Tuesday, June 4, 2002 -- Evening
5:00-7:00 PM	Evening Registration at Given Institute Wine and cheese reception sponsored by Ortho-McNeil Pharmaceutical, Inc.
Wednesday, June 5, 2002 -- Morning
8:00-8:15 AM	Welcome Richard J. Martin, M.D., Chair and Monica Kraft, M.D., Co-Chair
8:15-8:30 AM	Introduction Thomas L. Petty, M.D.
Morning Session - Moderator - Richard Martin, M.D.
8:30-9:15 AM	STATE OF THE ART "Biology of Inflammation in Asthma" Jack A. Elias, M.D., Yale University School of Medicine
9:15-9:30 AM	Discussion
9:30-9:45 AM	OVERLAP BETWEEN DEATH RECEPTOR MEDIATED AND NON-RECEPTOR MEDIATED MECHANISMS DURING APOPTOSIS IN HUMAN EOSINOPHILS. S. Niazi, N.M. Robertson, A. Agrawal, A.T. Hastie, S.P. Peters, J. Zangrilli*, Thomas Jefferson University Hospital, Philadelphia, PA.
9:45-10:00 AM	ISOLATION AND CHARACTERIZATION OF HEMOPOIETIC CELLS FROM LUNGS OF ALLERGIC MICE. M.I.C.G. Elsasº, E.S. Maximianoæ, D. JosephÑ, A. Bonomoæ, B.B. VargaftigÑ, P.X. Elsasæ*, ºDepto. Pediatria, Inst. Fernandes Figueira, FIOCRUZ, æDepto. Imunologia, Inst. Microbiologia Prof. Paulo de G¤es, UFRJ, Rio de Janeiro, BRAZIL, and ÑUnit» de Pharmacologie Cellulaire, Unit» Associ»e INSERM-Institute Pasteur, Paris, FRANCE.
10:00-10:30 AM	Coffee Break
10:30-11:15 AM	ROGER S. MITCHELL LECTURE "THE DISTAL LUNG IN ASTHMA" Qutayba Hamid, M.D., Ph.D., McGill University, Meakins-Christie Laboratories, Montreal, Quebec, CANADA
11:15-11:30 AM	Discussion
11:30-11:45 AM	HYDROLYSIS OF SURFACTANT PHOSPHOLIPIDS CATALYZED BY PHOSPHOLIPASE A2 AND EOSINOPHIL LYSOPHOSPHOLIPASES CAUSES SURFACTANT DYSFUNCTION: A MECHANISM FOR SMALL AIRWAY CLOSURE IN ASTHMA. S.J. Ackerman*, M.A. Kwatia, G. Enhorning, University of Illinois at Chicago and State University of New York at Buffalo.
11:45-12:00 PM	INTERLEUKIN (IL)-4 AND IL-13 AUGMENT THE PROLIFERATIVE EFFECT OF DEXAMETHASONE ON DISTAL LUNG FIBROBLASTS. M. Kraft*, E.R. Sutherland, T.A. Moss, T.L. Metze, M.D. Rex, C.C. Lewis, National Jewish Medical and Research Center, University of Colorado School of Medicine, Denver, CO.
12:00-1:30 PM	Lunch
Wednesday, June 5, 2002 -- Afternoon
Afternoon Session - Moderator - Monica Kraft, M.D.
1:30-2:15 PM	STATE OF THE ART "Airway Dimension in Asthma" Peter A. Par», M.D., St. Paul's Hospital, Vancouver, BC, Canada
2:15-2:30 PM	Discussion
2:30-2:45 PM	ROLE OF FIBRIN IN DETERMINING AIRWAY CLOSURE. S. Wagers*, R. Norton, J. Bates, C.G. Irvin, Vermont Lung Center, University of Vermont, Burlington, VT.
2:45-3:00 PM	PERIPHERAL LUNG RESPONSIVENESS ASSESSED BY FORCED OSCILLATIONS THROUGH THE WEDGED BRONCHOSCOPE. D.A. Kaminsky*, C.G. Irvin, H.T. Moriya, M. Lynn, S. Lang, J.H.T. Bates, Vermont Lung Center, Department of Medicine, University of Vermont College of Medicine, Burlington, VT.
