A.R. Martin

Curriculum vitae

A.R. Martin, Ph.D.

Professor Emeritus
Department of Physiology
MS 3613. Campus Box C-240. Tel (303) 315-6910. Fax (303) 315-8110.
Email martina@jove.UCHSC.edu.

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CONTENTS
| Education | Appointments | Honors | Committees | Extramural funding
| Publications: |Pre 1982 | Post 1982 | Books, etc | Supervised | Abstracts
Education
  • University of Manitoba (Canada) 1951 B.Sc. (Physics & Math)
  • University of Manitoba 1953 M.Sc. (Physics)
  • University of London (England) 1955 Ph.D. (Biophysics)
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    Academic positions:
  • 1993- Professor Emeritus, Department of Physiology, University of Colorado School of Medicine
  • 1970-93 Professor of of Physiology, University of Colorado School of Medicine (Department Chairman 1970-85, 1989-93)
  • 1968-70 Professor of Physiology, Yale University School of Medicine
  • 1966-68 Associate Professor of Physiology, Yale University School of Medicine
  • 1963-66 Associate Professor of Physiology, University of Utah College of Medicine
  • 1957-63 Assistant Professor of Physiology, University of Utah College of Medicine
  • 1955-57 Research Fellow, Montreal Neurological Institute, McGill University
    Visiting Appointments:
  • 05/96-07/96 Visiting Professor, The Biocenter, Basel University, Switzerland.
  • 07/93-09/93 Visiting Professor, The Biocenter, Basel University, Switzerland.
  • 09/87-11/87 Visiting Scientist, CNRS, Gif sur Yvette, France
  • 09/85-2/86 Visiting Professor, John Curtin School of Medical Research, The Australian National University.
  • l978-79 Visiting Professor, Department of Pharmacology, Edinburgh University
  • 1964 Research Fellow, Monash University, Australia
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    Major scientific interest: Mechanisms of synaptic transmission, Ion channels in neurons.
    Other activities and honors:
    Awards:
  • Bronfmann Fellowship in Neurophysiology, Montreal Neurological Institute, 1955-57
  • NSF/APS Travel Fellowship to XXII International Congress, Leiden, Holland, 1962
  • NIH Special Fellowship to Monash University, 1964
  • Josiah Macy Jr. Foundation Faculty Scholar, 1978-79
  • Jacob Javits Neuroscience Investigator, 1984-92
  • INSERM Visiting Scientist, CNRS, Gif-sur-Yvette, France, Sept.- Nov., 1987
  • Simone et Cino del Duca Fondation (Paris) travel bursary, Sept. 1987
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    Committees:
  • Neurological Science Research Training Committee B, National Institute of Neurological Diseases and Stroke; 1968-71
  • Biological Sciences Advisory Committee, Yale University; 1968-69
  • Admissions Committee, Yale Medical School; 1969-70
  • Neurological Disorders Program Project Review Committee B, National Institutes of Neurological Disorders and Stroke, 1973-75
  • Neurology 'B' Study section, National Institutes of Health, 1976-78
  • Neurology 'B' Study Section, National Institutes of Health, Chairman, 1979-81
  • National Board of Medical Examiners (Physiology Test Committee) 1977-78
  • Advisory Committee, University of Puerto Rico Insititute of Neurobiology,
  • 1985-91
    Editor:
  • The Journal of Physiology (London) 1973-78
  • Journal of Neurophysiology, 1983-86, 1988-93
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    Extramural Support:
  • Principal Investigator: Research Grant NS 09660, "Mechanisms of Synaptic Transmission", NINCDS, 1970-1992 (Full period 1958-1992).
  • Program Director, Training Grant NS07083. "Training in Neurophysiology", NINCDS, 1979-1993.
    CONTENTS
    Bibliography:
    Full papers in refereed journals:
  • Martin, A.R. (1954) The effect of change in length on conduction velocity in muscle. J. Physiol 125:215-220.
  • Martin, A.R. (1955) A further study of the statistical composition of the end-plate potential. J. Physiol. 130:114-122.
  • Boyd, I.A. and Martin, A.R. (1956) Spontaneous subthreshold activity at mammalian neuromuscular junctions. J. Physiol. 132:61-73.
  • Boyd, I.A. and Martin, A.R. (1956) The end-plate potential in mammalian muscle. J. Physiol. 132:74-91.
