Tuesday, June 3, 2003 -- Evening
5:00-7:00 PM	Evening Registration -- Wine and Cheese Reception	Given Institute
Wednesday, June 4, 2003 -- Morning
8:00-8:15 AM	Welcome	York E. Miller, M.D., Chair Robert L. Keith, M.D., Co-Chair
8:15-8:30 AM	Introduction	Thomas L. Petty, M.D.
Moderator - York E. Miller, M.D.
8:30-9:15 AM	STATE OF THE ART "Environment and Lung Cancer Epidemiology"	Jonathan M. Samet, M.D. Johns Hopkins University
9:15-9:30 AM	Discussion
9:30-9:45 AM	INCREASED URINARY 8-ISOPROSTAGLANDIN F2a (8-EPG) IS ASSOCIATED WITH LOWER PLASMA SELENIUM LEVELS AND LOWER VEGETABLE AND FRUIT INTAKE IN AN ASBESTOS EXPOSED COHORT AT RISK FOR LUNG CANCER. E.B. Gottschall*†, P. Wolfe§. A. Haegele§, Z. Zhu§, W. Jiang§, C. Rose†, T. Sells†, B. Lee†, J. McGinley§, H. Thompson§, †National Jewish Medical and Research Center, Denver, CO and §Colorado State University, Fort Collins, CO.
9:45-10:30 AM	STATE OF THE ART "Molecular Epidemiology"	Curtis C. Harris, M.D. National Cancer Institute, NIH
10:30-10:45 AM	Discussion
10:45-11:15 AM	......Coffee Break
11:15-11:30 AM	DEVELOPMENT OF LUNG TUMORS IN MUTANT P53-EXPRESSING MICE AFTER INHALATION EXPOSURE TO ASBESTOS. G.F. Morris,* A. Notwick, O. David, C. Fermin, A.R. Brody, M. Friedman, Program in Lung Biology, Departments of Pathology and Medicine, Tulane University Medical Center, New Orleans, LA.
11:30-12:15 AM	STATE OF THE ART "Genetic Predisposition to Lung Cancer"	Ann G. Schwartz, Ph.D., MPH Karmanos Cancer Institute
12:15-12:30 PM	Discussion
12:30-12:45 PM	LUNG CANCER RISK IN RELATIVES OF EARLY-ONSET LUNG CANCER CASES. M. Cote*, A.J. Spindler, A.G. Schwartz, Wayne State University School of Medicine and the Karmanos Cancer Institute.
12:45-1:30 PM	......Lunch
Wednesday, June 4, 2003 -- Afternoon
Moderator - Norbert F. Voelkel, M.D.
1:30-2:15 PM	GILES F. FILLEY LECTURE "PREMALIGNANT EVOLUTION OF LUNG CANCER" Wilbur A. Franklin, M.D. Professor of Pathology University of Colorado Health Sciences Center Denver, Colorado
2:15-2:30 PM	Discussion
2:30-2:45 PM	PRE-INVASIVE BRONCHIAL LESIONS: SURVEILLANCE OR INTERVENTION? A. Banerjee¹, P. Rabbitts¹, J. George²*, ¹University of Cambridge and ²University College Hospital NHS Trust, UNITED KINGDOM.
2:45-3:00 PM	SERIAL ANALYSIS OF GENE EXPRESSION PROFILES OF DEVELOPMENTAL STAGES IN NON-SMALL CELL LUNG CARCINOMA. C. MacAulay*¹, K. Lonergan², B. Chi², S. Zuyderduyn³, J Shein³, M. Tsao4, J. LeRiche4, S. Jones³, M. Marra³, S. Lam¹, W.L. Lam², Departments of Cancer Imaging¹, Cancer Genetics², Genome Sciences Centre³, and BC Cancer Agency/Research Centre, Vancouver, BC; 4Ontario Cancer Institute, Princess Margaret Hospital, Toronto, ON, CANADA.
3:00-3:30 PM	......Break