3:00-3:30 PM	Break
3:30-4:15 PM	STATE OF THE ART "The Genetics/Genomics of Asthma" Eugene R. Bleecker, M.D., Wake Forest University
4:15-4:30 PM	Discussion
4:30-4:45 PM	EFFECT OF DEXAMETHASONE ON BETA-2-ADRENERGIC DESENSITIZATION IN AIRWAY SMOOTH MUSCLE: ROLE OF THE ARG19 POLYMORPHISM. P.E. Mooreº*, M. Calderº, R.A. Panettieri, Jr.æ, S.A. Shoreº, ºPhysiology Program, Harvard School of Public Health, Boston, MA, and æDepartment of Medicine, University of Pennsylvania, Philadelphia, PA.
4:45-5:00 PM	THE GENETICS OF INNATE IMMUNITY IN THE LUNG. D.N. Cook*, S. Wang, G.P. Howles, M. Speer, G. Churchhill, J. Quackenbush, D.A. Schwartz, Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC, The Institute for Genomic Research, Rockville, MD, Jackson Laboratories, Bar Harbor, ME.
5:00 PM	POSTER VIEWING --- SOCIAL HOUR Sponsored by a Grant from GlaxoSmithKline
Thursday, June 6, 2002 -- Morning
Morning Session - Moderator - Sally Wenzel M.D.
8:00-8:45 AM	GILES F. FILLEY LECTURE "The Epithelium in Asthma" Michael J. Holtzman, M.D., Washington University School of Medicine, St. Louis, Missouri
8:45-9:00 AM	Discussion
9:00-9:15 AM	PROLIFERATION OF THE AIRWAY EPITHELIUM IN ASTHMA: ARE INFLAMMATORY CELLS REQUIRED? B.W. Boothº, D.C. Newcombº, S.A. McKaneº, A.L. Crewsº, K.B. Adlerº, J.C. Bonneræ, L.D. Martin*º, ºNorth Carolina State University, Raleigh, NC and æNIEHS, Research Triangle Park, NC.
9:15-9:30 AM	HISTAMINE DECREASES E-CADHERIN BASED ADHESION TO INCREASE PERMEABILITY OF HUMAN AIRWAY EPITHELIUM. J. Zabner, M.C. Winter, S. Shasby, D. Ries, D.M. Shasby*, Division of Pulmonary and Critical Care Medicine, University of Iowa, Iowa City, IA.
9:30-10:00 AM	Coffee Break
10:00-10:45 AM	THOMAS A. NEFF LECTURE "IS ASTHMA AN INFECTIOUS DISEASE?" Robert F. Lemanske, Jr., M.D., University of Wisconsin Children's Hospital
10:45-11:00 AM	Discussion
11:00-11:15 AM	HYGIENE HYPOTHESIS OF ASTHMA: A MURINE ASTHMA MODEL WITH MYCOPLASMA PNEUMONIAE INFECTION. H.W. Chu, J.M. Honour, C.A. Rawlinson, R.J. Harbeck, R.J. Martin*, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO.
11:15-11:30 AM	MECHANISMS THAT POTENTIALLY UNDERLIE VIRAL-INDUCED EXAGGERATED INFLAMMATORY RESPONSES BY AIRWAY EPITHELIAL CELLS. R. Lutter*, M. van Wissen, T. Roger, P. Bresser, M. Snoek, K. van der Sluijs, B. Smids, M. Nijhuis, H.M. Jansen, Departments of Pulmonology, Experimental Immunology and Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, THE NETHERLANDS, and Eijkman-Winkler Institute, Department of Virology, University Medical Center Utrecht, THE NETHERLANDS.
11:30 AM	Instructions for Picnic
12:00 Noon	Picnic at East Maroon Bells Portal
Friday, June 7, 2002 -- Morning
Morning Session - Moderator - Norbert Voelkel, M.D.
8:00-8:45 AM	PARKER B. FRANCIS LECTURESHIP "SMOOTH MUSCLE: THE FORGOTTEN CELL" Julian Solway, M.D., Professor of Medicine and Pediatrics, University of Chicago
8:45-9:00 AM	Discussion
9:00-9:15 AM	CONCENTRATIONS OF CYTOKINES & GROWTH FACTORS IN BAL FLUID AFTER ANTIGEN CHALLENGE IN ASTHMATICS & THEIR EFFECT ON ALPHA-SMOOTH MUSCLE ACTIN AND COLLAGEN III SYNTHESIS BY HUMAN LUNG FIBROBLASTS. V. Batra*, S. Khurana, A.I. Musani, A.T. Hastie, K.A. Carpenter, J.G. Zangrilli, S.P. Peters, Thomas Jefferson University, Philadelphia, PA.
