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Department of Psychiatry

Developmental Brain Research:
Eating Disorders and Impulsive Aggression

Publications

Articles

  1. Spannagl M, Trauner A, Birg A, Frank G, Hoffmann H, Siebeck M, Lill H. Sensitive detection of the activation state of blood coagulation in porcine DIC models by a new fibrin immunoassay. Blood Coag Fibrinol, 1993, Vol. Nr. 4, 103-106.
  2. Spannagl M, Frank G, Goedde M, Hoffmann H. The Xanthine derivatives HWA 138 and A 80 attenuate activation of coagulation in porcine endotoxin shock. In: Mueller-Berghaus G, Madlener K, Blombeck M, ten Cate JW (eds.): Pathogenesis, diagnosis and therapy of disseminated intravascular fibrin formation. Amsterdam: Excerpta Medica International Congress Series Nr. 1044, 1993, pp 239-242.
  3. Hoffmann H, Weis M, Frank G, Birg A, Schoenharting MM, Jochum M. Amelioration of endotoxin-induced acute lung injury in pigs by HWA 138 and A 80 2715: new analogs of Pentoxifylline. Shock, 1995, Vol. Nr. 4, Nr. 3, pp 166-170.
  4. Kaye WH, Frank GK, McConaha C. Altered dopamine activity after recovery from restricting-type anorexia nervosa. Neuropsychopharmacology (1999), Vol 21:503-506.
  5. Cuntz U, Frank G, Fichter MM. Interrelationships between the size of pancreas and the weight of patients with eating disorders. Int J of Eat Disord 27: 297-303, 2000.
  6. Frank GK, Kaye WH, Altemus M, Greeno CG. Oxytocin and Vasopressin after recovery from Bulimia Nervosa and binge-eating/purging type Anorexia Nervosa. Biol Psychiatry 2000; 48:315-318.
  7. Meltzer CC, Cantwell MN, Greer PJ, Ben-Eliezer D, Smith G, Frank G, Kaye WH, Houck PR, Price JC. Does cerebral blood flow decline in healthy aging? A PET study with partial-volume correction. J Nucl Med. 2000;41(11):1842-8.
  8. Frank GK, Kaye WH, Greer P, Meltzer CC, Price JC. Regional cerebral blood flow after recovery from bulimia nervosa, and possible relations to state anxiety and novelty seeking. Psychiatry Research: Neuroimaging 2000. 100(1):31-39.
  9. Frank GK, Kaye WH. Sertraline in binge eating/purging type anorexia - five case reports. Int J Eat Disorders 29(4):495-498, 2001.
  10. Kaye WH, Frank GK,  Meltzer CC, Price JC, McConaha C, Crossan PJ, Klump KK,  Bernie J. Devlin BJ. Altered medial orbital frontal serotonin receptor activity after recovery from bulimia nervosa. Am J Psychiatry 158(7):1152-1155, 2001
  11. Frank GK, Kaye WH, Weltzin TE, Perel J, Moss H, McConaha C, Pollice C. Altered response to m-CPP in anorexia nervosa: support for a persistent alteration of serotonin activity after short term weight restoration. Int J Eat Disorders 30(1):57-68, 2001.
  12. Frank GK, Kaye WH, Ladenheim EE, McConaha C. Reduced Gastrin Releasing Peptide in CSF after recovery from Bulimia Nervosa. Appetite 37:871-879, 2001.
  13. Frank GK, Kaye WH, Sahu A, Fernstrom J, McConaha C. Does reduced CSF Galanin contribute to altered taste related  hedonics in anorexia nervosa?  Neuropsychopharmacology 24(6):705-709, 2001
  14. Frank GK, Kaye WH, Meltzer CC, Price JC, Greer P, McConaha C, Skovira K. Reduced 5-HT2A receptor binding after recovery from anorexia nervosa. Biol Psychiatry. 2002 Nov 1;52(9):896-906.
  15. Stein D, Kaye WH, Matsunaga H, Orbach I, Har-Even D, Frank G, McConaha CW, Rao R. Eating-related concerns, mood, and personality traits in recovered bulimia nervosa subjects: a replication study. Int J Eat Disord. 2002 Sep;32(2):225-9.
  16. Malina A, Gaskill J, McConaha C, Frank G, LaVia M, Scholar L, Kaye W.  Olanzapine treatment of anorexia nervosa. A retrospective study. Int J Eat Disord. 2003 Mar;33(2):234-7.
  17. Stein D, Kaye WH, Matsunaga H, Myers D, Orbach I, Har-Even D, Frank G, Rao R. Pain perception in recovered eating disorder patients. Int J Eat Disord. 2003 Nov;34(3):331-6.
  18. Frank GK, Kaye WH, Carter CS, Brooks S, May C, Fissel K, Stenger VA. The evaluation of brain activity in response to taste stimuli-a pilot study and method for central taste activation as assessed by event-related fMRI. J Neurosci Methods. 2003 Dec 30;131(1-2):99-105.
  19. Bovo V, Bertoldo A, Price JC, Frank GK, Kaye WH, Cobelli C. Examination of a three-tissue compartment model for [11C]WAY-100635: Insight and comparison with a two-tissue compartment model. Neuroimage 22: T65-T66 Suppl. 2, 2004