3:30-4:15 PM	STATE OF THE ART "Biomarkers as Potential Targets for Molecular Intervention"	Adi F. Gazdar, M.D. University of Texas Southwestern Medical Center
4:15-4:30 PM	Discussion
4:30-4:45 PM	TOBACCO CARCINOGEN INDUCED CELLULAR TRANSFORMATION INCREASES AKT ACTIVATION IN VITRO AND IN VIVO. K.A. West, I.R. Linnoila, J. Brognard, S. Belinsky, C. Harris, P.A. Dennis*, Cancer Therapeutics Branch, Center for Cancer Research, NCI, Bethesda, MD.
4:45-5:00 PM	SIGNIFICANCE OF P63 AMPLIFICATION AND OVEREXPRESSION IN LUNG TUMORIGENESIS. P.P. Massion*, P.M. Taflan, S.M. Jamshedur Rahman, P. Yildiz, Y. Shyr, M.E. Edgerton, J.R. Roberts, D.P. Carbone, A.L. Gonzalez, The Vanderbilt Ingram Comprehensive Cancer Center, and the Nashville VA Medical Center, Nashville, TN.
5:00 PM	POSTER VIEWING --- SOCIAL HOUR
Thursday, June 5, 2003 -- Morning
Moderator - Edward Gabrielson, M.D.
8:00-8:45 AM	STATE OF THE ART "Gene Expression Analysis, Risk Biomarkers and Tumor Biology"	Naftali Kaminski, M.D. University of Pittsburgh Medical Center
8:45-9:00 AM	Discussion
9:00-9:15 AM	IMPACT OF CIGARETTE SMOKE ON THE NORMAL AIRWAY TRANSCRIPTOME. A. Spira*, F. Schembri, J. Beane, V. Shah, G. Liu, J.S. Brody, Pulmonary Center Boston University School of Medicine and Bioinformatics Program, Boston University, Boston, MA.
9:15-9:30 AM	NONSMALL CELL LUNG CANCER MOLECULAR PROFILES ARE ASSOCIATED WITH LUNG DEVELOPMENT. A.C. Borczuk. A.M. Assaad, L.Q. Wang, K.L. Walter*, C.A. Powell, Columbia University College of Physicians & Surgeons, New York, NY.
9:30-9:45 AM	ELEVATED HEPATOCYTE GROWTH FACTOR PROTEIN CORRELATES WITH POOR SURVIVAL IN EARLY STAGE ADENOCARCINOMA OF THE LUNG. J.M. Siegfried*, J.D. Luketich, N. Christie, C. Gubish, A.Gaither Davis, S. Land, Departments of Pharmacology and Surgery, University of Pittsburgh Cancer Institute SPORE in Lung Cancer, Pittsburgh, PA.
9:45-10:15 AM	......Coffee Break
Moderator - Mark W. Geraci, M.D.
10:15-11:00 AM	STATE OF THE ART "Epigenetics in Lung Cancer"	James G. Herman, M.D. Johns Hopkins University
11:00-11:15 AM	Discussion
11:15-11:30 AM	y-CATENIN EXPRESSION IS REDUCED OR ABSENT IN A SUBSET OF HUMAN NSCLC AND RE-EXPRESSION INHIBITS TRANSFORMED CELL GROWTH. R. Winn*, L. Heasley, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO.
11:30 AM	Instructions for Picnic
12:00 Noon	Picnic at East Maroon Bells Portal
Friday, June 6, 2003 -- Morning
Moderator - Alvin Malkinson, Ph.D.
8:00-8:45 AM	PARKER B. FRANCIS LECTURESHIP "HUMAN CHEMOPREVENTION STRATEGIES" Gilbert S. Omenn, M.D., Ph.D. Executive Vice President Medical Affairs University of Michigan Ann Arbor, Michigan
8:45-9:00 AM	Discussion