9:15-10:00 AM	STATE OF THE ART "Nocturnal Asthma" William J. Calhoun, M.D., University of Pittsburgh
10:00-10:15 AM	Discussion
10:15-10:30 AM	HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS DYSFUNCTION DURING SLEEP IN NOCTURNAL ASTHMA. E.R. Sutherland*, M. Kraft, M.D. Rex, M.C. Ellison, R.J. Martin, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO.
10:30-11:00 AM	Coffee Break
11:00-11:45 AM	STATE OF THE ART "Severe/Fatal Asthma" Sally E. Wenzel, M.D., National Jewish Medical & Research Center
11:45-12:00	Discussion
12:00-12:15 PM	ALLERGEN SPECIFIC EARLY NEUTROPHIL INFILTRATION AFTER ALLERGEN CHALLENGE IN A MURINE MODEL. C. Taube*, A. Dakhama, K. Takeda, Y.-H. Rha, A. Joetham, A. Balhorn, J.A. Nickº, E.W. Gelfan, Division of Cell Biology, Department of Pediatrics, ºDepartment of Medicine, National Jewish Medical and Research Center, Denver, CO.
12:15-1:30 PM	Lunch
Friday, June 7, 2002 -- Afternoon
Afternoon Session - Moderator
1:30-2:15 PM	STATE OF THE ART "Bronchial Hyperresponsiveness" Paul O'Byrne, M.D., St. Joseph's Hospital, Hamilton, ON, Canada
2:15-2:30 PM	Discussion
2:30-2:45 PM	ICAM-1 PLAYS A PIVOTAL ROLE IN ENDOTOXIN INDUCED AIRWAY DISEASE. D.M. Brass*, J.D. Savov, D.A. Schwartz, Duke University Medical Center, Department of Respiratory and Critical Care Medicine, Durham, NC.
2:45-3:00 PM	PROVOCATION WITH AMP INCREASES SPUTUM EOSINOPHILS. M. van den Bergeº*, H.A.M. Kerstjensº, D.M. de Reusæ, H.F. Kauffmanæ, G.H. Ko‘terº, D.S. Postmaº, Departments of Pulmonologyº and Allergologyæ, University Hospital Groningen, Groningen, THE NETHERLANDS.
3:00-3:30 PM	Break
3:30-4:15 PM	STATE OF THE ART "Airway Remodeling" A. Maurizio Vignola, M.D., Instituto di Fisispatologia Respiratoria, Palmero, Italy
4:15-4:30 PM	Discussion
4:30-4:45 PM	INTERLEUKIN-13 STIMULATES THE PROLIFERATION OF LUNG MYOFIBROBASTS VIA A STAT-6-DEPENDENT MECHANISM: A POSSIBLE MECHANISM FOR THE DEVELOPMENT OF AIRWAY FIBROSIS IN ASTHMA. J.L. Ingramº, A. Riceº, K. Geisenhofferº, D.K. Madtesæ, J.C. Bonnerº*, ºLaboratory of Pulmonary Pathobiology, NIEHS, Research Triangle Park, NC and æFred Hutchinson Cancer Research Center, Seattle, WA.
4:45-5:00 PM	INTERLEUKIN-4 PROMOTES AIRWAY REMODELLING IN ASTHMA: REGULATION OF PROCOLLAGEN I (ALPHA1) GENE BY IL-4. C. Bergeron*º, N. Pag»º, B. Barbeauæ, J. Chakirº, ºCentre de Recherche, H�pital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Sainte-Foy, Qu»bec, CANADA, æCentre de Recherche en Infectiologie, CHUQ-Pavillon CHUL, Universit» Laval, Sainte-Foy, Qu»bec, CANADA.
5:00-7:00 PM	POSTER VIEWING Wine and cheese reception sponsored by Pfizer Inc.
