Education
Institution Date Degree Field
Univ. of Colo. Boulder 1994 B.A Biology,Anthropology
Univ. of Colo. Hlth Sci Cntr 2003 Ph.D. Neuropharmacology
Professional Experience
2008 – present Research Biologist, Denver Veterans Affairs Medical Center Research Service
2007 – present Associate Director, University of Colorado Denver Brain Imaging Center
2006 – 2008 Associate Investigator, Denver Veterans Affairs Medical Center Research Service
2006 – present Assistant Professor, Neuroscience Program, University of Colorado at Denver and Health Sciences Center
2005 – present Assistant Professor, Department of Psychiatry, University of Colorado at Denver and Health Sciences Center
2004 – 2005 Instructor/Fellow, Developmental Psychobiology Research Group, Department of Psychiatry, University of Colorado Health Sciences Center
2004 - 2004 Postdoctoral Fellow, Institute of Cognitive Neuroscience, Wellcome Dept. of Imaging Neuroscience, University College, London
1999 - 2003 Graduate studies, Pharmacology, University of Colorado Health Sciences Center
1994 - 1999 Research Assistant, Organic Chemistry, U.S. Geological Survey
Papers
Tregellas, J.R., Olincy, A., Johnson, L., Tanabe, J., Shatti, S., Martin, L.F., Singel, D., Du, Y.P., Soti, F., Kem, W.R., Freedman, R. Functional Magnetic Resonance Imaging of Effects of a Nicotinic Agonist in Schizophrenia. Neuropsychopharmacology (In Press).
Cornier, M.A., Salzberg, A.K., Endly, D.C., Bessesen, D.H., Rojas, D.C., Tregellas, J.R. The Effects of Overfeeding on the Neuronal Response to Visual Food Cues in Thin and Reduced-Obese Individuals. PLoS ONE (In Press).
Tregellas, J.R., Ellis, J., Shatti, S., Du, Y.P., Rojas D.C. Increased Hippocampal, Thalamic and Prefrontal Responses During a Novel Sensory Gating Task in Schizophrenia. Am J Psychiatry 2009; Mar;166(3):354-60.
Tregellas, J.R. Connecting Brain Structure and Function in Schizophrenia. Am J Psychiatry. 2009; Feb;166(2):134-6.
Wilson, L.B., Tregellas, J.R., Hagerman, R.J., Rogers, S.J., Rojas, D.C. A voxel-based morphometry comparison of regional gray matter between fragile X syndrome and autism. Psychiatry Research: Neuroimaging (In Press).
Tanabe J., Tregellas J.R., Dalwani M., Thompson L., Owens E., Crowley T., Banich M. Medial Orbitofrontal Cortex Gray Matter Is Reduced in Abstinent Substance-Dependent Individuals. Biol.Psychiatry 2008.
Tregellas, J.R., Shatti, S., Tanabe, J.L., Martin, L.F., Gibson, L., Wylie, K., Rojas, D.C. Gray Matter Volume Differences and the Effects of Smoking on Gray Matter in Schizophrenia. Schizophr Res. 2007; 97:242-249.
Tregellas, J.R., Davalos, D.B., Rojas, D.C., Waldo, M.C., Gibson, L, Wylie, K, Du, Y.P., Freedman R: Increased hemodynamic response in the hippocampus, thalamus and prefrontal cortex during abnormal sensory gating in schizophrenia. Schizophr Res. 2007; 92:262-272.
Cornier, M.A., VonKaenel, S.S., Bessesen, D.H., Tregellas, J.R. The effects of overfeeding on the neuronal response to visual food cues. Am J Clin.Nutr. 2007; 86:965-971.
Du, Y.P., Dalwani, M., Wylie, K., Claus, E, Tregellas, J.R. Reducing Susceptibility Artifacts in fMRI Using Volume-Selective Z-Shim Compensation. Magnetic Resonance in Medicine 2007; 57:396-404.
Martin LF, Leonard S, Hall MH, Tregellas JR, Freedman R, Olincy A: Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar type. Am J Med Genet B Neuropsychiatr Genet 2007; 144B(5):611-4.
Rojas, D.C., Peterson, E., Winterrowd, E., Reite, M.L., Rogers, S.J., Tregellas, J.R. Regional Gray Matter Volumetric Changes in Autism Associated with Social and Repetitive Behavior Symptoms. BMC Psychiatry. 2006; Dec 13;6:56.