9:00-9:15 AM	AIRWAY ANTIOXIDANTS AND OXIDATIVE STRESS AS PREDICTORS OF SPUTUM ATYPIA AND AIRFLOW OBSTRUCTION. R.P. Bowler*¹, B. Duda¹, K.O. Vu², T. Byers², W. Franklin², E.D. Chan¹, Y. Miller³. ¹National Jewish Medical and Research Center, Denver, CO; ²University of Colorado Health Sciences Center, Denver, CO; ³Veterans Affairs Medical Center, Denver, CO.
9:15-9:30 AM	CHEMOPREVENTION OF TOBACCO SMOKE-INDUCED LUNG CANCER: WHAT ANIMAL STUDIES TELL US. H. Witschi*, I. Espiritu, D. Uyeminami, K.E. Pinkerton, O.G. Raabe, Center for Health and the Environment (CHE), University of California, Davis.
9:30-10:00 AM	......Coffee Break
10:00-10:45 AM	STATE OF THE ART "Mechanisms of Chemoprevention"	Thomas J. Slaga, Ph.D. American Medical Center
10:45-11:00 AM	Discussion
11:00-11:15 AM	THE CHEMOKINE RECEPTOR, CXCR2, MEDIATES THE TUMORIGENIC EFFECTS OF ELR+ CXC CHEMOKINES. M.P. Keane*, M.D. Burdick, Y.Y. Xue, M. Lutz, J.A. Belperio, R.M. Strieter±, Lung Cancer SPORE at the David Geffen School of Medicine at UCLA, Departments of Medicine and ±Pathology, Division of Pulmonary and Critical Care Medicine, Los Angeles, CA.
11:15-11:30 AM	LIGANDS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPAR?) INHIBIT LUNG CANCER CELL GROWTH AND INDUCE APOPTOSIS BY STIMULATION OF P21 EXPRESSION. S. Han+, N. Sidell*, P.B. Fisher#, J. Roman¥, +Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, *Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, #Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, NY.
11:30-1:30 PM	......Lunch
Friday, June 6, 2003 -- Afternoon
Moderator - Robert L. Keith, M.D.
1:30-2:15 PM	ROGER S. MITCHELL LECTURE "EICOSANOIDS IN LUNG CARCINOGENESIS AND CHEMOPREVENTION" Raymond N. DuBois, M.D., Ph.D. Professor of Medicine Department of Medicine and G.I. Vanderbilt University Medical Center Nashville, Tennessee
2:15-2:30 PM	Discussion
2:30-2:45 PM	COX-2 DEPENDENT EXPRESSION OF SURVIVIN IN NON-SMALL CELL LUNG CANCER. K. Krysan, M. Dohadwala, J. Luo, Y. Lin, L. Zhu, N. Heuze-Vourc'h, L. Goodglick, F. Merchant, D. Seligson, M. Pold, R. Strieter, S. Sharma, S. Dubinett*, David Geffen School of Medicine at UCLA, Lung Cancer Research Program, Jonsson Comprehensive Cancer Center, Los Angeles, CA.
2:45-3:00 PM	PROSTACYCLIN IN HUMAN NON-SMALL CELL LUNG CANCERS AND REGULATORY MECHANISMS. P. Nana-Sinkam*¹, H. Golpon¹, R.L. Keith¹, M.D. Moore¹, N.F. Voelkel¹, W. Franklin³, R.A. Nemenoff², M.W. Geraci¹, ¹Division of Pulmonary Sciences and Critical Care Medicine, ²Division of Nephrology, ³Department of Pathology, University of Colorado Health Sciences Center, Denver, CO.
3:00-3:30 PM	......Break
Moderator - Karen Kelly, M.D.