  • Martin, A.R. and Lewis, R.S. (1957) Variation with electrode size of thresholds for motor responses to cortical stimulation. E.E.G. Clin. Neurophysiol. 9:726-728.
  • Martin, A.R. and Branch, C.L. (1958) Spontaneous activity of Betz cells in cats with midbrain lesions. J. Neurophysiol. 21:368-379.
  • Branch, C.L. and Martin, A.R. (1958) Inhibition of Betz cell activity by thalamic and cortical stimulation. J. Neurophysiol. 21:380-390.
  • Boyd, I.A. and Martin, A.R. (1959) Membrane constants of mammalian muscle fibres. J. Physiol. 147:450-457.
  • Martin, A.R. and Orkand, R.K. (1960) Postsynaptic action of HC-3 at the neuromuscular junction of the frog. Fed. Proc. 20:343-349.
  • Martin, A.R. and Orkand, R. K. (1961) Postsynaptic effects of HC-3 at the neuromuscular junction of the frog. Can. J. Biochem. Physiol. 39:343-349.
  • Martin, A.R. and Pilar G. (1963) Dual mode of synaptic transmission in the avian ciliary ganglion. J. Physiol. 168:443-463.
  • Martin, A.R. and Pilar, G. (1963) Transmission through the ciliary ganglion of the chick. J. Physiol. 168:464-475.
  • Martin, A.R. and Pilar, G. (1964) an analysis of electrical coupling at synapses in the avian ciliary ganglion. J. Physiol. 171:454-475.
  • Martin, A.R. and Pilar, G. (1964) Quantal components of the synaptic potential in the ciliary ganglion of the chick. J. Physiol. 175:1-15.
  • Martin, A.R. and Pilar, G. (1964) Presynaptic and postsynaptic events during post-tetanic potentialtion and facilitation in the avian ciliary ganglion. J. Physiol. 175:16-30.
  • Mallart, A. and Martin, A.R. (1967) An analysis of facilitation of transmitter release at the neuromuscular junction of the frog. J. Physiol. 193: 679-697.
  • Mallart, A. and Martin, A.R. (1968) The relation between quantum content and facilitation at the neuromuscular junction of the frog. J. Physiol. 196:593-604.
  • Martin, A.R. and Snell, R.S. (1968) A note on transmembrane potential in dermal melanophores of the frog and movement of melanin granules. J. Physiol. 195: 755-759.
  • Martin, A.R., Wickelgren, W.O. and Beranek, R. (1970) Effects iontophoretically applied drugs on spinal interneurones of the lamprey. J. Physiol. 207:653-665.
  • Christensen, B.N. and Martin, A.R. (1970) Estimates of probability of transmitter release at the mammalian neuromuscular junction. J. Physiol. 210: 933-945.
  • Martin, A.R. and Wickelgren, W.O. (1971) Sensory neurones in the spinal cord of the lamprey. J. Physiol. 212:65-84.
  • Barrett, E.F., Barrett, J.N., Martin, A.R. and Rahaminoff, R. (1974) A note on the interaction of spontaneous and evoked release at the frog neuromuscular junction. J. Physiol. 237:453-463.
  • Martin, A.R. and Ringham, G.L. (1975) Synaptic transfer at a vertebrate central nervous system synapse. J. Physiol. 251:409-426.
  • Martin, A.R. (1976) The effect of membrane capacitance on nonlinear summation of synaptic potentials. J. Theor. Biol. 59:179-188.
  • Brenner, H.R. and Martin, A.R. (1976) Reduction in acetylcholine sensitivity of axotomized ciliary ganglion cells. J. Physiol. 260:159-175.
  • Lassignal, N.L. and Martin, A.R. (1976) Reversal of acetylcholine potentials in eel electroplaque. Science 191:464-466.
  • Lassignal, N.L. and Martin, A.R. (1977) Effect of acetylcholine on post-junctional membrane permeability in eel electroplaque. J. Gen. Physiol. 70:23-36.
  • Martin, A.R. (1979) Appendix to: Matthews, G. and Wickelgren, W.O. Glycine, GABA and synaptic inhibition of reticulospinal neurones of lamprey. J. Physiol. 293:393-414
  • Mitchell, M.R. and Martin, A.R. (1980) An electrophysiological study of the effects of ionophore A23817 on Nauphoeta salivary glands. Quart. J. Exp. Physiol.65:309-320
  • McLachlan, E.M. and Martin, A.R. (1981) Non-linear summation of end-plate potentials. J. Physiol. 311:307-324.