  20. Barbarich N, McConaha C, Gaskill J, LaVia M. Frank GK, Brooks S, Kaye WH, Plotnicov K. An open trial of olanzapine in anorexia nervosa. Int J Eat Disord. 2004 Jan;35(1):10-5.
  21. Barbarich NC, McConaha CW, Halmi KA, Gendall K, Sunday SR, Gaskill J, La Via M, Frank GK, Brooks S, Plotnicov KH, Kaye WH. Use of nutritional supplements to increase the efficacy of fluoxetine in the treatment of anorexia nervosa. Int J Eat Disord. 2004 Jan;35(1):10-5.
  22. Bailer UF, Price JC, Meltzer CC, Mathis CA, Frank GK, Weissfeld L, et al. Altered 5-HT2A Receptor Activity after Recovery from Bulimia-type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness. Neuropsychopharmacology. 2004;29(6):1143-55.
  23. Bailer UF, Frank GK, Henry SE, Price JC, Meltzer CC, Weissfeld L, Mathis CA, Drevets WC, Wagner A, Hoge J, Ziolko SK, McConaha CW, Kaye WH.  Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635. Arch Gen Psychiatry. 2005 Sep;62(9):1032-41.
  24. Lee M, Bailer UF, Frank GK, Henry SE, Meltzer CC, Price JC, Kaye WH. Relationship of a 5-HT transporter functional polymorphism to 5-HT1A receptor binding in healthy women. Mol Psychiatry. 2005 Aug;10(8):715-6.
  25. Frank GK, Wagner A, Brooks-Achenbach S, McConaha C, Skovira K, Aizenstein H Cameron S. Carter, Walter H. Kaye. Altered Brain Activity in Women Recovered From Bulimic Type Eating Disorders After A Glucose Challenge. Int J Eat Disord. 2006; 39(1):76-79.
  26. Frank GK, Bailer UF, Henry SE, Price JC, Meltzer CC, Weissfeld L, Mathis C, Drevets WC, Wagner A, Hoge J, Ziolko SK, McConaha CW, Kaye WH. Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11C]raclopride. Biol Psychiatry. 2006: 58(11):908-12.
  27. Wagner A, Greer P, Bailer UF, Frank GK, Henry SE, Putnam K, Meltzer CC, Ziolko SK, Hoge J, McConaha C, Kaye WH. Normal Brain Tissue Volumes after Long-Term Recovery in Anorexia and Bulimia Nervosa. Biol Psychiatry. 2006 Feb 1;59(3):291-293.
  28. Wagner A, Aizenstein H, Frank GK, Figurski J, May JC, Putnam K, Fischer L, Bailer UF, Henry SE, McConaha C, Vogel V, Kaye WH. Neural correlates of habituation to taste stimuli in healthy women. Psychiatry Res. 2006 Jun 23; [Epub ahead of print]
  29. Wagner A, Barbarich-Marsteller NC, Frank GK, Bailer UF, Wonderlich SA, Crosby RD, Henry SE, Vogel V, Plotnicov K, McConaha C, Kaye WH. Personality traits after recovery from eating disorders: do subtypes differ? Int J Eat Disord. 2006 May;39(4):276-84.
  30. Bailer UF, Frank GK, Henry SE, Price JC, Meltzer CC, Mathis CA, Wagner A, Thornton L, Hoge J, Ziolko SK, Becker CR, McConaha CW, Kaye WH. Exaggerated 5-HT1A but Normal 5-HT2A Receptor Activity in Individuals Ill with Anorexia Nervosa. Biol Psychiatry. 2007 Jan 19; [Epub ahead of print]
  31. Soloff PH, Price JC, Meltzer CC, Fabio A, Frank GK, Kaye WH. 5HT(2A) Receptor Binding Is Increased in Borderline Personality Disorder. Biol Psychiatry. 2007 Apr 18; [Epub ahead of print]
  32. Wagner A, Aizenstein H, Mazurkewicz L, Fudge J, Frank GK, Putnam K, Bailer UF, Fischer L, Kaye WH.. Altered Insula Response to Taste Stimuli in Individuals Recovered from Restricting-Type Anorexia Nervosa. Neuropsychopharmacology. 2007 May 9; [Epub ahead of print]
  33. Frank GK, Bailer UF, Meltzer CC, Price JC, Mathis CA, Wagner A, Becker C, Kaye WH. Regional cerebral blood flow after recovery from anorexia or bulimia nervosa. Int J Eat Disord. 2007 May 24; [Epub ahead of print]
  34. Bailer UF, Frank GK, Henry SE, Price JC, Meltzer CC, Becker C, Ziolko SK, Mathis CA, Wagner A, Barbarich-Marsteller NC, Putnam K, Kaye WH. Serotonin transporter binding after recovery from eating disorders.
    Psychopharmacology (Berl). 2007 Aug 11; [Epub ahead of print]
  35. Yang TT, Simmons AN, Matthews SC, Tapert SF, Bischoff-Grethe A, Frank GK, Arce E, Paulus MP. Increased amygdala activation is related to heart rate during emotion processing in adolescent subjects. Neurosci Lett. 2007 Sep 26 [Epub ahead of print]
  36. Wagner A, Aizenstein H, Venkatraman VK, Fudge J, May JC, Mazurkewicz L, Frank GK, Bailer UF, Fischer L, Nguyen V, Carter C, Putnam K, Kaye WH. Altered Reward Processing in Women Recovered From Anorexia Nervosa. Am J Psychiatry. 2007 Dec;164(12):1842-1849.
  37. Frank GKW et al. Sucrose activates human taste pathways differently from artificial sweetener. Neuroimage. 2008 Feb 15;39(4):1559-69.