3:30-4:15 PM	STATE OF THE ART "Targeting P13K-Dependent Signaling in Lung Cancer Prevention and Therapy"	Jonathan Kurie, M.D. M.D. Anderson Cancer Center
4:15-4:30 PM	Discussion
4:30-4:50 PM	MICE WITH ALTERATIONS IN BOTH P53 AND INK 4A/ARF DISPLAY A STRONG INCREASE IN LUNG TUMOR MULTIPLICITY AND PROGRESSION: DIFFERENTIAL CHEMOPREVENTIVE EFFECTS OF THE GLUCOCORTICOID BUDESONIDE AND FARNESYLTRANSFERASE INHIBITOR L-778,123 IN WILD TYPE AND MUTANT A/J MICE Ronald Lubet*1, Zhongqiu Zhang2 , Elizabeth Kastens2, Yian Wang2, Ming You2 , 2Alvin Siteman Cancer Center, Washington University School of Medicine, St Louis MO; 1 CADRG, National Cancer Institute
4:50-5:05 PM	NEW LUNG CANCER DRUGS FROM BRADYKININ ANTAGONISTS. J.M. Stewart*, L. Gera, D.C. Chan, P.A. Bunn, Jr., E.J. York, V. Simkeviciene, B. Helfrich, Department of Biochemistry and Cancer Center, University of Colorado Health Sciences Center, Denver, CO.
5:05-7:00 PM	POSTER VIEWING -- WINE AND CHEESE RECEPTION
Saturday June 7, 2003 -- Morning
Moderator - Richard A. Matthay, M.D.
8:00-8:45 AM	THOMAS A. NEFF LECTURE "FUTURE STRATEGIES FOR SCREENING" James R. Jett, M.D. Professor of Medicine Thoracic Diseases Mayo Medical School Rochester, Minnesota
8:45-9:00 AM	Discussion
9:00-9:15 AM	LUNG CANCER DETECTION IN ASYMPTOMATIC PATIENTS WITH AIRFLOW OBSTRUCTION. J.J. Bechtel*, W. Kelley, T. Coons, G. Klein, D. Slagel, T.L. Petty, Saccomanno Research Institute, St. Mary's Hospital, Grand Junction, Colorado and Health One Center, Denver, CO.
9:15-9:30 AM	BIMODALITY LUNG CANCER SCREENING IN HIGH RISK PATIENTS. G.M. Loewen*, M.E. Reid, D.F. Tan, D.L. Klippenstein, Z.D. Grossman, E. Nava, A.J. Hyland, M.K. Cummings, M.C. Mahoney, Roswell Park Cancer Institute, Buffalo, NY.
9:30-9:45 AM	DETECTION OF MAGE-A EXPRESSION IN SPUTUM AND BRONCHIAL LAVAGE FLUID OF PATIENTS WITH LUNG CANCER. I. Mecklenburg¹, R.M. Huber²*, D.F. Stratakis², K. Häussinger³, A. Morresi-Hauf4, G. Riethmüller¹, P. Kufer¹, ¹Institute of Immunology, Ludwig-Maximilians-University, Munich, GERMANY, ²Department of Pneumology, Medizinische Klinik Innenstadt, Ludwig-Maximillans-University, Munich, GERMANY, ³Department of Pneumology, Asklepios Fachkliniken München-Gauting, Munich, GERMANY, 4Department of Pathology, Asklepios Fachkliniken München-Gauting, Munich, GERMANY.
9:45-10:15 AM	......Coffee Break
10:15-11:00 AM	STATE OF THE ART "Experience with Surgical Intervention of Screen Detected Lung Cancer"	Masahiro Tsuboi, M.D. Tokyo Medical College
11:00-11:15 AM	Discussion
11:15-12:00 PM	CONFERENCE SUMMARY David P. Carbone, M.D., Ph.D. Department of Medicine and Cellular Biology Vanderbilt University Vanderbilt-Ingram Cancer Center Nashville, Tennessee
12:30 PM	Adjourn