Tregellas J.R., Davalos D.B., Rojas D.C. Effect of task difficulty on the functional anatomy of temporal processing. Neuroimage 2006; 32:307-315.
Peterson, E., Schmidt, G.L., Tregellas, J.R., Winterrowd, E., Kopelioff, L., Hepburn, S., Reite, M., Rojas, D.C. A Voxel-Based Morphometry Study of Gray Matter in Parents of Children with Autism. Neuroreport 2006; 17:1289-1292.
Tanabe J, Tregellas JR, Martin LF, Freedman R. Effects of nicotine on hippocampal and cingulate activity during smooth pursuit eye movement in schizophrenia. Biol Psychiatry 2006; 59(8):754-761.
Haynes, J., Tregellas, J., Rees, G. Attentional Integration Between Anatomically Distinct Stimulus Representations in Early Visual Cortex. Proc Natl Acad Sci USA. 2005; 102(41):14925-14930.
Freedman, R., Ross, R., Leonard, S., Myles-Worsley, M., Adams, C.E., Waldo, M., Tregellas, J., Martin, L., Olincy, A., Tanabe, J., Kisley, M.A., Hunter, S., Stevens, K.E. Early Biomarkers of Psychosis. Dialogues in Clinical Neuroscience. 2005; 7(1):17-29.
Tregellas, J. R., Tanabe, J. L., Martin, L. F. and Freedman, R. fMRI of Response to Nicotine During a Smooth Pursuit Eye Movement Task in Schizophrenia. Am J Psychiatry. 2005 Feb;162(2):391-3.
Harris J.G., Kongs S., Allensworth D., Martin L., Tregellas J., Sullivan B., Zerbe G., Freedman R. Effects of Nicotine on Cognitive Deficits in Schizophrenia. Neuropsychopharmacology. 2004 Jul;29(7):1378-85.
Tregellas, J. R., Tanabe, J. L., Miller, D. S., Ross, R.G., Olincy, A. and Freedman, R. Neurobiology of Smooth Pursuit Eye Movement Deficits in Schizophrenia: An fMRI Study. Am J Psychiatry. 2004;161(2):315-21.
Tregellas, J. R., Tanabe, J L., Miller, D. S., and Freedman, R. Monitoring Eye Movements During fMRI Tasks with Echo Planar Images. Hum Brain Mapp. 2002; 17(4):237-243.
Tanabe, J. L., Tregellas, J. R., Miller, D. S., Ross, R.G. and Freedman, R. Brain activation during smooth pursuit eye movements. NeuroImage. 2002; 17, 1315–1324.
Tanabe,J., Miller,D., Tregellas,J., Freedman,R., and Meyer,F.G. Comparison of Detrending Methods for Optimal fMRI Preprocessing. Neuroimage. 2002; 15, 902-907.
Abstracts
Waldo, M.C., Tregellas, J.R., Singel, D., Astur, R.S., Adler, L.E. Neuronal Response to Virtual Navigation in Schizophrenics and Controls. International Congress on Schizophrenia Research, 2009.
Pelak VS, Dubin M, Filley CM, Tregellas J, Rojas D. “Functional MRI of Dynamic 3D Visual Object Perception.” Abstract: 3594AAN09D1. Poster Presentation P07.029. 61st American Academy of Neurology Meeting. Seattle, Washington. April 2009.
Tregellas, J.R., Law, J., Shatti, S.M., Rojas, D.C. The Effect of Distracting Noise on Cognition in Schizophrenia. American College of Neurspychopharmacology 47th Annual Meeting, 2008.
Cornier M.A., Salzberg A.K., Bessesen D.H., Tregellas J.R. Effects of Overfeeding and Propensity to Weight Gain on the Neuronal Responses to Visual Food Cues. Society for the Study of Ingestive Behavior Annual Meeting. Appetite, 51:359, 2008.
Cornier M.A, Salzberg A.K, Bessesen D.H, Tregellas J.R. Neuronal Responses to Visual Food Cues and Measures of Appetite in Obese Resistant and Obese Prone Individuals. The Obesity Society Annual Scientific Meeting 2008, Obesity, 16(suppl 1):S88.
Tregellas, J.R., Ellis, J., Shatti, S.M., Du, Y.P., Rojas, D.C. Increased Hemodynamic Response in Schizophrenia During a Novel, Ecologically Valid Sensory Gating Task. American College of Neurspychopharmacology 46th Annual Meeting, 2007.