  • Ginsborg, B.L., McLachlan, E.M., Martin, A.R. and Searl, J.W. (1981) The computation of simulated end-plate potentials. Proc. Roy. Soc. (London) Ser. B. 213:233-242.
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  • Gold, M.R. and Martin, A.R. (1982) Intracellular Cl- accumulation reduces Cl- conductance in inhibitory synaptic channels. Nature 299:828-830.
  • Gold, M.R. and Martin, A.R. (1983) Inhibitory conductance changes in the brain-stem of the lamprey. Science 221:85-87.
  • Gold, M.R. and Martin, A.R. (1983) Analysis of glycine-activated inhibitory post-synaptic channels in brain-stem neurones of the lamprey. J. Physiol. 342:99-117.
  • Gold, M.R. and Martin, A.R. (1983) Characteristics of inhibitory post-synaptic currents in brain-stem neurones of the lamprey. J. Physiol. 342:85-98.
  • Gold, M.R. and Martin, A.R. (1984) GABA and glycine activate Cl-channels with different characteristics in CNS neurons. Nature 30:639-641.
  • Martin, A.R. and Levinson, S.R. (1985) Contribution of the Na+-K+ pump to membrane potential in familial periodic paralysis. Muscle & Nerve 8:359-362.
  • Dryer, S. E., Fujii, J. T. and Martin, A. R. (1989) A Na+-activated K+ current in cultured brain stem neurones from chicks. J. Physiol. 410:283-296.
  • Martin, A. R., Patel, V., Faille, L. and Mallart, A. (1989) Presynaptic calcium currents recorded from calyciform nerve terminals in the lizard ciliary ganglion. Neuroscience Letters 105:14-18.
  • Martin, A. R., and Dryer, S. E. (1989) Potassium channels activated by sodium. Quart. J. exp. Physiol. 74: 1033-1041.
  • Martin, A. R. and Fuchs, P. A. (1992) The dependence of calcium-activated potassium currents on membrane potential. Proc. Roy. Soc. B 250:71-76
  • McNiven, A. I. and Martin, A. R. (1993) The effect of cytoplasmic chloride concentration on open state preference of glycine-activated chloride channels in cultured spinal cord cells. J. Neurophysiol. 69:860-867
  • Martin, A. R. (1994) Amplification of neuromuscular transmission by postjunctional folds. Proc. Roy. Soc. B. 258:321-326
  • Varga, Z.M., Fernandez, J., Blackshaw, S., Martin, A.R., Muller, K.J., Adam, W.B. and Nicholls, J.G. (1996). Neurite outgrowth through lesions of neonatal opossum spinal cord in culture. J. Comp. Neural. 366:600-612.
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    Reviews, Books, and Letters
  • Martin, A.R. (1966) Quantal nature of synaptic transmission. Physiol. Rev.46:51-66.
  • Martin, A.R. and Veale, J.L. (1967) The nervous system at the cellular level. Ann. Rev. Physiol. 29:401-426.
  • Nicholls, J.G., Baylor, D., Wickelgren, W.O., Rosenthal, J., Martin, A.R., Betz,
  • W.J., Chandler, W.K., Fein, H., Stuart, A.E., Finn, A.L., Odurih, M. & Ridge, R.A. (1967). Persistence transfer, Science 158:1524-1525.
  • Martin, A.R. (1970). Nobel prize: Three share 1970 award for medical research; 2. Katz. Science 170:423-424.
  • Martin, A.R. (1975) Synaptic Transmission. MTP International Review of Science, Physiology Series One, Vol. 3: Neurophysiology. London, Butterworths (Baltimore University Park Press), C.C. Hunt,
  • Martin, A.R. (1976) Current concepts of pre- and post-junctional mechanisms in neuromuscular transmission. Ann. N.Y. Acd. Sci. 274:3-5.Ed. PP. 53-80.
  • Martin, A.R. (1977) Junctional transmission II: Presynaptic mechanisms. Handbook of the nervous system. Vol.1, pp. 329-355. Bethesda, Amer. Physiol. Soc.
  • Martin, A.R. (1981). Book review: "The art of electronics", Horowitz & Hill (Cambridge University Press). Quart. J. exp. Physiol. 66:543-544.
  • Kuffler, S.W., Nicholls, J.G. and Martin, A.R. (1984). From Neuron to Brain, A cellular approach to the function of the nervous system. 2nd ed. Sinauer, Sunderland, Mass.
