Curriculum vitae
Robert H. Eckel, M.D.
Professor
Department of Physiology and Biophysics
BRB Room #611. Campus Box B-151. Tel (303) 315-8443. Fax (303) 315-4525.
Email Robert.Eckel@UCHSC.edu.
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EDUCATION
B.S., Bacteriology, University of Cincinnati, Cincinnati, Ohio, 1969
M.D., University of Cincinnati College of Medicine, Cincinnati, Ohio, 1973
POSTGRADUATE TRAINING
Internship in Medicine, University of Wisconsin Hospitals, Madison, Wisconsin, 1973-1974
Medical Residency, University of Wisconsin Hospitals, Madison, Wisconsin, 1974-1976
Senior Fellowship in Metabolism and Endocrinology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, 1976-1979
APPOINTMENTS
07/79 - 06/85 Assistant Professor of Medicine, Div of Endocrinology, Univ of Colo HSC, Denver
07/85 - 09/89 Associate Professor of Medicine, Div of Endocrinology, Univ of Colo HSC, Denver
07/87 - present Adjunct Appointment, Dept of Food Science & Human Nutrition, Colorado State Univ
10/89 - present Professor of Medicine, Division of Endocrinology, Metabolism and Diabetes
10/89 - 06/95 Professor of Biochemistry, Biophysics and Genetics, Univ of Colo HSC, Denver
12/95 - present Professor of Physiology, Univ of Colo HSC, Denver
07/90 - present Graduate Faculty Appointment, Dept of Food Science & Human Nutrition, Colo State Univ
EXPERIENCE
1. Animal Care Control Committee, Univ. of Colorado HSC, 1980-83.
2. Associate Director of the Clinical Research Center, Univ. of Colorado HSC, 1981-1993.
3. Grant Review Committee, Colorado Heart Association, 1982-87.
4. Counselor, American Federation for Clinical Research, 1982-84.
5. Acting Chairman, Division of Endocrinology, Univ. of Colorado HSC, November 1983-June 1985.
6. Secretary-Treasurer, American Federation for Clinical Research (Western Section), 1985-88.
7. Graduate School Faculty Appointment, Univ. of Colorado HSC, 1984-present.
8. Faculty Senate, Univ. of Colorado School of Medicine, 1985-87, 1990-present.
9. Research and Development Committee, Veteran's Administration Medical Center, Denver, CO, Dean's Committee Representative, 1985-88.
10. General Clinical Research Center Site Visits, Stanford Univ., December 3,4, 1986; Brown Univ., April 5-6, 1989; Univ. of Cincinnati, December 1-2, 1989; Univ. of Florida, April 10-11, 1990; Rockefeller Univ., April 12, 1993.
11. Seminars in Medicine, Beth Israel Hospital, Harvard Medical School, Boston, MA, December 15, 1987.
12. NIH Nutrition Study Section, 1989-93; Chairman, 1991-93.
13. Co-Director, Center for Human Nutrition, Univ. of Colorado HSC, 1991-present.
14. Program Director, General Clinical Research Center, Univ. of Colorado HSC, Dec. 1993-present.
15. Co-Director, Clinical Nutrition Research Unit, University of Colorado Denver, June 1997-present.
HONORS: B.S. with Honors in Bacteriology, University of Cincinnati, 1969.
Alpha Omega Alpha, University of Cincinnati College of Medicine, 1973.
American Society for Clinical Investigation, 1988.
Outstanding Faculty Award for Housestaff Teaching, UCD, 1988.
Editorial Board, Diabetes, International Journal of Obesity, and Obesity Research, 1990-94.
Western Association of Physicians, 1989.
Moses Barron Award, American Diabetes Association - Minnesota Affiliate, 1990.
Colorado Dietetic Association Award of Excellence, 1991.
Best Doctors in America, 1994, 1995.
SELECTED PUBLICATIONS
1. Sadur CN, Eckel RH. Insulin stimulation of adipose tissue lipoprotein lipase: Use of the euglycemic clamp technique. J Clin Invest 69:1119-1125, 1982.
2. Kern PA, Knedler A, Eckel RH. Isolation and culture of microvascular endothelium from human adipose tissue. J Clin Invest 71:1822-1829, 1983.
3. Eckel RH, Prasad JE, Kern PA, Marshall S. Insulin regulation of lipoprotein lipase in cultured isolated rat adipocytes. Endocrinology 114:1665-1671, 1984.
4. Eckel RH, Robbins RJ. Lipoprotein lipase is produced, regulated and functional in rat brain. Proc Natl Acad Sci USA 81:76047607, 1984.
5. Sadur CN, Yost TJ, Eckel RH. Insulin responsiveness of adipose tissue lipoprotein lipase is delayed but preserved in obesity. J Clin Endo Metab 59:1176-1182, 1984.
6. Kern PA, Marshall S, Eckel RH. Regulation of lipoprotein lipase in primary cultures of isolated human adipocytes. J Clin Invest 75:199-208, 1985.
7. Eckel RH. Adipose tissue lipoprotein lipase. IN: Lipoprotein Lipase. J Borensztajn (Ed.), Evener Inc., Chicago IL, 1987, pp. 79-132.
8. Eckel RH, Yost TJ. Weight reduction increases adipose tissue lipoprotein lipase responsiveness in obese women. J Clin Invest 80:992-997, 1987.
9. Eckel RH, Goldberg IF, Steiner L, Yost TJ, Paterniti JR, Jr. Plasma lipolytic activity: Relationship to postheparin lipolytic activity and evidence for metabolic regulation. Diabetes 37:610-615, 1988.
