Department of Psychiatry

Gelhorn HL, Sakai JT, Price RK, Crowley TJ. (in press). DSM-IV Conduct disorder criteria as predictors of antisocial personality disorder. Comprehensive Psychiatry.

Hartman CA, Gelhorn H, Crowley TJ, Sakai J, Stallings MC, Young SE, Corley R, Hewitt JK, Hopfer CJ. (in press). An Item Response Theory analysis of DSM-IV marijuana abuse and dependence criteria in adolescents. Journal of the American Academy of Child and Adolescent Psychiatry.

Tanabe J, Crowley T, Hutchison K, Miller D, Johnson G, Du YP, Zerbe G, Freedman R. (in press). Ventral striatal blood flow is altered by acute nicotine but not withdrawal from nicotine. Neuropsychopharmacology.

Anderson KG, Tapert SF, Moadab I, Crowley TJ, Brown SA. (2007). Personality risk profile for conduct disorder and substance use disorders in youth. Addictive Behaviors, 32: 2377-2382.

Banich MT, Crowley TJ, Thompson LL, Jacobson BJ, Liu X, Raymond KM, Claus ED. (2007). Brain activation during the Stroop task in adolescents with severe substance and conduct problems: A pilot study. Drug and Alcohol Dependence, 90, 175-182.

Crowley TJ. (2007). Adolescents and substance related disorders: Research agenda to guide decisions in DSM-V, in Diagnostic Issues in Substance Use Disorders: Refining the Research Agenda for DSM-V. eds. Saunders, J.B., Schuckit M.A., Sirovatka, P.J., Regier, D.A. pages 203-220.

Ehringer MA, Clegg HV, Collins AC, Corley RP, Crowley TJ, Hewitt JK, Hopfer CJ, Krauter K, Lessem J, Rhee SH, Schlaepfer I, Smolen A, Stallings MC, Young SE, Zeiger JS. (2007). Association of the neuronal nicotinic receptor b2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine. American Journal of Medical Genetics – Neuropsychiatric Genetics, 144B, 596-604.

Hopfer CJ, Lessem JM, Hartman CA, Stallings MC, Cherny SS, Corley RP, Hewitt JK, Krauter KS, Mikulich-Gilbertson SK, Rhee SH, Smolen A, Young SE, Crowley TJ. (2007). A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: Evidence for linkage on chromosomes 3 and 9. Drug and Alcohol Dependence, 89: 34-41.

Schlaepfer I, Clegg HV, Corley RP, Crowley T, Hewitt JK, Hopfer CJ, Krauter K, Lessem J, Rhee SH, Stallings MC, Wehner JM, Young SE, Ehringer MA. (2007). The human protein kinase C-gamma gene (PRKCG) as a susceptibility locus for hyperactive/impulsive behaviors. Addiction Biology, 12, 200-209.

Sakai JT, Hopfer CJ, Hartman C, Haberstick BC, Smolen A, Corley RP, Stallings MC, Young SE, Timberlake D, Hewitt JK, Crowley TJ. (2007). Test of association between TaqIA A1 allele and alcohol use disorder phenotypes in a sample of adolescent patients with serious substance and behavioral problems. Drug and Alcohol Dependence, 88, 130-137.

Crowley TJ, Raymond KM, Mikulich-Gilbertson SK, Thompson LL, Lejuez CW. (2006). A risk-taking “set” in a novel task among adolescents with serious conduct and substance problems. Journal of the American Academy of Child and Adolescent Psychiatry, 45: 175-183.

Title: Antisocial Drug Dependence: Genetics
Core A: Administrative and Educational Core - Crowley, PI
Comp. 1: Antisocial Drug Dependence: Genetics, Chromosomal Loci- Crowley, PI
Center representing the University of Colorado’s Division of Substance Dependence, Institute for Behavioral Genetics, and Molecular, Cellular, and Developmental Biology. This center conducts research in antisocial drug dependence and human behavioral genetics.
2 P60 DA 011015-10 (Crowley)
NIH/NIDA / $1,582,724 (current year direct costs)
Dates: 08/01/1997 - 04/30/2008

Title: A Family Study of Substance Use and Conduct Disorder.
The objectives of this research are to test competing models of comorbidity between SUD and CD, examine the influence of parents and siblings on the development of SUD and CD, and compare the familial aggregation of SUD and CD between an adjudicated and treatment sample.
2 R01 DA 015522-05 (Hopfer)
NIH/NIDA / $339,384 (current year direct costs)
Dates: -9/10/2003 - 06/30/2008