  • Martin, A. R. (1990). Glycine- and GABA-activated chloride conductances in lamprey neurons. Glycine Neurotransmission, Eds. O.P. Otterson and J. Storm-Mathisen. Wiley and Sons, New York.
  • Nicholls, J.G., Martin, A.R. and Wallace, B. G. (1992). From Neuron to Brain, A cellular and molecular approach to the function of the nervous system. 3rd ed. Sinauer, Sunderland, Mass.
  • Martin, A. R. (1992) Neuromuscular Transmission. Hospital Practice 27(8):147-158.
  • Martin, A. R. (1994) Health Care Costs. Science 263:157.
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    Abstracts:
  • Martin, A.R. (1954) The effect of change in length on conduction velocity in muscle. J. Physiol. 124:22P.
  • Martin, A.R. and Boyd, I.A. (1955) Miniature endplate potentials in isolated mammalian muscle. J. Physiol. 128:30P.
  • Martin, A.R. and Boyd, I.A. (1955) The quantum content of mammalian endplate potential. J. Physiol. 129:14P.
  • Martin, A.R. and Branch, C.L. (1957) Microelectrode studies of thalamic afferents pyramidal cells of the motor cortex of cats. E.E.G. Clin. Neurophhysiol 9:381.
  • Martin, A.R. and Orkand, R.K. (1959) Effects of hemicholineum No. 3 (H.C.3) on neuromuscular transmission. Fed. Proc. 18:430.
  • Martin, A.R. and Pilar, G. (1962) Dual mechanisms of synaptic transmission in the ciliary ganglion of the chick. Fed. Proc. 21:355.
  • Martin, A.R. and Pilar, G. (1962) Electrical coupling at a vertebrate synapse. Abstr. XXII Int. Physiol. Congr. 2:805.
  • Martin, A.R. and Pilar, G. (1963) Presynaptic events during potentiation of the synaptic potential. The Physiologist 6:253.
  • Pilar, G. and Martin, A.R. (1964) Spontaneous electrical activity in synapses of the chick's ciliary ganglion. Proc. Austral. Physiol Soc. p.5.
  • Mallart, A. and Martin, A.R. (1967) Two components of facilitation at the neuromuscular junction of the frog. J. Physiol. 191:19-20p.
  • Mallart, A. and Martin, A.R. (1967) Rapports entre la facilitation et la depression au niveau de la plaque motrice chez grénouille. J. de Physiol. 59:455.
  • Martin, A.R. (1968) Mechanisms of transmitter transmitter release Proc. XXIV Int. Physiol. Congr. 6: 279.
  • Martin, A.R. and Ringham, G. (1974) Synaptic transfer curves at a vertebrate central synapse. J. Physiol. 242:84-86P.
  • Martin, A.R. and Brenner, H.R. (1975) Changes in acetylcholine sensitivity of chick ciliary ganglion cells after post-ganglionic axotomy. The Physiologist 18:306.
  • Lassignal, N.L. and Martin, A.R. (1976) Conductance changes produced by acetylcholine in eel electroplaque. Neurosci. Abstr. Vol. 2, Part 1:413.
  • McLachlan, E.M. and Martin, A.R. (1979) The relationship between end-plate potential and end-plate current at the frog neuromuscular junction. J. Physiol. 296:82P.
  • Gold, M.R. and Martin, A.R. (1980) VIP increases quantal content at the neuromuscular junction. Neurosci. Abstr. 6:97.
  • Martin, A.R. (1980) Some electrophysiological properties of pituitary tumor cells. Neurosci. Abstr. 6:842.
  • Mitchell, M.R. and Martin, A.R. (1981) An electrophysiological study of thge effects of ionophore A23817 in an insect salivary gland. Brit. J. Pharmacol. 72:556P.
  • Gold, M.R. and Martin, A.R. (1982) Characteristics of inhibitory synapses in the brainstem of the lamprey. J. Physiol. 332:19-20P.
  • Gold, M.R. and Martin, A.R. (1982) Analysis of inhibitory postsynaptic currents in the brainstem of the lamprey. Neurosci. Abstr. 8:832.
  • Martin, A.R. and Gold, M.R. (1982) Characteristics of glycine-activated channels in lamprey brainstem neurons. Neurosci. Abstr. 8:832.