Saturday June 8, 2002 -- Morning
Morning Session - Moderator
8:00-8:45 AM	STATE OF THE ART "Pediatric Asthma" Stanley J. Szefler, M.D., National Jewish Medical and Research Center
8:45-9:00 AM	Discussion
9:00-9:15 AM	POLYMORPHISMS OF THE GM-CSF GENES AND THE DEVELOPMENT OF ATOPIC DISEASES IN AT-RISK CHILDREN. J.-Q. He*º, J. Ruanº, M. Chan-Yeungæ, A.B. Beckeræ, H. Dimich-Wardæ, P.D. Par»º, A.J. Sandfordº, ºUniversity of British Columbia, McDonald Research Laboratories/iCAPTURE Center, St. Paul's Hospital, Vancouver, B.C., CANADA.
9:15-9:30 AM	IL-13 & IFN-GAMMA MODULATORS OF DENDRITIC CELL MIGRATION IN THE LUNGS. J. Hwangº, D. Yenæ, T. TschernigÑ, D. Rennickæ, G.Gr½nigº*, ºDepartment of Pathology, Columbia University and J.P. Mara Center for Respiratory Diseases, St. Luke's-Roosevelt Hospital, New York, NY; æDNAX Research Institute for Molecular and Cellular Biology, Palo Alto, CA; ÑDepartment of Anatomy, Medical University of Hannover, GERMANY.
9:30-10:00 AM	Coffee Break
10:00-10:45 AM	STATE OF THE ART "New and Exploratory Therapies in Asthma" Homer A. Boushey, Jr., M.D., University of California-San Francisco
10:45-11:00 AM	Discussion
11:00-11:15 AM	ZINC STATUS MODULATES BRONCHOPULMONARY EOSINOPHILIC INFILTRATION IN A MURINE MODEL OF ALLERGIC INFLAMMATION. M. Richter, R. Bonneau, M.-A. Girard, C. Beaulieu, P. Lariv»e*, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Qu»bec, CANADA.
11:15-11:30 AM	INHIBITION OF AIRWAY INFLAMMATION AND HYPERREACTIVITY BY A CATALYTIC ANTIOXIDANT. L.Y. Chang*, J.D. Crapo, National Jewish Medical and Research Center, Denver, CO.
11:30-12:30 PM	CONFERENCE SUMMARY Jeffrey M. Drazen, M.D., Editor-in-Chief, New England Journal of Medicine Parker B. Francis Professor of Medicine, Harvard Medical School
12:30 PM	Adjourn
Poster Viewing -- Social Hour -- Wednesday, June 5, 2002
5:00-7:00 PM	MACROPHAGE INFLAMMATORY PROTEIN-2 (MIP-2) LEVELS ARE ASSOCIATED WITH CHANGES IN SERUM LEPTIN CONCENTRATIONS FOLLOWING OZONE-INDUCED AIRWAY INFLAMMATION. R.A. Johnston*, I.N. Schwartzman, S.A. Shore, Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA.
	INCREASED EXPRESSION OF c-maf and GATA-3 mRNA AFTER SEGMENTAL ALLERGEN CHALLENGE IN ALLERGIC ASTHMATICS. V.J. Erpenbeck*#É, J.M. Hohlfeld#É, M. DischerÉ, H. KrentelÉ, A. HagenbergÉ, A. Braun#, N. Krug#, #Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, GERMANY and ÉDepartment of Respiratory Medicine, Hannover Medical School, GERMANY.
	THE EFFECTS OF ACTIVE AND PASSIVE SMOKING ON ALLERGIC AIRWAY INFLAMMATION AND AIRWAY HYPERRESPONSIVENESS IN MICE. B.N. Melgert*, D.S. Postma*, M. Luinge, M. Geerlings, L. Wind, B.W.A. van der Strate, H.A.M. Kerstjens*, W. Timens, M.N. Hylkema, Department of Pathology and Laboratory Medicine and *Department of Pulmonology, University Hospital Groningen, Groningen, THE NETHERLANDS.
	EFFECTS OF AN ANTI-IL-5 ANTIBODY ON IL-5 LEVEL AND EOSINOPHILA IN SERUM AND IN BAL FROM MOUSE ASTHMA MODEL. L. Wenfang*, X. Xiaoshung, D. Qingcheng, et al, Chinese Academy of Preventive Medicine, Institute of Occupational Medicine, Beijing, People's Republic of CHINA.