10. Yost TJ, Eckel RH. Fat calories may be preferentially stored in reduced-obese women: A permissive pathway for resumption of the obese state. J Clin Endo Metab 67:259-264, 1988.
11. Yost TJ, Eckel RH. Metabolic effects of medium chain triglyceride substitution during hypocaloric feeding in obese women. Am J Clin Nutr 49:326-330, 1989.
12. Eckel RH, Yost TJ. HDL subfractions and adipose tissue metabolism in the reduced-obese state. Am J Phys 256:E740-E746, 1989.
13. Eckel RH. Lipoprotein lipase: A multifunctional enzyme relevant to common metabolic diseases. New Engl J Med 320:1060-1068, 1989.
14. Raynolds MV, Awald PD, Gordon DF, Gutierrez-Hartmann A, Rule DC, Wood WM, Eckel RH. Lipoprotein lipase gene expression in rat adipocytes is regulated by isoproterenol and insulin through different mechanisms. Molec Endo 4:1416-1422, 1990.
15. Neville MC, Waxman LJ, Jensen D, Eckel RH. Lipoprotein lipase in human milk: Compartmentalization and effect of fasting, insulin and glucose. J Lipid Res 32:251-257, 1991.
16. Bessesen DH, Robertson AD, Eckel RH. Tissue-specific effect of sustained weight reduction on lipoprotein lipase in reduced-obese Zucker rats. Am J Phys 261:E246-E251, 1991.
17. Glaser DS, Yost TJ, Eckel RH. Preheparin lipoprotein lipolytic activities: Relationship to plasma lipoproteins and postheparin lipolytic activities. J Lipid Res 33:209-214, 1992.
18. Eckel RH, Hanson AS, Chen AY, Berman JN, Yost TJ, Brass EP. Dietary substitution of medium-chain triglycerides improves insulin-mediated glucose metabolism in non-insulin dependent diabetes. Diabetes 41:641-647, 1992.
19. Currie RA, Eckel RH. Characterization of a high affinity octamer transcription factor binding site in the human lipoprotein lipase promoter. Archives of Biochem Biophys 298:630-639, 1992.
20. Eckel RH. Insulin resistance: An adaptation for weight maintenance. The Lancet 340:1452-1453, 1992.
21. Yost TJ, Rodgers CM and Eckel RH. Suction lipectomy: Outcome relates to region-specific lipoprotein lipase activity and interval weight change. J Plastic and Reconstructive Surgery 92:1101-1108, 1993.
22. Ferraro RT, Eckel RH, Larson DE, Fontvieille A-M, Rising R, Jensen DR and Ravussin E. Relationship between skeletal muscle lipoprotein lipase activity and 24-hr macronutrient oxidation. J Clin Invest 92:441-445, 1993.
23. Erskine JM, Jensen DR and Eckel RH. Macronutrient regulation of lipoprotein lipase is posttranslational. J Nutrition 124:500-507, 1994.
24. Yost TJ, Froyd KK, Jensen DR and Eckel RH. Change in skeletal muscle lipoprotein lipase activity in response to insulin/glucose in non-insulin-dependent diabetes mellitus. Metabolism 44:786-790, 1995.
25. Travers SH, Jeffers BW, Bloch CA, Hill JO and Eckel RH. Gender and Tanner stage differences in body composition and insulin sensitivity in early pubertal children. J Clin Endocrinol Metab 80:172-178, 1995.
26. Eckel RH, Yost TJ and Jensen DR. Sustained weight reduction in moderately obese women results in decreased activity of skeletal muscle lipoprotein lipase. Eur J Clin Invest 25:396-402, 1995.
27. Bessesen DH, Rupp CL and Eckel RH. Dietary fat is shunted away from oxidation, towards storage in obese Zucker rats. Obesity Research 3:179-190, 1995.
28. Morin CL, Schlaepfer IR and Eckel RH. Transcriptional control of lipoprotein lipase by tumor necrosis-( in 3T3-L1 adipocytes: A loss of DNA:protein interactions in the proximal promoter. J Clin Invest 95:1684-1689, 1995.
29. Yost TJ, Jensen DR and Eckel RH. Weight regain following sustained weight reduction is predicted by relative insulin sensitivity. Obesity Research 3:583-587, 1995.
30. Eckel RH, Jensen DR, Schlaepfer IR and Yost TJ. Tissue-specific regulation of lipoprotein lipase by isoproterenol in normal weight humans. Amer J Physiol 270 (Regulatory Integrative Comp. Physiol 39):R785-R792, 1996.
31. Morin CL, Pagliassotti MJ, Windmiller D and Eckel RH. The involvement of adipose tissue-derived tumor necrosis factor-alpha in age-associated insulin resistance. Journal of Gerontology. In Press.
32. Jensen DR, Schlaepfer IR, Morin CL, Pennington DS, Marcell T, Ammon SM, Gutierrez-Hartmann, and Eckel RH. Prevention of diet-induced obesity in transgenic mice overexpressing skeletal muscle lipoprotein lipase. American Journal of Physiology (Regulatory Integrative Comp. Physiol.). In Press.
33. Morin CL, Eckel RH, Marcel T and Pagliassotti. High fat diets elevate adipose tissue-derived tumor necrosis facator-alpha activity. Endocrinology. In Press.
34. Morin CL and Eckel RH. Transgenic and knockout animals: Novel mechanisms of body weight regulation. Journal of Nutritional Biochemistry. In Press.
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