Tregellas, J.R., Waldo, M.C., Shatti, S.M., Du, Y.P., Rojas, D.C., Increased Activation of the Hippocampus During Auditory Gating in Schizophrenia. International Congress on Schizophrenia Research, 2007.
Waldo, M.C., Tregellas, J.R., Morris, R., Antonova, E., Alderfer, B. S., Woodward, L., Cawthra, E.M., Singel, D., Adler, L.E. Brain Function Assessed by fMRI in Schizophrenics and Controls Using Virtual Tests of Learning and Memory. International Congress on Schizophrenia Research, 2007.
Cornier M.A, Von Kaenel S.S., Bessesen D.H., Tregellas J.R. The Effects of Overfeeding on Neuronal Activation in Obese Prone Versus Obese Resistant Individuals. The Obesity Society Annual Scientific Meeting 2007, Obesity, 15(suppl):A179-A180.
Tregellas, J.R., Gibson, L.M., Davalos, D.B., Rojas, D.C., Waldo, M.C., Freedman, R. Increased Hemodynamic Response in the Hippocampus, Thalamus and Prefrontal Cortex During Abnormal Sensory Gating in Schizophrenia. 12th International Conference on Functional Mapping of the Human Brain, Florence, Italy, 2006.
Du, Y.P., Chu, R, Tregellas, J.R. Improving the Detection of fMRI Signal Using Zero-Filled Interpolation. 12th International Conference on Functional Mapping of the Human Brain, Florence, Italy, 2006.
Tregellas, J.R., Gibson, L.M., Davalos, D.B., Rojas, D.C., Waldo, M.C., Freedman, R. fMRI of Auditory Sensory Gating Deficits in Schizophrenia. 61st Annual Meeting of the Society of Biological Psychiatry. Toronto, Canada, 2006.
Reed, C.R., Reding, P., Tregellas, J.R., Du, Y., Singel, D. What’s up in the Brain, An fMRI Study. Cognitive Neuroscience Annual Meeting, San Francisco, CA, 2006.
Cornier M.A., Von Kaenel S.S., Tregellas J.R. Effects of Short-Term Overfeeding on Neuronal Activation in Thin and Reduced-Obese Individuals. Clinical Research 2006, J Invest Med, 54:S374,2006.
Tregellas, J.R., Tanabe, J.L., Martin, L.F, Freedman, R. The Effect of Nicotine on Hemodynamic Response during a Smooth Pursuit Eye Movement Task in Schizophrenia. 2005 International Congress on Schizophrenia Research. Schizophr Res Vol 31, No 2 Suppl. 437.
Cornier M.A., Von Kaenel S.S., Tregellas J.R. Short-Term Overfeeding Inhibits Hypothalamic Activity in Thin Women. NAASO Annual Meeting, Obesity Research, 13(suppl):A164, 2005.
Rojas, D. C., Tregellas, J., Peterson, E., Kopelioff, L., Reite, M., Hepburn, S. & Rogers, S. J. Voxel-Based Morphometry in Autism. 35th Annual Meeting of the Society for Neuroscience, Washington, D.C. Program No. 448.17, 2005.
Peterson, E., Schmidt, G., L., Tregellas, J., Winterrowd, E., Kopelioff, L., Pennington, B. F., Hepburn, S., Reite, M., & Rojas, D. C. A voxel-based morphometric whole-brain analysis of parents of children with autism. 35th Annual Meeting of the Society for Neuroscience, Washington, D.C. Program No. 654.12, 2005.
Cornier M.A., Von Kaenel S.S., Tregellas J.R., The Effects of Short-Term Overfeeding on Neuronal Activity in Thin Individuals. American Diabetes Association 65th Scientific Sessions. Diabetes, 54 (suppl):1595-P, 2005.
Cornier M.A., Von Kaenel S.S., Tregellas J.R., Bessesen D.H. The Effects of Short-Term Overfeeding on Intake Behaviors and Neuronal Activity. Society of the Study of Ingestive Behavior 12th Annual Meeting. Appetite, 44:342, 2005.
Banich, M.T., Crowley, T.J., Tregellas, J., Liu, X., Tanabe, J.L., Thompson, L., Ehlers, K., Du, Y.-P., & Miller, D. Attentional control in adolescent substance abusers. Presented at the 9th International Conference on Functional Mapping of the Human Brain, New York, USA. June 2003.