 

Review Articles (peer reviewed)

  1. Kaye WH, Klump K, Frank GK, Strober M. Anorexia and Bulimia Nervosa. Annu Rev Med 2000. 51:299-313.
  2. Frank GK, Bailer UF, Wagner A, Henry S, Kaye WH. Neuroimaging Studies in Eating Disorders. CNS Spectr. 2004;9(7):539-548.
  3. Frank GK, Kaye WH. Positron emission tomography studies in eating disorders: multireceptor brain imaging, correlates with behavior and implications for pharmacotherapy. Nucl Med Biol. 2005 Oct;32(7):755-61.
  4. Kaye WH, Frank GK, Bailer UF, Henry SE, Meltzer CC, Price JC, Mathis CA, Wagner A.  Serotonin alterations in anorexia and bulimia nervosa: new insights from imaging studies. Physiol Behav. 2005 May 19;85(1):73-81.
  5. Kaye WH, Bailer UF, Frank GK, Wagner A, Henry SE. Brain imaging of serotonin after recovery from anorexia and bulimia nervosa. Physiol Behav. 2005 Sep 15;86(1-2):15-7.
  6. Kaye WH, Frank GK, Bailer UF, Henry SE. Related Articles,  Neurobiology of anorexia nervosa: clinical implications of alterations of the function of serotonin and other neuronal systems. Int J Eat Disord. 2005;37 Suppl:S15-9; discussion S20-1.

 

Book Chapters

  1. Frank GK. Perspectives for Pharmacological Interventions in Eating Disorders. In: Handbook of Medical Psychiatry. Gershon S and Soares J (Editors). Marcel Dekker, New York. 2003.
  2. Louis J. Kraus, M.D., Co-chair, William Arroyo, M.D., Co-chair, Shiraz Butt, M.D., William Buzogany, M.D., Guido Frank, M.D., Carol Kessler, M.D., Richard Malone, M.D., Joseph Penn, M.D., Kenneth M. Rogers, M.D.  Recommendations for Juvenile Justice Reform. Second Edition. American Academy of Child and Adolescent Psychiatry. Committee on Juvenile Justice Reform. October 2005
  3. Kaye, W.H., Frank, G.K., & Klump, K.L.(2000). Psychophysiology of obsessional behaviors in anorexia and bulimia nervosa. In L. Bellodi and F. Brambilla (Eds.), Eating Disorders and Obsessive Compulsive Disorder: An Etiopathogenetic Link? Turin, Italy: Centro Scientifico Editore.
  4. Frank GK, Kaye WH. Neuroimaging as a Tool for Unlocking Developmental Pathophysiology in Anorexia and Bulimia Nervosa.Neuroimaging in Developmental Clinical Neuroscience. Judith Rumsey, Ph.D. & Monique Ernst, M.D., Ph.D., NIMH, Editors. In press.
  

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