	DIFFERENCES IN ALLERGEN-INDUCED BRONCHIAL INFLAMMATION BETWEEN ASTHMATIC AND NON-ASTHMATIC ALLERGIC INDIVIDUALS. J.S. van der Zee*, C.E. Lopuhaa, R.E. Nocker, R.C. Aalberse, T.A. Out, H.M. Jansen, Departments of Pulmonology and Experimental Immunology, Academic Medical Center and CLB Sanquin Blood Supply Foundation, Amsterdam, THE NETHERLANDS.
	INCREASED EXPRESSION OF IL-9 mRNA AFTER SEGMENTAL ALLERGEN CHALLENGE IN ALLERGIC ASTHMATICS. V.J. Erpenbeck*#É, J.M. Hohlfeld#É, M. DischerÉ, H. KrentelÉ, A. HagenbergÉ, A. Braun#, N. Krug#, #Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, GERMANY and ÉDepartment of Respiratory Medicine, Hannover Medical School, GERMANY.
	UCB 62045: PHARMACOLOGY OF A NOVEL, DUAL FUNCTION ANTI-INFLAMMATORY AGENT WITH HISTAMINE-1 RECEPTOR ANTAGONIST AND 5-LIPOXYGENASE INHIBITOR ACTIVITY. W.M. Selig*, L. Bayless, L. Libertine, J.B. Eckman, D.M. Wypij, B.F. Wels, M. Eckert, M.A. Young, J.M. Nicolas, R.T. Scannell, J.L. Ellis, UCB Pharma, Cambridge, MA.
	THE RELATIONSHIP OF INDUCED SPUTUM INFLAMMATION TO BAL AND BIOPSY IN SEVERE ASTHMA. P.E. Silkoff*, J. Trudeau, R. Gibbs, S. Wenzel, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO
	EOSINOPHIL CATIONIC PROTEIN (ECP) CONCENTRATION IN SALIVA DOES NOT PARALLEL ECP CONCENTRATION IN SPUTUM. D.L. Bowton*, M.C. Seeds, D.A. Bass, Department of Medicine-Sections on Pulmonary and Critical Care and Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC.
	IFN-GAMMA REDUCES IL-4 AND IL-13 AUGMENTED TGF-BETA2 PRODUCTION IN HUMAN BRONCHIAL EPITHELIAL CELLS BY TARGETING SMADS. F.Q. Wen*, X.D. Liu, Y. Terasaki, Q.H. Fang, T. Kobayashi, S. Abe, S.I. Rennard, Pulmonary Critical Care Medicine, University of Nebraska Medical Center, Omaha, NE.
	IL-13 ALTERS MUCOCILIARY DIFFERENTIATION OF HUMAN NASAL EPITHELIAL CELL. M. Skowron, E. Perret*, F. Marano, D. Caput*, F. Tournier, LCTC, Universit» Paris, FRANCE, *Sanofi-Synthelabo Recherche, LabÀge, FRANCE.
	IDENTIFICATION OF GENES AND PROTEINS REGULATED BY INTERLEUKIN-5 IN HUMAN EOSINOPHILS USING MICROARRAYS AND 2D ELECTROPHORESIS/MASS SPECTROMETRY. S. H¬kansson, K. Behrens, G. Marko-Varga, H. Lindberg, S. Pierrou, W. Koopmann*, Department of Molecular Sciences, AstraZeneca R&D Lund, SWEDEN.
	LACK OF ASSOCIATION BETWEEN THE TNF-ALPHA REGULATORY REGION GENETIC POLYMORPHISMS ASSOCIATED WITH ELEVATED TNF-ALPHA LEVELS AND CHILDREN WITH ASTHMA. L. Bahlawan*, M. Christensen, S. Binaei, C. Murphy, Q. Zhang, M. Quasney, Children's Foundation Research Center, Departments of Pediatrics and Clinical Pharmacy, University of Tennessee, Memphis, TN.
	BETA2-ADRENERGIC RECEPTOR POLYMORPHISMS IN CHILDREN WITH STATUS ASTHMATICUS. S. Binaei*, M. Christensen, C. Murphy, Q. Zhang, M. Quasney, Children's Foundation Research Center, Departments of Pediatrics and Clinical Pharmacy, University of Tennessee, Memphis, TN.