POSTER VIEWING -- SOCIAL HOUR
Wednesday, June 4, 2003
5:00 PM

POSTERS

EVALUATION OF H37, A CANDIDATE 3P21.3 TUMOR SUPPRESSOR GENE, AS A THERAPEUTIC AND DIAGNOSTIC MARKER IN LUNG CANCER. J.J. Oh*, M.C. Fishbein, B. Boctor, C.A. Jimenez, R. Lopez, D.J. Slamon, Division of Hematology/Oncology and Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, CA.

INDUCTION OF TISSUE FACTOR PATHWAY INHIBITOR 2 (TFPI-2) EXPRESSION IN LUNG CANCER CELLS FOLLOWING SEQUENTIAL 5-Aza 2'-DEOXYCYTIDINE/DEPSIPEPTIDE FR-901228 EXPOSURE. F.A. Steiner, J.A. Hong, M.R. Fischette, E.S. Kassis, G.A. Chen, D.M. Nguyen, D.S. Schrump*, Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD.

TUMOR-ASSOCIATED MACROPHAGES CAN PROMOTE TUMOR PROGRESSION IN LUNG CANCER: GENE EXPRESSION PROFILE BY cDNA MICROARRAY ANALYSIS. P-C. Yang*, National Taiwan University College of Medicine and Institute of Biomedical Sciences, Academia Sinica, Taipei, TAIWAN.

MOLECULAR CLASSIFICATION OF LUNG CANCER: A CROSS PLATFORM COMPARISON OF GENE EXPRESSION DATA SETS. G. Parmigiani, E. Garrett, R. Anbazhagan, E. Gabrielson*, The Johns Hopkins University School of Medicine, Baltimore, MD.

class PREDICTION OF LUNG NODULE GENE EXPRESSION PROFILES. K.L. Walter*, A.C. Borczuk, L.Q. Wang, A.M. Assaad, J.H.M. Austin, G.D. Pearson, M.C. Shiau, C.A. Powell, Columbia University College of Physicians and Surgeons, New York, NY.

CONSTRUCTION AND OPTIMIZATION OF CHROMOSOME ARM-SPECIFIC COMPARATIVE GENOMIC HYBRIDIZATION ARRAYS FOR IDENTIFYING GENETIC ALTERATIONS IN PRE-INVASIVE LUNG CANCERS. C. Garnis¹, B. Coe¹, L-J. Henderson¹, A. Ishkanian¹, S. Watson¹, M. Marra¹, J. Minna², S. Lam¹, C. MacAulay¹, W. Lam*¹, ¹British Columbia Cancer Research Centre, Vancouver, BC, CANADA, ²Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX.

EFFICIENT IDENTIFICATION AND USE OF TUMOR-ASSOCIATED ANTIBODIES AS MARKERS OF NSCLC. L. Zhong, X. Peng, G.E. Hidalgo, D.E. Doherty, A.S. Stromberg, E.A. Hirschowitz*, Lexington VA Medical Center, University of Kentucky, Chandler Medical Center, Lexington, KY.

CAVEOLIN-1 IS DOWN-REGULATED IN HUMAN LUNG CARCINOMA AND ACTS AS A CANDIDATE TUMOR SUPPRESSOR GENE. M.M. Bélanger,*¹ ² H. Hirabayashi,¹ ² ³ É. Roussel,² C. Racine,² H. Matsuda,³ S. Miyoshi,³ H. Tanaka,³ J. Couet.² ¹These authors have contributed equally to this work; ²Unité de Recherche en Pneumologie, Institut Universitaire de Cardiologie et de Pneumologie de l'Université Laval, Centre de Recherche Hôpital Laval, Chemin Sainte-Foy, Sainte-Foy (Québec) CANADA, ³Department of Surgery, Osaka University Graduate School of Medicine, Yamadaoka, Suite, Osaka, JAPAN.

RETROVIRUS-INDUCED LUNG CANCER: MECHANISMS OF TRANSFORMATION OF ALVEOLAR TYPE II EPITHELIAL CELLS. J.C. DeMartini*¹, J.A. Platt¹, M. Evans², D.R. Voelker², T.E. Allen1, Department of Microbiology, Immunology and Pathology¹, Colorado State University, Fort Collins, CO, and National Jewish Medical and Research Center², Denver, CO.

SELECTIVE SUPPRESSION OF DENDRITIC CELL FUNCTIONS BY CIGARETTE SMOKE EXTRACT. R. Vassallo, L. Chen, Mayo Clinic, Rochester, MN.