Tanabe, J., Tregellas, J., Miller, D., Freedman, R. Hippocampal BOLD response during eye movements in schizophrenia at 1.5T. Eleventh Annual Meeting of the International Society for Magnetic Resonance in Medicine, Toronto, ON, Canada, May, 2003.
Du, Y. P., Tregellas, J.R.. Uftring, S. J. Signal Temporal Instability Correction in fMRI. Eleventh Annual Meeting of the International Society for Magnetic Resonance in Medicine, Toronto, ON, Canada, May, 2003.
Tregellas, J., Tanabe, J., Miller, D., Ross, R., Freedman, R. fMRI of Smooth Pursuit Eye Movement Abnormalities in Schizophrenia. 9th International Congress on Schizophrenia Research, 2003. Schizophr Res Vol 16, No 1 Suppl. 235.
Tanabe, J., Tregellas, J., Miller, D., Freedman, R. Brain activation during pursuit eye tracking is increased in schizophrenic subjects compared to controls. Presented at the 8th International Conference on Functional Mapping of the Human Brain, June 2-6, 2002, Sendai, Japan. Available on CD-ROM in Neuroimage, Vol 16, No 2.
Tregellas, J., Tanabe, J., Miller, D., Freedman, R. Activation and habituation during smooth pursuit eye movements as revealed by fMRI. Neuroimage 13 (6): S1271-S1271 Part 2 Suppl. S JUN 2001
Tanabe, J., Miller, D., Tregellas, J., Freedman, R., Meyer, F. Comparison of detrending methods for optimal fMRI pre-processing. Amer Soc Neuroradiology, 2001, Boston, MA
Book chapters:
Tregellas, J.R. and Freedman, R. (2008) Nicotinic Cholinergic Cortical Dysfunction in Schizophrenia. In Cortical Deficits in Schizophrenia: from Genes to Function , P. O’Donnell (ed.), Springer Publishing.
Ross, R.G., Kisley, M.A., & Tregellas, J. (2005) Neurophysiology and the neurodevelopmental hypothesis In Juvenile-Onset Schizophrenia, R.L. Finding, & S.C. Schulz (eds.), Baltimore: Johns Hopkins University Press, 148-173.
Fellowships/Awards
American College of Neuropsychopharmacology Young Investigator Award, 2007
Dana Foundation Program in Brain and Immuno-imaging Grant, Effect of Genotype on Brain Function and Structure in Schizophrenia, 2006-2009
Veterans Affairs Medical Center Research Service Associate Investigator Award, 2006 - 2009
National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award. “fMRI of Auditory Gating in Schizophrenia.” 2005.
International Congress on Schizophrenia Research Young Investigator Award, 2005.
National Research Service Award, National Institute of Mental Health. "FMRI of Cholinergic Dysfunction in Schizophrenia," Grant Number # 1 F31 MH66533-01 August, 2002-August, 2004.
Univ. of Colorado Health Sciences Center Graduate School Ph.D. Training Fellowship, 1999-2003.
Invited Presentations
“Understanding Brain Dysfunction in Schizophrenia” Department of Psychology Neuroscience Research Group, University of Denver, 2009.
“Imaging Inhibitory Dysfunction in Schizophrenia” Grand Rounds, Departments of Neurology and Psychiatry, University of Texas Southwestern, 2007.
“Inhibitory Dysfunction in Schizophrenia” Neuroscience Program, University of Colorado at Denver and Health Sciences Center, 2006.
“Nicotine in Schizophrenia: Effects on Physiological, Neuropsychological and Brain Function” with Deana Davalos, Ph.D., and Ann Olincy, M.D. , Grand Rounds, Department of Psychiatry, University of Colorado Health Sciences Center , Denver , Colorado , 2004.
“fMRI of Inhibitory Dysfunction in Schizophrenia” Department of Psychology, University of Denver , 2004.
"fMRI of Smooth Pursuit Abnormalities and Cholinergic Dysfunction in Schizophrenia" Colorado State University. Mar. 2002.
“Functional MRI of Smooth Pursuit Eye Movement Abnormalities in Schizophrenia” Office of National Drug Control Policy (ONDCP) MR Retreat, Denver, CO 2002.
"Sensory Deficits and the Role of Nicotinic Receptors in Schizophrenia" Mental Health Corporation of Denver. Nov. 2000.