	INTERLEUKIN-13 INDUCES SURFACTANT FUNCTION ABNORMALITY IN THE MURINE LUNG. Z. Zhu*, G. Enhorning·, T. Zheng, Q. Chen, R. Homer, J.A. Elias, Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, ·Departments of Ob/Gyn and Physiology, New York University at Buffalo, Buffalo NY.
	HUMAN EOSINOPHIL GROUP IID SECRETORY PHOSPHOLIPASE A2 CAUSES SURFACTANT DYSFUNCTION. M.C. Seeds, D.L. Bowton, R.D. Hite, J. Gyves, A. Safta, D.A. Bass*, Internal Medicine-Sections on Pulmonary and Critical Care and on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC.
	MODULATION OF VASODILATOR-STIMULATED PHOSPHOPROTEIN IN VIVO IN HUMAN EPITHELIAL CELLS BY SEGMENTAL ALLERGEN CHALLENGE AND BETA2-AGONIST THERAPY. A.T. Hastie*, V. Batra, S. Khurana, K.A. Carpenter, R. Cirelli, J.G. Zangrilli, S.P. Peters, Thomas Jefferson University, Philadelphia, PA.
	IL-13 ACTS DIRECTLY ON EPITHELIAL CELLS TO CAUSE AIRWAY HYPERREACTIVITY AND MUCUS OVERPRODUCTION WITHOUT INFLAMMATION, FIBROSIS, OR EMPHYSEMA. D.A. Kuperman, X. Huang, L.L. Koth, G.H. Chang, G.M. Dolganov, Z. Zhu, J.A. Elias, D. Sheppard, D.J. Erle*, Lung Biology Center, Department of Medicine, Cardiovascular Research Institute, and Program in Immunology, University of California, San Francisco, and Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.
Poster Viewing -- Social Hour -- Friday, June 7, 2002
5:00-7:00 PM	MYCOPLASMA PNEUMONIAE ANTIGENS STIMULATE IL-8 PRODUCTION IN HUMAN BRONCHIAL EPITHELIAL CELLS. K. Chmura*, R.D. Lutz, H. Chiba, M.S. Numata, H-J. Choi, G. Fantuzzi, D.R. Voelker, E.D. Chan, Department of Medicine, National Jewish Medical and Research Center, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Denver, CO.
	LIPOPOLYSACCHARIDE CELL-SPECIFICALLY DOWNREGULATES LEUKOTRIENE C4 SYNTHASE GENE EXPRESSION IN THE MONOCYTE-LIKE CELL LINE, THP-1. K.J. Serio*, S.C. Johns, L. Luo, C.R. Hodulik, T.D. Bigby, Department of Medicine, Veterans Affairs San Diego Healthcare System and the University of California, San Diego, CA.
	PULMONARY SURFACTANT PROTEINS A AND D RECOGNIZE LIPID LIGANDS ON MYCOPLASMA PNEUMONIAE AND MARKEDLY AUGMENT THE INNATE IMMUNE RESPONSE TO THE ORGANISM. H. Chiba, S. Pattanajitvilai, H. Mitsuzawa, Y. Kuroki, A. Evans, D.R. Voelker*, Program in Cell Biology, Pulmonary Division, Department of Medicine, National Jewish Medical and Research Center, Denver, CO.
	EFFECTS OF INHALED FLUTICASONE ON BRONCHIAL HYPERRESPONSIVENESS (BHR) AND AIRWAY INFLAMMATION IN M. PNEUMONIAE INFECTED MICE. H.W. Chu*, J. Campbell, R.J. Harbeck, R.J. Martin, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO.
	SYNERGETIC EFFECT OF IL-4 AND TGF-BETA1 ON TYPE I COLLAGEN GEL CONTRACTION AND DEGRADATION BY HFL-1 CELLS: IMPLICATION IN TISSUE REMODELING. X.D. Liu*, H. Conner, T. Kobayashi, S. Abe, Q.H. Fang, F.Q. Wen, S.I. Rennard, University of Nebraska Medical Center, Omaha, NE.
	QUANTITATIVE ASSESSMENT OF SUB-EPITHELIAL COLLAGEN DEPOSITION IN THE AIRWAYS OF MICE FOLLOWING OVALBUMIN SENSITISATION AND INTRA-TRACHEAL CHALLENGE. A.K. Reinhardt*, S.E. Bottoms, G.J. Laurent and R.J. McAnulty, Centre for Respiratory Research, University College London, London, UNITED KINGDOM.