Title: Substance Dependent Adolescents: Imaging Risk-Taking
The objective of this research is to better understand whether substances diminish the capacity to inhibit behavior by altering brain processing of risky decisions, or do pre-existing, anatomically-based variations of brain processing produce risk-taking propensities, or both.
2 R01 DA009842-12 (Crowley)
NIH/NIDA / $405,568
Dates: 09/05/2006 - 04/30/2011

Title: NIAAA Institutional Postdoctoral Training Grant: Behavioral Pharmacogenetics of Drug and Alcohol Abuse
The major goal of this project is to produce well-trained independent researchers in the area of alcohol effects, alcoholism, and drug abuse.
5T32 AA007-7464-31 (Hoffman)
NIH/NIAAA / $347,048 (yr. 31)
Dates: 07/01/2007-06/30/2012

Title: Genetics of Adolescent Antisocial Drug Dependence
The major goal (NIDA RFA DA-99-003) is to conduct a multi-site whole-genome search for chromosomal loci influencing early-onset antisocial drug dependence. Ascertainment, assessment, and collection of blood from probands and family members will be conducted through clinical research programs in two cities (Denver and San Diego). Data analyses and molecular studies at University of Colorado, Boulder.
5 R01 DA 012845-05 (Crowley)
NIH/NIDA
Dates: 09/15/2000 - 02/28/2007

Title: Randomized Controlled Trial of Osmotic-Release Methylphenidate (OROS-MPH) for Attention Deficit Hyperactivity Disorder (ADHD) in Adolescents with Substance Use Disorders (SUD) - Pharmacogenetics of Treatment Response This study seeks to collect DNA from participants in a double-blind, placebo-controlled, multisite trial of OROS-MPH for adolescents with attention-deficit/hyperactivity disorder and at least one substance use disorder. Genotypes in the dopamine system will be determined and their possible association with treatment response will be tested.
2 P60 DA 011015-09S1 (Crowley)
NIH/NIDA
Dates: 08/15/2005 - 08/31/2006

Title: Method to Extend Research in Time Award Substance-Use & Conduct Disorder: Motility, Neuropsych
The major goals of this project are to examine with new procedures, and describe, neuropsychological function of adolescents with Conduct Disorder and Substance Dependence, in preparation for later imaging studies.
5 R37 DA 009842-10 (Crowley)
NIH/NIDA
Dates: 09/01/1995 - 06/30/2006

Rocky Mountain Regional Clinical Trials Node Conduct studies of behavioral, pharmacological, and integrated behavioral and pharmacological treatment inventions of therapeutic effect in rigorous, multi-site clinical trials to determine effectiveness across a broad range of community-based treatment settings and diversified patient populations.
5 U10 DA13716-05 (Riggs)
NIH/NIDA
09/30/2000 - 08/31/2005

Medical Students
Course Director, Big Six Substance Abuse Problems in Primary Care Medicine (Psych 8001). This is a 2 – 4 week full-time elective course for 3rd and 4th year medical students.  It aims to introduce students to the detection, evaluation, and treatment of the most important substance issues in primary care medicine. Tutors are members of the Division of Substance Dependence and community practitioners.

Lecturer, The Multiple Etiologies of Substance Dependence. 2 hrs in second-year Medical Student Neuroblock course.

Course Director, Research in Drug and Alcohol Abuse (Psych 8610). Students in this elective research course participate in the ongoing research projects of the Division of Substance Dependence.

Mentor, Psychiatry Scholars Program, Division Faculty serve as mentors to medical students wishing to fulfill their independent learning requirement.

Psychiatric Residents
Course Director, Introduction to Substance Dependence for PGY III Residents. This course meets for 1 hr / week for 10 weeks each year. Teachers are faculty in the Division of Substance Dependence and community practitioners. Scheduled Lectures in 2007.

Mentoring of Junior Faculty & Post-Doctoral Fellows
Dr. Crowley is, or was, a designated mentor on K-award grants for the following faculty members: Paula Riggs, Christian Hopfer, Joseph Sakai, and Jody Tanabe

Dr. Crowley is an “outside” mentor in the special NIDA K-award program of the American Academy of Child and Adolescent Psychiatry. This program is directed by Dr. Paula Riggs.

Dr. Crowley mentors Dr. Heather Gelhorn, a post-doctoral fellow in the Division of Substance Dependence.

Opportunities for Research Participation of Medical Students and Residents
Medical Students: In the Division’s research elective, Psychiatry 8610, students will work on projects currently pursued by Division faculty, or in associated labs on the CU-Boulder campus.

Residents: Numerous residents in adult and child psychiatry have conducted research leading to published papers during electives with Dr. Crowley. They have worked on projects currently ongoing in the Division.