BUCCAL - LUNG COMPARISON OF QUANTITATIVE EXPRESSION OF CARCINOGEN AND OXIDANT METABOLISM GENES IN HUMAN SUBJECTS. R.J. Jain, S. Varma, G.J. Hurteau, S.D. Spivack*, NYS Department of Health/SUNY School of Public Health, Albany, NY.

DIFFUSE IDIOPATHIC PULMONARY NEUROENDOCRINE CELL HYPERPLASIA AS A PRECURSOR TO PULMONARY NEUROENDOCRINE TUMOURS. J.R. Gosney*, Royal Liverpool University Hospital, Liverpool, UNITED KINGDOM.

CIGARETTE SMOKING, GENETIC SUSCEPTIBILITY AND RISK OF LUNG CANCER, A POPULATION-BASED CASE-CONTROL STUDY. Z-F. Zhang*¹, D.P. Tashkin², M. Hashibe¹, W. Cao¹, N-C. You¹, J. Fan¹, P-W. Wang¹, S. Greenland¹, J. Rao², W. Cozen³, T.M. Mack³, H. Morgenstern¹, UCLA Schools of ¹Public Health and ²Medicine, and ³USC School of Medicine.

SERUM LEVELS OF SURFACTANT PROTEIN D ARE INCREASED IN MICE WITH LUNG TUMORS. F. Zhang, W. Pao, S. Umphress, S. Jakowlew, A.M. Meyer, L.D. Dwyer-Nield, K. Takeda, E.W. Gelfand, J. Fisher, A.M. Malkinson, R.J. Mason*, University of Colorado, Denver, CO; Memorial Sloan Kettering Cancer Center, New York, NY; and National Cancer Institute, Rockville, MD.

HIGH PREVALENCE OF ENDOBRONCHIAL MALIGNANCY IN HIGH-RISK PATIENTS WHO HAVE MODERATE DYSPLASIA IN SPUTUM. T.C. Kennedy*, W.A. Franklin, S.A. Prindiville, R. Cook, E.C. Dempsey, R.L. Keith, F.R. Hirsch, T.A. Merrick, K. Shroyer, T.L. Petty, T. Byers, P.A. Bunn, Y.E. Miller, Specialized Program of Research Excellence (SPORE) in Lung Cancer, University of Colorado Cancer Center, Denver Veterans Affairs Medical Center and Lung Cancer Institute of Colorado/Health One Alliance, Denver, CO.

REGULATED GAP JUNCTION-CYTOSKELETAL ASSOCIATIONS IN RAT ALVEOLAR EPITHELIAL CELLS. Y. Guo, C. Martinez-Williams, D.E. Rannels*, Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA.

IMPROVEMENT AND APPLICATION OF FLUORESENCE INTER-SIMPLE SEQUENCE REPEAT PCR FOR THE STUDY OF SUBCLONAL GROWTHS IN LUNG EPITHELIAL CELL POPULATIONS. Tao Lu* and Walter N. Hittelman, Dept. of Experimental Therapeutics, UT MD Anderson Cancer Center, Houston, Texas

SPROUTY 2 IN MOUSE LUNG TUMORIGENESIS. G. Minowada*, Y.E. Miller, University Hospitals of Cleveland, Case Western Reserve University; Denver VAMC, University of Colorado Health Sciences Center, Denver, CO.

POSTER VIEWING -- WINE AND CHEESE RECEPTION
Friday, June 6, 2003
5:00-7:00 PM

POSTERS

A MULTI-CENTER STUDY COMPARING AUTOFLUORESCENCE BRONCHOSCOPY TO WHITE LIGHT BRONCHOSCOPY USING A NON-LASER LIGHT STIMULATION SYSTEM. J. Beamis*, Burlington, MA; A. Ernst, Boston, MA; M. Simoff, Detroit, MI; R. Yung, Baltimore, MD; P. Mathur, Indianapolis, IN.

MODELING OF PERIODIC SCREENING FOR LUNG CANCER OF SMOKERS WITH INCREASED MUTAGEN SENSITIVITY AND REDUCED DNA REPAIR CAPACITY: IMPACT ON POPULATION-BASED MORTALITY. O.Y. Gorlova, L. Lei, C. Amos, M. Spitz, C. Henschke, X. Wu, Q. Wei, M. Kimmel*, The U.T.M.D. Anderson Cancer Center, Houston, TX; New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY; Rice University, Houston, TX.