	INCREASED EXPRESSION OF PLATELET-DERIVED GROWTH FACTOR RECEPTOR-BETA IN AIRWAY FIBROBLASTS OF SEVERE ASTHMATICS. C.C. Lewis*, H.W. Chu, J.Y. Westcott, E.R. Sutherland, A.D. Stevens, T.L. Metze, M. Kraft, National Jewish Medical and Research Center, Denver, CO.
	MODULATION OF FIBROBLAST GROWTH FACTOR EXPRESSION AND SIGNAL TRANSDUCTION IN TYPE II CELLS. C-M. Li, D. Newman, M. Cesta, L. Tompkins, J. Khosla, P.L. Sannes*, Department of Anatomy, Physiological Sciences and Radiology, North Carolina State University, Raleigh, NC.
	AIRWAY RESPONSE TO LOW DOSE ALLERGEN EXPOSURE IN ALLERGIC NON-ASTHMATIC AND ASTHMATIC SUBJECTS: EOSINOPHILS FIBRONECTIN AND VEGF. M.-E. Boulay*, L.-P. Boulet, Centre de Recherche de l'H�pital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l'Universit» Laval, Sainte-Foy, Qu»bec, CANADA.
	RISK-BENEFIT VALUE OF INHALED CORTICOSTEROIDS: A PHARMACOKINETIC/PHARMACODYNAMIC PERSPECTIVE. S. Rohatagi*º, H. Derendorfæ, K. ZechÑ, Aventis Pharmaceuticalsº, University of Floridaæ, Byk-Gulden PharmaceuticalsÑ.
	IL-16 INHIBITS TH2 CYTOKINE PRODUCTION AND AIRWAY HYPER-REACTIVITY IN A MURINE MODEL OF ALLERGIC AIRWAY INFLAMMATION. F.F. Little*º, J. deBieæ, E. Sandersonº, A. van Oosterhoutæ, H. Kornfeldº, D.M. Centerº, W.W. Cruikshankº, ºPulmonary Center, Boston University School of Medicine, Boston, MA, æDepartment of Pharmacology, Utrecht University, Utrecht, THE NETHERLANDS.
	THE STAT PATHWAY PARTICIPATES HUMAN AIRWAY SMOOTH MUSCLE CELL MITOGENESIS. A.R. Simon*, M. Severgnini, S. Takahashi, B.L. Fanburg, B.H. Cochran, Pulmonary and Critical Care Division/Department of Physiology, New England Medical Center/Tufts University School of Medicine, Tupper Research Institute, Boston, MA.
	DOES LEARNING OCCUR WITH REPETITIONS OF INSPIRATORY LOADING? S. Jastrzembski-Wieber*, M. Lavietes, A. Ritter, T.C. Banwell, J. Ricci, N.S. Cherniack, University of Medicine and Dentistry of New Jersey, Newark, NJ.
	IDENTIFICATION OF BIRCH POLLEN RESPIRABLE PARTICLES. P.E. Taylor*, R. Flagan, A.G. Miguel, R. Valenta, M.M. Glovsky, Pasadena, CA and Vienna, AUSTRIA.
	REGULATION OF PHOSPHOLIPASE A2 (PLA2) BY INTERLEUKIN-1BETA (IL-1BETA) IN HUMAN AIRWAY SMOOTH MUSCLE. R.M. Pascual*, B.K. Awsare, S.A. Farber, R.A. Panettieri Jr., S.P. Peters, R.B. Penn, Department of Medicine, Jefferson Medical College, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA.
	THE EFFECT OF HOUSE DUST MITE AEROALLERGEN AND AIR POLLUTANT EXPOSURES DURING INFANCY. L.A. Miller*, D.M. Hyde, L.J. Gershwin, E.S. Schelegle, M.V. Fanucchi, M.J. Evans, J.E. Gerriets, L.F. Putney, M.Y. Stovall, N.K. Tyler, J.L. Usachenko, C.G. Plopper, Center for Comparative Respiratory Biology and Medicine and the California Regional Primate Research Center, School of Veterinary Medicine.