-783.
P. Kirwan, T.A. Gould, S. Bearden, H.P. Schweizer, R.C. Murphy, and M.E.A. Churchill*, “Quorum sensing signal synthesis by Yersinia pestis acylhomoserine lactone synthase YspI” (2006) J. Bacteriology 188, 785-788.
C.M. English, M.W. Adkins, J.J. Carson, M.E.A. Churchill*, and J.K. Tyler* “Structural Basis for the Histone Chaperone Activity of Asf1” (2006) Cell 127, 495-508.
S.C. Roemer, D. Donham, L. Sherman, V.H. Pon, D.P. Edwards, and M.E.A. Churchill* “Structure of the Progesterone Receptor-DNA complex: Novel Interactions Required for Binding to Half-site Response Elements” (2006) Molecular Endocrinology 20, 3042-3052 (with cover photo).
D.J. Kao, M.E.A. Churchill, R.T. Irvin and R.S. Hodges* “Animal protection and structural studies of a consensus sequence vaccine targeting the receptor binding domain of the type IV pilus of Pseudomonas aeruginosa” (2007) J. Mol. Biol. 374, 426-442.
S.R. Khan, J. Herman, J. Krank, N.J. Serkova, M.E.A. Churchill, H. Suga, and S.K. Farrand* “N-(3-Hydroxy-Hexanoyl)-L-Homoserine Lactone Is the Biologically Relevant Quormone that Regulates the phz Operon of Pseudomonas chlororaphis (aureofaciens) Strain 30-84” (2007) Applied and Environmental Microbiology, ???, ???-???.
M.E.A. Churchill*, J. Klass, and D. Zoetewey “Structural analysis of a DNA bending deficient HMGB protein-DNA complex” (2007, in preparation) ??????. ???, ???-???.
Invited Peer-reviewed and Non-peer-reviewed Book Chapters and Reviews:
N.C. Seeman, J.E. Mueller, J.-H. Chen, M.E.A. Churchill, A. Kimball, T.D. Tullius, B. Kemper, R.P. Cunningham & N.R. Kallenbach “Immobile Junctions Suggest New Features of the Structural Chemistry of Recombination” (1990) In Structure and Methods, Vol. 1 (R.H. Sarma and M.H. Sarma, eds.).
M.E.A. Churchill “Nucleic Acid Structure” (1994) Long entry for The Encyclopedia of Molecular Biology (J. Kendrew, ed.).
M. Buckle, M.E.A. Churchill, L.R. Lazarus, & A.A. Travers, “The Topology of Bacterial Transcription Initiation Complexes” (1996) In Biomolecular Interactions in DNA and Proteins (V. Buckin & T. Funck, eds.).
A. H.J. Wang & M.E.A. Churchill “Bite-size DNA” Invited book review (1995) Nature Structural Biology 2, 934-936.
M.E.A. Churchill “The Latest on DNA Form and Function” Invited book review (1996) Chemistry and Biology 3, 729-730.
M.E.A. Churchill “Watching Flipping Junctions” News and Views Report (2003) Nature Structural Biology 10, 73-75.
M.E.A. Churchill “A new GNAT in bacterial signaling " Invited Preview for Structure (2006)14, 1342-1344.
M.E.A. Churchill and J. Herman “Acyl-homoserinelactone Biosynthesis: Structure and Mechanism." Invited book chapter (2007).
M.E.A. Churchill “Throwing a curve at DNA: high mobility group box(HMGB) protein structure, binding, and bending." Invited review for Nucleic Acids Research (2007, in preparation).
Abstracts and published symposium papers (not recorded after 1997):
M.E.A. Churchill, T.D. Tullius (1985) “A Platinum Antitumor Drug Detects an Unusual DNA Conformation in the Promoter Region of a Eukaryotic Gene” Abstracts of Papers of the American Chemical Society 189: (APR-) 33-INOR.
M.E.A. Churchill, and T.D. Tullius, “A Model for the Complex of TFIIIA with the 5S-RNA Gene of Xenopus” (1987) Biophysical Journal 51: A422-A422.
K.E. Vrana, M.E.A. Churchill, T.D. Tullius, & D.D. Brown (1987) “Fingerprinting the TFIIIA-DNA Complex” Abstracts of Papers of the American Chemical Society 194: 138-INOR.
N.C. Seeman, N.R. Kallenbach, M.E.A. Churchill, T.D. Tullius, C. Newton, J.-H. Chen, M. Petrillo,J.E. Mueller, B. Kemper, R. Cunningham (1988) “Nucleic-Acid Branched Junctions” Biophysical Journal 53: A620-A620.
R.D. Powell, J.A. Hainfeld, M.E.A. Churchill, & A.S. Belmont “Combined fluorescent and gold nucleic acid probes” (1994) Proc. Micros. Soc. of America, 52nd annual meeting, pgs 176-177 (G.W. Bailey, A.J. Garrett-Reed, eds.; San Francisco Press, San Francisco).
Balaeff, M.E.A. Churchill, & K. Schulten “Structure of the Complex of HMG-D Protein with DNA Predicted by Means of Molecular Modeling” (1997) Biophysical Journal 72: (2), MP474-MP474.
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