MODULATION OF BIOMARKERS DURING CHEMOPREVENTION OF MOUSE LUNG TUMORIGENESIS BY D-GLUCARATE. M. Hanausek*, Z. Walaszek. J. Szemraj, T.J. Slaga, AMC Cancer Research Center, Denver, CO.

MECHANISMS OF LUNG CANCER CHEMOPREVENTION BY D-GLUCARATE. Z. Walaszek*, M. Hanausek, M. Narog, P.C. Raich, T.J. Slaga, AMC Cancer Research Center, Denver, CO.

ROLE OF PARATHYROID HORMONE-RELATED PROTEIN IN LUNG CANCER CELL SURVIVAL. R.H. Hastings*, F. Araiza, D.W. Burton, L.J. Deftos, VA San Diego Health Care System, San Diego, CA.

POTENTIAL ROLE FOR ALCAM AND N-CADHERIN IN METASTASIS TO THE LUNG MICROCIRCULATION. J. King*1,2,4, S. Ofori-Acquah1,3, T. Stevens1,4, A-B. Al-Mehdi1,4, Center for Lung Biology¹, Department of Pathology², Department of Cell Biology and Neuroscience³, Department of Pharmacology4, University of South Alabama, Mobile, AL.

SPUTUM DYSPLASIA, RELATED TO BACTERIAL LOAD, OXIDATIVE STRESS AND AIRWAY INFLAMMATION IN COPD. P.E. Silkoff*, J. Tilstra, A. Busacker, J. Trudeau, M. Jackson, W. Franklin, National Jewish Medical and Research Center, Denver, CO and the University of Colorado Health Sciences Center (UCHSC), Denver, CO.

PHOSPHOAKT OVEREXPRESSION IN NON-SMALL CELL LUNG CANCER CONFERS SIGNIFICANT STAGE-INDEPENDENT SURVIVAL DISADVANTAGE. O. David¹*, H. LaBeau¹, A.R. Brody¹, M. Friedman¹, J. Jett², Program in Lung Biology, Departments of Pathology and Medicine, Tulane University Health Sciences Center, New Orleans, LA¹ and Division of Pulmonary Medicine, Mayo Clinic, Rochester, MN².

LUNG CANCER SCREENING USING LOW DOSE HRCT IN A HIGH RISK WORKFORCE (3500 NUCLEAR FUEL WORKERS IN THREE U.S. STATES). A. Miller*, S. Markowitz, A. Manowitz, J.A. Miller, Center for the Biology of Natural Systems, Queens College, SUNY, Flushing, NY.

ACTIVATION OF THE AKT/NF-KB SIGNALING AXIS IN DEVELOPING LUNG NEOPLASIA. J.W. Tichelaar*, Y. Zhang, J.C. leRiche^, S. Lam^, M.W. Anderson, University of Cincinnati, Cincinnati, OH and ^British Columbia Cancer Agency, Vancouver, BC, CANADA.

NEW TARGETS FOR DETECTION AND TREATMENT OF SMALL CELL LUNG CANCER. N. Pedersen, M.W. Pedersen, T.T. Poulsen, S. Mortensen, S.B. Sørensen, K. Rieneck¹, L.F. Bovin¹, H.S. Poulsen*, Department of Radiation Biology, Institute for Inflammation Research¹, National University Hospital, Copenhagen, Denmark.

EVIDENCE THAT INFLAMMATION ENCOURAGES PULMONARY ADENOCARCINOMA FORMATION IN MICE: CLINICAL IMPLICATIONS. A.M. Malkinson*, Department of Pharmaceutical Sciences and University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, CO.