  • Gold, M.R. and Martin, A.R. (1983) Inhibitory channels in lamprey brainstem neurons activated by glycine and g-aminobutyric acid. Proc. 29th I.U.P.S. Congress 15:89.
  • Gold, M.R. and Martin, A.R. (1983) Comparison of glycine and GABA channels in C.N.S. neurons of the lamprey. The Physiologist 26:A110.
  • Nussinovitch, I. and Martin, A.R. (1984) a-adrenergic agonist affects electrical activity in primary anterior pituitary cells: a patch clamp study. Soc. Neurosci. Abstr. 10:560.
  • Nussinovitch, I. and Martin, A.R. (1986) Rhythmic hyperpolarizations evoked in anterior pituitary cells by GHRF. Soc. Neurosci Abstr. 12:14.
  • Dryer, S. and Martin, A.R. (1986). Characteristics of excitatory amino acid-evoked currents and excitatory synaptic transmission in lamprey reticulospinal neurons. Soc. Neurosci. Abstr. 12:14
  • Dryer, S. E., Fujii, Joanne, and Martin, A. R. (1988). A sodium-activated potassium current in cultured brainstem neurones. J. Physiol. 398:12p
  • Dryer, S. E., Fujii, J. T., and Martin, A. R. (1988) A sodium-activated potassium current in brainstem neurons. Biophys. J. 53: 552a
  • McNiven, A. I., DeGrandchamp, R. L. and Martin, A. R. (1991) Conductance properties of glycine-activated chloride channels depend on cytoplasmic chloride concentration. Biophys. J. 59: 20a McNiven, A. I. and Martin, A. R. (1991) Increased cytoplasmic chloride causes glycine-activated chloride channels to shift to lower-permeability open states. Soc. Neurosci. Abstr. 17:1521.
  • Martin, A. R. and Fuchs, P. A. (1992) The effect of membrane potential on calcium-activated currents. Soc. Neurosci. Abstr. 18:1341.
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    Publications of directly supervised research by students and postdoctoral fellows:.
  • Rosenthal, Jean L. (1969). Post-tetanic potentiation at the neuromuscular junction of the frog. J. Physiol. 203:121-133.
  • Betz, W. (1970). Depression of transmitter release at the neuromuscular junction of the frog. J. Physiol. 206:629-644.
  • Johnson, E.W. & Wernig, A. (1971). The binomial nature of transmitter release at the crayfish neuromuscular junction. J. Physiol. 218:757-767.
  • Wernig, A. (1972). Changes in statistical parameters during facilitation at the crayfish neuromuscular junction. J. Physiol. 226:751-759.
  • Wernig, A. (1972). The effects of calcium and magnesium on statistical release parameters at the crayfish neuromuscular junction. J. Physiol. 226:761-768.
  • Ringham, G. (1975). Localization and electrical characteristics of a giant synapse in the spinal cord of the Lamprey. J. Physiol. 251:385-407.
  • Johnson, E.W. & Brenner, H.R. (1975). Preganglionic effects of post-ganglionic nerve section. The Physiologist 18:265.
  • Brenner, H.R. & Johnson, E.W. (1976). Physiological and morphological effects of post-ganglionic axotomy on presynaptic nerve terminals. J. Physiol. 260:143-158.
  • Brenner, H.R. (1976). Reduction of quantum contents of synaptic potentials after postsynaptic axotomy. Nature 262:598-599.
  • Banks, F.W. (1978). The effect of guanidine on transmitter release in the ciliary ganglion of the chick. J. Physiol. 278:425-433.
  • Gold, M.R. (1982). The effects of vasoactive intestinal peptide on neuromuscular transmission in the frog. J. Physiol. 327:325-335.
  • Surprenant, A. (1982). Correlation between electrical activity and ACTH/beta-endorphin secretion in mouse pituitary tumor cells. J. Cell Biol. 95:559-566.
  • Gold, M.R. (1984). The action of vasoactive intestinal peptide at the frog's neuromuscular junction. In V. Chan-Palay (eds.) Coexistence of Neuroactive Substances in Neurons: Wiley and Sons, New York.
  • Nussinovitch, I. (1988). Growth hormone releasing factor evokes rhythmic hyperpolarizing currents in rat anterior pituitary cells. J. Physiol. 395: 303-318.
  • Dryer. S. E. (1988). Excitatory amino-acid-evoked membrane currents and excitatory synaptic transmission in reticulospinal neurons of the lamprey. Brain Research 443: 173-182
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