USE OF START-PCR AND THE STANDARDIZED EXPRESSION MEASUREMENT CENTER IN MULTI-INSTITUTIONAL TRIALS TO DEVELOP MEANINGFUL LUNG CANCER CLASSIFICATION BASED ON MOLECULAR GENETIC CRITERIA. J.C. Willey*¹, C.R. Knight, E.L. Crawford¹, D.E. Olson, J. Hammersley, Y. Yoon, R. Assally, I. Sharief, A. Al-Astal, K.A. Warner¹, B.J. Austermiller, C.A. Motten, T. Graves, R. Zahorchak, E. Herness, A. Zaher, T. Osborn, A. Moreira, W.N. Rom, Departments of Medicine and Pathology, Medical College of Ohio, Toledo, OH, Departments of Medicine and Pathology, New York University, New York, NY, and Gene Express, Inc., Toledo, OH.

MODELING SMOKING-INDUCED LUNG CANCER IN MICE. J. Xu*, J. Tian, S.D. Shapiro, Brigham and Women's Hospital at Harvard Medical School, Boston, MA.

THE SDF-1/CXCL12/CXCR4 BIOLOGICAL AXIS IN NON-SMALL CELL LUNG CANCER METASTASES. J.A. Belperio*, R.J. Phillips, M.D. Burdick, M. Lutz, M.P. Keane, R.M. Strieter, Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Pathology, David Geffen School of Medicine at UCLA, Los Angeles, CA.

A PILOT EVALUATION OF MICROMETASTASES FOR THE PREDICTION OF OUTCOME IN LUNG CANCER. A.B. Thompson*, A. Kessinger, J.G. Sharp, Departments of Internal Medicine and Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE.

EFFECTS OF BUDESONIDE ON OVERALL 5-METHYLCYTOSINE LEVELS AND SPECIFIC METHYLATION AND MRNA EXPRESSION OF THE INSULIN-LIKE GROWTH FACTOR 2 GENE IN MOUSE LUNG TUMORS. Ronald Lubet*, Lianhui Tao; Wei Wang; Paula Kramer, Michael Perreira CADRG-DCP, Natl Cancer Inst. (Rockville MD); Dept. of Pathology , Medical College of Ohio (L.T., W.W., P. K., M. P. )

IMPROVED DIAGNOSTIC SENSITIVITY FOR LUNG CANCER USING AN AUTOMATED QUANTITATIVE CYTOLOGY (AQC) SYSTEM AND UTP-INDUCED SPUTUM SPECIMENS. F.L. Johnson*, B. Turic2, Roger Kemp2, B. Palcic2.3, R. Sussman4, K.G. Voelker5, E. Robinette6, R. ZuWallack7, M. Morganroth8, R. Yung9, S. Simon10, J. Osmanski11. 1Inspire Pharmaceuticals, Inc., Durham, NC; 2Perceptronix Medical Inc. Vancouver, Canada; 3British Columbia Cancer Agency, Vancouver, Canada; 4Pulmonary & Allergy Associates, Springfield, NJ; 5Lung Associates of Sarasota, Sarasota, FL; 6Abingdon Internal Medicine, Abingdon, VA; 7Saint Francis Hospital, Hartford, CT; 8The Oregon Clinic, Portland, OR; 9Johns Hopkins Hospital, Baltimore, MD; 10Southeast Research Associates, Austell, GA; 11Pulmonary Consultants of North Idaho, Coeur d'Alene, ID.

EXPRESSION OF SIALYL LEWIS ANTIGENS LINKED TO PATTERNS OF POSTOPERATIVE RECURRENCE AND POOR OUTCOME IN PATIENTS WITH NON-SMALL CELL LUNG CANCER. C-J. Yu*¹, Y-C. Lee², C-T. Sun³, P-C. Yang¹, Departments of Internal Medicine¹, Surgery², Pathology³, National Taiwan University Hospital, Taipei, Taiwan.

GP91PHOX-DEPENDENT EXPRESSION OF ANGIOGENIC CXC CHEMOKINES IN HUMAN NON-SMALL CELL LUNG CANCER. D. Arenberg*, S. Carskadon, V. Thannickal, Pulmonary and Critical Care, University of Michigan, Ann Arbor, MI.